Montserrat Sanchez-Cespedes

Summary

Country: Spain

Publications

  1. ncbi A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndrome
    M Sanchez-Cespedes
    Molecular Pathology Programme, Spanish National Cancer Centre CNIO, Melchor Fernandez Almagro, Madrid, Spain
    Oncogene 26:7825-32. 2007
  2. ncbi Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung
    Montserrat Sanchez-Cespedes
    Department of Otolaryngology Head and Neck Surgery, Head and Neck Cancer Research Division, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2196, USA
    Cancer Res 62:3659-62. 2002
  3. ncbi The impact of gene expression microarrays in the evaluation of lung carcinoma subtypes and DNA copy number
    Montserrat Sanchez-Cespedes
    Lung Cancer Group, Molecular Pathology Program, Spanish National Cancer Centre CNIO, Calle Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Arch Pathol Lab Med 132:1562-5. 2008
  4. ncbi Dissecting the genetic alterations involved in lung carcinogenesis
    Montserrat Sanchez-Cespedes
    Molecular Pathology Program, Spanish National Cancer Center, C Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Lung Cancer 40:111-21. 2003
  5. ncbi Transgenic mice expressing constitutively active Akt in oral epithelium validate KLFA as a potential biomarker of head and neck squamous cell carcinoma
    Marta Moral
    Molecular Oncology Unit, Division of Biomedicine, CIEMAT, Madrid, Spain
    In Vivo 23:653-60. 2009
  6. ncbi Transcriptional targets of the chromatin-remodelling factor SMARCA4/BRG1 in lung cancer cells
    Pedro P Medina
    Lung Cancer Group, Molecular Pathology Programme, Spanish National Cancer Centre, C Melchior Fernandez Almagro 3, 28029 Madrid, Spain
    Hum Mol Genet 14:973-82. 2005
  7. ncbi Genetic and epigenetic screening for gene alterations of the chromatin-remodeling factor, SMARCA4/BRG1, in lung tumors
    Pedro P Medina
    Lymphoma and Lung Cancer Group, Molecular Pathology Program Spanish National Cancer Centre CNIO, Madrid, Spain
    Genes Chromosomes Cancer 41:170-7. 2004
  8. ncbi Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in normal tissues and human primary tumors
    Maria F Paz
    Cancer Epigenetics Laboratory, Molecular Pathology Program, Spanish National Cancer Research Center CNIO, 28029 Madrid, Spain
    Cancer Res 62:4519-24. 2002
  9. ncbi Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer
    Ruben Agrelo
    Cancer Epigenetics Laboratory, Spanish National Cancer Centre, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Proc Natl Acad Sci U S A 103:8822-7. 2006
  10. ncbi Distinctive gene expression of human lung adenocarcinomas carrying LKB1 mutations
    Paloma Fernandez
    Lymphomas and Lung Cancer Laboratory, Spanish National Cancer Centre CNIO, Madrid, Spain
    Oncogene 23:5084-91. 2004

