Ruben Nogueiras

Summary

Affiliation: Santiago de Compostela
Country: Spain

Publications

  1. doi request reprint Ghrelin: new molecular pathways modulating appetite and adiposity
    Ruben Nogueiras
    Department of Physiology, University of Santiago de Compostela, Santiago de Compostela, Spain
    Obes Facts 3:285-92. 2010
  2. pmc The central Sirtuin 1/p53 pathway is essential for the orexigenic action of ghrelin
    Douglas A Velásquez
    Department of Physiology, School of Medicine Instituto de Investigaciones Sanitarias IDIS, University of Santiago de Compostela, Santiago de Compostela, Spain
    Diabetes 60:1177-85. 2011
  3. pmc Heterozygous deficiency of endoglin decreases insulin and hepatic triglyceride levels during high fat diet
    Daniel Beiroa
    Department of Physiology, School of Medicine CIMUS Instituto de Investigaciones Sanitarias IDIS, CIBER Fisiopatologia de la Obesidad y Nutricion CIBEROBN, University of Santiago de Compostela, Santiago de Compostela, A Coruna, Spain
    PLoS ONE 8:e54591. 2013
  4. pmc Female Nur77-deficient mice show increased susceptibility to diet-induced obesity
    Sonia Perez-Sieira
    Department of Physiology, School of Medicine CIMUS Instituto de Investigaciones Sanitarias, Santiago de Compostela, Spain
    PLoS ONE 8:e53836. 2013
  5. doi request reprint Ghrelin requires p53 to stimulate lipid storage in fat and liver
    Begoña Porteiro
    Department of Physiology, Centre of Research in Molecular Medicine and Chronic Diseases of the University of Santiago de Compostela CIMUS, University of Santiago de Compostela Instituto de Investigación Sanitaria, Avda Barcelona s n, 15782, Santiago de Compostela A Coruña, Spain, and CIBER Fisiopatologia de la Obesidad y Nutricion, Instituto de Salud Carlos III, Spain
    Endocrinology 154:3671-9. 2013
  6. pmc Mice lacking δ-opioid receptors resist the development of diet-induced obesity
    Traci A Czyzyk
    Obesity Research, Lilly Research Laboratories, Indianapolis, Indiana, USA
    FASEB J 26:3483-92. 2012
  7. ncbi request reprint The endocannabinoid system: role in glucose and energy metabolism
    Ruben Nogueiras
    Department of Physiology, University of Santiago de Compostela Instituto de Investigación Sanitaria IDIS, Santiago de Compostela 15782, Spain
    Pharmacol Res 60:93-8. 2009
  8. doi request reprint Regulation of lipid metabolism by energy availability: a role for the central nervous system
    R Nogueiras
    Department of Physiology, School of Medicine Instituto de Investigación Sanitaria IDIS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain
    Obes Rev 11:185-201. 2010
  9. pmc Peripheral, but not central, CB1 antagonism provides food intake-independent metabolic benefits in diet-induced obese rats
    Ruben Nogueiras
    Department of Psychiatry, Obesity Research Centre, Genome Research Institute, University of Cincinnati, Cincinnati, Ohio, USA
    Diabetes 57:2977-91. 2008
  10. pmc The L-α-lysophosphatidylinositol/GPR55 system and its potential role in human obesity
    José María Moreno-Navarrete
    Department of Diabetes, Endocrinology, and Nutrition, Institut d Investigació Biomédica de Girona Catalonia, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición, Girona, Spain
    Diabetes 61:281-91. 2012

Detail Information

Publications64

  1. doi request reprint Ghrelin: new molecular pathways modulating appetite and adiposity
    Ruben Nogueiras
    Department of Physiology, University of Santiago de Compostela, Santiago de Compostela, Spain
    Obes Facts 3:285-92. 2010
    ..This review aims to summarize novel roles of ghrelin in energy balance, focusing particularly on both the newly identified neuronal pathways mediating the effects of ghrelin and on peripheral mechanisms leading to increased adiposity...
