Josep Saura

Summary

Country: Spain

Publications

  1. ncbi Intranigral infusion of interleukin-1beta activates astrocytes and protects from subsequent 6-hydroxydopamine neurotoxicity
    Josep Saura
    Experimental Neurology Laboratory, Neurological Service, Fundació Clínic, IDIBAPS, Barcelona, Spain
    J Neurochem 85:651-61. 2003
  2. ncbi Microglial apolipoprotein E and astroglial apolipoprotein J expression in vitro: opposite effects of lipopolysaccharide
    Josep Saura
    Department of Pharmacology, Toxicology and Psychiatry, Indiana School of Medicine, Indianapolis, Indiana, USA
    J Neurochem 85:1455-67. 2003
  3. ncbi High-yield isolation of murine microglia by mild trypsinization
    Josep Saura
    Department of Pharmacology and Toxicology, Institut d Investigacions Biomediques de Barcelona, IIBB CSIC, Barcelona, Spain
    Glia 44:183-9. 2003
  4. ncbi Absence of the cell cycle inhibitor p21Cip1 reduces LPS-induced NO release and activation of the transcription factor NF-kappaB in mixed glial cultures
    Josep Maria Tusell
    Department of Neurochemistry, Institut d Investigacions Biomediques de Barcelona, IIBB CSIC, IDIBAPS, Barcelona, Spain
    Glia 49:52-8. 2005
  5. ncbi Adenosine A2A receptor stimulation potentiates nitric oxide release by activated microglia
    Josep Saura
    Department of Pharmacology and Toxicology, IIBB, CSIC, IDIBAPS, Barcelona, Spain
    J Neurochem 95:919-29. 2005
  6. pmc Microglial cells in astroglial cultures: a cautionary note
    Josep Saura
    Department of Cerebral Ischaemia and Neurodegeneration, Institute for Biomedical Research of Barcelona IIBB, CSIC, IDIBAPS, 08036 Barcelona, Spain
    J Neuroinflammation 4:26. 2007
  7. doi Upregulation of p21Cip1 in activated glial cells
    Josep Maria Tusell
    Department of Cerebral Ischemia and Neurodegeneration, IIBB CSIC, IDIBAPS, Rossello 161, Barcelona, Spain
    Glia 57:524-34. 2009
  8. doi CCAAT/enhancer binding protein delta in microglial activation
    Aroa Ejarque-Ortiz
    Department of Cerebral Ischaemia and Neurodegeneration, IIBB, CSIC, IDIBAPS, Barcelona, Spain
    J Neurosci Res 88:1113-23. 2010
  9. pmc Pro-inflammatory gene expression and neurotoxic effects of activated microglia are attenuated by absence of CCAAT/enhancer binding protein β
    Marco Straccia
    Biochemistry and Molecular Biology Unit, School of Medicine, University of Barcelona, IDIBAPS, Barcelona, Spain
    J Neuroinflammation 8:156. 2011
  10. doi CCAAT/enhancer binding protein δ regulates glial proinflammatory gene expression
    Tony Valente
    Biochemistry and Molecular Biology Unit, School of Medicine, University of Barcelona, IDIBAPS, Barcelona, Spain
    Neurobiol Aging 34:2110-24. 2013

