Miguel Lopez

Summary

Affiliation: Santiago de Compostela
Country: Spain

Publications

  1. pmc Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance
    Miguel Lopez
    Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela, A Coruna, Spain
    Nat Med 16:1001-8. 2010
  2. pmc Hypothalamic mTOR signaling mediates the orexigenic action of ghrelin
    Luis Martins
    Department of Physiology, Research Center of Molecular Medicine and Chronic Diseases CIMUS, University of Santiago de Compostela Instituto de Investigación Sanitaria IDIS, Santiago de Compostela, Spain
    PLoS ONE 7:e46923. 2012
  3. pmc Nicotine induces negative energy balance through hypothalamic AMP-activated protein kinase
    Pablo B Martínez de Morentin
    Department of Physiology, School of Medicine CIMUS, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela, A Coruna, Spain
    Diabetes 61:807-17. 2012
  4. doi request reprint The orexigenic effect of orexin-A revisited: dependence of an intact growth hormone axis
    Mayte Alvarez-Crespo
    Department of Physiology, CIMUS, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela, 15782, Spain and CIBER Fisiopatología de la Obesidad y Nutrición CIBERobn, 15706, Spain
    Endocrinology 154:3589-98. 2013
  5. doi request reprint Energy balance regulation by thyroid hormones at central level
    Miguel Lopez
    Department of Physiology, CIMUS, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela, 15782, Spain
    Trends Mol Med 19:418-27. 2013
  6. doi request reprint Cross-talk between orexins (hypocretins) and the neuroendocrine axes (hypothalamic-pituitary axes)
    Miguel Lopez
    Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela 15782, Spain
    Front Neuroendocrinol 31:113-27. 2010
  7. doi request reprint Orexins (hypocretins) actions on the GHRH/somatostatin-GH axis
    M Lopez
    Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
    Acta Physiol (Oxf) 198:325-34. 2010
  8. pmc Ghrelin effects on neuropeptides in the rat hypothalamus depend on fatty acid metabolism actions on BSX but not on gender
    Ricardo Lage
    Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela A Coruña, Spain
    FASEB J 24:2670-9. 2010
  9. ncbi request reprint Agouti-related peptide, neuropeptide Y, and somatostatin-producing neurons are targets for ghrelin actions in the rat hypothalamus
    Luisa M Seoane
    Department of Physiology, Faculty of Medicine, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain
    Endocrinology 144:544-51. 2003
  10. doi request reprint Hypothalamic mTOR pathway mediates thyroid hormone-induced hyperphagia in hyperthyroidism
    Luis Varela
    Department of Physiology, School of Medicine CIMUS, University of Santiago de Compostela, Instituto de Investigacion Sanitaria, Santiago de Compostela A Coruña 15782, Spain
    J Pathol 227:209-22. 2012

Collaborators

Detail Information

Publications56

  1. pmc Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balance
    Miguel Lopez
    Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela, A Coruna, Spain
    Nat Med 16:1001-8. 2010
    ..These effects are reversed by pharmacological blockade of the SNS. Thus, thyroid hormone-induced modulation of AMPK activity and lipid metabolism in the hypothalamus is a major regulator of whole-body energy homeostasis...
  2. pmc Hypothalamic mTOR signaling mediates the orexigenic action of ghrelin
    Luis Martins
    Department of Physiology, Research Center of Molecular Medicine and Chronic Diseases CIMUS, University of Santiago de Compostela Instituto de Investigación Sanitaria IDIS, Santiago de Compostela, Spain
    PLoS ONE 7:e46923. 2012
    ..Taken together, these data indicate that, in addition to previous reported mechanisms, ghrelin also promotes feeding through modulation of hypothalamic mTOR pathway...
  3. pmc Nicotine induces negative energy balance through hypothalamic AMP-activated protein kinase
    Pablo B Martínez de Morentin
    Department of Physiology, School of Medicine CIMUS, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela, A Coruna, Spain
    Diabetes 61:807-17. 2012
    ..Overall these data demonstrate that the effects of nicotine on energy balance involve specific modulation of the hypothalamic AMPK-BAT axis. These targets may be relevant for the development of new therapies for human obesity...
