Maria E Saez

Summary

Country: Spain

Publications

  1. pmc The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease
    Carmen Antunez
    Department of Structural Genomics, Neocodex, Avda, Charles Darwin, Sevilla, s n 41092, Spain
    Genome Med 3:33. 2011
  2. pmc Genetic structure of the Spanish population
    Javier Gayan
    Department of Structural Genomics, Neocodex, Sevilla, Spain
    BMC Genomics 11:326. 2010
  3. pmc A method for detecting epistasis in genome-wide studies using case-control multi-locus association analysis
    Javier Gayan
    Neocodex, Avda, Charles Darwin 6, ACC, A, 41092 Sevilla, Spain
    BMC Genomics 9:360. 2008
  4. pmc Association analysis of urotensin II gene (UTS2) and flanking regions with biochemical parameters related to insulin resistance
    Maria E Saez
    Department of Structural Genomics, Neocodex, Sevilla, Spain
    PLoS ONE 6:e19327. 2011
  5. pmc WWOX gene is associated with HDL cholesterol and triglyceride levels
    Maria E Saez
    Departamento de Genomica Estructural, Neocodex, 41092 Sevilla, Spain
    BMC Med Genet 11:148. 2010
  6. pmc The CAPN10 gene is associated with insulin resistance phenotypes in the Spanish population
    Maria E Saez
    Neocodex, Departamento de Genomica Estructural, Seville, Spain
    PLoS ONE 3:e2953. 2008
  7. pmc Interaction between Calpain 5, Peroxisome proliferator-activated receptor-gamma and Peroxisome proliferator-activated receptor-delta genes: a polygenic approach to obesity
    Maria E Saez
    Departamento de Genomica Estructural, Neocodex, C, Charles Darwin 6, Acc A, 41092, Sevilla, Spain
    Cardiovasc Diabetol 7:23. 2008
  8. pmc Calpain-5 gene variants are associated with diastolic blood pressure and cholesterol levels
    Maria E Saez
    Departamento de Genomica Estructural, Neocodex, Sevilla, Spain
    BMC Med Genet 8:1. 2007
  9. ncbi The therapeutic potential of the calpain family: new aspects
    Maria E Saez
    Department of Structural Genomics, Neocodex, Centro de Negocios Charles Darwin s n, Isla de la Cartuja, 41092 Sevilla, Spain
    Drug Discov Today 11:917-23. 2006
  10. ncbi Bone morphogenetic protein 15 (BMP15) alleles predict over-response to recombinant follicle stimulation hormone and iatrogenic ovarian hyperstimulation syndrome (OHSS)
    Francisco J Moron
    Departamento de Genomica Estructural, Neocodex, Avda Charles Darwin s n, Parque Tecnológico Isla de la Cartuja, 41092 Seville, Spain
    Pharmacogenet Genomics 16:485-95. 2006

Collaborators

  • Reposo Ramirez-Lorca
  • Alejandro Vallejo
  • Antonio Grilo
  • Luis Manzano
  • Agustin Ruiz
  • Alejandro Gonzalez
  • Javier Gayan
  • Antonio Gonzalez-Perez
  • Francisco J Moron
  • Carmen Antunez
  • Concha Moreno-Rey
  • Manuel Serrano-Rios
  • Enrique Vazquez
  • Juan Velasco
  • Francisco Jesus Moron
  • Jose Jorge Galan
  • Luis Miguel Real
  • Ana Salinas
  • Jose Luis Royo
  • Luis M Real
  • Natalia Soriano-Sarabia
  • Merce Boada
  • Salvadora Manzanares
  • Juan Marin
  • Anna Espinosa
  • Isabel Hernandez
  • Montserrat Alegret
  • Jesus Lopez-Arrieta
  • Georgina Vinyes
  • Martirio Antequera-Torres
  • Begoña Martínez-Herrada
  • Fuensanta Noguera-Perea
  • Laura Vivancos-Moreau
  • Susana Ruiz
  • Agustina Legaz-García
  • Oscar L Lopez
  • Asunción Lafuente
  • James T Becker
  • Alejandro Romo
  • Maitée Rosende-Roca
  • Blanca Garcia
  • Irene Blanca
  • Ana Mauleon
  • Jose Miguel Carrasco
  • Lluis Tarraga
  • Sandra Castaño
  • Eva Molero
  • Alejandro Romo-Astorga
  • Jose J Galan
  • Juan Luis Susillo-González
  • Jose M Carrasco
  • María Dolores Ochoa
  • Marta Gutiérrez
  • Rocío Pascual
  • Mercedes Reina
  • Carina Zabena
  • Carolina Ochoa
  • Maria Teresa Martinez-Larrad
  • M Carmen Rivero
  • María del Mar Rodríguez
  • Antonio Quintas
  • Fernando Bermudo
  • Manuel Leal
  • Ildefonso Pulido
  • Francisco De Castro
  • Santos Manes
  • Emilia Mira
  • Jose L Royo
  • Luis Montoro

