Ruben Nogueiras


Affiliation: Santiago de Compostela
Country: Spain


  1. Nogueiras R, Williams L, Dieguez C. Ghrelin: new molecular pathways modulating appetite and adiposity. Obes Facts. 2010;3:285-92 pubmed publisher
    ..This review aims to summarize novel roles of ghrelin in energy balance, focusing particularly on both the newly identified neuronal pathways mediating the effects of ghrelin and on peripheral mechanisms leading to increased adiposity. ..
  2. Folgueira C, Beiroa D, González Rellán M, Porteiro B, Milbank E, Castelao C, et al. Uroguanylin Improves Leptin Responsiveness in Diet-Induced Obese Mice. Nutrients. 2019;11: pubmed publisher
    ..At a functional level, the blockade of PI3K, but not STAT3, blunted UGN-mediated leptin responsiveness in DIO mice. Overall, these findings indicate that UGN improves leptin sensitivity in DIO mice. ..
  3. Folgueira C, Barja Fernandez S, Gonzalez Saenz P, Castelao C, Vázquez Cobela R, Pena Leon V, et al. Circulating Pro-Uroguanylin Levels In Children And Their Relation To Obesity, Sex And Puberty. Sci Rep. 2018;8:14541 pubmed publisher
    ..We conclude that a sexual dimorphism exists in circulating pro-uroguanylin levels with respect to BMI. Uroguanylin presents also an opposed circulating pattern during puberty in both sexes. ..
  4. Sanchez Rebordelo E, Cuñarro J, Pérez Sieira S, Seoane L, Dieguez C, Nogueiras R, et al. Regulation of Chemerin and CMKLR1 Expression by Nutritional Status, Postnatal Development, and Gender. Int J Mol Sci. 2018;19: pubmed publisher
    ..Our data indicate that regulation of the expression of this new adipokine and its receptor by nutritional status and gonadal hormones may be a part of the adaptive mechanisms related to altered fat mass and its metabolic complications. ..
  5. Quiñones M, Al Massadi O, Folgueira C, Bremser S, Gallego R, Torres Leal L, et al. p53 in AgRP neurons is required for protection against diet-induced obesity via JNK1. Nat Commun. 2018;9:3432 pubmed publisher
    ..Finally, p53 in AgRP neurons regulates the ghrelin-induced food intake and body weight. Overall, our findings provide evidence that p53 in AgRP neurons is required for normal adaptations against diet-induced obesity. ..
  6. Liñares Pose L, Rial Pensado E, Estévez Salguero Á, Milbank E, González García I, Rodriguez C, et al. Genetic Targeting of GRP78 in the VMH Improves Obesity Independently of Food Intake. Genes (Basel). 2018;9: pubmed publisher
    ..Overall, these results indicate that the modulation of GRP78 in the VMH may be a target against obesity. ..
  7. Quiñones M, Al Massadi O, Fernø J, Nogueiras R. Cross-talk between SIRT1 and endocrine factors: effects on energy homeostasis. Mol Cell Endocrinol. 2014;397:42-50 pubmed publisher
    ..In addition, we analyze the potential of targeting SIRT1 for the treatment of obesity and type 2 diabetes mellitus. ..
  8. Al Massadi O, López M, Fernø J, Diéguez C, Nogueiras R. What is the real relevance of endogenous ghrelin?. Peptides. 2015;70:1-6 pubmed publisher
    ..Despite the numerous reports using different genetically engineered mouse models targeting the ghrelin system, its endogenous relevance in metabolism seems to be less important than its pharmaceutical options. ..
  9. Al Massadi O, Müller T, Tschop M, Dieguez C, Nogueiras R. Ghrelin and LEAP-2: Rivals in Energy Metabolism. Trends Pharmacol Sci. 2018;39:685-694 pubmed publisher
    ..Here, we discuss not only the current understanding of LEAP-2 in metabolic regulation, but also the potential of this peptide in the treatment of obesity and other diseases that involve dysregulation of the ghrelin system. ..