  4. doi request reprint The orexigenic effect of orexin-A revisited: dependence of an intact growth hormone axis
    Mayte Alvarez-Crespo
    Department of Physiology, CIMUS, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela, 15782, Spain and CIBER Fisiopatología de la Obesidad y Nutrición CIBERobn, 15706, Spain
    Endocrinology 154:3589-98. 2013
    ..Overall, this evidence suggests that the orexigenic action of OX-A depends on an intact GH axis and that this neuroendocrine feedback loop may be of interest in the understanding of orexins action on energy balance and GH deficiency. ..
  5. doi request reprint Energy balance regulation by thyroid hormones at central level
    Miguel Lopez
    Department of Physiology, CIMUS, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela, 15782, Spain
    Trends Mol Med 19:418-27. 2013
    ..Here, we review what is currently known about THs and their regulation of energy balance and metabolism in both peripheral and central tissues. ..
  6. doi request reprint Cross-talk between orexins (hypocretins) and the neuroendocrine axes (hypothalamic-pituitary axes)
    Miguel Lopez
    Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela 15782, Spain
    Front Neuroendocrinol 31:113-27. 2010
    ..Understanding this aspect of orexin/hypocretin physiology could open new therapeutic possibilities in the treatment of sleep, energy homeostasis and endocrine pathologies...
  7. doi request reprint Orexins (hypocretins) actions on the GHRH/somatostatin-GH axis
    M Lopez
    Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
    Acta Physiol (Oxf) 198:325-34. 2010
    ....
  8. pmc Ghrelin effects on neuropeptides in the rat hypothalamus depend on fatty acid metabolism actions on BSX but not on gender
    Ricardo Lage
    Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela A Coruña, Spain
    FASEB J 24:2670-9. 2010
    ..Notably, this effect is associated with decreased BSX expression and reduced food intake. Overall, our data suggest that BSX integrates changes in neuronal metabolic status with ARC-derived neuropeptides in a gender-independent manner...
  9. ncbi request reprint Agouti-related peptide, neuropeptide Y, and somatostatin-producing neurons are targets for ghrelin actions in the rat hypothalamus
    Luisa M Seoane
    Department of Physiology, Faculty of Medicine, University of Santiago de Compostela, 15705 Santiago de Compostela, Spain
    Endocrinology 144:544-51. 2003
    ..This study furthers our understanding of the molecular basis and mechanisms involved in the effect of ghrelin on food intake and GH secretion...
  10. doi request reprint Hypothalamic mTOR pathway mediates thyroid hormone-induced hyperphagia in hyperthyroidism
    Luis Varela
    Department of Physiology, School of Medicine CIMUS, University of Santiago de Compostela, Instituto de Investigacion Sanitaria, Santiago de Compostela A Coruña 15782, Spain
    J Pathol 227:209-22. 2012
    ....
  11. ncbi request reprint Central resistin regulates hypothalamic and peripheral lipid metabolism in a nutritional-dependent fashion
    Maria J Vazquez
    Department of Physiology, School of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain
    Endocrinology 149:4534-43. 2008
    ..Overall, our results indicate that RSTN controls feeding and peripheral lipid metabolism and suggest that hepatic RSTN-induced insulin resistance may be mediated by central activation of de novo lipogenesis in liver...
  12. ncbi request reprint Thyroid status regulates CART but not AgRP mRNA levels in the rat hypothalamus
    Miguel Lopez
    Department of Physiology, Faculty of Medicine, University of Santiago de Compostela, A Coruna, Spain
    Neuroreport 13:1775-9. 2002
    ....
  13. doi request reprint Hyperthyroidism differentially regulates neuropeptide S system in the rat brain
    Carmen R González
    Department of Physiology, School of Medicine CIMUS, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela A Coruña, Spain
    Brain Res 1450:40-8. 2012
    ..Thus, the NPS/NPS-R system may be involved in several hyperthyroidism-associated comorbidities...
  14. ncbi request reprint Orexin-A regulates growth hormone-releasing hormone mRNA content in a nucleus-specific manner and somatostatin mRNA content in a growth hormone-dependent fashion in the rat hypothalamus
    Miguel Lopez
    Department of Physiology School of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain
    Eur J Neurosci 19:2080-8. 2004
    ..These data improve our understanding of the interactions among the different systems involved in the control and pathophysiology of food intake, sleep and GH secretion...
  15. doi request reprint Regulation of lipin1 by nutritional status, adiponectin, sex and pituitary function in rat white adipose tissue
    C Ruth González
    Department of Physiology, School of Medicine Instituto de Investigaciones Sanitarias IDIS, University of Santiago de Compostela, Spain
    Physiol Behav 105:777-83. 2012
    ..To dissect the complicated interactions between key regulators of lipid metabolism like lipin1, may be important for the development of new therapies for the treatment and prevention of obesity and its associated disorders...
