Research Topics
Genomes and GenesSpecies | Francisco OralloSummaryAffiliation: Santiago de Compostela Country: Spain Publications
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Publications
Comparative study of the vasorelaxant activity, superoxide-scavenging ability and cyclic nucleotide phosphodiesterase-inhibitory effects of hesperetin and hesperidinFrancisco Orallo
Departamento de Farmacologia, Facultad de Farmacia, Universidad de Santiago de Compostela, Campus Universitario Sur, 15782 Santiago de Compostela La Coruña, Spain
Naunyn Schmiedebergs Arch Pharmacol 370:452-63. 2004..These results suggest that the vasorelaxant effects of hesperetin are basically due to the inhibition of PDE1 and PDE4 activities...- Acute cardiovascular effects of (+)-nantenine, an alkaloid isolated from Platycapnos spicata, in anaesthetised normotensive ratsFrancisco Orallo
Departamento de Farmacologia, Facultad de Farmacia, Universidad de Santiago de Compostela, Spain
Planta Med 70:117-26. 2004..Abbreviations. BP:blood pressure HR:heart rate 5-HT:5-hydroxytryptamine i. v.:intravenous L-NOARG: NG-nitro- L-arginine MAP:mean arterial pressure NO:nitric oxide PE:phenylephrine.. - Pharmacological effects of (+)-nantenine, an alkaloid isolated from Platycapnos spicata, in several rat isolated tissuesFrancisco Orallo
Departamento de Farmacologia, Facultad de Farmacia, Universidad de Santiago de Compostela, Spain
Planta Med 69:135-42. 2003.... - Trans-resveratrol: a magical elixir of eternal youth?Francisco Orallo
Departamento de Farmacologia, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela La Coruña, Spain
Curr Med Chem 15:1887-98. 2008..g.: rodents). Therefore, this review will basically focus on the possible role of t-RESV to extend life duration and on some of the mechanisms by which t-RESV may act as an anti-aging agent... - Comparative studies of the antioxidant effects of cis- and trans-resveratrolF Orallo
Departamento de Farmacologia, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela La Coruña Spain
Curr Med Chem 13:87-98. 2006..In this review, I will focus on the few comparative studies of the antioxidant effects of the two RESV isomers in different experimental models... - Implication of cyclic nucleotide phosphodiesterase inhibition in the vasorelaxant activity of the citrus-fruits flavonoid (+/-)-naringeninFrancisco Orallo
Departamento de Farmacologia, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela La Coruña, Spain
Planta Med 71:99-107. 2005..3 mM), was totally inactive in all experiments. These results indicate that the vasorelaxant effects of (+/-)-naringenin seem to be basically related to the inhibition of PDE1, PDE4 and PDE5 activities... - The possible implication of trans-Resveratrol in the cardioprotective effects of long-term moderate wine consumptionFrancisco Orallo
Departamentos de Farmacologia, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela La Coruña, Espana
Mol Pharmacol 61:294-302. 2002.... - Preliminary study of the vasorelaxant effects of (+)-nantenine, an alkaloid isolated from Platycapnos spicata, in rat aortaF Orallo
Departamento de Farmacologia, Facultad de Farmacia, Universidad de Santiago de Compostela, Spain
Planta Med 67:800-6. 2001.... - Preliminary study of the potential vasodilator effects on rat aorta of centaurein and centaureidin, two flavonoids from Centaurea corcubionensisF Orallo
Departamento de Farmacologia, Facultad de Farmacia, Universidad de Santiago de Compostela, Spain
Planta Med 64:116-9. 1998..These results indicate that substitution by glucose in the chemical structure of centaureidin leads to the loss of its vasodilator activity... - Antioxidant activity and inhibitory effects of hydralazine on inducible NOS/COX-2 gene and protein expression in rat peritoneal macrophagesJosé M Leiro
Laboratorio de Parasitologia, Instituto de Investigación y Análisis Alimentanós, Universidad de Santiago de Compostela, C Constantino Candeira s n, 15782, Santiago de Compostela, A Coruna, Spain
Int Immunopharmacol 4:163-77. 2004..These data suggest that hydralazine, at the concentrations tested, show antioxidant properties and strongly attenuates the macrophage activation... - Effects of cis-resveratrol on inflammatory murine macrophages: antioxidant activity and down-regulation of inflammatory genesJose Leiro
Facultad de Farmacia, Universidad de Santiago de Compostela, Campus Universitario Sur, E 15782 Santiago de Compostela La Coruña, Spain
J Leukoc Biol 75:1156-65. 2004..and of the proinflammatory mediators NO(.-) and PGE(2))... 