More Information


  1. Nogueiras R, Veyrat Durebex C, Suchanek P, Klein M, Tschop J, Caldwell C, et al. Peripheral, but not central, CB1 antagonism provides food intake-independent metabolic benefits in diet-induced obese rats. Diabetes. 2008;57:2977-91 pubmed publisher
    ..Several relevant metabolic processes appear to independently benefit from peripheral blockade of CB1, while CNS-CB1 blockade alone predominantly affects food intake and body weight. ..
  2. Martínez Sánchez N, Alvarez C, Fernø J, Nogueiras R, Diéguez C, López M. Hypothalamic effects of thyroid hormones on metabolism. Best Pract Res Clin Endocrinol Metab. 2014;28:703-12 pubmed publisher
    ..More extensive knowledge about these molecular mechanisms will be of great relevance for the treatment of obesity and metabolic syndrome. ..
  3. Tudurí E, Beiroa D, Stegbauer J, Fernø J, Lopez M, Dieguez C, et al. Acute stimulation of brain mu opioid receptors inhibits glucose-stimulated insulin secretion via sympathetic innervation. Neuropharmacology. 2016;110:322-332 pubmed publisher
    ..Our results show for the first time a new role of the central opioid system, specifically the MOR, in the regulation of insulin secretion and glucose metabolism. ..
  4. Porteiro B, Fondevila M, Buqué X, Gonzalez Rellan M, Fernandez U, Mora A, et al. Pharmacological stimulation of p53 with low-dose doxorubicin ameliorates diet-induced nonalcoholic steatosis and steatohepatitis. Mol Metab. 2018;8:132-143 pubmed publisher
    ..These data provide new evidence for targeting p53 as a strategy to treat liver disease. ..
  5. Al Massadi O, López M, Tschöp M, Diéguez C, Nogueiras R. Current Understanding of the Hypothalamic Ghrelin Pathways Inducing Appetite and Adiposity. Trends Neurosci. 2017;40:167-180 pubmed publisher
  6. Imbernon M, Sanchez Rebordelo E, Romero Picó A, Kallo I, Chee M, Porteiro B, et al. Hypothalamic kappa opioid receptor mediates both diet-induced and melanin concentrating hormone-induced liver damage through inflammation and endoplasmic reticulum stress. Hepatology. 2016;64:1086-104 pubmed publisher
    ..Hepatology 2016;64:1086-1104). ..
  7. Folgueira C, Sanchez Rebordelo E, Barja Fernandez S, Leis R, Tovar S, Casanueva F, et al. Uroguanylin levels in intestine and plasma are regulated by nutritional status in a leptin-dependent manner. Eur J Nutr. 2016;55:529-536 pubmed publisher
    ..Our findings suggest that UGN levels are correlated with energy balance status and that the regulation of UGN by nutritional status is leptin-dependent. ..
  8. Nogueiras R, Perez Tilve D, Veyrat Durebex C, Morgan D, Varela L, Haynes W, et al. Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity. J Neurosci. 2009;29:5916-25 pubmed publisher
    ..Importantly, the CNS GLP-1 system loses the capacity to modulate adipocyte metabolism in obese states, suggesting an obesity-induced adipocyte resistance to CNS GLP-1. ..
  9. Tudurí E, Lopez M, Dieguez C, Nadal A, Nogueiras R. GPR55 and the regulation of glucose homeostasis. Int J Biochem Cell Biol. 2017;88:204-207 pubmed publisher
    ..Finally, the therapeutic potential of targeting the GPR55 receptor is also discussed. ..
  10. Romero Picó A, Sanchez Rebordelo E, Imbernon M, González Touceda D, Folgueira C, Senra A, et al. Melanin-Concentrating Hormone acts through hypothalamic kappa opioid system and p70S6K to stimulate acute food intake. Neuropharmacology. 2018;130:62-70 pubmed publisher
    ..Our results reveal that lateral hypothalamic k-OR system modulates the orexigenic action of MCH via the p70S6K/S6 pathway. ..
  11. Tudurí E, López M, Diéguez C, Nadal A, Nogueiras R. Glucagon-Like Peptide 1 Analogs and their Effects on Pancreatic Islets. Trends Endocrinol Metab. 2016;27:304-318 pubmed publisher
  12. Imbernon M, Whyte L, Diaz Arteaga A, Russell W, Moreno N, Vazquez M, et al. Regulation of GPR55 in rat white adipose tissue and serum LPI by nutritional status, gestation, gender and pituitary factors. Mol Cell Endocrinol. 2014;383:159-69 pubmed publisher
    ..Our findings indicate that GPR55 and LPI are regulated by different physiological and pathophysiological settings known to be associated with marked alterations in energy status. ..
  13. Porteiro B, Diaz Ruiz A, Martinez G, Senra A, Vidal A, Serrano M, et al. Ghrelin requires p53 to stimulate lipid storage in fat and liver. Endocrinology. 2013;154:3671-9 pubmed publisher
    ..Thus, our results show that p53 is necessary for the actions of ghrelin on WAT and liver, leading to changes in expression levels of lipogenic and adipogenic genes, and modifying body weight. ..