Research Topics
Genomes and Genes
| Ruben NogueirasSummaryAffiliation: Santiago de Compostela Country: Spain Publications
| Collaborators
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Detail Information
Publications
Ghrelin: new molecular pathways modulating appetite and adiposityRuben Nogueiras
Department of Physiology, University of Santiago de Compostela, Santiago de Compostela, Spain
Obes Facts 3:285-92. 2010..This review aims to summarize novel roles of ghrelin in energy balance, focusing particularly on both the newly identified neuronal pathways mediating the effects of ghrelin and on peripheral mechanisms leading to increased adiposity...
The central Sirtuin 1/p53 pathway is essential for the orexigenic action of ghrelinDouglas A Velásquez
Department of Physiology, School of Medicine Instituto de Investigaciones Sanitarias IDIS, University of Santiago de Compostela, Santiago de Compostela, Spain
Diabetes 60:1177-85. 2011..We tested the hypothesis that the central SIRT1/p53 pathway might be mediating the orexigenic action of ghrelin...- Mice lacking δ-opioid receptors resist the development of diet-induced obesityTraci A Czyzyk
Obesity Research, Lilly Research Laboratories, Indianapolis, Indiana, USA
FASEB J 26:3483-92. 2012..05) in response to an HED. These findings reveal a novel role of DOR in the control of thermogenic markers and energy expenditure, and they provide a potential new therapeutic approach for the treatment of obesity... - The L-α-lysophosphatidylinositol/GPR55 system and its potential role in human obesityJosé María Moreno-Navarrete
Department of Diabetes, Endocrinology, and Nutrition, Institut d Investigació Biomédica de Girona Catalonia, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición, Girona, Spain
Diabetes 61:281-91. 2012..These findings indicate that the LPI/GPR55 system is positively associated with obesity in humans... - Regulation of lipid metabolism by energy availability: a role for the central nervous systemR Nogueiras
Department of Physiology, School of Medicine Instituto de Investigación Sanitaria IDIS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain
Obes Rev 11:185-201. 2010.... - The endocannabinoid system: role in glucose and energy metabolismRuben Nogueiras
Department of Physiology, University of Santiago de Compostela Instituto de Investigación Sanitaria IDIS, Santiago de Compostela 15782, Spain
Pharmacol Res 60:93-8. 2009..In obese states, endocannabinoid levels are increased and might exert unfavorable effects on insulin-sensitive tissues. This review summarizes the effects of the endocannabinoid system on glucose metabolism in humans and rodents... - Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesityRuben Nogueiras
Department of Psychiatry, Obesity Research Centre, University of Cincinnati, Cincinnati, Ohio 45226, USA
J Neurosci 29:5916-25. 2009..Importantly, the CNS GLP-1 system loses the capacity to modulate adipocyte metabolism in obese states, suggesting an obesity-induced adipocyte resistance to CNS GLP-1... - Peripheral, but not central, CB1 antagonism provides food intake-independent metabolic benefits in diet-induced obese ratsRuben Nogueiras
Department of Psychiatry, Obesity Research Centre, Genome Research Institute, University of Cincinnati, Cincinnati, Ohio, USA
Diabetes 57:2977-91. 2008.... - Ghrelin effects on neuropeptides in the rat hypothalamus depend on fatty acid metabolism actions on BSX but not on genderRicardo Lage
Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela A Coruña, Spain
FASEB J 24:2670-9. 2010..Notably, this effect is associated with decreased BSX expression and reduced food intake. Overall, our data suggest that BSX integrates changes in neuronal metabolic status with ARC-derived neuropeptides in a gender-independent manner... - Regulation of lipin1 by nutritional status, adiponectin, sex and pituitary function in rat white adipose tissueC Ruth González
Department of Physiology, School of Medicine Instituto de Investigaciones Sanitarias IDIS, University of Santiago de Compostela, Spain
Physiol Behav 105:777-83. 2012..To dissect the complicated interactions between key regulators of lipid metabolism like lipin1, may be important for the development of new therapies for the treatment and prevention of obesity and its associated disorders... - Ghrelin and lipid metabolism: key partners in energy balanceLuis Varela
Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela A Coruña 15782, Spain
J Mol Endocrinol 46:R43-63. 2011..Understanding this new metabolic pathway can provide new therapeutic targets for the treatment of obesity and the metabolic syndrome... - Hypothalamic mTOR pathway mediates thyroid hormone-induced hyperphagia in hyperthyroidismLuis Varela
Department of Physiology, School of Medicine CIMUS, University of Santiago de Compostela, Instituto de Investigacion Sanitaria, Santiago de Compostela A Coruña 15782, Spain
J Pathol 227:209-22. 2012.... - Action profile of the antiobesity drug candidate oleoyl-estrone in ratsSabine Strassburg
Obesity Research Center, Department of Internal Medicine, University of Cincinnati Metabolic Diseases Institute, Cincinnati, Ohio, USA
Obesity (Silver Spring) 18:2260-7. 2010..The present data suggest that OE decreases food intake and body weight but also appears to cause a significant impact on the hypothalamus-pituitary-reproductive axis... - Melanocortin signaling in the CNS directly regulates circulating cholesterolDiego Perez-Tilve
Metabolic Diseases Institute, Division of Endocrinology, Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
Nat Neurosci 13:877-82. 2010..Our data suggest that a neural circuit in the brain is directly involved in the control of cholesterol metabolism by the liver... 
