Lucas Sanchez


Country: Spain


  1. Sanchez L, Chaouiya C. Logical modelling uncovers developmental constraints for primary sex determination of chicken gonads. J R Soc Interface. 2018;15: pubmed publisher
    ..Our model further clarified the role of OESTROGEN in maintaining FOXL2 function during ovary development. ..
  2. Ruiz M, Alvarez M, Eirín López J, Sarno F, Kremer L, Barbero J, et al. An Unusual Role for doublesex in Sex Determination in the Dipteran Sciara. Genetics. 2015;200:1181-99 pubmed publisher
    ..It is suggested that the doublesex gene is involved in Sciara sex determination although it appears not to play the discriminatory role performed in other insects. ..
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    Sanchez L. Sciara as an experimental model for studies on the evolutionary relationships between the zygotic, maternal and environmental primary signals for sexual development. J Genet. 2010;89:325-31 pubmed
    ..This makes Sciara a unique experimental model for studying the evolutionary relationships between the three primary signals triggering sexual development. ..
  4. Sanchez L. Sex-determining mechanisms in insects. Int J Dev Biol. 2008;52:837-56 pubmed publisher
    ..Representative examples of sex determination mechanisms that differ in their primary signal are also described. Finally, some evolutionary aspects of these mechanisms are discussed. ..
  5. Sanchez L, Chaouiya C. Primary sex determination of placental mammals: a modelling study uncovers dynamical developmental constraints in the formation of Sertoli and granulosa cells. BMC Syst Biol. 2016;10:37 pubmed publisher
    ..It also provides a formal support to crucial aspects of the gonad sexual development and predicts gonadal phenotypes for mutations not tested yet. ..
  6. Sarno F, Ruiz M, Eirín López J, Perondini A, Selivon D, Sanchez L. The gene transformer-2 of Anastrepha fruit flies (Diptera, Tephritidae) and its evolution in insects. BMC Evol Biol. 2010;10:140 pubmed publisher
    ..In this work, the characterisation of this gene in eleven tephritid species belonging to the less extensively analysed genus Anastrepha was undertaken in order to throw light on the evolution of transformer-2...
  7. Martín I, Ruiz M, Sanchez L. The gene transformer-2 of Sciara (Diptera, Nematocera) and its effect on Drosophila sexual development. BMC Dev Biol. 2011;11:19 pubmed publisher
    ..This suggests the existence of species-specific co-evolution of the Transformer and Transformer-2 proteins. ..
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    Sanchez L, Thieffry D. A logical analysis of the Drosophila gap-gene system. J Theor Biol. 2001;211:115-41 pubmed
    ..The proposed model allows not only the qualitative reproduction of the patterns of gene expression characterized experimentally, but also the simulation and prediction of single and multiple mutant phenotypes. ..
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    Sanchez L, Guerrero I. The development of the Drosophila genital disc. Bioessays. 2001;23:698-707 pubmed
    ..This input acts by modulating the response to Hedgehog, Wingless, and Decapentaplegic morphogenetic signals. ..

More Information


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    Sanchez L, Thieffry D. Segmenting the fly embryo: a logical analysis of the pair-rule cross-regulatory module. J Theor Biol. 2003;224:517-37 pubmed
    ..Finally, it provides new insights into the roles and evolutionary origins of the apparent redundancies in the regulatory architecture of the pair-rule module. ..
  2. Sanchez L, Chaouiya C, Thieffry D. Segmenting the fly embryo: logical analysis of the role of the segment polarity cross-regulatory module. Int J Dev Biol. 2008;52:1059-75 pubmed publisher
    ..Finally, the simulation of altered expressions of segment polarity genes leads to results consistent with the published data. ..