Rosa Roldan

Summary

Country: Spain

Publications

  1. ncbi Repetitive DNA hypomethylation in the advanced phase of chronic myeloid leukemia
    Jose Roman-Gomez
    Hematology Department, Reina Sofia Hospital, Avda Menendez Pidal s n, 14004 Cordoba, Spain
    Leuk Res 32:487-90. 2008
  2. pmc Frequent and simultaneous epigenetic inactivation of TP53 pathway genes in acute lymphoblastic leukemia
    Amaia Vilas-Zornoza
    Hematology Service and Area of Cell Therapy, Clinica Universidad de Navarra, Foundation for Applied Medical Research, University of Navarra, Pamplona, Spain
    PLoS ONE 6:e17012. 2011
  3. pmc MicroRNA expression profiling in Imatinib-resistant Chronic Myeloid Leukemia patients without clinically significant ABL1-mutations
    Edurne San Jose-Eneriz
    Foundation for Applied Medical Research, Division of Cancer, Area of Cell Therapy and Hematology Service, Clinica Universitaria, Universidad de Navarra, Spain
    Mol Cancer 8:69. 2009
  4. ncbi Efficacy of bosentan in treatment of unresponsive cutaneous ulceration in disabling pansclerotic morphea in children
    Rosa Roldan
    Department of Rheumatology, Reina Sofia Hospital, Cordoba, Spain
    J Rheumatol 33:2538-40. 2006
  5. ncbi Epigenetic regulation of human cancer/testis antigen gene, HAGE, in chronic myeloid leukemia
    Jose Roman-Gomez
    Hematology Department, Reina Sofia Hospital, Avda Menendez Pidal s n 14004 Cordoba, Spain
    Haematologica 92:153-62. 2007
  6. ncbi Epigenetic regulation of PRAME gene in chronic myeloid leukemia
    Jose Roman-Gomez
    Hematology Department, Reina Sofia Hospital, Avda, Menendez Pidal s n, 14004, Cordoba, Spain
    Leuk Res 31:1521-8. 2007
  7. ncbi Poor prognosis in acute lymphoblastic leukemia may relate to promoter hypermethylation of cancer-related genes
    Jose Roman-Gomez
    Hematology Department, Reina Sofia Hospital, Cordoba, Spain
    Leuk Lymphoma 48:1269-82. 2007
  8. ncbi WNT5A, a putative tumour suppressor of lymphoid malignancies, is inactivated by aberrant methylation in acute lymphoblastic leukaemia
    Jose Roman-Gomez
    Hematology Department, Reina Sofia Hospital, Avda Menendez Pidal s n, 14004 Cordoba, Spain
    Eur J Cancer 43:2736-46. 2007
  9. doi Anakinra: new therapeutic approach in children with Familial Mediterranean Fever resistant to colchicine
    Rosa Roldan
    Rheumatology Department, Reina Sofia Hospital, Avenida Menendez Pidal s n, 14004 Cordoba, Spain
    Joint Bone Spine 75:504-5. 2008
  10. doi Epigenetic regulation of microRNAs in acute lymphoblastic leukemia
    Jose Roman-Gomez
    Hematology Department Reina Sofia Hospital Avda Menendez Pidal s n 14004 Cordoba Spain
    J Clin Oncol 27:1316-22. 2009