Orexin-A regulates growth hormone-releasing hormone mRNA content in a nucleus-specific manner and somatostatin mRNA content in a growth hormone-dependent fashion in the rat hypothalamusMiguel Lopez
Department of Physiology School of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain
Eur J Neurosci 19:2080-8. 2004..These data improve our understanding of the interactions among the different systems involved in the control and pathophysiology of food intake, sleep and GH secretion...- Nicotine induces negative energy balance through hypothalamic AMP-activated protein kinasePablo B Martínez de Morentin
Department of Physiology, School of Medicine CIMUS, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela, A Coruna, Spain
Diabetes 61:807-17. 2012..Overall these data demonstrate that the effects of nicotine on energy balance involve specific modulation of the hypothalamic AMPK-BAT axis. These targets may be relevant for the development of new therapies for human obesity... - Adiponectin receptor 2 is regulated by nutritional status, leptin and pregnancy in a tissue-specific mannerCarmen Ruth González
Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, 15782 Santiago de Compostela, Spain
Physiol Behav 99:91-9. 2010.... - Central nervous system regulation of energy metabolism: ghrelin versus leptinRuben Nogueiras
Obesity Research Center, Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio, USA
Ann N Y Acad Sci 1126:14-9. 2008..Rather than comprehensively discussing the field, we instead will discuss some of the key findings made regarding the interaction of the hormones ghrelin and leptin with the CNS... - The central melanocortin system directly controls peripheral lipid metabolismRuben Nogueiras
Obesity Research Center, Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237, USA
J Clin Invest 117:3475-88. 2007..We also reveal molecular underpinnings for direct control of the CNS-Mcr over lipid metabolism. These results suggest ways to design more efficient pharmacological methods for controlling adiposity... - Hyperthyroidism differentially regulates neuropeptide S system in the rat brainCarmen R González
Department of Physiology, School of Medicine CIMUS, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela A Coruña, Spain
Brain Res 1450:40-8. 2012..Thus, the NPS/NPS-R system may be involved in several hyperthyroidism-associated comorbidities... - Ghrelin, peptide YY and their hypothalamic targets differentially regulate spontaneous physical activityPaul T Pfluger
Obesity Research Center, Dept of Internal Medicine, University of Cincinnati, Cincinnati, OH, USA
Physiol Behav 105:52-61. 2011..Our data suggest that the control of spontaneous physical activity by gut hormones or their neuropeptide targets may represent an important mechanistic component of energy balance regulation... - Hypothalamic mTOR signaling mediates the orexigenic action of ghrelinLuis Martins
Department of Physiology, Research Center of Molecular Medicine and Chronic Diseases CIMUS, University of Santiago de Compostela Instituto de Investigación Sanitaria IDIS, Santiago de Compostela, Spain
PLoS ONE 7:e46923. 2012..Taken together, these data indicate that, in addition to previous reported mechanisms, ghrelin also promotes feeding through modulation of hypothalamic mTOR pathway... - Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balanceMiguel Lopez
Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela, A Coruna, Spain
Nat Med 16:1001-8. 2010..These effects are reversed by pharmacological blockade of the SNS. Thus, thyroid hormone-induced modulation of AMPK activity and lipid metabolism in the hypothalamus is a major regulator of whole-body energy homeostasis... - Central resistin regulates hypothalamic and peripheral lipid metabolism in a nutritional-dependent fashionMaria J Vazquez
Department of Physiology, School of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain
Endocrinology 149:4534-43. 2008..Overall, our results indicate that RSTN controls feeding and peripheral lipid metabolism and suggest that hepatic RSTN-induced insulin resistance may be mediated by central activation of de novo lipogenesis in liver... - Expression and regulation of adiponectin and receptor in human and rat placentaJ Eduardo Caminos
