Maria E Saez

Summary

Country: Spain

Publications

  1. ncbi The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease
    Carmen Antunez
    Department of Structural Genomics, Neocodex, Avda, Charles Darwin, Sevilla, s n 41092, Spain
    Genome Med 3:33. 2011
  2. ncbi Genetic structure of the Spanish population
    Javier Gayan
    Department of Structural Genomics, Neocodex, Sevilla, Spain
    BMC Genomics 11:326. 2010
  3. ncbi A method for detecting epistasis in genome-wide studies using case-control multi-locus association analysis
    Javier Gayan
    Neocodex, Avda, Charles Darwin 6, ACC, A, 41092 Sevilla, Spain
    BMC Genomics 9:360. 2008
  4. ncbi Association analysis of urotensin II gene (UTS2) and flanking regions with biochemical parameters related to insulin resistance
    Maria E Saez
    Department of Structural Genomics, Neocodex, Sevilla, Spain
    PLoS ONE 6:e19327. 2011
  5. ncbi WWOX gene is associated with HDL cholesterol and triglyceride levels
    Maria E Saez
    Departamento de Genomica Estructural, Neocodex, 41092 Sevilla, Spain
    BMC Med Genet 11:148. 2010
  6. ncbi The CAPN10 gene is associated with insulin resistance phenotypes in the Spanish population
    Maria E Saez
    Neocodex, Departamento de Genomica Estructural, Seville, Spain
    PLoS ONE 3:e2953. 2008
  7. ncbi Interaction between Calpain 5, Peroxisome proliferator-activated receptor-gamma and Peroxisome proliferator-activated receptor-delta genes: a polygenic approach to obesity
    Maria E Saez
    Departamento de Genomica Estructural, Neocodex, C, Charles Darwin 6, Acc A, 41092, Sevilla, Spain
    Cardiovasc Diabetol 7:23. 2008
  8. ncbi Calpain-5 gene variants are associated with diastolic blood pressure and cholesterol levels
    Maria E Saez
    Departamento de Genomica Estructural, Neocodex, Sevilla, Spain
    BMC Med Genet 8:1. 2007
  9. ncbi The therapeutic potential of the calpain family: new aspects
    Maria E Saez
    Department of Structural Genomics, Neocodex, Centro de Negocios Charles Darwin s n, Isla de la Cartuja, 41092 Sevilla, Spain
    Drug Discov Today 11:917-23. 2006
  10. ncbi Influence of the Toll-like receptor 9 1635A/G polymorphism on the CD4 count, HIV viral load, and clinical progression
    Natalia Soriano-Sarabia
    Laboratory of Immunovirology, Seville Biomedicine Institute IBIS, Service of Infectious Diseases, Virgen del Rocio Hospital, Seville, Spain
    J Acquir Immune Defic Syndr 49:128-35. 2008

Collaborators

  • Agustin Ruiz
  • Reposo Ramirez-Lorca
  • Alejandro Gonzalez
  • Alejandro Vallejo
  • Antonio Grilo
  • Luis Manzano
  • Javier Gayan
  • Antonio Gonzalez-Perez
  • Francisco J Moron
  • Carmen Antunez
  • Enrique Vazquez
  • Manuel Serrano-Rios
  • Concha Moreno-Rey
  • Juan Velasco
  • Francisco Jesus Moron
  • Luis Miguel Real
  • Jose Jorge Galan
  • Jose Luis Royo
  • Ana Salinas
  • Natalia Soriano-Sarabia
  • Luis M Real
  • Laura Vivancos-Moreau
  • Isabel Hernandez
  • Georgina Vinyes
  • Begoña Martínez-Herrada
  • Oscar L Lopez
  • Blanca Garcia
  • Anna Espinosa
  • Juan Marin
  • Alejandro Romo
  • Irene Blanca
  • Jose Miguel Carrasco
  • Fuensanta Noguera-Perea
  • Agustina Legaz-García
  • Sandra Castaño
  • Lluis Tarraga
  • Salvadora Manzanares
  • Asunción Lafuente
  • Ana Mauleon
  • Jesus Lopez-Arrieta
  • Montserrat Alegret
  • Merce Boada
  • Susana Ruiz
  • James T Becker
  • Maitée Rosende-Roca
  • Martirio Antequera-Torres
  • Jose M Carrasco
  • María Dolores Ochoa
  • M Carmen Rivero
  • Mercedes Reina
  • Jose J Galan
  • Rocío Pascual
  • Carina Zabena
  • Maria Teresa Martinez-Larrad
  • Marta Gutiérrez
  • Carolina Ochoa
  • Eva Molero
  • Juan Luis Susillo-González
  • Alejandro Romo-Astorga
  • Fernando Bermudo
  • Ildefonso Pulido
  • Manuel Leal
  • María del Mar Rodríguez
  • Antonio Quintas
  • Emilia Mira
  • Jose L Royo
  • Santos Manes
  • Luis Montoro
  • Francisco De Castro