  2. pmc The central Sirtuin 1/p53 pathway is essential for the orexigenic action of ghrelin
    Douglas A Velásquez
    Department of Physiology, School of Medicine Instituto de Investigaciones Sanitarias IDIS, University of Santiago de Compostela, Santiago de Compostela, Spain
    Diabetes 60:1177-85. 2011
    ..We tested the hypothesis that the central SIRT1/p53 pathway might be mediating the orexigenic action of ghrelin...
  3. pmc Heterozygous deficiency of endoglin decreases insulin and hepatic triglyceride levels during high fat diet
    Daniel Beiroa
    Department of Physiology, School of Medicine CIMUS Instituto de Investigaciones Sanitarias IDIS, CIBER Fisiopatologia de la Obesidad y Nutricion CIBEROBN, University of Santiago de Compostela, Santiago de Compostela, A Coruna, Spain
    PLoS ONE 8:e54591. 2013
    ..Overall, our findings indicate that endoglin is a potentially important physiological mediator of insulin levels and hepatic lipid metabolism...
  4. pmc Female Nur77-deficient mice show increased susceptibility to diet-induced obesity
    Sonia Perez-Sieira
    Department of Physiology, School of Medicine CIMUS Instituto de Investigaciones Sanitarias, Santiago de Compostela, Spain
    PLoS ONE 8:e53836. 2013
    ..The decreased energy expenditure and the actions of Nur77 on liver, muscle, brown and white adipose tissue contribute to the increased susceptibility to diet-induced obesity in females lacking Nur77...
  5. doi request reprint Ghrelin requires p53 to stimulate lipid storage in fat and liver
    Begoña Porteiro
    Department of Physiology, Centre of Research in Molecular Medicine and Chronic Diseases of the University of Santiago de Compostela CIMUS, University of Santiago de Compostela Instituto de Investigación Sanitaria, Avda Barcelona s n, 15782, Santiago de Compostela A Coruña, Spain, and CIBER Fisiopatologia de la Obesidad y Nutricion, Instituto de Salud Carlos III, Spain
    Endocrinology 154:3671-9. 2013
    ..Thus, our results show that p53 is necessary for the actions of ghrelin on WAT and liver, leading to changes in expression levels of lipogenic and adipogenic genes, and modifying body weight. ..
  6. pmc Mice lacking δ-opioid receptors resist the development of diet-induced obesity
    Traci A Czyzyk
    Obesity Research, Lilly Research Laboratories, Indianapolis, Indiana, USA
    FASEB J 26:3483-92. 2012
    ..05) in response to an HED. These findings reveal a novel role of DOR in the control of thermogenic markers and energy expenditure, and they provide a potential new therapeutic approach for the treatment of obesity...
  7. ncbi request reprint The endocannabinoid system: role in glucose and energy metabolism
    Ruben Nogueiras
    Department of Physiology, University of Santiago de Compostela Instituto de Investigación Sanitaria IDIS, Santiago de Compostela 15782, Spain
    Pharmacol Res 60:93-8. 2009
    ..In obese states, endocannabinoid levels are increased and might exert unfavorable effects on insulin-sensitive tissues. This review summarizes the effects of the endocannabinoid system on glucose metabolism in humans and rodents...
  8. doi request reprint Regulation of lipid metabolism by energy availability: a role for the central nervous system
    R Nogueiras
    Department of Physiology, School of Medicine Instituto de Investigación Sanitaria IDIS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain
    Obes Rev 11:185-201. 2010
    ....
  9. pmc Peripheral, but not central, CB1 antagonism provides food intake-independent metabolic benefits in diet-induced obese rats
    Ruben Nogueiras
    Department of Psychiatry, Obesity Research Centre, Genome Research Institute, University of Cincinnati, Cincinnati, Ohio, USA
    Diabetes 57:2977-91. 2008
    ....
