Francisco Orallo

Summary

Affiliation: Santiago de Compostela
Country: Spain

Publications

  1. ncbi request reprint Comparative study of the vasorelaxant activity, superoxide-scavenging ability and cyclic nucleotide phosphodiesterase-inhibitory effects of hesperetin and hesperidin
    Francisco Orallo
    Departamento de Farmacologia, Facultad de Farmacia, Universidad de Santiago de Compostela, Campus Universitario Sur, 15782 Santiago de Compostela La Coruña, Spain
    Naunyn Schmiedebergs Arch Pharmacol 370:452-63. 2004
  2. ncbi request reprint Acute cardiovascular effects of (+)-nantenine, an alkaloid isolated from Platycapnos spicata, in anaesthetised normotensive rats
    Francisco Orallo
    Departamento de Farmacologia, Facultad de Farmacia, Universidad de Santiago de Compostela, Spain
    Planta Med 70:117-26. 2004
  3. ncbi request reprint Pharmacological effects of (+)-nantenine, an alkaloid isolated from Platycapnos spicata, in several rat isolated tissues
    Francisco Orallo
    Departamento de Farmacologia, Facultad de Farmacia, Universidad de Santiago de Compostela, Spain
    Planta Med 69:135-42. 2003
  4. ncbi request reprint Trans-resveratrol: a magical elixir of eternal youth?
    Francisco Orallo
    Departamento de Farmacologia, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela La Coruña, Spain
    Curr Med Chem 15:1887-98. 2008
  5. ncbi request reprint Comparative studies of the antioxidant effects of cis- and trans-resveratrol
    F Orallo
    Departamento de Farmacologia, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela La Coruña Spain
    Curr Med Chem 13:87-98. 2006
  6. ncbi request reprint Implication of cyclic nucleotide phosphodiesterase inhibition in the vasorelaxant activity of the citrus-fruits flavonoid (+/-)-naringenin
    Francisco Orallo
    Departamento de Farmacologia, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela La Coruña, Spain
    Planta Med 71:99-107. 2005
  7. ncbi request reprint The possible implication of trans-Resveratrol in the cardioprotective effects of long-term moderate wine consumption
    Francisco Orallo
    Departamentos de Farmacologia, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela La Coruña, Espana
    Mol Pharmacol 61:294-302. 2002
  8. ncbi request reprint Preliminary study of the vasorelaxant effects of (+)-nantenine, an alkaloid isolated from Platycapnos spicata, in rat aorta
    F Orallo
    Departamento de Farmacologia, Facultad de Farmacia, Universidad de Santiago de Compostela, Spain
    Planta Med 67:800-6. 2001
  9. ncbi request reprint Preliminary study of the potential vasodilator effects on rat aorta of centaurein and centaureidin, two flavonoids from Centaurea corcubionensis
    F Orallo
    Departamento de Farmacologia, Facultad de Farmacia, Universidad de Santiago de Compostela, Spain
    Planta Med 64:116-9. 1998
  10. ncbi request reprint Antioxidant activity and inhibitory effects of hydralazine on inducible NOS/COX-2 gene and protein expression in rat peritoneal macrophages
    José M Leiro
    Laboratorio de Parasitologia, Instituto de Investigación y Análisis Alimentanós, Universidad de Santiago de Compostela, C Constantino Candeira s n, 15782, Santiago de Compostela, A Coruna, Spain
    Int Immunopharmacol 4:163-77. 2004

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Comparative study of the vasorelaxant activity, superoxide-scavenging ability and cyclic nucleotide phosphodiesterase-inhibitory effects of hesperetin and hesperidin
    Francisco Orallo
    Departamento de Farmacologia, Facultad de Farmacia, Universidad de Santiago de Compostela, Campus Universitario Sur, 15782 Santiago de Compostela La Coruña, Spain
    Naunyn Schmiedebergs Arch Pharmacol 370:452-63. 2004
    ..These results suggest that the vasorelaxant effects of hesperetin are basically due to the inhibition of PDE1 and PDE4 activities...