Department of Physiology, University of Santiago de Compostela School of Medicine, C S Francisco 1, 15782 Santiago de Compostela, Spain
J Clin Endocrinol Metab 90:4276-86. 2005..Adiponectin is an adipocyte hormone involved in glucose and lipid metabolism. Recently, two receptors of this protein, called adiponectin receptor 1 (Adipo-R1) and Adipo-R2, have been cloned... - The obestatin/GPR39 system is up-regulated by muscle injury and functions as an autocrine regenerative systemUxía Gurriarán-Rodríguez
Area de Endocrinología Molecular y Celular, Instituto de Investigación Sanitaria de Santiago IDIS, Santiago de Compostela, Spain
J Biol Chem 287:38379-89. 2012..These data elucidate a novel mechanism whereby the obestatin/GPR39 system is coordinately regulated as part of the myogenic program and operates as an autocrine signal regulating skeletal myogenesis... - Novel expression of resistin in rat testis: functional role and regulation by nutritional status and hormonal factorsRuben Nogueiras
Department of Physiology, University of Santiago de Compostela, C San Francisco s n, 15705, Spain
J Cell Sci 117:3247-57. 2004..These data underscore a reproductive facet of this recently cloned molecule, which may operate as a novel endocrine integrator linking energy homeostasis and reproduction... - Resistin is expressed in different rat tissues and is regulated in a tissue- and gender-specific mannerRuben Nogueiras
Department of Physiology, University of Santiago de Compostela, School of Medicine, 15705, Santiago de Compostela, Spain
FEBS Lett 548:21-7. 2003..Thus, our data suggest that resistin is not exclusively localized in adipocytes, and indicate that its expression is regulated in a tissue- and sex-specific manner... - Bsx, a novel hypothalamic factor linking feeding with locomotor activity, is regulated by energy availabilityRuben Nogueiras
Department of Psychiatry, Obesity Research Center, University of Cincinnati, Cincinnati, Ohio 45237, USA
Endocrinology 149:3009-15. 2008..Future studies will be necessary to test if Bsx may be involved in the pathogenesis of leptin resistance... - Negative energy balance and leptin regulate neuromedin-U expression in the rat pars tuberalisRuben Nogueiras
Department of Physiology, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain
J Endocrinol 190:545-53. 2006..These results demonstrate a link between energy balance and NMU expression in the pars tuberalis of the pituitary... - New insights in ghrelin orexigenic effectCarlos Dieguez
Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, S Francisco s n, Santiago de Compostela, A Coruna, 15782, Spain
Front Horm Res 38:196-205. 2010..In this review, we summarize several aspects of ghrelin effects at hypothalamic level and their implications in the control of food intake and energy balance... - Hypothalamic control of lipid metabolism: focus on leptin, ghrelin and melanocortinsCarlos Dieguez
Department of Physiology, School of Medicine, Instituto de Investigación Sanitaria IDIS, University of Santiago de Compostela, Spain carlos dieguez usc es
Neuroendocrinology 94:1-11. 2011..In this short review, we highlight the main molecular pathways triggered by leptin and ghrelin altering both central and peripheral lipid metabolism and, therefore, controlling feeding behavior and energy expenditure... - Gut hormones ghrelin, PYY, and GLP-1 in the regulation of energy balance [corrected] and metabolismDiego Perez-Tilve
Department of Psychiatry, University of Cincinnati Genome Research Institute, Cincinnati, OH 45237, USA
Endocrine 29:61-71. 2006..Here, we examine the role of gut hormones in energy balance regulation and their possible use as pharmaceutical targets for obesity... - A functional role for the p62-ERK1 axis in the control of energy homeostasis and adipogenesisSang Jun Lee
Department of Cancer and Cell Biology, The Vontz Center for Molecular Studies, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
EMBO Rep 11:226-32. 2010..These results establish genetically that p62 is a crucial regulator of ERK1 in metabolism... - Central GLP-1 actions on energy metabolismDouglas A Velásquez
Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela, A Coruna, Spain
Vitam Horm 84:303-17. 2010..In this review, we will focus on the metabolic actions and mechanisms of the central GLP-1 system: modulation of energy intake, glucose metabolism, and fatty acid metabolism... - Resistin: regulation of food intake, glucose homeostasis and lipid metabolismRuben Nogueiras
Department of Physiology, School of Medicine, University of Santiago de Compostela, Instituto de Investigacion Sanitaria, and CIBER Fisiopatologia de la Obesidad y Nutricion, Santiago de Compostela, Spain
Endocr Dev 17:175-84. 2010..In this short review, we will summarize the most relevant findings of this hormone in rodents... - PKCzeta-regulated inflammation in the nonhematopoietic compartment is critical for obesity-induced glucose intoleranceSang Jun Lee
Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, 3125 Eden Avenue, Cincinnati, OH 45267, USA
Cell Metab 12:65-77. 2010..These results establish PKCzeta as a critical negative regulator of IL-6 in the control of obesity-induced inflammation in adipocytes... - Ghrelin localization in rat and human thyroid and parathyroid glands and tumoursKawtar Raghay
Department of Morphological Sciences, University Clinical Hospital, University of Santiago de Compostela, c S Francisco, 15782 Santiago de Compostela, Spain
Histochem Cell Biol 125:239-46. 2006..Overall, expression of ghrelin in human and rat thyroid and parathyroid glands is highly suggestive of a conserved role of this molecule in the regulation of thyroid and parathyroid cell function... - Vaspin and amylin are expressed in human and rat placenta and regulated by nutritional statusJorge E Caminos
Department of Physiology, School of Medicine Instituto de Investigación Sanitaria IDIS, University of Santiago de Compostela USC, Santiago de Compostela, Spain
Histol Histopathol 24:979-90. 2009..Taken together, our results demonstrate that vaspin and amylin are modulated by energy status in the placenta, which suggests that these proteins may be involved in the regulation of placental metabolic functions... - Regulation of peptide YY levels by age, hormonal, and nutritional statusSulay A Tovar
Department of Physiology, Faculty of Medicine, University of Santiago de Compostela, Spain
Obes Res 12:1944-50. 2004..This hormone has been suggested as an attractive therapeutic option for obesity. The aim of this study was to assess the influence of age, sex, thyroid status, growth hormone (GH), pregnancy, and food restriction on PYY levels in rat... - Central melanin-concentrating hormone influences liver and adipose metabolism via specific hypothalamic nuclei and efferent autonomic/JNK1 pathwaysMonica Imbernon
Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, S Francisco s n, Santiago de Compostela A Coruña, Spain
Gastroenterology 144:636-649.e6. 2013..Herein, we sought to investigate the role of MCH, an orexigenic neuropeptide specifically expressed in the lateral hypothalamic area, on hepatic and adipocyte metabolism... - Sensing the fat: fatty acid metabolism in the hypothalamus and the melanocortin systemMiguel Lopez
Department of Physiology, School of Medicine, University of Santiago de Compostela, C S Francisco 1, 15705 Santiago de Compostela, Spain
Peptides 26:1753-8. 2005..Understanding these molecular mechanisms could provide new pharmacological targets for the treatment of obesity and appetite disorders, as well as novel concepts in the nutritional design... - Preproghrelin expression is a key target for insulin action on adipogenesisUxía Gurriarán-Rodríguez
Area de Endocrinología Molecular y Celular, Instituto de Investigación Sanitaria de Santiago IDIS, Hospital Clinico Universitario de Santiago, Servicio Gallego de Salud SERGAS, Santiago de Compostela, Spain
J Endocrinol 210:R1-7. 2011..The results underscore a key role for preproghrelin-derived peptides on adipogenesis through an autocrine/paracrine mechanism... - Leptin and fasting regulate rat gastric glucose-regulated protein 58Susana B Bravo
Department of Physiology, School of Medicine, Instituto de Investigaciones Sanitarias IDIS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain
Int J Pept 2011:969818. 2011..Dissection of the molecular pathways mediating the interactions between ER stress-related factors and nutrient availability, as well as their target genes, may open a new avenue for the study of obesity and other metabolic disorders... - Long-term effects of ghrelin and ghrelin receptor agonists on energy balance in ratsSabine Strassburg
Department of Psychiatry, Obesity Research Centre Genome Research Institute, Univ of Cincinnati College of Medicine, Cincinnati, OH, USA
Am J Physiol Endocrinol Metab 295:E78-84. 2008..These results characterize BIM-28131 as a promising GHS-R agonist with an attractive action profile for the treatment of catabolic disease states such as cachexia... - Hypothalamic lipotoxicity and the metabolic syndromePablo B Martínez de Morentin
Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, S Francisco s n, Santiago de Compostela, A Coruna, 15782, Spain
Biochim Biophys Acta 1801:350-61. 2010..A better understanding of these molecular mechanisms will help to identify new drug targets for the treatment of obesity and metabolic syndrome... - Sirtuin 1 and sirtuin 3: physiological modulators of metabolismRuben Nogueiras
Department of Physiology, School of Medicine Instituto de Investigaciones Sanitarias, University of Santiago de Compostela, Santiago de Compostela, Spain
Physiol Rev 92:1479-514. 2012..Consequently, activation of sirtuins by genetic or pharmacological means can elicit multiple metabolic benefits that protect mice from diet-induced obesity, type 2 diabetes, and nonalcoholic fatty liver disease... - Regulation of growth hormone secretagogue receptor gene expression in the arcuate nuclei of the rat by leptin and ghrelinRuben Nogueiras
Departmetn of Physiology, University of Santiago de Compostela, Spain
Diabetes 53:2552-8. 2004..Ghrelin significantly increased GHS-R expression but not in dwarf rats. These results show that the level of GHS-R expression in the ARC is reduced by leptin and increased by ghrelin and that the effect of ghrelin may be GH dependent... - Female Nur77-deficient mice show increased susceptibility to diet-induced obesitySonia Perez-Sieira
Department of Physiology, School of Medicine CIMUS Instituto de Investigaciones Sanitarias, Santiago de Compostela, Spain
PLoS ONE 8:e53836. 2013..The decreased energy expenditure and the actions of Nur77 on liver, muscle, brown and white adipose tissue contribute to the increased susceptibility to diet-induced obesity in females lacking Nur77... - GOAT: the master switch for the ghrelin system?Amparo Romero
Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela, A Coruña 15782, Spain
Eur J Endocrinol 163:1-8. 2010.... - Central nervous system regulation of adipocyte metabolismRuben Nogueiras
Department of Psychiatry, Obesity Research Centre, University of Cincinnati, Cincinnati, OH 45226, USA
Regul Pept 149:26-31. 2008..In this review, we discuss the central actions of some peptides with an important role in energy balance regulation on adipocyte metabolism and the physiological relevance of these actions... - Biomedicine. Separation of conjoined hormones yields appetite rivalsRuben Nogueiras
Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45237, USA
Science 310:985-6. 2005 - Heterozygous deficiency of endoglin decreases insulin and hepatic triglyceride levels during high fat dietDaniel Beiroa
Department of Physiology, School of Medicine CIMUS Instituto de Investigaciones Sanitarias IDIS, CIBER Fisiopatologia de la Obesidad y Nutricion CIBEROBN, University of Santiago de Compostela, Santiago de Compostela, A Coruna, Spain
PLoS ONE 8:e54591. 2013..Overall, our findings indicate that endoglin is a potentially important physiological mediator of insulin levels and hepatic lipid metabolism... - Regulation of resistin by gonadal, thyroid hormone, and nutritional statusRuben Nogueiras
Department of Physiology, Universitario de Santiago, Santiago de Compostela, Spain
Obes Res 11:408-14. 2003..The aim of this study was to assess the influence of gender, gonadal status, thyroid hormones, pregnancy, and food restriction on resistin mRNA levels in adipose tissue of rats...