A new series of 3-phenylcoumarins as potent and selective MAO-B inhibitorsMaria Joao Matos
Departamento de Quimica Organica, Facultad de Farmacia, 15782 Santiago de Compostela, Spain
Bioorg Med Chem Lett 19:3268-70. 2009..They show high selectivity to the MAO-B isoenzyme, with IC(50) values in the nanomolar range. Compound 5 is the most active compound and is several times more potent and selective than the reference compound, R-(-)-deprenyl...
Study of the mechanisms involved in the vasorelaxation induced by (-)-epigallocatechin-3-gallate in rat aortaEzequiel Alvarez
, Facultad de Farmacia, Universidad de Santiago de Compostela, Campus Universitario Sur, , E-15782, Spain
Br J Pharmacol 147:269-80. 2006....- (-)-Trans-epsilon-viniferin, a polyphenol present in wines, is an inhibitor of noradrenaline and 5-hydroxytryptamine uptake and of monoamine oxidase activityMatilde Yáñez
Departamento de Farmacologia, Facultad de Farmacia, Universidad de Santiago de Compostela, Campus Universitario Sur, E 15782 Santiago de Compostela La Coruña, Spain
Eur J Pharmacol 542:54-60. 2006.... - Design, synthesis, and vasorelaxant and platelet antiaggregatory activities of coumarin-resveratrol hybridsSantiago Vilar
Departamento de Quimica Organica, Facultad de Farmacia, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain
Bioorg Med Chem Lett 16:257-61. 2006..These results suggest that these novel compounds may have potential as structural templates for the design and subsequent development of new vasodilatory and platelet antiaggregatory drugs... - Effects of (-)-epigallocatechin-3-gallate in Ca2+ -permeable non-selective cation channels and voltage-operated Ca2+ channels in vascular smooth muscle cellsManuel Campos Toimil
Departamento de Farmacoloxía, Facultade de Farmacia, Universidade de Santiago de Compostela, Campus Universitario Sur, E 15782 Santiago de Compostela A Coruña, Spain
Life Sci 80:2147-53. 2007..On the other hand, the inhibition of VOCC after > 10 min of incubation may be, in part, responsible for the relaxation of rat aorta induced by EGCG... - Expression profiles of genes involved in the mouse nuclear factor-kappa B signal transduction pathway are modulated by mangiferinJose Leiro
Laboratorio de Parasitologia, Instituto de Investigacion y Analisis Alimentarios, Universidad de Santiago de Compostela, C Constantino Candeira s n, 15782 Santiago de Compostela, La Coruna, Spain
Int Immunopharmacol 4:763-78. 2004.... - Synthesis and evaluation of 6-methyl-3-phenylcoumarins as potent and selective MAO-B inhibitorsMaria Joao Matos
Departamento de Quimica Organica, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela, Spain
Bioorg Med Chem Lett 19:5053-5. 2009..Compound 4, with the methoxy group in meta position, is the most active of this series, with an IC(50) against MAO-B of 0.80 nM, and is several times more potent and MAO-B selective than the R-(-)-deprenyl (reference compound)... - Inhibitory effects of cis- and trans-resveratrol on noradrenaline and 5-hydroxytryptamine uptake and on monoamine oxidase activityMatilde Yáñez
Departamento de Farmacologia, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela La Coruña, Spain
Biochem Biophys Res Commun 344:688-95. 2006.... - Inhibitory effects of leaf extracts of Stachytarpheta jamaicensis (Verbenaceae) on the respiratory burst of rat macrophagesEzequiel Alvarez
, Facultad de Farmacia, Universidad de Santiago de Compostela, Santiago de Compostela, Spain
Phytother Res 18:457-62. 2004..At 40 microg/ml, EAcE also inhibited XO activity. These results suggest that the EAcE extract of S. jamaicensis may be a potential pharmaceutical value in treatment of immunopathological diseases related to oxidative stress... - Trans- and cis-resveratrol increase cytoplasmic calcium levels in A7r5 vascular smooth muscle cellsManuel Campos-Toimil
, Facultad de Farmacia, Universidad de Santiago de Compostela, , Spain