  2. ncbi request reprint Acute cardiovascular effects of (+)-nantenine, an alkaloid isolated from Platycapnos spicata, in anaesthetised normotensive rats
    Francisco Orallo
    Departamento de Farmacologia, Facultad de Farmacia, Universidad de Santiago de Compostela, Spain
    Planta Med 70:117-26. 2004
    ..Abbreviations. BP:blood pressure HR:heart rate 5-HT:5-hydroxytryptamine i. v.:intravenous L-NOARG: NG-nitro- L-arginine MAP:mean arterial pressure NO:nitric oxide PE:phenylephrine..
  3. ncbi request reprint Pharmacological effects of (+)-nantenine, an alkaloid isolated from Platycapnos spicata, in several rat isolated tissues
    Francisco Orallo
    Departamento de Farmacologia, Facultad de Farmacia, Universidad de Santiago de Compostela, Spain
    Planta Med 69:135-42. 2003
    ....
  4. ncbi request reprint Trans-resveratrol: a magical elixir of eternal youth?
    Francisco Orallo
    Departamento de Farmacologia, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela La Coruña, Spain
    Curr Med Chem 15:1887-98. 2008
    ..g.: rodents). Therefore, this review will basically focus on the possible role of t-RESV to extend life duration and on some of the mechanisms by which t-RESV may act as an anti-aging agent...
  5. ncbi request reprint Comparative studies of the antioxidant effects of cis- and trans-resveratrol
    F Orallo
    Departamento de Farmacologia, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela La Coruña Spain
    Curr Med Chem 13:87-98. 2006
    ..In this review, I will focus on the few comparative studies of the antioxidant effects of the two RESV isomers in different experimental models...
  6. ncbi request reprint Implication of cyclic nucleotide phosphodiesterase inhibition in the vasorelaxant activity of the citrus-fruits flavonoid (+/-)-naringenin
    Francisco Orallo
    Departamento de Farmacologia, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela La Coruña, Spain
    Planta Med 71:99-107. 2005
    ..3 mM), was totally inactive in all experiments. These results indicate that the vasorelaxant effects of (+/-)-naringenin seem to be basically related to the inhibition of PDE1, PDE4 and PDE5 activities...
  7. ncbi request reprint The possible implication of trans-Resveratrol in the cardioprotective effects of long-term moderate wine consumption
    Francisco Orallo
    Departamentos de Farmacologia, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela La Coruña, Espana
    Mol Pharmacol 61:294-302. 2002
    ....
  8. ncbi request reprint Preliminary study of the vasorelaxant effects of (+)-nantenine, an alkaloid isolated from Platycapnos spicata, in rat aorta
    F Orallo
    Departamento de Farmacologia, Facultad de Farmacia, Universidad de Santiago de Compostela, Spain
    Planta Med 67:800-6. 2001
    ....
  9. ncbi request reprint Preliminary study of the potential vasodilator effects on rat aorta of centaurein and centaureidin, two flavonoids from Centaurea corcubionensis
    F Orallo
    Departamento de Farmacologia, Facultad de Farmacia, Universidad de Santiago de Compostela, Spain
    Planta Med 64:116-9. 1998
    ..These results indicate that substitution by glucose in the chemical structure of centaureidin leads to the loss of its vasodilator activity...
  10. ncbi request reprint Antioxidant activity and inhibitory effects of hydralazine on inducible NOS/COX-2 gene and protein expression in rat peritoneal macrophages
    José M Leiro
    Laboratorio de Parasitologia, Instituto de Investigación y Análisis Alimentanós, Universidad de Santiago de Compostela, C Constantino Candeira s n, 15782, Santiago de Compostela, A Coruna, Spain
    Int Immunopharmacol 4:163-77. 2004
    ..These data suggest that hydralazine, at the concentrations tested, show antioxidant properties and strongly attenuates the macrophage activation...
  11. ncbi request reprint Effects of cis-resveratrol on inflammatory murine macrophages: antioxidant activity and down-regulation of inflammatory genes
    Jose Leiro
    Facultad de Farmacia, Universidad de Santiago de Compostela, Campus Universitario Sur, E 15782 Santiago de Compostela La Coruña, Spain
    J Leukoc Biol 75:1156-65. 2004
    ..and of the proinflammatory mediators NO(.-) and PGE(2))...
  12. doi request reprint A new series of 3-phenylcoumarins as potent and selective MAO-B inhibitors
    Maria Joao Matos
    Departamento de Quimica Organica, Facultad de Farmacia, 15782 Santiago de Compostela, Spain
    Bioorg Med Chem Lett 19:3268-70. 2009
    ..They show high selectivity to the MAO-B isoenzyme, with IC(50) values in the nanomolar range. Compound 5 is the most active compound and is several times more potent and selective than the reference compound, R-(-)-deprenyl...