  10. pmc The L-α-lysophosphatidylinositol/GPR55 system and its potential role in human obesity
    José María Moreno-Navarrete
    Department of Diabetes, Endocrinology, and Nutrition, Institut d Investigació Biomédica de Girona Catalonia, Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y Nutrición, Girona, Spain
    Diabetes 61:281-91. 2012
    ..These findings indicate that the LPI/GPR55 system is positively associated with obesity in humans...
  11. doi request reprint Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity
    Ruben Nogueiras
    Department of Psychiatry, Obesity Research Centre, University of Cincinnati, Cincinnati, Ohio 45226, USA
    J Neurosci 29:5916-25. 2009
    ..Importantly, the CNS GLP-1 system loses the capacity to modulate adipocyte metabolism in obese states, suggesting an obesity-induced adipocyte resistance to CNS GLP-1...
  12. pmc Ghrelin effects on neuropeptides in the rat hypothalamus depend on fatty acid metabolism actions on BSX but not on gender
    Ricardo Lage
    Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela A Coruña, Spain
    FASEB J 24:2670-9. 2010
    ..Notably, this effect is associated with decreased BSX expression and reduced food intake. Overall, our data suggest that BSX integrates changes in neuronal metabolic status with ARC-derived neuropeptides in a gender-independent manner...
  13. pmc Central ghrelin regulates peripheral lipid metabolism in a growth hormone-independent fashion
    Susana Sangiao-Alvarellos
    Department of Medicine, School of Health Science, University of A Coruna, A Coruna, Spain
    Endocrinology 150:4562-74. 2009
    ....
  14. ncbi request reprint Central administration of resistin promotes short-term satiety in rats
    Sulay Tovar
    Department of Physiology, University of Santiago de Compostela, Santiago de Compostela 15 782, Spain
    Eur J Endocrinol 153:R1-5. 2005
    ....
  15. doi request reprint The orexigenic effect of orexin-A revisited: dependence of an intact growth hormone axis
    Mayte Alvarez-Crespo
    Department of Physiology, CIMUS, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela, 15782, Spain and CIBER Fisiopatología de la Obesidad y Nutrición CIBERobn, 15706, Spain
    Endocrinology 154:3589-98. 2013
    ..Overall, this evidence suggests that the orexigenic action of OX-A depends on an intact GH axis and that this neuroendocrine feedback loop may be of interest in the understanding of orexins action on energy balance and GH deficiency. ..
  16. pmc Melanocortin signaling in the CNS directly regulates circulating cholesterol
    Diego Perez-Tilve
    Metabolic Diseases Institute, Division of Endocrinology, Department of Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA
    Nat Neurosci 13:877-82. 2010
    ..Our data suggest that a neural circuit in the brain is directly involved in the control of cholesterol metabolism by the liver...
  17. doi request reprint Regulation of lipin1 by nutritional status, adiponectin, sex and pituitary function in rat white adipose tissue
    C Ruth González
    Department of Physiology, School of Medicine Instituto de Investigaciones Sanitarias IDIS, University of Santiago de Compostela, Spain
    Physiol Behav 105:777-83. 2012
    ..To dissect the complicated interactions between key regulators of lipid metabolism like lipin1, may be important for the development of new therapies for the treatment and prevention of obesity and its associated disorders...
  18. doi request reprint Ghrelin and lipid metabolism: key partners in energy balance
    Luis Varela
    Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela A Coruña 15782, Spain
    J Mol Endocrinol 46:R43-63. 2011
    ..Understanding this new metabolic pathway can provide new therapeutic targets for the treatment of obesity and the metabolic syndrome...
  19. doi request reprint Hypothalamic mTOR pathway mediates thyroid hormone-induced hyperphagia in hyperthyroidism
    Luis Varela
    Department of Physiology, School of Medicine CIMUS, University of Santiago de Compostela, Instituto de Investigacion Sanitaria, Santiago de Compostela A Coruña 15782, Spain
    J Pathol 227:209-22. 2012
    ....