  16. doi request reprint Ghrelin and lipid metabolism: key partners in energy balance
    Luis Varela
    Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela A Coruña 15782, Spain
    J Mol Endocrinol 46:R43-63. 2011
    ..Understanding this new metabolic pathway can provide new therapeutic targets for the treatment of obesity and the metabolic syndrome...
  17. pmc Central ghrelin regulates peripheral lipid metabolism in a growth hormone-independent fashion
    Susana Sangiao-Alvarellos
    Department of Medicine, School of Health Science, University of A Coruna, A Coruna, Spain
    Endocrinology 150:4562-74. 2009
    ....
  18. ncbi request reprint Nicotine improves obesity and hepatic steatosis and ER stress in diet-induced obese male rats
    Patricia Seoane-Collazo
    Department of Physiology P S C, P B M d M, C D, R N, M L, NeuObesity Group, Centro singular de investigación en medicina molecular y enfermedades crónicas CIMUS, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela 15782, Spain Centro de investigación biomédica en red Fisiopatología de la Obesidad y Nutrición P S C, P B M d M, C D, R N, M L, Santiago de Compostela 15706, Spain and Department of Clinical Science J F, University of Bergen, N 5020 Bergen, Norway
    Endocrinology 155:1679-89. 2014
    ....
  19. pmc Central melanin-concentrating hormone influences liver and adipose metabolism via specific hypothalamic nuclei and efferent autonomic/JNK1 pathways
    Monica Imbernon
    Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, S Francisco s n, Santiago de Compostela A Coruña, Spain
    Gastroenterology 144:636-649.e6. 2013
    ..Herein, we sought to investigate the role of MCH, an orexigenic neuropeptide specifically expressed in the lateral hypothalamic area, on hepatic and adipocyte metabolism...
  20. pmc Female Nur77-deficient mice show increased susceptibility to diet-induced obesity
    Sonia Perez-Sieira
    Department of Physiology, School of Medicine CIMUS Instituto de Investigaciones Sanitarias, Santiago de Compostela, Spain
    PLoS ONE 8:e53836. 2013
    ..The decreased energy expenditure and the actions of Nur77 on liver, muscle, brown and white adipose tissue contribute to the increased susceptibility to diet-induced obesity in females lacking Nur77...
  21. pmc Food-intake-regulating-neuropeptides are expressed and regulated through pregnancy and following food restriction in rat placenta
    Jorge E Caminos
    Department of Physiology, School of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain
    Reprod Biol Endocrinol 6:14. 2008
    ..Recent evidence has demonstrated their expression in rat and human placenta...
  22. doi request reprint Ghrelin requires p53 to stimulate lipid storage in fat and liver
    Begoña Porteiro
    Department of Physiology, Centre of Research in Molecular Medicine and Chronic Diseases of the University of Santiago de Compostela CIMUS, University of Santiago de Compostela Instituto de Investigación Sanitaria, Avda Barcelona s n, 15782, Santiago de Compostela A Coruña, Spain, and CIBER Fisiopatologia de la Obesidad y Nutricion, Instituto de Salud Carlos III, Spain
    Endocrinology 154:3671-9. 2013
    ..Thus, our results show that p53 is necessary for the actions of ghrelin on WAT and liver, leading to changes in expression levels of lipogenic and adipogenic genes, and modifying body weight. ..
  23. doi request reprint Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelin
    Miguel Lopez
    Department of Physiology, School of Medicine, University of Santiago de Compostela, S Francisco s n, 15782 Santiago de Compostela A Coruña, Spain
    Cell Metab 7:389-99. 2008
    ..Overall, our results indicate that modulation of hypothalamic fatty acid metabolism specifically in the VMH in response to ghrelin is a physiological mechanism that controls feeding...
  24. doi request reprint Adiponectin receptor 2 is regulated by nutritional status, leptin and pregnancy in a tissue-specific manner
    Carmen Ruth González
    Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, 15782 Santiago de Compostela, Spain
    Physiol Behav 99:91-9. 2010
    ....