  13. pmc Study of the mechanisms involved in the vasorelaxation induced by (-)-epigallocatechin-3-gallate in rat aorta
    Ezequiel Alvarez
    Departamento de Farmacologia, Facultad de Farmacia, Universidad de Santiago de Compostela, Campus Universitario Sur, Santiago de Compostela A Coruña, E 15782, Spain
    Br J Pharmacol 147:269-80. 2006
    ....
  14. ncbi request reprint (-)-Trans-epsilon-viniferin, a polyphenol present in wines, is an inhibitor of noradrenaline and 5-hydroxytryptamine uptake and of monoamine oxidase activity
    Matilde Yáñez
    Departamento de Farmacologia, Facultad de Farmacia, Universidad de Santiago de Compostela, Campus Universitario Sur, E 15782 Santiago de Compostela La Coruña, Spain
    Eur J Pharmacol 542:54-60. 2006
    ....
  15. ncbi request reprint Design, synthesis, and vasorelaxant and platelet antiaggregatory activities of coumarin-resveratrol hybrids
    Santiago Vilar
    Departamento de Quimica Organica, Facultad de Farmacia, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain
    Bioorg Med Chem Lett 16:257-61. 2006
    ..These results suggest that these novel compounds may have potential as structural templates for the design and subsequent development of new vasodilatory and platelet antiaggregatory drugs...
  16. ncbi request reprint Effects of (-)-epigallocatechin-3-gallate in Ca2+ -permeable non-selective cation channels and voltage-operated Ca2+ channels in vascular smooth muscle cells
    Manuel Campos-Toimil
    Departamento de Farmacoloxía, Facultade de Farmacia, Universidade de Santiago de Compostela, Campus Universitario Sur, E 15782 Santiago de Compostela A Coruña, Spain
    Life Sci 80:2147-53. 2007
    ..On the other hand, the inhibition of VOCC after > 10 min of incubation may be, in part, responsible for the relaxation of rat aorta induced by EGCG...
  17. ncbi request reprint Inhibitory effects of leaf extracts of Stachytarpheta jamaicensis (Verbenaceae) on the respiratory burst of rat macrophages
    Ezequiel Alvarez
    Departamento de Farmacologia, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela, Spain
    Phytother Res 18:457-62. 2004
    ..At 40 microg/ml, EAcE also inhibited XO activity. These results suggest that the EAcE extract of S. jamaicensis may be a potential pharmaceutical value in treatment of immunopathological diseases related to oxidative stress...
  18. ncbi request reprint Expression profiles of genes involved in the mouse nuclear factor-kappa B signal transduction pathway are modulated by mangiferin
    Jose Leiro
    Laboratorio de Parasitologia, Instituto de Investigacion y Analisis Alimentarios, Universidad de Santiago de Compostela, C Constantino Candeira s n, 15782 Santiago de Compostela, La Coruna, Spain
    Int Immunopharmacol 4:763-78. 2004
    ....
  19. doi request reprint Synthesis and evaluation of 6-methyl-3-phenylcoumarins as potent and selective MAO-B inhibitors
    Maria Joao Matos
    Departamento de Quimica Organica, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela, Spain
    Bioorg Med Chem Lett 19:5053-5. 2009
    ..Compound 4, with the methoxy group in meta position, is the most active of this series, with an IC(50) against MAO-B of 0.80 nM, and is several times more potent and MAO-B selective than the R-(-)-deprenyl (reference compound)...
  20. ncbi request reprint Inhibitory effects of cis- and trans-resveratrol on noradrenaline and 5-hydroxytryptamine uptake and on monoamine oxidase activity
    Matilde Yáñez
    Departamento de Farmacologia, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela La Coruña, Spain
    Biochem Biophys Res Commun 344:688-95. 2006
    ....
  21. ncbi request reprint Trans- and cis-resveratrol increase cytoplasmic calcium levels in A7r5 vascular smooth muscle cells
    Manuel Campos-Toimil
    Departamento de Farmacologia, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela A Coruña, Spain
    Mol Nutr Food Res 49:396-404. 2005
    ..Additionally, a direct activation of transmembrane Ca2+ influx through another type of channel may be also implicated...