Mol Nutr Food Res 49:396-404. 2005..Additionally, a direct activation of transmembrane Ca2+ influx through another type of channel may be also implicated... - In vitro effects of resveratrol on the viability and infectivity of the microsporidian Encephalitozoon cuniculiJose Leiro
Laboratorio de Parasitologia, Instituto de Investigacion y Analisis Alimentarios, Universidad de Santiago de Compostela, C Constantino Candeira s n, 15782 Santiago de Compostela, Spain
Antimicrob Agents Chemother 48:2497-501. 2004..At 10 microM RESV also significantly inhibited intracellular development of the parasite, without affecting host cell viability. These results suggest that RESV may be useful in the treatment of Encephalitozoon infections... - (-)-Epigallocatechin-3-gallate induces contraction of the rat aorta by a calcium influx-dependent mechanismEzequiel Alvarez-Castro
Departamento de Farmacologia, Facultad de Farmacia, Universidad de Santiago de Compostela, Campus Universitario Sur, 15782 Santiago de Compostela, Spain
Naunyn Schmiedebergs Arch Pharmacol 369:496-506. 2004.... - In vitro effects of mangiferin on superoxide concentrations and expression of the inducible nitric oxide synthase, tumour necrosis factor-alpha and transforming growth factor-beta genesJosé Manuel Leiro
Departamento de Microbiologia y Parasitologia, Universidad de Santiago de Compostela, Spain
Biochem Pharmacol 65:1361-71. 2003..In addition, the finding that MA enhances TGF-beta gene expression suggests that this polyphenol might also be of value in the prevention of cancer, autoimmune disorders, atherosclerosis and coronary heart disease... - In vivo and in vitro pharmacological studies of a new hypotensive compound (QF0301B) in rat: comparison with prazosin, a known alpha1-adrenoceptor antagonistFrancisco Orallo
Department of Pharmacology, Faculty of Pharmacy, University of Santiago de Compostela, Campus Universitario Sur, Spain
Vascul Pharmacol 40:97-108. 2003.... - Resveratrol induces mitochondrial alterations, autophagy and a cryptobiosis-like state in scuticociliatesPedro Morais
Laboratorio de Parasitologia, Departamento de Microbiologia y Parasitologia, Instituto de Investigacion y Analisis Alimentarios, Universidad de Santiago de Compostela, C Constantino Candeira s n, 15782, Santiago de Compostela La Coruña, Spain
Protist 160:552-64. 2009..dicentrarchi. The ciliate may therefore be a good experimental organism for identifying autophagy-inducing drugs with therapeutic potential in diseases in which autophagy plays a protective role... - Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitorsLourdes Santana
Department of Organic Chemistry, Department of Pharmacology, Faculty of Pharmacy, University of Santiago de Compostela 15782, Spain
J Med Chem 51:6740-51. 2008..On the other hand, compounds 24 (IC 50 = 1.2 nM) and 28 (IC 50 = 1.5 nM) show higher activity than selegiline (IC 50 = 19.6 nM) and high MAO-B selectivity with 100-fold and 1600-fold inhibition levels, with respect to the MAO-A isoform... - Resveratrol modulates rat macrophage functionsJ Leiro
Departamento de Microbiologia y Parasitologia, Facultad de Farmacia, Universidad de Santiago de Compostela, Spain
Int Immunopharmacol 2:767-74. 2002.... - An Anacardiaceae preparation reduces the expression of inflammation-related genes in murine macrophagesJ Leiro
Laboratorio de Parasitologia, Instituto de Investigaciones y Análisis Alimentarios, Universidad de Santiago de Compostela, Constantino Candeira, sn, 15782 Santiago de Compostela, Spain
Int Immunopharmacol 4:991-1003. 2004..These data indicate that the potent anti-inflammatory effects of Vimang are due to selective modulation of the expression of inflammation-related genes, leading to attenuation of macrophage activation... - Effect of cis-resveratrol on genes involved in nuclear factor kappa B signalingJ Leiro