  20. doi request reprint Action profile of the antiobesity drug candidate oleoyl-estrone in rats
    Sabine Strassburg
    Obesity Research Center, Department of Internal Medicine, University of Cincinnati Metabolic Diseases Institute, Cincinnati, Ohio, USA
    Obesity (Silver Spring) 18:2260-7. 2010
    ..The present data suggest that OE decreases food intake and body weight but also appears to cause a significant impact on the hypothalamus-pituitary-reproductive axis...
  21. ncbi request reprint Central resistin regulates hypothalamic and peripheral lipid metabolism in a nutritional-dependent fashion
    Maria J Vazquez
    Department of Physiology, School of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain
    Endocrinology 149:4534-43. 2008
    ..Overall, our results indicate that RSTN controls feeding and peripheral lipid metabolism and suggest that hepatic RSTN-induced insulin resistance may be mediated by central activation of de novo lipogenesis in liver...
  22. doi request reprint Ghrelin, peptide YY and their hypothalamic targets differentially regulate spontaneous physical activity
    Paul T Pfluger
    Obesity Research Center, Dept of Internal Medicine, University of Cincinnati, Cincinnati, OH, USA
    Physiol Behav 105:52-61. 2011
    ..Our data suggest that the control of spontaneous physical activity by gut hormones or their neuropeptide targets may represent an important mechanistic component of energy balance regulation...
  23. pmc Nicotine induces negative energy balance through hypothalamic AMP-activated protein kinase
    Pablo B Martínez de Morentin
    Department of Physiology, School of Medicine CIMUS, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela, A Coruna, Spain
    Diabetes 61:807-17. 2012
    ..Overall these data demonstrate that the effects of nicotine on energy balance involve specific modulation of the hypothalamic AMPK-BAT axis. These targets may be relevant for the development of new therapies for human obesity...
  24. pmc The central melanocortin system directly controls peripheral lipid metabolism
    Ruben Nogueiras
    Obesity Research Center, Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio 45237, USA
    J Clin Invest 117:3475-88. 2007
    ..We also reveal molecular underpinnings for direct control of the CNS-Mcr over lipid metabolism. These results suggest ways to design more efficient pharmacological methods for controlling adiposity...
  25. doi request reprint Adiponectin receptor 2 is regulated by nutritional status, leptin and pregnancy in a tissue-specific manner
    Carmen Ruth González
    Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, 15782 Santiago de Compostela, Spain
    Physiol Behav 99:91-9. 2010
    ....
  26. pmc Central nervous system regulation of energy metabolism: ghrelin versus leptin
    Ruben Nogueiras
    Obesity Research Center, Department of Psychiatry, University of Cincinnati, Cincinnati, Ohio, USA
    Ann N Y Acad Sci 1126:14-9. 2008
    ..Rather than comprehensively discussing the field, we instead will discuss some of the key findings made regarding the interaction of the hormones ghrelin and leptin with the CNS...
  27. ncbi request reprint Nicotine improves obesity and hepatic steatosis and ER stress in diet-induced obese male rats
    Patricia Seoane-Collazo
    Department of Physiology P S C, P B M d M, C D, R N, M L, NeuObesity Group, Centro singular de investigación en medicina molecular y enfermedades crónicas CIMUS, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela 15782, Spain Centro de investigación biomédica en red Fisiopatología de la Obesidad y Nutrición P S C, P B M d M, C D, R N, M L, Santiago de Compostela 15706, Spain and Department of Clinical Science J F, University of Bergen, N 5020 Bergen, Norway
    Endocrinology 155:1679-89. 2014
    ....
  28. ncbi request reprint Orexin-A regulates growth hormone-releasing hormone mRNA content in a nucleus-specific manner and somatostatin mRNA content in a growth hormone-dependent fashion in the rat hypothalamus
    Miguel Lopez
    Department of Physiology School of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain
    Eur J Neurosci 19:2080-8. 2004
    ..These data improve our understanding of the interactions among the different systems involved in the control and pathophysiology of food intake, sleep and GH secretion...