Detail Information

Publications11

  1. ncbi The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease
    Carmen Antunez
    Department of Structural Genomics, Neocodex, Avda, Charles Darwin, Sevilla, s n 41092, Spain
    Genome Med 3:33. 2011
    ..In order to identify novel loci associated with Alzheimer's disease (AD), we conducted a genome-wide association study (GWAS) in the Spanish population...
  2. ncbi Genetic structure of the Spanish population
    Javier Gayan
    Department of Structural Genomics, Neocodex, Sevilla, Spain
    BMC Genomics 11:326. 2010
    ..Genetic admixture is a common caveat for genetic association analysis. Therefore, it is important to characterize the genetic structure of the population under study to control for this kind of potential bias...
  3. ncbi A method for detecting epistasis in genome-wide studies using case-control multi-locus association analysis
    Javier Gayan
    Neocodex, Avda, Charles Darwin 6, ACC, A, 41092 Sevilla, Spain
    BMC Genomics 9:360. 2008
    ..Some of these genetic effects may interact in complex ways, proving undetectable by current single-locus methodology...
  4. ncbi Association analysis of urotensin II gene (UTS2) and flanking regions with biochemical parameters related to insulin resistance
    Maria E Saez
    Department of Structural Genomics, Neocodex, Sevilla, Spain
    PLoS ONE 6:e19327. 2011
    ..UII exerts a broad spectrum of actions in several systems such as vascular cell, heart muscle or pancreas, where it inhibits insulin release...
  5. ncbi WWOX gene is associated with HDL cholesterol and triglyceride levels
    Maria E Saez
    Departamento de Genomica Estructural, Neocodex, 41092 Sevilla, Spain
    BMC Med Genet 11:148. 2010
    ..This gene is located at chromosome 16q23, a region previously linked to familial combined hyperlipidemia (FCHL) and HDL. Our objective is to perform a genetic association analysis at the WWOX gene region with HDL, TG and TG/HDL ratio...
  6. ncbi The CAPN10 gene is associated with insulin resistance phenotypes in the Spanish population
    Maria E Saez
    Neocodex, Departamento de Genomica Estructural, Seville, Spain
    PLoS ONE 3:e2953. 2008
    ..Our results suggest that CAPN10 gene is associated with insulin resistance phenotypes in the Spanish population...
  7. ncbi Interaction between Calpain 5, Peroxisome proliferator-activated receptor-gamma and Peroxisome proliferator-activated receptor-delta genes: a polygenic approach to obesity
    Maria E Saez
    Departamento de Genomica Estructural, Neocodex, C, Charles Darwin 6, Acc A, 41092, Sevilla, Spain
    Cardiovasc Diabetol 7:23. 2008
    ..Obesity is a multifactorial disorder, that is, a disease determined by the combined effect of genes and environment. In this context, polygenic approaches are needed...
  8. ncbi Calpain-5 gene variants are associated with diastolic blood pressure and cholesterol levels
    Maria E Saez
    Departamento de Genomica Estructural, Neocodex, Sevilla, Spain
    BMC Med Genet 8:1. 2007
    ..In this new study, we have analysed the association of four CAPN5 gene variants(rs948976A>G, rs4945140G>A, rs2233546C>T and rs2233549G>A) with several cardiovascular risk factors related to metabolic syndrome in general population...
  9. ncbi The therapeutic potential of the calpain family: new aspects
    Maria E Saez
    Department of Structural Genomics, Neocodex, Centro de Negocios Charles Darwin s n, Isla de la Cartuja, 41092 Sevilla, Spain
    Drug Discov Today 11:917-23. 2006
    ..g. Parkinson's disease and Duchenne muscular dystrophy). Conversely, calpain activators could be a useful approach for those diseases where reduced calpain activity has been observed, such as type 2 diabetes or metabolic syndrome...
  10. ncbi Influence of the Toll-like receptor 9 1635A/G polymorphism on the CD4 count, HIV viral load, and clinical progression
    Natalia Soriano-Sarabia
    Laboratory of Immunovirology, Seville Biomedicine Institute IBIS, Service of Infectious Diseases, Virgen del Rocio Hospital, Seville, Spain
    J Acquir Immune Defic Syndr 49:128-35. 2008
    ....
  11. ncbi Bone morphogenetic protein 15 (BMP15) alleles predict over-response to recombinant follicle stimulation hormone and iatrogenic ovarian hyperstimulation syndrome (OHSS)
    Francisco J Moron
    Departamento de Genomica Estructural, Neocodex, Avda Charles Darwin s n, Parque Tecnológico Isla de la Cartuja, 41092 Seville, Spain
    Pharmacogenet Genomics 16:485-95. 2006
    ..We performed a pharmacogenetic analysis of bone morphogenetic protein 15 (BMP15) gene using single nucleotide polymorphisms (SNPs) in COS. We also investigated the role of the BMP15 gene in ovarian hyperstimulation syndrome (OHSS)...