Carlos A Saura

Summary

Country: Spain

Publications

  1. pmc Short-term environmental enrichment rescues adult neurogenesis and memory deficits in APP(Sw,Ind) transgenic mice
    Jorge Valero
    Institut de Neurociencies, Department de Bioquimica i Biologia Molecular, Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas, Universitat Autonoma de Barcelona, Barcelona, Spain
    PLoS ONE 6:e16832. 2011
  2. pmc Presenilin/gamma-Secretase and Inflammation
    Carlos A Saura
    Institut de Neurociencies, Departament Bioquimica i Biologia Molecular, Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas CIBERNED, Universitat Autònoma de Barcelona Bellaterra, Spain
    Front Aging Neurosci 2:16. 2010
  3. doi CREB-regulated transcription coactivator 1-dependent transcription in Alzheimer's disease mice
    Carlos A Saura
    Institut de Neurociencies, Departament Bioquimica i Biologia Molecular, Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Neurodegener Dis 10:250-2. 2012
  4. doi The role of CREB signaling in Alzheimer's disease and other cognitive disorders
    Carlos A Saura
    Institut de Neurociencies, Departament Bioquimica i Biologia Molecular, Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas CIBERNED, Universitat Autonoma de Barcelona, E 08193 Bellaterra, Spain
    Rev Neurosci 22:153-69. 2011
  5. doi beta-Amyloid disrupts activity-dependent gene transcription required for memory through the CREB coactivator CRTC1
    Judit España
    Institut de Neurociencies, Universitat Autonoma de Barcelona, Barcelona, Spain
    J Neurosci 30:9402-10. 2010
  6. ncbi Crtc1 activates a transcriptional program deregulated at early Alzheimer's disease-related stages
    Arnaldo Parra-Damas
    Institut de Neurociencies, Department de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Barcelona 08193, Spain, and Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas CIBERNED and Institut de Neuropatologia, IDIBELL Hospital Universitari de Bellvitge, Universitat de Barcelona, Barcelona 08907, Spain
    J Neurosci 34:5776-87. 2014
  7. doi Intraneuronal beta-amyloid accumulation in the amygdala enhances fear and anxiety in Alzheimer's disease transgenic mice
    Judit España
    Institut de Neurociencies, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Biol Psychiatry 67:513-21. 2010
  8. pmc Ras protein activation is a key event in activity-dependent survival of cerebellar granule neurons
    Xavier Xifro
    From the Institut de Neurociencies and Department of Bioquímica i Biología Molecular, Universitat Autonoma de Barcelona, 08193 Cerdanyola del Valles, Spain
    J Biol Chem 289:8462-72. 2014
  9. pmc Bone morphogenetic protein-6 promotes cerebellar granule neurons survival by activation of the MEK/ERK/CREB pathway
    Bruna Barneda-Zahonero
    Institut de Neurociències and Departament de Bioquímica i Biologia Molecular, Universitat Autonoma de Barcelona, 08193 Cerdanyola del Valles, Barcelona, Spain
    Mol Biol Cell 20:5051-63. 2009
  10. pmc Soluble oligomers of amyloid-β peptide disrupt membrane trafficking of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor contributing to early synapse dysfunction
    Alfredo J Miñano-Molina
    Institut de Neurociències and Departament de Bioquímica i Biologia Molecular, Universitat Autonoma de Barcelona, 08193 Cerdanyola del Valles, Barcelona
    J Biol Chem 286:27311-21. 2011

