Research Topics
Genomes and Genes
| Miguel LopezSummaryAffiliation: Santiago de Compostela Country: Spain Publications
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Detail Information
Publications
Hypothalamic AMPK and fatty acid metabolism mediate thyroid regulation of energy balanceMiguel Lopez
Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela, A Coruna, Spain
Nat Med 16:1001-8. 2010..These effects are reversed by pharmacological blockade of the SNS. Thus, thyroid hormone-induced modulation of AMPK activity and lipid metabolism in the hypothalamus is a major regulator of whole-body energy homeostasis...
Cross-talk between orexins (hypocretins) and the neuroendocrine axes (hypothalamic-pituitary axes)Miguel Lopez
Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela 15782, Spain
Front Neuroendocrinol 31:113-27. 2010..Understanding this aspect of orexin/hypocretin physiology could open new therapeutic possibilities in the treatment of sleep, energy homeostasis and endocrine pathologies...- Orexins (hypocretins) actions on the GHRH/somatostatin-GH axisM Lopez
Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
Acta Physiol (Oxf) 198:325-34. 2010.... 
Orexin-A regulates growth hormone-releasing hormone mRNA content in a nucleus-specific manner and somatostatin mRNA content in a growth hormone-dependent fashion in the rat hypothalamusMiguel Lopez
Department of Physiology School of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain
Eur J Neurosci 19:2080-8. 2004..These data improve our understanding of the interactions among the different systems involved in the control and pathophysiology of food intake, sleep and GH secretion...- Ghrelin effects on neuropeptides in the rat hypothalamus depend on fatty acid metabolism actions on BSX but not on genderRicardo Lage
Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela A Coruña, Spain
FASEB J 24:2670-9. 2010..Notably, this effect is associated with decreased BSX expression and reduced food intake. Overall, our data suggest that BSX integrates changes in neuronal metabolic status with ARC-derived neuropeptides in a gender-independent manner... - Thyroid status regulates CART but not AgRP mRNA levels in the rat hypothalamusMiguel Lopez
Department of Physiology, Faculty of Medicine, University of Santiago de Compostela, A Coruna, Spain
Neuroreport 13:1775-9. 2002.... - Hyperthyroidism differentially regulates neuropeptide S system in the rat brainCarmen R González
Department of Physiology, School of Medicine CIMUS, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela A Coruña, Spain
Brain Res 1450:40-8. 2012..Thus, the NPS/NPS-R system may be involved in several hyperthyroidism-associated comorbidities... - Hypothalamic mTOR pathway mediates thyroid hormone-induced hyperphagia in hyperthyroidismLuis Varela
Department of Physiology, School of Medicine CIMUS, University of Santiago de Compostela, Instituto de Investigacion Sanitaria, Santiago de Compostela A Coruña 15782, Spain
J Pathol 227:209-22. 2012.... - Central ghrelin regulates peripheral lipid metabolism in a growth hormone-independent fashionSusana Sangiao-Alvarellos
Department of Medicine, School of Health Science, University of A Coruna, A Coruna, Spain
Endocrinology 150:4562-74. 2009.... - Ghrelin and lipid metabolism: key partners in energy balanceLuis Varela
Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela A Coruña 15782, Spain
J Mol Endocrinol 46:R43-63. 2011..Understanding this new metabolic pathway can provide new therapeutic targets for the treatment of obesity and the metabolic syndrome... - Central melanin-concentrating hormone influences liver and adipose metabolism via specific hypothalamic nuclei and efferent autonomic/JNK1 pathwaysMonica Imbernon
Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, S Francisco s n, Santiago de Compostela A Coruña, Spain
Gastroenterology 144:636-649.e6. 2013..Herein, we sought to investigate the role of MCH, an orexigenic neuropeptide specifically expressed in the lateral hypothalamic area, on hepatic and adipocyte metabolism... - Nicotine induces negative energy balance through hypothalamic AMP-activated protein kinasePablo B Martínez de Morentin
Department of Physiology, School of Medicine CIMUS, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela, A Coruna, Spain
Diabetes 61:807-17. 2012..Overall these data demonstrate that the effects of nicotine on energy balance involve specific modulation of the hypothalamic AMPK-BAT axis. These targets may be relevant for the development of new therapies for human obesity... - Regulation of lipin1 by nutritional status, adiponectin, sex and pituitary function in rat white adipose tissueC Ruth González