  22. pmc In vitro effects of resveratrol on the viability and infectivity of the microsporidian Encephalitozoon cuniculi
    Jose Leiro
    Laboratorio de Parasitologia, Instituto de Investigacion y Analisis Alimentarios, Universidad de Santiago de Compostela, C Constantino Candeira s n, 15782 Santiago de Compostela, Spain
    Antimicrob Agents Chemother 48:2497-501. 2004
    ..At 10 microM RESV also significantly inhibited intracellular development of the parasite, without affecting host cell viability. These results suggest that RESV may be useful in the treatment of Encephalitozoon infections...
  23. ncbi request reprint (-)-Epigallocatechin-3-gallate induces contraction of the rat aorta by a calcium influx-dependent mechanism
    Ezequiel Alvarez-Castro
    Departamento de Farmacologia, Facultad de Farmacia, Universidad de Santiago de Compostela, Campus Universitario Sur, 15782 Santiago de Compostela, Spain
    Naunyn Schmiedebergs Arch Pharmacol 369:496-506. 2004
    ....
  24. ncbi request reprint In vitro effects of mangiferin on superoxide concentrations and expression of the inducible nitric oxide synthase, tumour necrosis factor-alpha and transforming growth factor-beta genes
    José Manuel Leiro
    Departamento de Microbiologia y Parasitologia, Universidad de Santiago de Compostela, Spain
    Biochem Pharmacol 65:1361-71. 2003
    ..In addition, the finding that MA enhances TGF-beta gene expression suggests that this polyphenol might also be of value in the prevention of cancer, autoimmune disorders, atherosclerosis and coronary heart disease...
  25. ncbi request reprint In vivo and in vitro pharmacological studies of a new hypotensive compound (QF0301B) in rat: comparison with prazosin, a known alpha1-adrenoceptor antagonist
    Francisco Orallo
    Department of Pharmacology, Faculty of Pharmacy, University of Santiago de Compostela, Campus Universitario Sur, Spain
    Vascul Pharmacol 40:97-108. 2003
    ....
  26. doi request reprint Resveratrol induces mitochondrial alterations, autophagy and a cryptobiosis-like state in scuticociliates
    Pedro Morais
    Laboratorio de Parasitologia, Departamento de Microbiologia y Parasitologia, Instituto de Investigacion y Analisis Alimentarios, Universidad de Santiago de Compostela, C Constantino Candeira s n, 15782, Santiago de Compostela La Coruña, Spain
    Protist 160:552-64. 2009
    ..dicentrarchi. The ciliate may therefore be a good experimental organism for identifying autophagy-inducing drugs with therapeutic potential in diseases in which autophagy plays a protective role...
  27. doi request reprint Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors
    Lourdes Santana
    Department of Organic Chemistry, Department of Pharmacology, Faculty of Pharmacy, University of Santiago de Compostela 15782, Spain
    J Med Chem 51:6740-51. 2008
    ..On the other hand, compounds 24 (IC 50 = 1.2 nM) and 28 (IC 50 = 1.5 nM) show higher activity than selegiline (IC 50 = 19.6 nM) and high MAO-B selectivity with 100-fold and 1600-fold inhibition levels, with respect to the MAO-A isoform...
  28. ncbi request reprint Resveratrol modulates rat macrophage functions
    J Leiro
    Departamento de Microbiologia y Parasitologia, Facultad de Farmacia, Universidad de Santiago de Compostela, Spain
    Int Immunopharmacol 2:767-74. 2002
    ....
  29. ncbi request reprint An Anacardiaceae preparation reduces the expression of inflammation-related genes in murine macrophages
    J Leiro
    Laboratorio de Parasitologia, Instituto de Investigaciones y Análisis Alimentarios, Universidad de Santiago de Compostela, Constantino Candeira, sn, 15782 Santiago de Compostela, Spain
    Int Immunopharmacol 4:991-1003. 2004
    ..These data indicate that the potent anti-inflammatory effects of Vimang are due to selective modulation of the expression of inflammation-related genes, leading to attenuation of macrophage activation...
  30. ncbi request reprint Effect of cis-resveratrol on genes involved in nuclear factor kappa B signaling
    J Leiro
    Laboratorio de Parasitologia, Instituto de Investigacion y Analisis Alimentarios, Universidad de Santiago de Compostela, Av Constatino Candeira s n, 15782 Santiago de Compostela, Spain
    Int Immunopharmacol 5:393-406. 2005
    ....