  29. pmc Central melanin-concentrating hormone influences liver and adipose metabolism via specific hypothalamic nuclei and efferent autonomic/JNK1 pathways
    Monica Imbernon
    Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, S Francisco s n, Santiago de Compostela A Coruña, Spain
    Gastroenterology 144:636-649.e6. 2013
    ..Herein, we sought to investigate the role of MCH, an orexigenic neuropeptide specifically expressed in the lateral hypothalamic area, on hepatic and adipocyte metabolism...
  30. pmc Hypothalamic mTOR signaling mediates the orexigenic action of ghrelin
    Luis Martins
    Department of Physiology, Research Center of Molecular Medicine and Chronic Diseases CIMUS, University of Santiago de Compostela Instituto de Investigación Sanitaria IDIS, Santiago de Compostela, Spain
    PLoS ONE 7:e46923. 2012
    ..Taken together, these data indicate that, in addition to previous reported mechanisms, ghrelin also promotes feeding through modulation of hypothalamic mTOR pathway...
  31. doi request reprint Hyperthyroidism differentially regulates neuropeptide S system in the rat brain
    Carmen R González
    Department of Physiology, School of Medicine CIMUS, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela A Coruña, Spain
    Brain Res 1450:40-8. 2012
    ..Thus, the NPS/NPS-R system may be involved in several hyperthyroidism-associated comorbidities...
  32. ncbi request reprint Novel expression of resistin in rat testis: functional role and regulation by nutritional status and hormonal factors
    Ruben Nogueiras
    Department of Physiology, University of Santiago de Compostela, C San Francisco s n, 15705, Spain
    J Cell Sci 117:3247-57. 2004
    ..These data underscore a reproductive facet of this recently cloned molecule, which may operate as a novel endocrine integrator linking energy homeostasis and reproduction...
  33. ncbi request reprint Negative energy balance and leptin regulate neuromedin-U expression in the rat pars tuberalis
    Ruben Nogueiras
    Department of Physiology, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain
    J Endocrinol 190:545-53. 2006
    ..These results demonstrate a link between energy balance and NMU expression in the pars tuberalis of the pituitary...
  34. pmc Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance
    Miguel Lopez
    Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela, A Coruna, Spain
    Nat Med 16:1001-8. 2010
    ..These effects are reversed by pharmacological blockade of the SNS. Thus, thyroid hormone-induced modulation of AMPK activity and lipid metabolism in the hypothalamus is a major regulator of whole-body energy homeostasis...
  35. doi request reprint Central GLP-1 actions on energy metabolism
    Douglas A Velásquez
    Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela, A Coruna, Spain
    Vitam Horm 84:303-17. 2010
    ..In this review, we will focus on the metabolic actions and mechanisms of the central GLP-1 system: modulation of energy intake, glucose metabolism, and fatty acid metabolism...
  36. ncbi request reprint Expression and regulation of adiponectin and receptor in human and rat placenta
    J Eduardo Caminos
    Department of Physiology, University of Santiago de Compostela School of Medicine, C S Francisco 1, 15782 Santiago de Compostela, Spain
    J Clin Endocrinol Metab 90:4276-86. 2005
    ..Adiponectin is an adipocyte hormone involved in glucose and lipid metabolism. Recently, two receptors of this protein, called adiponectin receptor 1 (Adipo-R1) and Adipo-R2, have been cloned...
  37. pmc The obestatin/GPR39 system is up-regulated by muscle injury and functions as an autocrine regenerative system
    Uxía Gurriarán-Rodríguez
    Area de Endocrinología Molecular y Celular, Instituto de Investigación Sanitaria de Santiago IDIS, Santiago de Compostela, Spain
    J Biol Chem 287:38379-89. 2012
    ..These data elucidate a novel mechanism whereby the obestatin/GPR39 system is coordinately regulated as part of the myogenic program and operates as an autocrine signal regulating skeletal myogenesis...
