Maria E Saez

Summary

Country: Spain

Publications

  1. pmc The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease
    Carmen Antunez
    Department of Structural Genomics, Neocodex, Avda, Charles Darwin, Sevilla, s n 41092, Spain
    Genome Med 3:33. 2011
  2. pmc Genetic structure of the Spanish population
    Javier Gayan
    Department of Structural Genomics, Neocodex, Sevilla, Spain
    BMC Genomics 11:326. 2010
  3. pmc A method for detecting epistasis in genome-wide studies using case-control multi-locus association analysis
    Javier Gayan
    Neocodex, Avda, Charles Darwin 6, ACC, A, 41092 Sevilla, Spain
    BMC Genomics 9:360. 2008
  4. pmc Association analysis of urotensin II gene (UTS2) and flanking regions with biochemical parameters related to insulin resistance
    Maria E Saez
    Department of Structural Genomics, Neocodex, Sevilla, Spain
    PLoS ONE 6:e19327. 2011
  5. pmc WWOX gene is associated with HDL cholesterol and triglyceride levels
    Maria E Saez
    Departamento de Genomica Estructural, Neocodex, 41092 Sevilla, Spain
    BMC Med Genet 11:148. 2010
  6. pmc The CAPN10 gene is associated with insulin resistance phenotypes in the Spanish population
    Maria E Saez
    Neocodex, Departamento de Genomica Estructural, Seville, Spain
    PLoS ONE 3:e2953. 2008
  7. pmc Interaction between Calpain 5, Peroxisome proliferator-activated receptor-gamma and Peroxisome proliferator-activated receptor-delta genes: a polygenic approach to obesity
    Maria E Saez
    Departamento de Genomica Estructural, Neocodex, C, Charles Darwin 6, Acc A, 41092, Sevilla, Spain
    Cardiovasc Diabetol 7:23. 2008
  8. pmc Calpain-5 gene variants are associated with diastolic blood pressure and cholesterol levels
    Maria E Saez
    Departamento de Genomica Estructural, Neocodex, Sevilla, Spain
    BMC Med Genet 8:1. 2007
  9. ncbi The therapeutic potential of the calpain family: new aspects
    Maria E Saez
    Department of Structural Genomics, Neocodex, Centro de Negocios Charles Darwin s n, Isla de la Cartuja, 41092 Sevilla, Spain
    Drug Discov Today 11:917-23. 2006
  10. pmc A colorectal cancer susceptibility new variant at 4q26 in the spanish population identified by genome-wide association analysis
    Luis M Real
    Department of Structural Genomics, Neocodex, Seville, Spain Infectious Diseases and Microbiology Unit, Hospital Nuestra Señora de Valme, Seville, Spain Institute of Biomedicine of Seville IBiS, Seville, Spain
    PLoS ONE 9:e101178. 2014

Collaborators

  • Angel Carracedo
  • Luis A Garcia Rodriguez
  • Antoni Castells
  • Sergi Castellvi-Bel
  • Saga Johansson
  • Antonio Grilo
  • Agustin Ruiz
  • Alejandro Vallejo
  • Reposo Ramirez-Lorca
  • Luis Manzano
  • Alejandro Gonzalez
  • Antonio Gonzalez-Perez
  • Javier Gayan
  • Luis M Real
  • Francisco J Moron
  • Enrique Vazquez
  • Concha Moreno-Rey
  • Juan Velasco
  • Jose M Carrasco
  • Carmen Antunez
  • Manuel Serrano-Rios
  • Francisco Jesus Moron
  • Jose Jorge Galan
  • Luis Miguel Real
  • Ana Salinas
  • Jose Luis Royo
  • Natalia Soriano-Sarabia
  • Ruth Marginet-Flinch
  • Sergio Alonso
  • Manuel Chaves-Conde
  • Eduardo Ferrero-Herrero
  • Manuel Hidalgo-Pascual
  • Eva Musulen
  • José A Moreno-Nogueira
  • Clara Ruiz-Ponte
  • Peter Nagy
  • Beatriz Gonzalez
  • Ceres Fernández-Rozadilla
  • Manuel Perucho
  • Merce Boada
  • Salvadora Manzanares
  • Juan Marin
  • Jesus Lopez-Arrieta
  • Georgina Vinyes
  • Begoña Martínez-Herrada
  • Laura Vivancos-Moreau
  • Agustina Legaz-García
  • Oscar L Lopez
  • Asunción Lafuente
  • James T Becker
  • Alejandro Romo
  • Maitée Rosende-Roca
  • Blanca Garcia
  • Irene Blanca
  • Jose Miguel Carrasco
  • Lluis Tarraga
  • Sandra Castaño
  • Anna Espinosa
  • Isabel Hernandez
  • Montserrat Alegret
  • Martirio Antequera-Torres
  • Fuensanta Noguera-Perea
  • Susana Ruiz
  • Ana Mauleon
  • Eva Molero
  • Alejandro Romo-Astorga
  • Jose J Galan
  • Juan Luis Susillo-González
  • Marta Gutiérrez
  • Rocío Pascual
  • Mercedes Reina
  • Carina Zabena
  • Carolina Ochoa
  • María Dolores Ochoa
  • Maria Teresa Martinez-Larrad
  • M Carmen Rivero
  • María del Mar Rodríguez
  • Antonio Quintas
  • Fernando Bermudo
  • Ildefonso Pulido
  • Manuel Leal
  • Emilia Mira
  • Jose L Royo
  • Francisco De Castro
  • Santos Manes
  • Luis Montoro

