Research Topics
| C SanchezSummaryCountry: Spain Publications
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Publications
Microtubule-associated protein-2 located in growth regions of rat hippocampal neurons is highly phosphorylated at its proline-rich regionC Sánchez Martín
Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Cantoblanco 28049, Madrid, Spain
Neuroscience 101:885-93. 2000..From these results we suggest that the phosphorylation of MAP2 at its proline-rich region is an important event during neuritogenesis...- GSK3beta-mediated phosphorylation of the microtubule-associated protein 2C (MAP2C) prevents microtubule bundlingC Sanchez
Centro de Biologia Molecular Severo Ochoa, Facultad de Ciencias, Universidad Autonoma de Madrid, Cantoblanco, Spain
Eur J Cell Biol 79:252-60. 2000..Interestingly, these MAP2C species were enriched in cytoskeleton-unbound protein preparations. These data suggests that GSK3-mediated phosphorylation of MAP2 may modify its binding to microtubules and regulate microtubule stability... - Phosphorylation of microtubule-associated protein 2 (MAP2) and its relevance for the regulation of the neuronal cytoskeleton functionC Sanchez
Centro de Biologia Molecular Severo Ochoa, Facultad de Ciencias, Universidad Autónoma de Madrid CSIC UAM, Cantoblanco, 28049, Madrid, Spain
Prog Neurobiol 61:133-68. 2000..Here we will review the current knowledge about the regulation of MAP2 function through phosphorylation/dephosphorylation and its relevance in the broader context of neuronal functions... - Full protection against African horsesickness (AHS) in horses induced by baculovirus-derived AHS virus serotype 4 VP2, VP5 and VP7J L Martinez-Torrecuadrada
INGENASA, Madrid, Spain
J Gen Virol 77:1211-21. 1996..An immunization experiment with four more horses confirmed these results. The vaccine described here would not only prevent the disease, but would drastically reduce the propagation of the virus by vectors... - Phosphorylation and dephosphorylation in the proline-rich C-terminal domain of microtubule-associated protein 2C Sanchez
Centro de Biologia Molecular Severo Ochoa, Facultad de Ciencias, Universidad Autonoma de Madrid, Spain
Eur J Biochem 241:765-71. 1996..This motif can be rapidly dephosphorylated in vitro by protein-phosphatase 1 (PP1) and 2A (PP2A) catalytic subunits but not by PP2B... - Microtubule-associated protein 2 phosphorylation is decreased in the human epileptic temporal lobe cortexC Sanchez
Centro de Biologia Molecular Severo Ochoa, Departamento de Biologia Molecular, Facultad de Ciencias, Universidad Autonoma de Madrid, Spain
Neuroscience 107:25-33. 2001..Also, MAP2 dephosphorylation may lead to alterations of the neuronal cytoskeleton and eventually to neuronal damage and loss, which is typical of epileptic patients... - Ceramide: a new second messenger of cannabinoid actionM Guzman
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, 28040, Madrid, Spain
Trends Pharmacol Sci 22:19-22. 2001..Ceramide in turn mediates cannabinoid-induced apoptosis, as shown by in vitro and in vivo studies. These findings provide a new perspective on how cannabinoids act, and raise exciting physiological and therapeutic questions... - The orphan receptor GPR55 drives skin carcinogenesis and is upregulated in human squamous cell carcinomasE Pérez-Gómez
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
Oncogene . 2012..Oncogene advance online publication, 2 July 2012; doi:10.1038/onc.2012.278... - Effects of cannabinoids on energy metabolismM Guzman
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
Life Sci 65:657-64. 1999..Anandamide has also been shown to exert metabolic effects in hepatocytes, cells that do not express cannabinoid receptors. The biological role of cannabinoids as modulators of metabolism is as yet unclear... 
Serologic markers in early stages of African horse sickness virus infectionJ L Martinez-Torrecuadrada
INGENASA, Madrid, Spain
J Clin Microbiol 35:531-5. 1997..VP7-specific antibodies were detected later in infection. These results make NS2 and VP6 the most attractive candidates for the rapid diagnosis of the infection...- Control of the cell survival/death decision by cannabinoidsM Guzman
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
J Mol Med (Berl) 78:613-25. 2001..Ongoing investigation is in search for cannabinoid-based therapeutic strategies devoid of nondesired psychotropic effects... 
The orphan G protein-coupled receptor GPR55 promotes cancer cell proliferation via ERKC Andradas
Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
Oncogene 30:245-52. 2011..These findings reveal the importance of GPR55 in human cancer, and suggest that it could constitute a new biomarker and therapeutic target in oncology...- Early detection of PrPres in BSE-infected bovine PrP transgenic miceJ Castilla
Centro de Investigacion en Sanidad Animal, INIA, Madrid, Spain
Arch Virol 148:677-91. 2003..Interestingly, transgenic mice-propagated sheep scrapie prions displayed distinct biochemical properties when compared to both the original sheep scrapie and transgenic mouse-propagated BSE inoculum...