  38. pmc Bsx, a novel hypothalamic factor linking feeding with locomotor activity, is regulated by energy availability
    Ruben Nogueiras
    Department of Psychiatry, Obesity Research Center, University of Cincinnati, Cincinnati, Ohio 45237, USA
    Endocrinology 149:3009-15. 2008
    ..Future studies will be necessary to test if Bsx may be involved in the pathogenesis of leptin resistance...
  39. ncbi request reprint Resistin is expressed in different rat tissues and is regulated in a tissue- and gender-specific manner
    Ruben Nogueiras
    Department of Physiology, University of Santiago de Compostela, School of Medicine, 15705, Santiago de Compostela, Spain
    FEBS Lett 548:21-7. 2003
    ..Thus, our data suggest that resistin is not exclusively localized in adipocytes, and indicate that its expression is regulated in a tissue- and sex-specific manner...
  40. doi request reprint Central manipulation of dopamine receptors attenuates the orexigenic action of ghrelin
    Amparo Romero-Picó
    Department of Physiology, School of Medicine CIMUS, Instituto de Investigación Sanitaria IDIS, University of Santiago de Compostela, Avda Barcelona 3, 15782, Santiago de Compostela, A Coruna, Spain
    Psychopharmacology (Berl) 229:275-83. 2013
    ..However, it is not known whether the orexigenic action of ghrelin is due to changes in central dopamine receptors...
  41. doi request reprint Energy balance regulation by thyroid hormones at central level
    Miguel Lopez
    Department of Physiology, CIMUS, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela, 15782, Spain
    Trends Mol Med 19:418-27. 2013
    ..Here, we review what is currently known about THs and their regulation of energy balance and metabolism in both peripheral and central tissues. ..
  42. doi request reprint New insights in ghrelin orexigenic effect
    Carlos Dieguez
    Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, S Francisco s n, Santiago de Compostela, A Coruna, 15782, Spain
    Front Horm Res 38:196-205. 2010
    ..In this review, we summarize several aspects of ghrelin effects at hypothalamic level and their implications in the control of food intake and energy balance...
  43. pmc Hypothalamic κ-opioid receptor modulates the orexigenic effect of ghrelin
    Amparo Romero-Picó
    Department of Physiology, School of Medicine CIMUS Instituto de Investigaciones Sanitarias IDIS, CIBER Fisiopatologia de la Obesidad y Nutricion CIBEROBN, San Francisco s n, Santiago de Compostela A Coruña, University of Santiago de Compostela, Santiago de Compostela, Spain
    Neuropsychopharmacology 38:1296-307. 2013
    ..Our novel data implicate hypothalamic KOR signaling in the orexigenic action of ghrelin...
  44. pmc PKCzeta-regulated inflammation in the nonhematopoietic compartment is critical for obesity-induced glucose intolerance
    Sang Jun Lee
    Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, 3125 Eden Avenue, Cincinnati, OH 45267, USA
    Cell Metab 12:65-77. 2010
    ..These results establish PKCzeta as a critical negative regulator of IL-6 in the control of obesity-induced inflammation in adipocytes...
  45. pmc A functional role for the p62-ERK1 axis in the control of energy homeostasis and adipogenesis
    Sang Jun Lee
    Department of Cancer and Cell Biology, The Vontz Center for Molecular Studies, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    EMBO Rep 11:226-32. 2010
    ..These results establish genetically that p62 is a crucial regulator of ERK1 in metabolism...
  46. doi request reprint Resistin: regulation of food intake, glucose homeostasis and lipid metabolism
    Ruben Nogueiras
    Department of Physiology, School of Medicine, University of Santiago de Compostela, Instituto de Investigacion Sanitaria, and CIBER Fisiopatologia de la Obesidad y Nutricion, Santiago de Compostela, Spain
    Endocr Dev 17:175-84. 2010
    ..In this short review, we will summarize the most relevant findings of this hormone in rodents...