Collaborators

Detail Information

Publications27

  1. ncbi A role for LKB1 gene in human cancer beyond the Peutz-Jeghers syndrome
    M Sanchez-Cespedes
    Molecular Pathology Programme, Spanish National Cancer Centre CNIO, Melchor Fernandez Almagro, Madrid, Spain
    Oncogene 26:7825-32. 2007
    ..The present review considers the frequency and pattern of LKB1 gene mutations in sporadic cancers of various origins, and the role of the encoded protein in cancer development...
  2. ncbi Inactivation of LKB1/STK11 is a common event in adenocarcinomas of the lung
    Montserrat Sanchez-Cespedes
    Department of Otolaryngology Head and Neck Surgery, Head and Neck Cancer Research Division, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 2196, USA
    Cancer Res 62:3659-62. 2002
    ..Thus, our findings demonstrate for the first time that LKB1/STK11 inactivation is a very common event and may be integrally involved in the development of sporadic lung adenocarcinoma...
  3. ncbi The impact of gene expression microarrays in the evaluation of lung carcinoma subtypes and DNA copy number
    Montserrat Sanchez-Cespedes
    Lung Cancer Group, Molecular Pathology Program, Spanish National Cancer Centre CNIO, Calle Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Arch Pathol Lab Med 132:1562-5. 2008
    ..Among the more pressing needs are the identification of the complete catalog of genes that are altered in cancer and the accurate discrimination of tumors based on their genetic background...
  4. ncbi Dissecting the genetic alterations involved in lung carcinogenesis
    Montserrat Sanchez-Cespedes
    Molecular Pathology Program, Spanish National Cancer Center, C Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Lung Cancer 40:111-21. 2003
    ..The present review describes the catalog of known genetic alterations and the recent advances in global expression profiles in lung tumors and briefly discusses their use in clinical management...
  5. ncbi Transgenic mice expressing constitutively active Akt in oral epithelium validate KLFA as a potential biomarker of head and neck squamous cell carcinoma
    Marta Moral
    Molecular Oncology Unit, Division of Biomedicine, CIEMAT, Madrid, Spain
    In Vivo 23:653-60. 2009
    ..Previously, we reported that mice expressing high levels of constitutively Akt activity (myrAkt) in oral epithelia develop lesions and tumors in the oral cavity...
  6. ncbi Transcriptional targets of the chromatin-remodelling factor SMARCA4/BRG1 in lung cancer cells
    Pedro P Medina
    Lung Cancer Group, Molecular Pathology Programme, Spanish National Cancer Centre, C Melchior Fernandez Almagro 3, 28029 Madrid, Spain
    Hum Mol Genet 14:973-82. 2005
    ....
  7. ncbi Genetic and epigenetic screening for gene alterations of the chromatin-remodeling factor, SMARCA4/BRG1, in lung tumors
    Pedro P Medina
    Lymphoma and Lung Cancer Group, Molecular Pathology Program Spanish National Cancer Centre CNIO, Madrid, Spain
    Genes Chromosomes Cancer 41:170-7. 2004
    ..We cannot rule out that other mechanisms, such as complete or partial deletions of the SMARCA4 gene, are contributing to the loss of the SMARCA4 protein in lung cancer...
  8. ncbi Germ-line variants in methyl-group metabolism genes and susceptibility to DNA methylation in normal tissues and human primary tumors
    Maria F Paz
    Cancer Epigenetics Laboratory, Molecular Pathology Program, Spanish National Cancer Research Center CNIO, 28029 Madrid, Spain
    Cancer Res 62:4519-24. 2002
    ..029). The existence of these associations may provide another example of the interplay between genetic and epigenetic factors in the cancer cell...
  9. ncbi Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer
    Ruben Agrelo
    Cancer Epigenetics Laboratory, Spanish National Cancer Centre, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Proc Natl Acad Sci U S A 103:8822-7. 2006
    ..These findings highlight the importance of WRN epigenetic inactivation in human cancer, leading to enhanced chromosomal instability and hypersensitivity to chemotherapeutic drugs...
  10. ncbi Distinctive gene expression of human lung adenocarcinomas carrying LKB1 mutations
    Paloma Fernandez
    Lymphomas and Lung Cancer Laboratory, Spanish National Cancer Centre CNIO, Madrid, Spain
    Oncogene 23:5084-91. 2004
    ....
  11. ncbi A microRNA DNA methylation signature for human cancer metastasis
    Amaia Lujambio
    Cancer Epigenetics Laboratory, Spanish National Cancer Research Center, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Proc Natl Acad Sci U S A 105:13556-61. 2008
    ..Our findings indicate that DNA methylation-associated silencing of tumor suppressor miRNAs contributes to the development of human cancer metastasis...
  12. ncbi Molecular context of the EGFR mutations: evidence for the activation of mTOR/S6K signaling
    Esther Conde
    Lung Cancer Group, Spanish National Cancer Centre, Hospital Universitario 12 de Octubre, Madrid, Spain
    Clin Cancer Res 12:710-7. 2006
    ....
  13. ncbi Specific pattern of LKB1 and phospho-acetyl-CoA carboxylase protein immunostaining in human normal tissues and lung carcinomas
    Esther Conde
    Lung Cancer Group, Pathology Programme, Spanish National Cancer Centre CNIO, 28029 Madrid, Spain
    Hum Pathol 38:1351-60. 2007
    ....
  14. ncbi Screening of homologous recombination gene polymorphisms in lung cancer patients reveals an association of the NBS1-185Gln variant and p53 gene mutations
    Pedro P Medina
    Molecular Pathology Program, Spanish National Cancer Center CNIO, 28029 Madrid, Spain