Collaborators

  • A Torres
  • Eduardo Collantes
  • J Roman
  • Vanesa Martin
  • F Prosper
  • Sara Alvarez
  • Jose Ignacio Martin-Subero
  • Angel Leon
  • Joaquin Sanchez
  • F Cervantes
  • Jose Roman-Gomez
  • Xabier Agirre
  • Anabel Heiniger
  • Antonio Jimenez-Velasco
  • Edurne San Jose-Eneriz
  • Leire Garate
  • Juan A Castillejo
  • Lucia Cordeu
  • German Navarro
  • Amaia Vilas-Zornoza
  • Manuel Barrios
  • Maria Jose Calasanz
  • Paula Rodriguez-Otero
  • Dolors Colomer
  • Antonio Jimenez
  • Juan Antonio Castillejo
  • Maria J Calasanz
  • J Roman-Gomez
  • Rosa Roldan-Molina
  • Vanesa Martín-Palanco
  • Estíbaliz Miranda
  • José Rifón
  • Juan Cruz Cigudosa
  • Victor Arqueros
  • Reiner Siebert
  • Eva Bandres
  • Iñaki Martin-Subero
  • E J Andreu
  • J A Castillejo
  • Veronica Perez-Guijo
  • Francisco G Martinez
  • A Heiniger
  • G Navarro
  • Francisco J Molina
  • X Agirre
  • Carmen Castro
  • M Barrios
  • A Jimenez-Velasco
  • Alejandro Escudero
  • Lourdes Hermosin
  • Concepcion Boque
  • Albert Granena
  • Juan Maldonado
  • Fernanda Moreno
  • Maria del Carmen Rodriguez
  • Maria Gracia Gonzalez