Department of Physiology, School of Medicine Instituto de Investigaciones Sanitarias IDIS, University of Santiago de Compostela, Spain
Physiol Behav 105:777-83. 2012..To dissect the complicated interactions between key regulators of lipid metabolism like lipin1, may be important for the development of new therapies for the treatment and prevention of obesity and its associated disorders... - Hypothalamic mTOR signaling mediates the orexigenic action of ghrelinLuis Martins
Department of Physiology, Research Center of Molecular Medicine and Chronic Diseases CIMUS, University of Santiago de Compostela Instituto de Investigación Sanitaria IDIS, Santiago de Compostela, Spain
PLoS ONE 7:e46923. 2012..Taken together, these data indicate that, in addition to previous reported mechanisms, ghrelin also promotes feeding through modulation of hypothalamic mTOR pathway... - Neuropeptide Y, but not agouti-related peptide or melanin-concentrating hormone, is a target peptide for orexin-A feeding actions in the rat hypothalamusMiguel Lopez
Department of Physiology, Faculty of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain
Neuroendocrinology 75:34-44. 2002.... - Central resistin regulates hypothalamic and peripheral lipid metabolism in a nutritional-dependent fashionMaria J Vazquez
Department of Physiology, School of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain
Endocrinology 149:4534-43. 2008..Overall, our results indicate that RSTN controls feeding and peripheral lipid metabolism and suggest that hepatic RSTN-induced insulin resistance may be mediated by central activation of de novo lipogenesis in liver... - Adiponectin receptor 2 is regulated by nutritional status, leptin and pregnancy in a tissue-specific mannerCarmen Ruth González
Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, 15782 Santiago de Compostela, Spain
Physiol Behav 99:91-9. 2010.... - AMPK: a metabolic gauge regulating whole-body energy homeostasisRicardo Lage
Department of Physiology, School of Medicine, University of Santiago de Compostela, 15782, Santiago de Compostela, Spain
Trends Mol Med 14:539-49. 2008..Here, we summarize the role of AMPK in the regulation of energy homeostasis. Understanding this key enzyme and its tissue-specific regulation will provide new targets for the treatment of metabolic disorders... - Central GLP-1 actions on energy metabolismDouglas A Velásquez
Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela, A Coruna, Spain
Vitam Horm 84:303-17. 2010..In this review, we will focus on the metabolic actions and mechanisms of the central GLP-1 system: modulation of energy intake, glucose metabolism, and fatty acid metabolism... - New insights in ghrelin orexigenic effectCarlos Dieguez
Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, S Francisco s n, Santiago de Compostela, A Coruna, 15782, Spain
Front Horm Res 38:196-205. 2010..In this review, we summarize several aspects of ghrelin effects at hypothalamic level and their implications in the control of food intake and energy balance... - The central Sirtuin 1/p53 pathway is essential for the orexigenic action of ghrelinDouglas A Velásquez
Department of Physiology, School of Medicine Instituto de Investigaciones Sanitarias IDIS, University of Santiago de Compostela, Santiago de Compostela, Spain
Diabetes 60:1177-85. 2011..We tested the hypothesis that the central SIRT1/p53 pathway might be mediating the orexigenic action of ghrelin... - Food-intake-regulating-neuropeptides are expressed and regulated through pregnancy and following food restriction in rat placentaJorge E Caminos
Department of Physiology, School of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain
Reprod Biol Endocrinol 6:14. 2008..Recent evidence has demonstrated their expression in rat and human placenta... - Hypothalamic AMP-activated protein kinase as a mediator of whole body energy balancePablo Blanco Martínez de Morentin
Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela, A Coruna, Spain
Rev Endocr Metab Disord 12:127-40. 2011..Understanding this key molecule and especially its functions at central level may provide new therapeutic targets for the treatment of metabolic alterations and obesity... - Hypothalamic control of lipid metabolism: focus on leptin, ghrelin and melanocortinsCarlos Dieguez
Department of Physiology, School of Medicine, Instituto de Investigación Sanitaria IDIS, University of Santiago de Compostela, Spain carlos dieguez usc es