Laboratorio de Parasitologia, Instituto de Investigacion y Analisis Alimentarios, Universidad de Santiago de Compostela, Av Constatino Candeira s n, 15782 Santiago de Compostela, Spain
Int Immunopharmacol 5:393-406. 2005.... - Synthesis and vasorelaxant activity of new coumarin and furocoumarin derivativesManuel Campos-Toimil
Departamento de Farmacoloxía, Facultade de Farmacia, Universidade de Santiago de Compostela, Campus Universitario Sur, 15782 Santiago de Compostela, Galicia, Spain
Bioorg Med Chem Lett 12:783-6. 2002.... - Effect of (-)-epigallocatechin-3-gallate on respiratory burst of rat macrophagesE Alvarez
, Facultad de Farmacia, Universidad de Santiago de Compostela, Spain
Int Immunopharmacol 2:849-55. 2002..EGCG may therefore be useful in the prevention and treatment of diseases due to increased free radical production... - Resveratrol promotes an inhibitory effect on the turbot scuticociliate parasite Philasterides dicentrarchi by mechanisms related to cellular detoxificationJ Lamas
Departamento de Biología Celular y Ecología, Facultad de Biologia, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain
Vet Parasitol 161:307-15. 2009..dicentrarchi is related to the induction of oxidative stress and to the inability of the parasite to eliminate ROS as a result of modified activity of antioxidant enzymes... - Study of the in vivo and in vitro cardiovascular effects of (+)-glaucine and N-carbethoxysecoglaucine in ratsF Orallo
, Facultad de Farmacia, Universidad de Santiago de Compostela, Spain
Br J Pharmacol 114:1419-27. 1995.... - Resveratrol modulates innate and inflammatory responses in fish leucocytesR Castro
Departamento de Biología Celular y Ecología, Facultad de Biologia, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain
Vet Immunol Immunopathol 126:9-19. 2008.... - Effects of trans- and cis-resveratrol on Ca2+ handling in A7r5 vascular myocytesManuel Campos Toimil
Departamento de Farmacoloxía, Facultade de Farmacia Universidade de Santiago de Compostela Campus Universitario Sur, E 15782, Santiago de Compostela, Spain
Eur J Pharmacol 577:91-9. 2007..Taken together, these effects may explain, in part, the endothelium-independent vasorelaxant effects of resveratrol in rat aorta... - Effects of hydrazine derivatives on vascular smooth muscle contractility, blood pressure and cGMP production in rats: comparison with hydralazineHoracio Vidrio
Departamento de Farmacologia, Facultad de Medicina, Universidad Nacional Autonoma de Mexico, Apartado Postal 70297, Mexico
Vascul Pharmacol 40:13-21. 2003..The fact that hydrazine and isoniazid produce methylene blue-sensitive relaxation, yet do not enhance cGMP production suggests the need for activating factors present in aortic rings but not in isolated cells... - Hydralazine decreases sodium nitroprusside-induced rat aortic ring relaxation and increased cGMP production by rat aortic myocytesHoracio Vidrio
Department of Pharmacology, School of Medicine, Universidad Nacional Autonoma de Mexico, Apartado Postal 70297, 04510 Mexico, D F, Mexico
Life Sci 77:3105-16. 2005..It was concluded that antagonism of sodium nitroprusside action by hydralazine could be a consequence of interference with bioactivation of the former, apparently through inhibition of vascular NADH oxidase... - Synthesis, stereochemical identification, and selective inhibitory activity against human monoamine oxidase-B of 2-methylcyclohexylidene-(4-arylthiazol-2-yl)hydrazonesFranco Chimenti
Dipartimento di Studi di Chimica e Tecnologia delle Sostanze Biologicamente Attive, Universita degli Studi di Roma La Sapienza, P le A Moro 5, 00185 Roma, Italy
J Med Chem 51:4874-80. 2008..A computational study was performed by molecular mechanics, DFT-based quantomechanics, and docking techniques on the most active and human MAO-B selective inhibitor 8... - Functional characterization of serotonin receptors in rat isolated aortaMaría Villazón
Department of Pharmacology, School of Pharmacy, A Coruna, Spain
Biol Pharm Bull 25:584-90. 2002....