  47. ncbi request reprint Gut hormones ghrelin, PYY, and GLP-1 in the regulation of energy balance [corrected] and metabolism
    Diego Perez-Tilve
    Department of Psychiatry, University of Cincinnati Genome Research Institute, Cincinnati, OH 45237, USA
    Endocrine 29:61-71. 2006
    ..Here, we examine the role of gut hormones in energy balance regulation and their possible use as pharmaceutical targets for obesity...
  48. doi request reprint Hypothalamic control of lipid metabolism: focus on leptin, ghrelin and melanocortins
    Carlos Dieguez
    Department of Physiology, School of Medicine, Instituto de Investigación Sanitaria IDIS, University of Santiago de Compostela, Spain carlos dieguez usc es
    Neuroendocrinology 94:1-11. 2011
    ..In this short review, we highlight the main molecular pathways triggered by leptin and ghrelin altering both central and peripheral lipid metabolism and, therefore, controlling feeding behavior and energy expenditure...
  49. ncbi request reprint Sensing the fat: fatty acid metabolism in the hypothalamus and the melanocortin system
    Miguel Lopez
    Department of Physiology, School of Medicine, University of Santiago de Compostela, C S Francisco 1, 15705 Santiago de Compostela, Spain
    Peptides 26:1753-8. 2005
    ..Understanding these molecular mechanisms could provide new pharmacological targets for the treatment of obesity and appetite disorders, as well as novel concepts in the nutritional design...
  50. ncbi request reprint Regulation of peptide YY levels by age, hormonal, and nutritional status
    Sulay A Tovar
    Department of Physiology, Faculty of Medicine, University of Santiago de Compostela, Spain
    Obes Res 12:1944-50. 2004
    ..This hormone has been suggested as an attractive therapeutic option for obesity. The aim of this study was to assess the influence of age, sex, thyroid status, growth hormone (GH), pregnancy, and food restriction on PYY levels in rat...
  51. ncbi request reprint Vaspin and amylin are expressed in human and rat placenta and regulated by nutritional status
    Jorge E Caminos
    Department of Physiology, School of Medicine Instituto de Investigación Sanitaria IDIS, University of Santiago de Compostela USC, Santiago de Compostela, Spain
    Histol Histopathol 24:979-90. 2009
    ..Taken together, our results demonstrate that vaspin and amylin are modulated by energy status in the placenta, which suggests that these proteins may be involved in the regulation of placental metabolic functions...
  52. doi request reprint Regulation of GPR55 in rat white adipose tissue and serum LPI by nutritional status, gestation, gender and pituitary factors
    Monica Imbernon
    Department of Physiology, CIMUS, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela 15782, Spain Ciber Fisiopatología de la Obesidad y Nutrición CIBERobn, Santiago de Compostela 15706, Spain
    Mol Cell Endocrinol 383:159-69. 2014
    ..Our findings indicate that GPR55 and LPI are regulated by different physiological and pathophysiological settings known to be associated with marked alterations in energy status. ..
  53. pmc Estradiol Regulates Brown Adipose Tissue Thermogenesis via Hypothalamic AMPK
    Pablo B Martínez de Morentin
    Department of Physiology, Research Center of Molecular Medicine and Chronic Diseases CIMUS, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela, 15782, Spain Ciber Fisiopatología de la Obesidad y Nutrición CIBERobn, Santiago de Compostela, 15706, Spain
    Cell Metab 20:41-53. 2014
    ....
  54. pmc Sirtuin 1 and sirtuin 3: physiological modulators of metabolism
    Ruben Nogueiras
    Department of Physiology, School of Medicine Instituto de Investigaciones Sanitarias, University of Santiago de Compostela, Santiago de Compostela, Spain
    Physiol Rev 92:1479-514. 2012
    ..Consequently, activation of sirtuins by genetic or pharmacological means can elicit multiple metabolic benefits that protect mice from diet-induced obesity, type 2 diabetes, and nonalcoholic fatty liver disease...