Detail Information

Publications11

  1. pmc The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease
    Carmen Antunez
    Department of Structural Genomics, Neocodex, Avda, Charles Darwin, Sevilla, s n 41092, Spain
    Genome Med 3:33. 2011
    ..In order to identify novel loci associated with Alzheimer's disease (AD), we conducted a genome-wide association study (GWAS) in the Spanish population...
  2. pmc Genetic structure of the Spanish population
    Javier Gayan
    Department of Structural Genomics, Neocodex, Sevilla, Spain
    BMC Genomics 11:326. 2010
    ..Genetic admixture is a common caveat for genetic association analysis. Therefore, it is important to characterize the genetic structure of the population under study to control for this kind of potential bias...
  3. pmc A method for detecting epistasis in genome-wide studies using case-control multi-locus association analysis
    Javier Gayan
    Neocodex, Avda, Charles Darwin 6, ACC, A, 41092 Sevilla, Spain
    BMC Genomics 9:360. 2008
    ..Some of these genetic effects may interact in complex ways, proving undetectable by current single-locus methodology...
  4. pmc Association analysis of urotensin II gene (UTS2) and flanking regions with biochemical parameters related to insulin resistance
    Maria E Saez
    Department of Structural Genomics, Neocodex, Sevilla, Spain
    PLoS ONE 6:e19327. 2011
    ..UII exerts a broad spectrum of actions in several systems such as vascular cell, heart muscle or pancreas, where it inhibits insulin release...
  5. pmc WWOX gene is associated with HDL cholesterol and triglyceride levels
    Maria E Saez
    Departamento de Genomica Estructural, Neocodex, 41092 Sevilla, Spain
    BMC Med Genet 11:148. 2010
    ..This gene is located at chromosome 16q23, a region previously linked to familial combined hyperlipidemia (FCHL) and HDL. Our objective is to perform a genetic association analysis at the WWOX gene region with HDL, TG and TG/HDL ratio...
  6. pmc The CAPN10 gene is associated with insulin resistance phenotypes in the Spanish population
    Maria E Saez
    Neocodex, Departamento de Genomica Estructural, Seville, Spain
    PLoS ONE 3:e2953. 2008
    ..Our results suggest that CAPN10 gene is associated with insulin resistance phenotypes in the Spanish population...
  7. pmc Interaction between Calpain 5, Peroxisome proliferator-activated receptor-gamma and Peroxisome proliferator-activated receptor-delta genes: a polygenic approach to obesity
    Maria E Saez
    Departamento de Genomica Estructural, Neocodex, C, Charles Darwin 6, Acc A, 41092, Sevilla, Spain
    Cardiovasc Diabetol 7:23. 2008
    ..Obesity is a multifactorial disorder, that is, a disease determined by the combined effect of genes and environment. In this context, polygenic approaches are needed...
  8. pmc Calpain-5 gene variants are associated with diastolic blood pressure and cholesterol levels
    Maria E Saez
    Departamento de Genomica Estructural, Neocodex, Sevilla, Spain
    BMC Med Genet 8:1. 2007
    ....
  9. ncbi The therapeutic potential of the calpain family: new aspects
    Maria E Saez
    Department of Structural Genomics, Neocodex, Centro de Negocios Charles Darwin s n, Isla de la Cartuja, 41092 Sevilla, Spain
    Drug Discov Today 11:917-23. 2006
    ..g. Parkinson's disease and Duchenne muscular dystrophy). Conversely, calpain activators could be a useful approach for those diseases where reduced calpain activity has been observed, such as type 2 diabetes or metabolic syndrome...
  10. ncbi Bone morphogenetic protein 15 (BMP15) alleles predict over-response to recombinant follicle stimulation hormone and iatrogenic ovarian hyperstimulation syndrome (OHSS)
    Francisco J Moron
    Departamento de Genomica Estructural, Neocodex, Avda Charles Darwin s n, Parque Tecnológico Isla de la Cartuja, 41092 Seville, Spain
    Pharmacogenet Genomics 16:485-95. 2006
    ..We performed a pharmacogenetic analysis of bone morphogenetic protein 15 (BMP15) gene using single nucleotide polymorphisms (SNPs) in COS. We also investigated the role of the BMP15 gene in ovarian hyperstimulation syndrome (OHSS)...
  11. doi Influence of the Toll-like receptor 9 1635A/G polymorphism on the CD4 count, HIV viral load, and clinical progression
    Natalia Soriano-Sarabia
    Laboratory of Immunovirology, Seville Biomedicine Institute IBIS, Service of Infectious Diseases, Virgen del Rocio Hospital, Seville, Spain
    J Acquir Immune Defic Syndr 49:128-35. 2008
    ....