- Signaling pathways in intestinal development and cancerElena Sancho
Institut de Recerca Biomedica de Barcelona IRBB PCB, Parc Cientific de Barcelona, 08028 Barcelona, Spain
Annu Rev Cell Dev Biol 20:695-723. 2004..Here, we integrate recent knowledge of the molecular inner workings of the prototype signaling cascades with their specific roles in intestinal epithelial homeostasis and in neoplastic transformation of the epithelium...
- The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cellsMarc van de Wetering
Department of Immunology and Center for Biomedical Genetics, University Medical Center, 3584 CX, Utrecht, The Netherlands
Cell 111:241-50. 2002..Thus, the beta-catenin/TCF-4 complex constitutes the master switch that controls proliferation versus differentiation in healthy and malignant intestinal epithelial cells...
- Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinBEduard Batlle
Department of Immunology and Center for Biomedical Genetics, University Medical Center, Utrecht, The Netherlands
Cell 111:251-63. 2002..We conclude that in the intestinal epithelium beta-catenin and TCF couple proliferation and differentiation to the sorting of cell populations through the EphB/ephrin-B system...
- Live and let die in the intestinal epitheliumElena Sancho
Centre for Biomedical Genetics, Hubrecht Laboratorium, Koninklijke Nederlandse Akademie van Wetenschappen, Utrecht, The Netherlands
Curr Opin Cell Biol 15:763-70. 2003..Wnt signalling appears to control most of these events...
- EphB-ephrin-B interactions suppress colorectal cancer progression by compartmentalizing tumor cellsCarme Cortina
Oncology Programme, Institute for Research in Biomedicine IRB, Josep Samitier 1 5, 08028 Barcelona Spain
Nat Genet 39:1376-83. 2007..Our results indicate that CRC cells must silence EphB expression to avoid repulsive interactions imposed by normal ephrin-B1-expressing intestinal cells at the onset of tumorigenesis...