  55. ncbi request reprint Regulation of growth hormone secretagogue receptor gene expression in the arcuate nuclei of the rat by leptin and ghrelin
    Ruben Nogueiras
    Departmetn of Physiology, University of Santiago de Compostela, Spain
    Diabetes 53:2552-8. 2004
    ..Ghrelin significantly increased GHS-R expression but not in dwarf rats. These results show that the level of GHS-R expression in the ARC is reduced by leptin and increased by ghrelin and that the effect of ghrelin may be GH dependent...
  56. ncbi request reprint Ghrelin localization in rat and human thyroid and parathyroid glands and tumours
    Kawtar Raghay
    Department of Morphological Sciences, University Clinical Hospital, University of Santiago de Compostela, c S Francisco, 15782 Santiago de Compostela, Spain
    Histochem Cell Biol 125:239-46. 2006
    ..Overall, expression of ghrelin in human and rat thyroid and parathyroid glands is highly suggestive of a conserved role of this molecule in the regulation of thyroid and parathyroid cell function...
  57. doi request reprint Preproghrelin expression is a key target for insulin action on adipogenesis
    Uxía Gurriarán-Rodríguez
    Area de Endocrinología Molecular y Celular, Instituto de Investigación Sanitaria de Santiago IDIS, Hospital Clinico Universitario de Santiago, Servicio Gallego de Salud SERGAS, Santiago de Compostela, Spain
    J Endocrinol 210:R1-7. 2011
    ..The results underscore a key role for preproghrelin-derived peptides on adipogenesis through an autocrine/paracrine mechanism...
  58. pmc Long-term effects of ghrelin and ghrelin receptor agonists on energy balance in rats
    Sabine Strassburg
    Department of Psychiatry, Obesity Research Centre Genome Research Institute, Univ of Cincinnati College of Medicine, Cincinnati, OH, USA
    Am J Physiol Endocrinol Metab 295:E78-84. 2008
    ..These results characterize BIM-28131 as a promising GHS-R agonist with an attractive action profile for the treatment of catabolic disease states such as cachexia...
  59. pmc Leptin and fasting regulate rat gastric glucose-regulated protein 58
    Susana B Bravo
    Department of Physiology, School of Medicine, Instituto de Investigaciones Sanitarias IDIS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain
    Int J Pept 2011:969818. 2011
    ..Dissection of the molecular pathways mediating the interactions between ER stress-related factors and nutrient availability, as well as their target genes, may open a new avenue for the study of obesity and other metabolic disorders...
  60. doi request reprint Hypothalamic lipotoxicity and the metabolic syndrome
    Pablo B Martínez de Morentin
    Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, S Francisco s n, Santiago de Compostela, A Coruna, 15782, Spain
    Biochim Biophys Acta 1801:350-61. 2010
    ..A better understanding of these molecular mechanisms will help to identify new drug targets for the treatment of obesity and metabolic syndrome...
  61. ncbi request reprint Biomedicine. Separation of conjoined hormones yields appetite rivals
    Ruben Nogueiras
    Department of Psychiatry, University of Cincinnati, Cincinnati, OH 45237, USA
    Science 310:985-6. 2005
  62. doi request reprint GOAT: the master switch for the ghrelin system?
    Amparo Romero
    Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela, A Coruña 15782, Spain
    Eur J Endocrinol 163:1-8. 2010
    ....
  63. ncbi request reprint Central nervous system regulation of adipocyte metabolism
    Ruben Nogueiras
    Department of Psychiatry, Obesity Research Centre, University of Cincinnati, Cincinnati, OH 45226, USA
    Regul Pept 149:26-31. 2008
    ..In this review, we discuss the central actions of some peptides with an important role in energy balance regulation on adipocyte metabolism and the physiological relevance of these actions...
  64. ncbi request reprint Regulation of resistin by gonadal, thyroid hormone, and nutritional status
    Ruben Nogueiras
    Department of Physiology, Universitario de Santiago, Santiago de Compostela, Spain
    Obes Res 11:408-14. 2003
    ..The aim of this study was to assess the influence of gender, gonadal status, thyroid hormones, pregnancy, and food restriction on resistin mRNA levels in adipose tissue of rats...