  25. doi request reprint Central manipulation of dopamine receptors attenuates the orexigenic action of ghrelin
    Amparo Romero-Picó
    Department of Physiology, School of Medicine CIMUS, Instituto de Investigación Sanitaria IDIS, University of Santiago de Compostela, Avda Barcelona 3, 15782, Santiago de Compostela, A Coruna, Spain
    Psychopharmacology (Berl) 229:275-83. 2013
    ..However, it is not known whether the orexigenic action of ghrelin is due to changes in central dopamine receptors...
  26. doi request reprint Hypothalamic AMP-activated protein kinase as a mediator of whole body energy balance
    Pablo Blanco Martínez de Morentin
    Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela, A Coruna, Spain
    Rev Endocr Metab Disord 12:127-40. 2011
    ..Understanding this key molecule and especially its functions at central level may provide new therapeutic targets for the treatment of metabolic alterations and obesity...
  27. pmc Hypothalamic κ-opioid receptor modulates the orexigenic effect of ghrelin
    Amparo Romero-Picó
    Department of Physiology, School of Medicine CIMUS Instituto de Investigaciones Sanitarias IDIS, CIBER Fisiopatologia de la Obesidad y Nutricion CIBEROBN, San Francisco s n, Santiago de Compostela A Coruña, University of Santiago de Compostela, Santiago de Compostela, Spain
    Neuropsychopharmacology 38:1296-307. 2013
    ..Our novel data implicate hypothalamic KOR signaling in the orexigenic action of ghrelin...
  28. ncbi request reprint Caffeine treatment regulates neuropeptide S system expression in the rat brain
    Ricardo Lage
    Department of Physiology, School of Medicine, University of Santiago de Compostela, S Francisco s n 15782, Santiago de Compostela, A Coruna, Spain
    Neurosci Lett 410:47-51. 2006
    ..Overall, these data suggest a possible role for the NPS system in mediating some of the behavioral effects of caffeine...
  29. ncbi request reprint Neuropeptide Y, but not agouti-related peptide or melanin-concentrating hormone, is a target peptide for orexin-A feeding actions in the rat hypothalamus
    Miguel Lopez
    Department of Physiology, Faculty of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain
    Neuroendocrinology 75:34-44. 2002
    ....
  30. pmc Heterozygous deficiency of endoglin decreases insulin and hepatic triglyceride levels during high fat diet
    Daniel Beiroa
    Department of Physiology, School of Medicine CIMUS Instituto de Investigaciones Sanitarias IDIS, CIBER Fisiopatologia de la Obesidad y Nutricion CIBEROBN, University of Santiago de Compostela, Santiago de Compostela, A Coruna, Spain
    PLoS ONE 8:e54591. 2013
    ..Overall, our findings indicate that endoglin is a potentially important physiological mediator of insulin levels and hepatic lipid metabolism...
  31. ncbi request reprint AMPK: a metabolic gauge regulating whole-body energy homeostasis
    Ricardo Lage
    Department of Physiology, School of Medicine, University of Santiago de Compostela, 15782, Santiago de Compostela, Spain
    Trends Mol Med 14:539-49. 2008
    ..Here, we summarize the role of AMPK in the regulation of energy homeostasis. Understanding this key enzyme and its tissue-specific regulation will provide new targets for the treatment of metabolic disorders...
  32. pmc The central Sirtuin 1/p53 pathway is essential for the orexigenic action of ghrelin
    Douglas A Velásquez
    Department of Physiology, School of Medicine Instituto de Investigaciones Sanitarias IDIS, University of Santiago de Compostela, Santiago de Compostela, Spain
    Diabetes 60:1177-85. 2011
    ..We tested the hypothesis that the central SIRT1/p53 pathway might be mediating the orexigenic action of ghrelin...
  33. doi request reprint Central GLP-1 actions on energy metabolism
    Douglas A Velásquez
    Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela, A Coruna, Spain
    Vitam Horm 84:303-17. 2010
    ..In this review, we will focus on the metabolic actions and mechanisms of the central GLP-1 system: modulation of energy intake, glucose metabolism, and fatty acid metabolism...
  34. doi request reprint New insights in ghrelin orexigenic effect
    Carlos Dieguez
    Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, S Francisco s n, Santiago de Compostela, A Coruna, 15782, Spain
    Front Horm Res 38:196-205. 2010
    ..In this review, we summarize several aspects of ghrelin effects at hypothalamic level and their implications in the control of food intake and energy balance...