    Cancer Epidemiol Biomarkers Prev 12:699-704. 2003
    ..42 for heterozygous and odds ratio = 38.3 for NBS1-185Gln homozygous). Germ-line variants in the NBS1 gene may play a role in the lung carcinogenesis in cigarette smokers...
  15. ncbi CpG island promoter hypermethylation of the Ras-effector gene NORE1A occurs in the context of a wild-type K-ras in lung cancer
    Manuel Irimia
    Molecular Pathology Program, Cancer Epigenetics Laboratory, Spanish National Cancer Centre CNIO, Melchor Fernandez Almagro 3, Madrid 28029, Spain
    Oncogene 23:8695-9. 2004
    ..008, Fisher's exact test). Thus, the mutual exclusivity of the epigenetic and genetic alterations in the two genes of the Ras pathway suggests that they play a critical and cooperative role in human tumorigenesis...
  16. ncbi An efficient expression system for the production of functionally active human LKB1
    Jorge Luis Martínez-Torrecuadrada
    Protein Technology Unit, Biotechnology Program, Centro Nacional de Investigaciones Oncologicas CNIO, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    J Biotechnol 115:23-34. 2005
    ..The purified protein was functionally active as being able to demonstrate autophosphorylation in the absence of any associated kinase...
  17. ncbi Analysis of the molecular expression profile of non small cell lung carcinoma associated to chronic obstructive pulmonary disease
    Ricardo García-Luján
    Department of Pneumology, Hospital Universitario 12 de Octubre, Avda Cordoba s n, Madrid, Spain
    Histol Histopathol 24:417-23. 2009
    ..26 (0.07-1.01). A significant lowest expression of membranous beta-catenin was detected in NSCLC of the patients with COPD...
  18. ncbi Growth and molecular profile of lung cancer cells expressing ectopic LKB1: down-regulation of the phosphatidylinositol 3'-phosphate kinase/PTEN pathway
    Ana I Jimenez
    Molecular Pathology Program, Spanish National Cancer Center, 28029 Madrid, Spain
    Cancer Res 63:1382-8. 2003
    ..Thus, our results give some insights into the understanding of how LKB1 inactivation contributes to lung carcinogenesis...
  19. ncbi Wnt signaling promoter hypermethylation distinguishes lung primary adenocarcinomas from colorectal metastasis to the lung
    Moying Tang
    Lung Cancer Group, Spanish National Cancer Centre (CNIO, Madrid, Spain
    Int J Cancer 119:2603-6. 2006
    ..This may have biological consequences for carcinogenesis...
  20. ncbi Genetic unmasking of an epigenetically silenced microRNA in human cancer cells
    Amaia Lujambio
    Cancer Epigenetics Laboratory and Lung Cancer Laboratory, Spanish National Cancer Centre CNIO, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Cancer Res 67:1424-9. 2007
    ..Interestingly, we functionally link the epigenetic loss of miRNA-124a with the activation of cyclin D kinase 6, a bona fide oncogenic factor, and the phosphorylation of the retinoblastoma, a tumor suppressor gene...
  21. ncbi Novel and natural knockout lung cancer cell lines for the LKB1/STK11 tumor suppressor gene
    Julian Carretero
    Lymphoma and Lung Cancer Group, Molecular Pathology Program, Centro Nacional de Investigaciones Oncologicas, , 3, 28029 Madrid, Spain
    Oncogene 23:4037-40. 2004
    ....
  22. ncbi Cyclin A as a predictive factor for chemotherapy response in advanced head and neck cancer
    Maria Rodriguez-Pinilla
    Molecular Pathology Program at the Spanish National Cancer Centre (CNIO, Madrid, Spain
    Clin Cancer Res 10:8486-92. 2004
    ....
  23. ncbi Akt activation synergizes with Trp53 loss in oral epithelium to produce a novel mouse model for head and neck squamous cell carcinoma
    Marta Moral
    Division of Biomedicine, Molecular Oncology Unit, CIEMAT, Madrid, Spain
    Cancer Res 69:1099-108. 2009
    ..These data identify activation of Akt and p53 loss as a major mechanism of oral tumorigenesis in vivo and suggest that blocking these signaling pathways could have therapeutic implications for the management of HNSCC...
  24. ncbi CpG island hypermethylation of the DNA repair enzyme methyltransferase predicts response to temozolomide in primary gliomas
    Maria F Paz
    Cancer Epigenetics Laboratory, Spanish National Cancer Centre, Madrid, Spain
    Clin Cancer Res 10:4933-8. 2004
    ..These results may open up possibilities for more customized treatments of human brain tumors...
  25. ncbi Mitochondrial C-tract alteration in premalignant lesions of the head and neck: a marker for progression and clonal proliferation
    Patrick K Ha
    Departments of Otolaryngology, Head and Neck Cancer Research Division, Johns Hopkins Medical Institution, Baltimore, Maryland 21205, USA
    Clin Cancer Res 8:2260-5. 2002
    ..These alterations are valuable as additional markers of histopathological progression...
  26. ncbi Therapeutic effect of γ-secretase inhibition in KrasG12V-driven non-small cell lung carcinoma by derepression of DUSP1 and inhibition of ERK
    Antonio Maraver
    Tumor Suppression Group, Spanish National Cancer Research Centre, Madrid, Spain
    Cancer Cell 22:222-34. 2012
    ..Accordingly, GSI treatment upregulates DUSP1 and decreases phospho-ERK. These data provide proof of the in vivo therapeutic potential of GSIs in primary NSCLCs...
  27. ncbi Oncogenic activity of Cdc6 through repression of the INK4/ARF locus
    Susana Gonzalez
    Tumor Suppression Group, Spanish National Cancer Research Center CNIO, E 28029 Madrid, Spain
    Nature 440:702-6. 2006
    ..We conclude that aberrant expression of Cdc6 is oncogenic by directly repressing the INK4/ARF locus through the RD(INK4/ARF) element...