A I Sanchez Fructuoso

Summary

Country: Spain

Publications

  1. ncbi request reprint Everolimus: an update on the mechanism of action, pharmacokinetics and recent clinical trials
    Ana I Sánchez-Fructuoso
    Nephorology Department, Hospital Clinico, Avda Martin Lagos s n, 28040 Madrid, Spain
    Expert Opin Drug Metab Toxicol 4:807-19. 2008
  2. doi request reprint Everolimus as primary immunosuppression in kidney transplantation: experience in conversion from calcineurin inhibitors
    Ana I Sánchez-Fructuoso
    Nephrology Department, Hospital Clinico Universitario San Carlos, Madrid, Spain
    Transplantation 93:398-405. 2012
  3. doi request reprint Limited-sampling strategy for mycophenolic acid in renal transplant recipients reciving enteric-coated mycophenolate sodium and tacrolimus
    Ana I Sánchez Fructuoso
    Department of Nephrology, Hospital Clinico Universitario San Carlos, Madrid, Spain
    Ther Drug Monit 34:298-305. 2012
  4. ncbi request reprint Effect of the brain-death process on acute rejection in renal transplantation
    A Sanchez-Fructuoso
    Nephrology Department, Hospital Clinico San Carlos, Madrid, Spain
    Transplant Proc 39:2214-6. 2007
  5. doi request reprint Changes in magnesium and potassium homeostasis after conversion from a calcineurin inhibitor regimen to an mTOR inhibitor-based regimen
    A I Sanchez-Fructuoso
    Nephrology Department, Hospital Clinico Universitario San Carlos, Madrid, Spain
    Transplant Proc 42:3047-9. 2010
  6. ncbi request reprint Conversion to sirolimus in renal transplant patients with tumors
    A Sanchez-Fructuoso
    Nephrology Department, Hospital Clinico San Carlos, Madrid, Spain
    Transplant Proc 38:2451-2. 2006
  7. ncbi request reprint Better mycophenolic acid 12-hour trough level after enteric-coated mycophenolate sodium in patients with gastrointestinal intolerance to mycophenolate mofetil
    A Sanchez Fructuoso
    Nephrology Department, Hospital Clinico San Carlos, Madrid, Spain
    Transplant Proc 39:2194-6. 2007
  8. doi request reprint De novo anti-HLA antibodies in renal allograft recipients: a cross-section study
    A I Sanchez-Fructuoso
    Nephrology Department, Hospital Clinico Universitario San Carlos, Madrid, Spain
    Transplant Proc 42:2874-6. 2010
  9. doi request reprint The prevalence of uridine diphosphate-glucuronosyltransferase 1A9 (UGT1A9) gene promoter region single-nucleotide polymorphisms T-275A and C-2152T and its influence on mycophenolic acid pharmacokinetics in stable renal transplant patients
    A I Sanchez-Fructuoso
    Nephrology Department, Hospital Clinico San Carlos, Madrid, Spain
    Transplant Proc 41:2313-6. 2009
  10. ncbi request reprint Study of anemia after late introduction of everolimus in the immunosuppressive treatment of renal transplant patients
    A Sanchez Fructuoso
    Nephrology Department, Hospital Clinico San Carlos, Madrid, Spain
    Transplant Proc 39:2242-4. 2007