  35. doi request reprint Hypothalamic lipotoxicity and the metabolic syndrome
    Pablo B Martínez de Morentin
    Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, S Francisco s n, Santiago de Compostela, A Coruna, 15782, Spain
    Biochim Biophys Acta 1801:350-61. 2010
    ..A better understanding of these molecular mechanisms will help to identify new drug targets for the treatment of obesity and metabolic syndrome...
  36. doi request reprint Resistin: regulation of food intake, glucose homeostasis and lipid metabolism
    Ruben Nogueiras
    Department of Physiology, School of Medicine, University of Santiago de Compostela, Instituto de Investigacion Sanitaria, and CIBER Fisiopatologia de la Obesidad y Nutricion, Santiago de Compostela, Spain
    Endocr Dev 17:175-84. 2010
    ..In this short review, we will summarize the most relevant findings of this hormone in rodents...
  37. ncbi request reprint Vaspin and amylin are expressed in human and rat placenta and regulated by nutritional status
    Jorge E Caminos
    Department of Physiology, School of Medicine Instituto de Investigación Sanitaria IDIS, University of Santiago de Compostela USC, Santiago de Compostela, Spain
    Histol Histopathol 24:979-90. 2009
    ..Taken together, our results demonstrate that vaspin and amylin are modulated by energy status in the placenta, which suggests that these proteins may be involved in the regulation of placental metabolic functions...
  38. doi request reprint Hypothalamic control of lipid metabolism: focus on leptin, ghrelin and melanocortins
    Carlos Dieguez
    Department of Physiology, School of Medicine, Instituto de Investigación Sanitaria IDIS, University of Santiago de Compostela, Spain carlos dieguez usc es
    Neuroendocrinology 94:1-11. 2011
    ..In this short review, we highlight the main molecular pathways triggered by leptin and ghrelin altering both central and peripheral lipid metabolism and, therefore, controlling feeding behavior and energy expenditure...
  39. doi request reprint Gastrointestinal peptides controlling body weight homeostasis
    Hugo Mendieta-Zerón
    Department of Physiology, School of Medicine, University of Santiago de Compostela, San Franscisco s n, 15782 Santiago de Compostea, A Coruna, Spain
    Gen Comp Endocrinol 155:481-95. 2008
    ..This review summarizes research into energy balance through gastrointestinal tract peptides. Understanding these molecular mechanisms will provide new pharmacological targets for the treatment of obesity and appetite disorders...
  40. pmc Leptin and fasting regulate rat gastric glucose-regulated protein 58
    Susana B Bravo
    Department of Physiology, School of Medicine, Instituto de Investigaciones Sanitarias IDIS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain
    Int J Pept 2011:969818. 2011
    ..Dissection of the molecular pathways mediating the interactions between ER stress-related factors and nutrient availability, as well as their target genes, may open a new avenue for the study of obesity and other metabolic disorders...
  41. doi request reprint Influence of chronic undernutrition and leptin on GOAT mRNA levels in rat stomach mucosa
    C Ruth González
    Department of Physiology, School of Medicine, University of Santiago de Compostela, 15782, Santiago de Compostela, Spain Ciber Fisiopatología de la Obesidad y Nutrición CIBERobn, Spain
    J Mol Endocrinol 41:415-21. 2008
    ....
  42. ncbi request reprint Nicotine treatment regulates neuropeptide S system expression in the rat brain
    Ricardo Lage
    Department of Physiology, School of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain
    Neurotoxicology 28:1129-35. 2007
    ..Overall, these data suggest that NPS system is specifically regulated by nicotine in the rat hypothalamus and brainstem...
  43. pmc Estradiol Regulates Brown Adipose Tissue Thermogenesis via Hypothalamic AMPK
    Pablo B Martínez de Morentin
    Department of Physiology, Research Center of Molecular Medicine and Chronic Diseases CIMUS, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela, 15782, Spain Ciber Fisiopatología de la Obesidad y Nutrición CIBERobn, Santiago de Compostela, 15706, Spain
    Cell Metab 20:41-53. 2014
    ....
  44. doi request reprint Regulation of GPR55 in rat white adipose tissue and serum LPI by nutritional status, gestation, gender and pituitary factors
    Monica Imbernon
    Department of Physiology, CIMUS, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela 15782, Spain Ciber Fisiopatología de la Obesidad y Nutrición CIBERobn, Santiago de Compostela 15706, Spain
    Mol Cell Endocrinol 383:159-69. 2014
    ..Our findings indicate that GPR55 and LPI are regulated by different physiological and pathophysiological settings known to be associated with marked alterations in energy status. ..