Neuroendocrinology 94:1-11. 2011..In this short review, we highlight the main molecular pathways triggered by leptin and ghrelin altering both central and peripheral lipid metabolism and, therefore, controlling feeding behavior and energy expenditure... - Hypothalamic fatty acid metabolism mediates the orexigenic action of ghrelinMiguel Lopez
Department of Physiology, School of Medicine, University of Santiago de Compostela, S Francisco s n, 15782 Santiago de Compostela A Coruña, Spain
Cell Metab 7:389-99. 2008..Overall, our results indicate that modulation of hypothalamic fatty acid metabolism specifically in the VMH in response to ghrelin is a physiological mechanism that controls feeding... - Vaspin and amylin are expressed in human and rat placenta and regulated by nutritional statusJorge E Caminos
Department of Physiology, School of Medicine Instituto de Investigación Sanitaria IDIS, University of Santiago de Compostela USC, Santiago de Compostela, Spain
Histol Histopathol 24:979-90. 2009..Taken together, our results demonstrate that vaspin and amylin are modulated by energy status in the placenta, which suggests that these proteins may be involved in the regulation of placental metabolic functions... - Resistin: regulation of food intake, glucose homeostasis and lipid metabolismRuben Nogueiras
Department of Physiology, School of Medicine, University of Santiago de Compostela, Instituto de Investigacion Sanitaria, and CIBER Fisiopatologia de la Obesidad y Nutricion, Santiago de Compostela, Spain
Endocr Dev 17:175-84. 2010..In this short review, we will summarize the most relevant findings of this hormone in rodents... - Influence of chronic undernutrition and leptin on GOAT mRNA levels in rat stomach mucosaC Ruth González
Department of Physiology, School of Medicine, University of Santiago de Compostela, 15782, Santiago de Compostela, Spain Ciber Fisiopatología de la Obesidad y Nutrición CIBERobn, Spain
J Mol Endocrinol 41:415-21. 2008.... - Leptin and fasting regulate rat gastric glucose-regulated protein 58Susana B Bravo
Department of Physiology, School of Medicine, Instituto de Investigaciones Sanitarias IDIS, University of Santiago de Compostela, 15782 Santiago de Compostela, Spain
Int J Pept 2011:969818. 2011..Dissection of the molecular pathways mediating the interactions between ER stress-related factors and nutrient availability, as well as their target genes, may open a new avenue for the study of obesity and other metabolic disorders... - Hypothalamic lipotoxicity and the metabolic syndromePablo B Martínez de Morentin
Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, S Francisco s n, Santiago de Compostela, A Coruna, 15782, Spain
Biochim Biophys Acta 1801:350-61. 2010..A better understanding of these molecular mechanisms will help to identify new drug targets for the treatment of obesity and metabolic syndrome... - Brain lipogenesis and regulation of energy metabolismMiguel Lopez
Department of Physiology, School of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain
Curr Opin Clin Nutr Metab Care 11:483-90. 2008..To revise current available information related to the role of brain lipogenic pathways in the regulation of energy homeostasis... - Gastrointestinal peptides controlling body weight homeostasisHugo Mendieta-Zerón
Department of Physiology, School of Medicine, University of Santiago de Compostela, San Franscisco s n, 15782 Santiago de Compostea, A Coruna, Spain
Gen Comp Endocrinol 155:481-95. 2008..This review summarizes research into energy balance through gastrointestinal tract peptides. Understanding these molecular mechanisms will provide new pharmacological targets for the treatment of obesity and appetite disorders... - Sensing the fat: fatty acid metabolism in the hypothalamus and the melanocortin systemMiguel Lopez
Department of Physiology, School of Medicine, University of Santiago de Compostela, C S Francisco 1, 15705 Santiago de Compostela, Spain
Peptides 26:1753-8. 2005..Understanding these molecular mechanisms could provide new pharmacological targets for the treatment of obesity and appetite disorders, as well as novel concepts in the nutritional design... - Hypothalamic lipids and the regulation of energy homeostasisCarlos Dieguez
Department of Physiology, University of Santiago de Compostela, Spain
Obes Facts 2:126-35. 2009..Defining these novel mechanisms may offer new therapeutic targets for the treatment of obesity and its associated pathologies... - Nicotine treatment regulates neuropeptide S system expression in the rat brainRicardo Lage
Department of Physiology, School of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain
Neurotoxicology 28:1129-35. 2007..Overall, these data suggest that NPS system is specifically regulated by nicotine in the rat hypothalamus and brainstem... - Female Nur77-deficient mice show increased susceptibility to diet-induced obesitySonia Perez-Sieira
Department of Physiology, School of Medicine CIMUS Instituto de Investigaciones Sanitarias, Santiago de Compostela, Spain
PLoS ONE 8:e53836. 2013..The decreased energy expenditure and the actions of Nur77 on liver, muscle, brown and white adipose tissue contribute to the increased susceptibility to diet-induced obesity in females lacking Nur77... - Expression of neuropeptide W in rat stomach mucosa: regulation by nutritional status, glucocorticoids and thyroid hormonesJorge E Caminos
Department of Physiology, School of Medicine, University of Santiago de Compostela, Santiago de Compostela, Spain
Regul Pept 146:106-11. 2008..Conversely, hypothyroidism induces a marked increase in the expression of NPW in rat stomach. Overall, these data indicate that stomach NPW is regulated by nutritional and hormonal status... - Direct control of peripheral lipid deposition by CNS GLP-1 receptor signaling is mediated by the sympathetic nervous system and blunted in diet-induced obesityRuben Nogueiras
Department of Psychiatry, Obesity Research Centre, University of Cincinnati, Cincinnati, Ohio 45226, USA
J Neurosci 29:5916-25. 2009..Importantly, the CNS GLP-1 system loses the capacity to modulate adipocyte metabolism in obese states, suggesting an obesity-induced adipocyte resistance to CNS GLP-1... - Hypothalamic fatty acid metabolism: a housekeeping pathway that regulates food intakeMiguel Lopez
Department of Clinical Biochemistry, University of Cambridge, Addenbrooke s Hospital, Cambridge, UK
Bioessays 29:248-61. 2007..Understanding these molecular mechanisms could provide new targets for the treatment of obesity and related disorders... - Heterozygous deficiency of endoglin decreases insulin and hepatic triglyceride levels during high fat dietDaniel Beiroa
Department of Physiology, School of Medicine CIMUS Instituto de Investigaciones Sanitarias IDIS, CIBER Fisiopatologia de la Obesidad y Nutricion CIBEROBN, University of Santiago de Compostela, Santiago de Compostela, A Coruna, Spain
PLoS ONE 8:e54591. 2013..Overall, our findings indicate that endoglin is a potentially important physiological mediator of insulin levels and hepatic lipid metabolism... - Role of ghrelin in reproductionMaria C Garcia
Department of Physiology, School of Medicine, University of Santiago de Compostela, R San Francisco s n, 15782 Santiago de Compostela A Coruña, Spain
Reproduction 133:531-40. 2007..We propose that ghrelin either acting as an endocrine and/or paracrine signal may play a major role in the endocrine network that integrates energy balance and reproduction... - The endocannabinoid system: role in glucose and energy metabolismRuben Nogueiras
Department of Physiology, University of Santiago de Compostela Instituto de Investigación Sanitaria IDIS, Santiago de Compostela 15782, Spain
Pharmacol Res 60:93-8. 2009..In obese states, endocannabinoid levels are increased and might exert unfavorable effects on insulin-sensitive tissues. This review summarizes the effects of the endocannabinoid system on glucose metabolism in humans and rodents... - Myostatin expression is regulated by underfeeding and neonatal programming in ratsIsabel Carneiro
Department of Physiology, School of Medicine, Instituto de Investigacion Sanitaria, University of Santiago de Compostela, S Francisco s n, Santiago de Compostela, A Coruna, Spain
J Physiol Biochem 69:15-23. 2013..Overall, these data suggest that myostatin gene expression is programmed by nutritional status in neonatal life... - AMP-activated protein kinase: 'a cup of tea' against cholesterol-induced neurotoxicityPablo Blanco Martínez de Morentin
Department of Physiology, School of Medicine, University of Santiago de Compostela Instituto de Investigación Sanitaria, Santiago de Compostela, Spain
J Pathol 222:329-34. 2010..Further work will be necessary to address whether AMPK may be a potential target to combat neurodegenerative diseases... - Peripheral tissue-brain interactions in the regulation of food intakeMiguel Lopez
Department of Physiology, School of Medicine, University of Santiago de Compostela, C San Francisco s n 15782, Santiago de Compostela, A Coruna, Spain
Proc Nutr Soc 66:131-55. 2007..Understanding these molecular mechanisms will provide new pharmacological targets for the treatment of obesity and appetite disorders...