Detail Information

Publications13

  1. pmc The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease
    Carmen Antunez
    Department of Structural Genomics, Neocodex, Avda, Charles Darwin, Sevilla, s n 41092, Spain
    Genome Med 3:33. 2011
    ..In order to identify novel loci associated with Alzheimer's disease (AD), we conducted a genome-wide association study (GWAS) in the Spanish population...
  2. pmc Genetic structure of the Spanish population
    Javier Gayan
    Department of Structural Genomics, Neocodex, Sevilla, Spain
    BMC Genomics 11:326. 2010
    ..Genetic admixture is a common caveat for genetic association analysis. Therefore, it is important to characterize the genetic structure of the population under study to control for this kind of potential bias...
  3. pmc A method for detecting epistasis in genome-wide studies using case-control multi-locus association analysis
    Javier Gayan
    Neocodex, Avda, Charles Darwin 6, ACC, A, 41092 Sevilla, Spain
    BMC Genomics 9:360. 2008
    ..Some of these genetic effects may interact in complex ways, proving undetectable by current single-locus methodology...
  4. pmc Association analysis of urotensin II gene (UTS2) and flanking regions with biochemical parameters related to insulin resistance
    Maria E Saez
    Department of Structural Genomics, Neocodex, Sevilla, Spain
    PLoS ONE 6:e19327. 2011
    ..UII exerts a broad spectrum of actions in several systems such as vascular cell, heart muscle or pancreas, where it inhibits insulin release...
  5. pmc WWOX gene is associated with HDL cholesterol and triglyceride levels
    Maria E Saez
    Departamento de Genomica Estructural, Neocodex, 41092 Sevilla, Spain
    BMC Med Genet 11:148. 2010
    ..This gene is located at chromosome 16q23, a region previously linked to familial combined hyperlipidemia (FCHL) and HDL. Our objective is to perform a genetic association analysis at the WWOX gene region with HDL, TG and TG/HDL ratio...
  6. pmc The CAPN10 gene is associated with insulin resistance phenotypes in the Spanish population
    Maria E Saez
    Neocodex, Departamento de Genomica Estructural, Seville, Spain
    PLoS ONE 3:e2953. 2008
    ..Our results suggest that CAPN10 gene is associated with insulin resistance phenotypes in the Spanish population...
  7. pmc Interaction between Calpain 5, Peroxisome proliferator-activated receptor-gamma and Peroxisome proliferator-activated receptor-delta genes: a polygenic approach to obesity
    Maria E Saez
    Departamento de Genomica Estructural, Neocodex, C, Charles Darwin 6, Acc A, 41092, Sevilla, Spain
    Cardiovasc Diabetol 7:23. 2008
    ..Obesity is a multifactorial disorder, that is, a disease determined by the combined effect of genes and environment. In this context, polygenic approaches are needed...
  8. pmc Calpain-5 gene variants are associated with diastolic blood pressure and cholesterol levels
    Maria E Saez
    Departamento de Genomica Estructural, Neocodex, Sevilla, Spain
    BMC Med Genet 8:1. 2007
    ....
  9. ncbi The therapeutic potential of the calpain family: new aspects
    Maria E Saez
    Department of Structural Genomics, Neocodex, Centro de Negocios Charles Darwin s n, Isla de la Cartuja, 41092 Sevilla, Spain
    Drug Discov Today 11:917-23. 2006
    ..g. Parkinson's disease and Duchenne muscular dystrophy). Conversely, calpain activators could be a useful approach for those diseases where reduced calpain activity has been observed, such as type 2 diabetes or metabolic syndrome...
  10. pmc A colorectal cancer susceptibility new variant at 4q26 in the spanish population identified by genome-wide association analysis
    Luis M Real
    Department of Structural Genomics, Neocodex, Seville, Spain Infectious Diseases and Microbiology Unit, Hospital Nuestra Señora de Valme, Seville, Spain Institute of Biomedicine of Seville IBiS, Seville, Spain
    PLoS ONE 9:e101178. 2014
    ..The aim of this work was to search for genetic risk factors for CRC, by performing single-locus and two-locus GWAS in the Spanish population...
  11. ncbi Bone morphogenetic protein 15 (BMP15) alleles predict over-response to recombinant follicle stimulation hormone and iatrogenic ovarian hyperstimulation syndrome (OHSS)
    Francisco J Moron
    Departamento de Genomica Estructural, Neocodex, Avda Charles Darwin s n, Parque Tecnológico Isla de la Cartuja, 41092 Seville, Spain
    Pharmacogenet Genomics 16:485-95. 2006
    ..We performed a pharmacogenetic analysis of bone morphogenetic protein 15 (BMP15) gene using single nucleotide polymorphisms (SNPs) in COS. We also investigated the role of the BMP15 gene in ovarian hyperstimulation syndrome (OHSS)...
  12. doi Influence of the Toll-like receptor 9 1635A/G polymorphism on the CD4 count, HIV viral load, and clinical progression
    Natalia Soriano-Sarabia
    Laboratory of Immunovirology, Seville Biomedicine Institute IBIS, Service of Infectious Diseases, Virgen del Rocio Hospital, Seville, Spain
    J Acquir Immune Defic Syndr 49:128-35. 2008
    ....
  13. ncbi Risk factors associated with uncomplicated peptic ulcer and changes in medication use after diagnosis
    Antonio Gonzalez-Perez
    The Spanish Centre for Pharmacoepidemiologic Research CEIFE, Madrid, Spain Andalusian Bioinformatics Research Centre CAEBi, Seville, Spain
    PLoS ONE 9:e101768. 2014
    ..Few epidemiologic studies have investigated predictors of uncomplicated peptic ulcer disease (PUD) separately from predictors of complicated PUD...