Collaborators

Detail Information

Publications15

  1. pmc Short-term environmental enrichment rescues adult neurogenesis and memory deficits in APP(Sw,Ind) transgenic mice
    Jorge Valero
    Institut de Neurociencies, Department de Bioquimica i Biologia Molecular, Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas, Universitat Autonoma de Barcelona, Barcelona, Spain
    PLoS ONE 6:e16832. 2011
    ..These results suggest that promoting the survival and maturation of adult generated newborn neurons in the hippocampus may contribute to cognitive benefits in AD mouse models...
  2. pmc Presenilin/gamma-Secretase and Inflammation
    Carlos A Saura
    Institut de Neurociencies, Departament Bioquimica i Biologia Molecular, Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas CIBERNED, Universitat Autònoma de Barcelona Bellaterra, Spain
    Front Aging Neurosci 2:16. 2010
    ..Understanding the cellular mechanisms regulated by presenilin/gamma-secretase during chronic inflammatory processes may provide new approaches for the development of effective therapeutic strategies for AD...
  3. doi CREB-regulated transcription coactivator 1-dependent transcription in Alzheimer's disease mice
    Carlos A Saura
    Institut de Neurociencies, Departament Bioquimica i Biologia Molecular, Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Neurodegener Dis 10:250-2. 2012
    ..The molecular mechanisms underlying changes on activity-dependent gene expression in Alzheimer's disease (AD) are largely unknown...
  4. doi The role of CREB signaling in Alzheimer's disease and other cognitive disorders
    Carlos A Saura
    Institut de Neurociencies, Departament Bioquimica i Biologia Molecular, Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas CIBERNED, Universitat Autonoma de Barcelona, E 08193 Bellaterra, Spain
    Rev Neurosci 22:153-69. 2011
    ..We also discuss the development of novel therapeutic strategies based on CREB targeting to ameliorate cognitive decline in aging and cognitive disorders...
  5. doi beta-Amyloid disrupts activity-dependent gene transcription required for memory through the CREB coactivator CRTC1
    Judit España
    Institut de Neurociencies, Universitat Autonoma de Barcelona, Barcelona, Spain
    J Neurosci 30:9402-10. 2010
    ..These findings suggest that CRTC1 plays a key role in coupling synaptic activity to gene transcription required for hippocampal-dependent memory, and that Abeta could disrupt cognition by affecting CRTC1 function...
  6. ncbi Crtc1 activates a transcriptional program deregulated at early Alzheimer's disease-related stages
    Arnaldo Parra-Damas
    Institut de Neurociencies, Department de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Barcelona 08193, Spain, and Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas CIBERNED and Institut de Neuropatologia, IDIBELL Hospital Universitari de Bellvitge, Universitat de Barcelona, Barcelona 08907, Spain
    J Neurosci 34:5776-87. 2014
    ..Our results reveal a critical role of Crtc1-dependent transcription on spatial memory formation and provide the first evidence that targeting brain transcriptome reverses memory loss in AD. ..
  7. doi Intraneuronal beta-amyloid accumulation in the amygdala enhances fear and anxiety in Alzheimer's disease transgenic mice
    Judit España
    Institut de Neurociencies, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Biol Psychiatry 67:513-21. 2010
    ..In this study, we examined the pathological mechanisms of emotional behavior in well-established AD transgenic mice expressing human mutant beta-amyloid (Abeta) precursor protein (APP(Ind) and APP(Sw,Ind)) and tau (3xTg-AD)...
  8. pmc Ras protein activation is a key event in activity-dependent survival of cerebellar granule neurons
    Xavier Xifro
    From the Institut de Neurociencies and Department of Bioquímica i Biología Molecular, Universitat Autonoma de Barcelona, 08193 Cerdanyola del Valles, Spain
    J Biol Chem 289:8462-72. 2014
    ....
  9. pmc Bone morphogenetic protein-6 promotes cerebellar granule neurons survival by activation of the MEK/ERK/CREB pathway
    Bruna Barneda-Zahonero
    Institut de Neurociències and Departament de Bioquímica i Biologia Molecular, Universitat Autonoma de Barcelona, 08193 Cerdanyola del Valles, Barcelona, Spain
    Mol Biol Cell 20:5051-63. 2009
    ..Thus, this study demonstrates that BMP-6 acting through the noncanonical MEK/ERK/CREB pathway plays a crucial role on CGC survival...
  10. pmc Soluble oligomers of amyloid-β peptide disrupt membrane trafficking of α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptor contributing to early synapse dysfunction
    Alfredo J Miñano-Molina
    Institut de Neurociències and Departament de Bioquímica i Biologia Molecular, Universitat Autonoma de Barcelona, 08193 Cerdanyola del Valles, Barcelona
    J Biol Chem 286:27311-21. 2011
    ..These findings indicate that Aβ oligomers could act as a synaptic depressor affecting the mechanisms involved in the targeting of AMPARs to the synapses during early stages of the disease...
  11. pmc X-linked inhibitor of apoptosis protein negatively regulates neuronal differentiation through interaction with cRAF and Trk
    Rut Fadó
    Institut de Neurociències and Dpt Bioquímica and Biología Molecular, Universitat Autonoma de Barcelona, 08193 Cerdanyola del Valles, Spain
    Sci Rep 3:2397. 2013
    ..In addition, we found that XIAP binds to cRaf and Trk receptors. Our results demonstrate that XIAP plays a new role as a negative regulator of neurotrophin-induced neurite outgrowth and neuronal differentiation in developing neurons. ..
  12. pmc Nurr1 protein is required for N-methyl-D-aspartic acid (NMDA) receptor-mediated neuronal survival
    Bruna Barneda-Zahonero
    Institut de Neurociències and Departament de Bioquímica i Biologia Molecular, Universitat Autonoma de Barcelona, 08193 Barcelona, Spain
    J Biol Chem 287:11351-62. 2012
    ..Thus, we conclude that Nurr1 is a downstream target of CREB and that it is responsible for the NMDA-mediated increase in BDNF, which is necessary for the NMDA-mediated prosurvival effect on neurons...
  13. doi ATP and noradrenaline activate CREB in astrocytes via noncanonical Ca(2+) and cyclic AMP independent pathways
    Paulina Carriba
    Institut de Neurociencies, Universitat Autonoma de Barcelona, Spain
    Glia 60:1330-44. 2012
    ..Our data thus point to the existence of an alternative, non-neuronal, glia-based role of CREB in plasticity...
  14. doi Estradiol facilitates neurite maintenance by a Src/Ras/ERK signalling pathway
    Alfredo Miñano
    Institut de Neurociencies, Departament de Bioquimica i Biologia Molecular, Universitat Autonoma de Barcelona, Spain
    Mol Cell Neurosci 39:143-51. 2008
    ..Moreover, we demonstrate that 17beta-estradiol-mediated ERK activation is involved in the maintenance of neuritic arborisation and neuronal morphology in proapoptotic conditions...
  15. pmc Presenilin/γ-secretase regulates neurexin processing at synapses
    Carlos A Saura
    Institut de Neurociencies, Departament de Bioquimica i Biologia Molecular, Centro de Investigación Biomédica en Red Enfermedades Neurodegenerativas CIBERNED, Universitat Autonoma de Barcelona, Bellaterra, Barcelona, Spain
    PLoS ONE 6:e19430. 2011
    ..These results suggest that PS regulate the synaptic function and processing of neurexins at glutamatergic synapses, and that impaired neurexin processing by PS may play a role in FAD...