Collaborators

Detail Information

Publications24

  1. ncbi Intranigral infusion of interleukin-1beta activates astrocytes and protects from subsequent 6-hydroxydopamine neurotoxicity
    Josep Saura
    Experimental Neurology Laboratory, Neurological Service, Fundació Clínic, IDIBAPS, Barcelona, Spain
    J Neurochem 85:651-61. 2003
    ..These data show the characterization of a novel model of local astroglial activation in the substantia nigra and support the hypothesis of a neuroprotective role of activated astrocytes in Parkinson's disease...
  2. ncbi Microglial apolipoprotein E and astroglial apolipoprotein J expression in vitro: opposite effects of lipopolysaccharide
    Josep Saura
    Department of Pharmacology, Toxicology and Psychiatry, Indiana School of Medicine, Indianapolis, Indiana, USA
    J Neurochem 85:1455-67. 2003
    ..The transcription factor NF-kappa B appears to be a critical mediator of LPS-stimulated apoJ expression from astroglia...
  3. ncbi High-yield isolation of murine microglia by mild trypsinization
    Josep Saura
    Department of Pharmacology and Toxicology, Institut d Investigacions Biomediques de Barcelona, IIBB CSIC, Barcelona, Spain
    Glia 44:183-9. 2003
    ..Because of its high yield, it can be especially convenient when high amounts of microglial protein/mRNA are required or in cases in which the starting material is limited, such as microglial cultures from transgenic animals...
  4. ncbi Absence of the cell cycle inhibitor p21Cip1 reduces LPS-induced NO release and activation of the transcription factor NF-kappaB in mixed glial cultures
    Josep Maria Tusell
    Department of Neurochemistry, Institut d Investigacions Biomediques de Barcelona, IIBB CSIC, IDIBAPS, Barcelona, Spain
    Glia 49:52-8. 2005
    ..In contrast, TNF-alpha release was enhanced in p21Cip1-/- glia. These results suggest that the cell cycle inhibitor p21Cip1 plays a role in the inflammatory response induced by LPS...
  5. ncbi Adenosine A2A receptor stimulation potentiates nitric oxide release by activated microglia
    Josep Saura
    Department of Pharmacology and Toxicology, IIBB, CSIC, IDIBAPS, Barcelona, Spain
    J Neurochem 95:919-29. 2005
    ....
  6. pmc Microglial cells in astroglial cultures: a cautionary note
    Josep Saura
    Department of Cerebral Ischaemia and Neurodegeneration, Institute for Biomedical Research of Barcelona IIBB, CSIC, IDIBAPS, 08036 Barcelona, Spain
    J Neuroinflammation 4:26. 2007
    ....
  7. doi Upregulation of p21Cip1 in activated glial cells
    Josep Maria Tusell
    Department of Cerebral Ischemia and Neurodegeneration, IIBB CSIC, IDIBAPS, Rossello 161, Barcelona, Spain
    Glia 57:524-34. 2009
    ..Our results support a role for p21(Cip1) in the activation of glial cells, particularly in microglia...
  8. doi CCAAT/enhancer binding protein delta in microglial activation
    Aroa Ejarque-Ortiz
    Department of Cerebral Ischaemia and Neurodegeneration, IIBB, CSIC, IDIBAPS, Barcelona, Spain
    J Neurosci Res 88:1113-23. 2010
    ..These results point to C/EBP delta as a putative key regulator of proinflammatory gene expression in microglial activation...
  9. pmc Pro-inflammatory gene expression and neurotoxic effects of activated microglia are attenuated by absence of CCAAT/enhancer binding protein β
    Marco Straccia
    Biochemistry and Molecular Biology Unit, School of Medicine, University of Barcelona, IDIBAPS, Barcelona, Spain
    J Neuroinflammation 8:156. 2011
    ..To explore the functional role of C/EBPβ in glial activation we have analyzed pro-inflammatory gene expression and neurotoxicity in murine wild type and C/EBPβ-null glial cultures...
  10. doi CCAAT/enhancer binding protein δ regulates glial proinflammatory gene expression
    Tony Valente
    Biochemistry and Molecular Biology Unit, School of Medicine, University of Barcelona, IDIBAPS, Barcelona, Spain
    Neurobiol Aging 34:2110-24. 2013
    ....
  11. ncbi CCAAT/enhancer binding protein-alpha is down-regulated by toll-like receptor agonists in microglial cells
    Aroa Ejarque-Ortiz
    Department of Pharmacology and Toxicology, IIBB CSIC, IDIBAPS, Barcelona, Spain
    J Neurosci Res 85:985-93. 2007
    ..These findings suggest that C/EBPalpha down-regulation in activated microglia could play an important role in the increased expression of genes that are potentially pathogenic in a variety of neurological disorders...
  12. doi Inhibition of CCAAT/enhancer binding protein δ expression by chrysin in microglial cells results in anti-inflammatory and neuroprotective effects
    Núria Gresa-Arribas
    Department of Cerebral Ischemia and Neurodegeneration, Institut d Investigacions Biomèdiques de Barcelona Consejo Superior de Investigaciones Científicas CSIC, Barcelona, Spain
    J Neurochem 115:526-36. 2010
    ..Consequently, C/EBPδ is a possible target to act against neuroinflammation in neurodegenerative processes...
  13. ncbi Upregulation of CCAAT/enhancer binding protein beta in activated astrocytes and microglia
    Aroa Ejarque-Ortiz
    Department of Pharmacology and Toxicology, IIBB CSIC, IDIBAPS, E 08036 Barcelona, Spain
    Glia 55:178-88. 2007
    ..Given the nature of the C/EBPbeta-regulated genes, we hypothesize that this factor participates in neurotoxic effects associated with glial activation. (c) 2006 Wiley-Liss, Inc...
  14. pmc Modelling neuroinflammation in vitro: a tool to test the potential neuroprotective effect of anti-inflammatory agents