  45. ncbi request reprint Sensing the fat: fatty acid metabolism in the hypothalamus and the melanocortin system
    Miguel Lopez
    Department of Physiology, School of Medicine, University of Santiago de Compostela, C S Francisco 1, 15705 Santiago de Compostela, Spain
    Peptides 26:1753-8. 2005
    ..Understanding these molecular mechanisms could provide new pharmacological targets for the treatment of obesity and appetite disorders, as well as novel concepts in the nutritional design...
  46. ncbi request reprint Brain lipogenesis and regulation of energy metabolism
    Miguel Lopez
    Department of Physiology, School of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain
    Curr Opin Clin Nutr Metab Care 11:483-90. 2008
    ..To revise current available information related to the role of brain lipogenic pathways in the regulation of energy homeostasis...
  47. ncbi request reprint Expression of neuropeptide W in rat stomach mucosa: regulation by nutritional status, glucocorticoids and thyroid hormones
    Jorge E Caminos
    Department of Physiology, School of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain
    Regul Pept 146:106-11. 2008
    ..Conversely, hypothyroidism induces a marked increase in the expression of NPW in rat stomach. Overall, these data indicate that stomach NPW is regulated by nutritional and hormonal status...
  48. doi request reprint Myostatin expression is regulated by underfeeding and neonatal programming in rats
    Isabel Carneiro
    Department of Physiology, School of Medicine, Instituto de Investigacion Sanitaria, University of Santiago de Compostela, S Francisco s n, Santiago de Compostela, A Coruna, Spain
    J Physiol Biochem 69:15-23. 2013
    ..Overall, these data suggest that myostatin gene expression is programmed by nutritional status in neonatal life...
  49. doi request reprint Hypothalamic lipids and the regulation of energy homeostasis
    Carlos Dieguez
    Department of Physiology, University of Santiago de Compostela, Spain
    Obes Facts 2:126-35. 2009
    ..Defining these novel mechanisms may offer new therapeutic targets for the treatment of obesity and its associated pathologies...
  50. ncbi request reprint The endocannabinoid system: role in glucose and energy metabolism
    Ruben Nogueiras
    Department of Physiology, University of Santiago de Compostela Instituto de Investigación Sanitaria IDIS, Santiago de Compostela 15782, Spain
    Pharmacol Res 60:93-8. 2009
    ..In obese states, endocannabinoid levels are increased and might exert unfavorable effects on insulin-sensitive tissues. This review summarizes the effects of the endocannabinoid system on glucose metabolism in humans and rodents...
  51. ncbi request reprint Role of ghrelin in reproduction
    Maria C Garcia
    Department of Physiology, School of Medicine, University of Santiago de Compostela, R San Francisco s n, 15782 Santiago de Compostela A Coruña, Spain
    Reproduction 133:531-40. 2007
    ..We propose that ghrelin either acting as an endocrine and/or paracrine signal may play a major role in the endocrine network that integrates energy balance and reproduction...
  52. doi request reprint Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesity
    Ruben Nogueiras
    Department of Psychiatry, Obesity Research Centre, University of Cincinnati, Cincinnati, Ohio 45226, USA
    J Neurosci 29:5916-25. 2009
    ..Importantly, the CNS GLP-1 system loses the capacity to modulate adipocyte metabolism in obese states, suggesting an obesity-induced adipocyte resistance to CNS GLP-1...
  53. ncbi request reprint Hypothalamic fatty acid metabolism: a housekeeping pathway that regulates food intake
    Miguel Lopez
    Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
    Bioessays 29:248-61. 2007
    ..Understanding these molecular mechanisms could provide new targets for the treatment of obesity and related disorders...
  54. ncbi request reprint Peripheral tissue-brain interactions in the regulation of food intake
    Miguel Lopez
    Department of Physiology, School of Medicine, University of Santiago de Compostela, C San Francisco s n 15782, Santiago de Compostela, A Coruna, Spain
    Proc Nutr Soc 66:131-55. 2007
    ..Understanding these molecular mechanisms will provide new pharmacological targets for the treatment of obesity and appetite disorders...
  55. doi request reprint AMP-activated protein kinase: 'a cup of tea' against cholesterol-induced neurotoxicity
    Pablo Blanco Martínez de Morentin
    Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
    J Pathol 222:329-34. 2010
    ..Further work will be necessary to address whether AMPK may be a potential target to combat neurodegenerative diseases...