  31. ncbi request reprint Synthesis and vasorelaxant activity of new coumarin and furocoumarin derivatives
    Manuel Campos-Toimil
    Departamento de Farmacoloxía, Facultade de Farmacia, Universidade de Santiago de Compostela, Campus Universitario Sur, 15782 Santiago de Compostela, Galicia, Spain
    Bioorg Med Chem Lett 12:783-6. 2002
    ....
  32. ncbi request reprint Effect of (-)-epigallocatechin-3-gallate on respiratory burst of rat macrophages
    E Alvarez
    Departamento de Farmacologia, Facultad de Farmacia, Universidad de Santiago de Compostela, Spain
    Int Immunopharmacol 2:849-55. 2002
    ..EGCG may therefore be useful in the prevention and treatment of diseases due to increased free radical production...
  33. doi request reprint Resveratrol promotes an inhibitory effect on the turbot scuticociliate parasite Philasterides dicentrarchi by mechanisms related to cellular detoxification
    J Lamas
    Departamento de Biología Celular y Ecología, Facultad de Biologia, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain
    Vet Parasitol 161:307-15. 2009
    ..dicentrarchi is related to the induction of oxidative stress and to the inability of the parasite to eliminate ROS as a result of modified activity of antioxidant enzymes...
  34. pmc Study of the in vivo and in vitro cardiovascular effects of (+)-glaucine and N-carbethoxysecoglaucine in rats
    F Orallo
    , Facultad de Farmacia, Universidad de Santiago de Compostela, Spain
    Br J Pharmacol 114:1419-27. 1995
    ....
  35. doi request reprint Resveratrol modulates innate and inflammatory responses in fish leucocytes
    R Castro
    Departamento de Biología Celular y Ecología, Facultad de Biologia, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain
    Vet Immunol Immunopathol 126:9-19. 2008
    ....
  36. ncbi request reprint Effects of trans- and cis-resveratrol on Ca2+ handling in A7r5 vascular myocytes
    Manuel Campos-Toimil
    Departamento de Farmacoloxía, Facultade de Farmacia Universidade de Santiago de Compostela Campus Universitario Sur, E 15782, Santiago de Compostela, Spain
    Eur J Pharmacol 577:91-9. 2007
    ..Taken together, these effects may explain, in part, the endothelium-independent vasorelaxant effects of resveratrol in rat aorta...
  37. ncbi request reprint Effects of hydrazine derivatives on vascular smooth muscle contractility, blood pressure and cGMP production in rats: comparison with hydralazine
    Horacio Vidrio
    Departamento de Farmacologia, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Apartado Postal 70297, Mexico
    Vascul Pharmacol 40:13-21. 2003
    ..The fact that hydrazine and isoniazid produce methylene blue-sensitive relaxation, yet do not enhance cGMP production suggests the need for activating factors present in aortic rings but not in isolated cells...
  38. ncbi request reprint Hydralazine decreases sodium nitroprusside-induced rat aortic ring relaxation and increased cGMP production by rat aortic myocytes
    Horacio Vidrio
    Department of Pharmacology, School of Medicine, Universidad Nacional Autonoma de Mexico, Apartado Postal 70297, 04510 Mexico, D F, Mexico
    Life Sci 77:3105-16. 2005
    ..It was concluded that antagonism of sodium nitroprusside action by hydralazine could be a consequence of interference with bioactivation of the former, apparently through inhibition of vascular NADH oxidase...
  39. doi request reprint Synthesis, stereochemical identification, and selective inhibitory activity against human monoamine oxidase-B of 2-methylcyclohexylidene-(4-arylthiazol-2-yl)hydrazones
    Franco Chimenti
    Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Universita degli Studi di Roma La Sapienza, P le A Moro 5, 00185 Roma, Italy
    J Med Chem 51:4874-80. 2008
    ..A computational study was performed by molecular mechanics, DFT-based quantomechanics, and docking techniques on the most active and human MAO-B selective inhibitor 8...
  40. ncbi request reprint Functional characterization of serotonin receptors in rat isolated aorta
    María Villazón
    Department of Pharmacology, School of Pharmacy, A Coruna, Spain
    Biol Pharm Bull 25:584-90. 2002
    ....