    Núria Gresa-Arribas
    Department of Cerebral Ischemia and Neurodegeneration, Institut d Investigacions Biomèdiques de Barcelona Consejo Superior de Investigaciones Científicas CSIC, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    PLoS ONE 7:e45227. 2012
    ..Consequently, among the anti-inflammatory agents, special attention should be paid to compounds that inhibit NO production...
  15. doi CCAAT/enhancer binding protein β regulates prostaglandin E synthase expression and prostaglandin E2 production in activated microglial cells
    Marco Straccia
    Biochemistry and Molecular Biology Unit, School of Medicine, University of Barcelona, IDIBAPS, Barcelona, Spain
    Glia 61:1607-19. 2013
    ..Altogether, these findings strengthen the proposed role of C/EBPβ as a key player in the orchestration of neuroinflammatory gene response...
  16. pmc Inhibition of CD200R1 expression by C/EBP β in reactive microglial cells
    Guido Dentesano
    Department of Cerebral Ischemia and Neurodegeneration, Institut d Investigacions Biomèdiques de Barcelona Consejo Superior de Investigaciones Científicas CSIC, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    J Neuroinflammation 9:165. 2012
    ..Little is known about the regulation of CD200R1 expression in microglia or possible alterations in the presence of pro-inflammatory stimuli...
  17. doi C/EBPβ expression in activated microglia in amyotrophic lateral sclerosis
    Tony Valente
    Biochemistry and Molecular Biology Unit, School of Medicine, University of Barcelona UB, IDIBAPS, Barcelona, Spain
    Neurobiol Aging 33:2186-99. 2012
    ....
  18. ncbi CD200R1 and CD200 expression are regulated by PPAR-γ in activated glial cells
    Guido Dentesano
    Department of Cerebral Ischemia and Neurodegeneration, Institut d Investigacions Biomèdiques de Barcelona Consejo Superior de Investigaciones Científicas CSIC, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    Glia 62:982-98. 2014
    ..These results suggest that PPAR-γ modulates CD200 and CD200R1 gene expression and that CD200-CD200R1 interaction is involved in the anti-inflammatory and neuroprotective action of PPAR-γ agonists...
  19. pmc Passive experimental autoimmune encephalomyelitis in C57BL/6 with MOG: evidence of involvement of B cells
    Francesco Mannara
    Center for Neuroimmunology, Service of Neurology, Hospital Clinic and Institut d Investigació Biomèdica August Pi i Sunyer IDIBAPS, Barcelona, Spain
    PLoS ONE 7:e52361. 2012
    ..The co-localization of these B cells with IgG and their predominant distribution in areas of demyelination would suggest that IgG-secreting B cells are involved in the neurodegenerative processes associated with at-EAE...
  20. ncbi Expression of C/EBPalpha and C/EBPbeta in glial cells in vitro after inducing glial activation by different stimuli
    Kamil Pérez-Capote
    Department of Pharmacology and Toxicology, Institut d Investigacions Biomèdiques de Barcelona Consejo Superior de Investigaciones Científicas, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    Neurosci Lett 410:25-30. 2006
    ..These results show that C/EBPbeta plays an active role in glial activation, but only when this involves an inflammatory reaction, suggesting a role for C/EBPbeta in neuroinflammation...
  21. doi Astrocytes are very sensitive to develop innate immune responses to lipid-carried short interfering RNA
    Roser Gorina
    Department of Brain Ischemia and Neurodegeneration, Institut d Investigacions Biomèdiques de Barcelona IIBB Consejo Superior de Investigaciones Científicas CSIC, IDIBAPS, Barcelona, Spain
    Glia 57:93-107. 2009
    ..The results show that, in astroglia, lipid-siRNA induces innate immune responses that are mediated, at least in part, by intracellular mechanism dependent on TLR7, TLR3, and helicases...
  22. ncbi Striatal 6-hydroxydopamine induces apoptosis of nigral neurons in the adult rat
    Maria J Marti
    Experimental Neurology Laboratory, Neurological Service, Fundació Clínic, Institut d Investigacions Biomèdiques Agustí Pi i Sunyer IDIBAPS, 08036, Barcelona, Spain
    Brain Res 958:185-91. 2002
    ..These data show that intrastriatal 6-hydroxydopamine-induced dopaminergic neuronal death in the adult rat is apoptotic and supports the use of this lesion protocol as an animal model of Parkinson's disease...
  23. ncbi RGD domains neuroprotect the immature brain by a glial-dependent mechanism
    Hugo Peluffo
    Medical Histology, Department of Cell Biology, Physiology and Immunology, Institute of Neurosciences, Autonomous University of Barcelona, Bellaterra, Spain
    Ann Neurol 62:251-61. 2007
    ..Previously, the gene therapy vector termed NLSCt, which displays an RGD motif, was shown to neuroprotect after immature brain excitotoxicity. We analyze whether neuroprotection is mediated by the RGD motif...
  24. ncbi Distribution of Clostridium perfringens epsilon toxin in the brains of acutely intoxicated mice and its effect upon glial cells
    Alex Soler-Jover
    Laboratori de Neurobiologia Cellular i Molecular, Departament de Patologia i Terapèutica Experimental, Campus de Bellvitge, Universitat de Barcelona IDIBELL, Spain
    Toxicon 50:530-40. 2007
    ..Moreover, cytotoxicity assays, performed with mixed glial primary cultures, demonstrate the cytotoxic effect of epsilon-toxin upon both astrocytes and microglial cells...