Detail Information

Publications33

  1. ncbi request reprint Everolimus: an update on the mechanism of action, pharmacokinetics and recent clinical trials
    Ana I Sánchez-Fructuoso
    Nephorology Department, Hospital Clinico, Avda Martin Lagos s n, 28040 Madrid, Spain
    Expert Opin Drug Metab Toxicol 4:807-19. 2008
    ....
  2. doi request reprint Everolimus as primary immunosuppression in kidney transplantation: experience in conversion from calcineurin inhibitors
    Ana I Sánchez-Fructuoso
    Nephrology Department, Hospital Clinico Universitario San Carlos, Madrid, Spain
    Transplantation 93:398-405. 2012
    ..We analyzed our clinical experience with everolimus (EVL) and identified prognostic factors for a successful conversion...
  3. doi request reprint Limited-sampling strategy for mycophenolic acid in renal transplant recipients reciving enteric-coated mycophenolate sodium and tacrolimus
    Ana I Sánchez Fructuoso
    Department of Nephrology, Hospital Clinico Universitario San Carlos, Madrid, Spain
    Ther Drug Monit 34:298-305. 2012
    ..However, no LSS has been validated for enteric-coated mycophenolate sodium (EC-MPS). Our aim was to develop an LSS to measure the AUC(0-12h) of mycophenolic acid in kidney recipients treated with tacrolimus and EC-MPS...
  4. ncbi request reprint Effect of the brain-death process on acute rejection in renal transplantation
    A Sanchez-Fructuoso
    Nephrology Department, Hospital Clinico San Carlos, Madrid, Spain
    Transplant Proc 39:2214-6. 2007
    ..Our aim was to compare explosive BD with gradual-onset injury in terms of a trigger of the host immune mechanisms accelerating acute rejection processes...
  5. doi request reprint Changes in magnesium and potassium homeostasis after conversion from a calcineurin inhibitor regimen to an mTOR inhibitor-based regimen
    A I Sanchez-Fructuoso
    Nephrology Department, Hospital Clinico Universitario San Carlos, Madrid, Spain
    Transplant Proc 42:3047-9. 2010
    ..Conversion to inhibitors of mammalian target of rapamycin (mTOR) could improve these electrolytic disturbances...
  6. ncbi request reprint Conversion to sirolimus in renal transplant patients with tumors
    A Sanchez-Fructuoso
    Nephrology Department, Hospital Clinico San Carlos, Madrid, Spain
    Transplant Proc 38:2451-2. 2006
    ..Conversion from calcineurin inhibitors (CNI) to sirolimus (SRL) is an option for renal transplant patients who develop a tumor. This strategy, however, may be associated with an increased risk of rejection...
  7. ncbi request reprint Better mycophenolic acid 12-hour trough level after enteric-coated mycophenolate sodium in patients with gastrointestinal intolerance to mycophenolate mofetil
    A Sanchez Fructuoso
    Nephrology Department, Hospital Clinico San Carlos, Madrid, Spain
    Transplant Proc 39:2194-6. 2007
    ..EC-MPS was developed to reduce the upper-gastrointestinal (GI) effects of mycophenolate mofetil. There are no studies available comparing trough plasma levels in patients with GI intolerance to MMF when they are converted to EC-MPS...
  8. doi request reprint De novo anti-HLA antibodies in renal allograft recipients: a cross-section study
    A I Sanchez-Fructuoso
    Nephrology Department, Hospital Clinico Universitario San Carlos, Madrid, Spain
    Transplant Proc 42:2874-6. 2010
    ..The occurrence of anti-HLA antibodies plays a well established role in solid organ rejection. The development of x-MAP multiple bead technology (Luminex) has enabled more accurate detection and definition of these alloantibodies...
  9. doi request reprint The prevalence of uridine diphosphate-glucuronosyltransferase 1A9 (UGT1A9) gene promoter region single-nucleotide polymorphisms T-275A and C-2152T and its influence on mycophenolic acid pharmacokinetics in stable renal transplant patients
    A I Sanchez-Fructuoso
    Nephrology Department, Hospital Clinico San Carlos, Madrid, Spain
    Transplant Proc 41:2313-6. 2009
    ....
  10. ncbi request reprint Study of anemia after late introduction of everolimus in the immunosuppressive treatment of renal transplant patients
    A Sanchez Fructuoso
    Nephrology Department, Hospital Clinico San Carlos, Madrid, Spain
    Transplant Proc 39:2242-4. 2007
    ..Because inflammation-related anemia is characterized by a functional iron deficiency, we studied whether everolimus influenced iron homeostasis...
  11. doi request reprint Inadequate mycophenolic acid exposure and acute rejection in kidney transplantation
    A I Sanchez-Fructuoso
    Department of Nephrology, Hospital Clinico San Carlos, Madrid, Spain
    Transplant Proc 41:2104-5. 2009
    ..The aim of this study was to evaluate the impact of adequate MPA levels in the incidence of acute rejection episodes among a cohort of kidney transplant recipients...
  12. doi request reprint Comparative analysis of adverse events requiring suspension of mTOR inhibitors: everolimus versus sirolimus
    A I Sanchez-Fructuoso
    Department of Nephrology, Hospital Clinico San Carlos, Madrid, Spain
    Transplant Proc 42:3050-2. 2010
    ..However, their use has been significantly limited owing to a high incidence of side effects...
  13. ncbi request reprint Victims of cardiac arrest occurring outside the hospital: a source of transplantable kidneys
    Ana I Sánchez-Fructuoso
    Hospital Clinico San Carlos, Universidad Complutense, and Servicio de Atención Municipal de Urgencias de Madrid, Madrid, Spain
    Ann Intern Med 145:157-64. 2006
    ....
  14. ncbi request reprint Daclizumab induction as an immunosuppressive regimen for renal transplant recipients from non-heart-beating donors
    A I Sanchez-Fructuoso
    Department of Nephrology, Hospital Clinico San Carlos, Madrid, Spain
    Transplant Proc 35:1689-90. 2003
    ....
  15. ncbi request reprint Increasing the donor pool using en bloc pediatric kidneys for transplant
    Ana I Sánchez-Fructuoso
    Department of Nephrology, Hospital Clinico San Carlos, Facultad de Medicina, Universidad Complutense, Madrid, Spain
    Transplantation 76:1180-4. 2003
    ..The aim of this study was to determine whether acceptable long-term graft survival and function can be achieved in EBPKT compared with the transplant of single, cadaveric, adult donor kidneys...
  16. ncbi request reprint Does donor brain death influence acute vascular rejection in the kidney transplant?
    Ana I Sánchez-Fructuoso
    Department of Nephrology, Hospital Clinico San Carlos, Facultad de Medicina, Universidad Complutense, Madrid, Spain
    Transplantation 78:142-6. 2004
    ....
  17. ncbi request reprint [Post-transplant lympho-proliferative disease associated to Epstein-Barr virus]
    A I Sanchez Fructuoso
    Servicio de Nefrologia, Hospital Clinico San Carlos, Madrid, Espana
    Nefrologia 25:20-30. 2005
  18. ncbi request reprint Use of different immunosuppressive strategies in recipients of kidneys from nonheart-beating donors
    Ana I Sánchez-Fructuoso
    Department of Nephrology, Hospital Clinico San Carlos, Facultad de Medicina, Universidad Complutense, Madrid, Spain
    Transpl Int 18:596-603. 2005
    ..7% in group IV at 2 years; P < 0.001). The use of daclizumab and low-dose tacrolimus could be effective at lowering the incidence of delayed graft function in NHBDT, with no negative repercussions on acute rejection...
  19. ncbi request reprint [Review of a new immunosuppressive drug: enteric-coated mycophenolate sodium (Myfortic)]
    A I Sanchez-Fructuoso
    Servicio de Nefrologia, Hospital Clinico San Carlos, Madrid
    Nefrologia 25:234-42, 244. 2005
  20. doi request reprint Mammalian target of rapamycin signal inhibitors could play a role in the treatment of BK polyomavirus nephritis in renal allograft recipients
    A I Sanchez Fructuoso
    Department of Nephrology, Hospital Clinico Universitario San Carlos, Madrid, Spain
    Transpl Infect Dis 13:584-91. 2011
    ..Furthermore, target levels of immunosuppressive drugs are poorly defined, as are criteria for replacing one immunosuppressive agent with another...
  21. doi request reprint Graft outcome and mycophenolic acid trough level monitoring in kidney transplantation
    A I Sanchez Fructuoso
    Department of Nephrology, Hospital Clinico San Carlos, Madrid, Spain
    Transplant Proc 41:2102-3. 2009
    ..As a consequence, the efficacy and safety of mycophenolate mofetil (MMF) may be optimized with individualized doses based on therapeutic drug monitoring...
  22. ncbi request reprint Experimental lead nephropathy: treatment with calcium disodium ethylenediaminetetraacetate
    Ana I Sánchez-Fructuoso
    Department of Nephrology, Hospital Clínico S Carlos, Madrid, Spain
    Am J Kidney Dis 40:59-67. 2002
    ..No damage associated with the use of the chelating agent was observed. Longer term studies of the effects of this drug are required to establish whether the damage caused by lead poisoning may be reversed...
  23. doi request reprint Role of fibroblast growth factor 23 (FGF23) in the metabolism of phosphorus and calcium immediately after kidney transplantation
    A I Sanchez Fructuoso
    Nephrology Department, Hospital Clinico San Carlos, Madrid, Spain
    Transplant Proc 44:2551-4. 2012
    ..The aim of the present study was to evaluate FGF23 in the early posttransplant period and study the complex associations between FGF23, parathyroid hormone (PTH), 1,25(OH)(2) vitamin D, and phosphate in transplant patients...
  24. ncbi request reprint [Immunosuppressors]
    A I Sanchez-Fructuoso
    Servicio de Nefrologia, Hospital Clinico San Carlos, Madrid, Spain
    Nefrologia 28:21-5. 2008
    ....
  25. ncbi request reprint Varicella infection in adult renal allograft recipients: experience at one center
    A Rodriguez-Moreno
    Department of Nephrology, Hospital Clinico San Carlos, Madrid, Spain
    Transplant Proc 38:2416-8. 2006
    ..Early diagnosis and treatment may improve the prognosis. Although further studies are required, chronic HBV or HCV infection seemed to be a risk factor for the disease...
  26. ncbi request reprint Lead mobilization during calcium disodium ethylenediaminetetraacetate chelation therapy in treatment of chronic lead poisoning
    Ana I Sánchez-Fructuoso
    Department of Nephrology, Hospital Clínico S Carlos, Madrid, Spain
    Am J Kidney Dis 40:51-8. 2002
    ..However, the chelating agent does not seem to have access to bone Pb deposits, such that the skeleton becomes a permanent source of poisoning for other tissues...
  27. ncbi request reprint Renal transplantation from non-heart beating donors: a promising alternative to enlarge the donor pool
    A I Sanchez-Fructuoso
    Department of Nephrology, Hospital Clinico San Carlos, Madrid, Spain
    J Am Soc Nephrol 11:350-8. 2000
    ....
  28. ncbi request reprint Renal transplant patients with gastrointestinal intolerability to mycophenolate mofetil: conversion to enteric-coated mycophenolate sodium
    N Calvo
    Nephrology Department, Hospital Clinico San Carlos, Madrid, Spain
    Transplant Proc 38:2396-7. 2006
    ..83 +/- 0.12 mg/dL to 1.70 +/- 0.10 mg/dL. In conclusion, EC-MPS was well tolerated in maintenance renal transplant patients with adverse gastrointestinal events secondary to MMF...
  29. ncbi request reprint Cytomegalovirus infection in seronegative patients treated with prophylaxis: case-controlled study
    M A Moreno de la Higuera Díaz
    Department of Nephrology and Renal Transplantation, Hospital Clinico San Carlos, Profesor Martín Lagos s n, Madrid, Spain
    Transplant Proc 39:2231-2. 2007
    ..CMV seronegativity may be a positive prognostic factor for graft survival...
  30. doi request reprint Sirolimus and everolimus induced pneumonitis in adult renal allograft recipients: experience in a center
    A Rodriguez-Moreno
    Department of Nephrology, Hospital Clinico San Carlos, Madrid, Spain
    Transplant Proc 41:2163-5. 2009
    ..Discontinuation of the mTOR inhibitor with steroid prescription resulted in adequate outcomes. A change to the other mTOR inhibitor should be contemplated if patient circumstances require this type of immunosuppression...
  31. ncbi request reprint Association of the genetic polymorphisms of the renin-angiotensin system with kidney graft long-term outcome: preliminary results
    A Rodriguez-Moreno
    Department of Nephrology, Hospital Clinico San Carlos, Universidad Complutense, Madrid, Spain
    Transplant Proc 37:3716-7. 2005
    ..In conclusion, ACE D-allele seems to be associated with a poorer kidney graft long-term outcome. ACE D and AGT T alleles may be implicated in glucose metabolism disorders after transplantation...
  32. ncbi request reprint Influenza virus immunization effectivity in kidney transplant patients subjected to two different triple-drug therapy immunosuppression protocols: mycophenolate versus azathioprine
    A I Sanchez-Fructuoso
    Servicio de Nefrologia, Hospital Clinico San Carlos, Universidad Complutense, Madrid, Spain
    Transplantation 69:436-9. 2000
    ..Due to possible complications and treatment limitations, the prevention of influenza in renal transplant (RT) patients is highly indicated...
  33. doi request reprint Improvement in late renal allograft survival between 1990 and 2002 in Spain: results from a multicentre case-control study
    Francesc Moreso
    Nephrology Department, Hospital Universitari Vall d Hebron Barcelona, Spain
    Transpl Int 23:907-13. 2010
    ..Graft survival beyond the first year between 1990 and 2002 significantly improved while patient survival did not. Transplant outcome has improved between 1990 and 2002 when donors and recipients of similar characteristics are compared...