Detail Information

Publications23

  1. ncbi Repetitive DNA hypomethylation in the advanced phase of chronic myeloid leukemia
    Jose Roman-Gomez
    Hematology Department, Reina Sofia Hospital, Avda Menendez Pidal s n, 14004 Cordoba, Spain
    Leuk Res 32:487-90. 2008
    ..Furthermore, a more profound level of hypomethylation was observed among BC samples compared with CP samples. Our data suggest that repetitive DNA hypomethylation are closely associated with CML progression...
  2. pmc Frequent and simultaneous epigenetic inactivation of TP53 pathway genes in acute lymphoblastic leukemia
    Amaia Vilas-Zornoza
    Hematology Service and Area of Cell Therapy, Clinica Universidad de Navarra, Foundation for Applied Medical Research, University of Navarra, Pamplona, Spain
    PLoS ONE 6:e17012. 2011
    ..Treatments with compounds that may reverse the epigenetic abnormalities or activate directly the p53 pathway represent a new therapeutic alternative for patients with ALL...
  3. pmc MicroRNA expression profiling in Imatinib-resistant Chronic Myeloid Leukemia patients without clinically significant ABL1-mutations
    Edurne San Jose-Eneriz
    Foundation for Applied Medical Research, Division of Cancer, Area of Cell Therapy and Hematology Service, Clinica Universitaria, Universidad de Navarra, Spain
    Mol Cancer 8:69. 2009
    ..In this study, we have identified a group of 19 miRNAs that may predict clinical resistance to IM in patients with newly diagnosed CML...
  4. ncbi Efficacy of bosentan in treatment of unresponsive cutaneous ulceration in disabling pansclerotic morphea in children
    Rosa Roldan
    Department of Rheumatology, Reina Sofia Hospital, Cordoba, Spain
    J Rheumatol 33:2538-40. 2006
    ..Joint mobility improved, and a substantial decrease of skin thickness was noted. No side effects were noted. In the context of other data in scleroderma, bosentan may be a promising option in the treatment of PM...
  5. ncbi Epigenetic regulation of human cancer/testis antigen gene, HAGE, in chronic myeloid leukemia
    Jose Roman-Gomez
    Hematology Department, Reina Sofia Hospital, Avda Menendez Pidal s n 14004 Cordoba, Spain
    Haematologica 92:153-62. 2007
    ..To date, CTA genes have been shown to be expressed in a range of solid tumors via demethylation of their promoter CpG islands, but rarely in chronic myeloid leukemia (CML) or other hematologic malignancies...
  6. ncbi Epigenetic regulation of PRAME gene in chronic myeloid leukemia
    Jose Roman-Gomez
    Hematology Department, Reina Sofia Hospital, Avda, Menendez Pidal s n, 14004, Cordoba, Spain
    Leuk Res 31:1521-8. 2007
    ..0001). These results suggest that hypomethylation of PRAME up-regulates its expression in CML and might play a significant role in the progression of the disease...
  7. ncbi Poor prognosis in acute lymphoblastic leukemia may relate to promoter hypermethylation of cancer-related genes
    Jose Roman-Gomez
    Hematology Department, Reina Sofia Hospital, Cordoba, Spain
    Leuk Lymphoma 48:1269-82. 2007
    ..Moreover, methylation status is able to redefine the prognosis of selected ALL groups with well-established prognostic features...
  8. ncbi WNT5A, a putative tumour suppressor of lymphoid malignancies, is inactivated by aberrant methylation in acute lymphoblastic leukaemia
    Jose Roman-Gomez
    Hematology Department, Reina Sofia Hospital, Avda Menendez Pidal s n, 14004 Cordoba, Spain
    Eur J Cancer 43:2736-46. 2007
    ....
  9. doi Anakinra: new therapeutic approach in children with Familial Mediterranean Fever resistant to colchicine
    Rosa Roldan
    Rheumatology Department, Reina Sofia Hospital, Avenida Menendez Pidal s n, 14004 Cordoba, Spain
    Joint Bone Spine 75:504-5. 2008
    ..The patient experienced immediate, sustained resolution of symptoms and laboratory markers of inflammation, and also, possibly, a reduced long-term risk of AA amyloidosis...
  10. doi Epigenetic regulation of microRNAs in acute lymphoblastic leukemia
    Jose Roman-Gomez
    Hematology Department Reina Sofia Hospital Avda Menendez Pidal s n 14004 Cordoba Spain
    J Clin Oncol 27:1316-22. 2009
    ..To identify microRNAs (miRNAs) epigenetically regulated in acute lymphoblastic leukemia (ALL)...
  11. ncbi CpG island methylator phenotype redefines the prognostic effect of t(12;21) in childhood acute lymphoblastic leukemia
    Jose Roman-Gomez
    Hematology Department, Reina Sofia Hospital, Cordoba, Spain
    Clin Cancer Res 12:4845-50. 2006
    ....
  12. ncbi Lack of CpG island methylator phenotype defines a clinical subtype of T-cell acute lymphoblastic leukemia associated with good prognosis
    Jose Roman-Gomez
    Hematology Department, Reina Sofia Hospital, Avda, Menendez Pidal s n, 14004 Cordoba, Spain
    J Clin Oncol 23:7043-9. 2005
    ....
  13. ncbi Promoter hypomethylation of the LINE-1 retrotransposable elements activates sense/antisense transcription and marks the progression of chronic myeloid leukemia
    Jose Roman-Gomez
    Hematology Department, Reina Sofia Hospital, Avda Menendez Pidal s n 14004, Cordoba, Spain
    Oncogene 24:7213-23. 2005
    ..005). The above results strongly suggest that activation of both sense and antisense transcriptions by aberrant promoter hypomethylation of the L1 elements plays a role in the progression and clinical behavior of the CML...
  14. ncbi Molecular basis for therapeutic decisions in chronic myeloid leukemia patients after allogeneic bone marrow transplantation
    J Roman
    Hematology Department, Reina Sofia Hospital, Avda Menendez Pidal s n, 14004 Cordoba, Spain
    Haematologica 85:1072-82. 2000
    ..It also presents guidelines for clinical use of PCR analyses and the most effective approaches to treat relapsed patients...
  15. ncbi E1A3 as a unique, naturally occurring BCR-ABL transcript in an indolent case of chronic myeloid leukaemia
    J Roman
    Haematology Department, Reina Sofia Hospital, Cordoba, Spain
    Br J Haematol 114:635-7. 2001
    ....
  16. ncbi 5' CpG island hypermethylation is associated with transcriptional silencing of the p21(CIP1/WAF1/SDI1) gene and confers poor prognosis in acute lymphoblastic leukemia
    Jose Roman-Gomez
    Hematology Department, Reina Sofia Hospital, Avda Menendez Pidal s n, 14004 Cordoba, Spain
    Blood 99:2291-6. 2002
    ..0001). Our results indicate that the p21 gene is subject to methylation regulation at the transcription level in ALL and seems to be an important factor in predicting the clinical outcome of these patients...
  17. ncbi Cadherin-13, a mediator of calcium-dependent cell-cell adhesion, is silenced by methylation in chronic myeloid leukemia and correlates with pretreatment risk profile and cytogenetic response to interferon alfa
    Jose Roman-Gomez
    Hematology Department, Reina Sofia Hospital, Avda, Menendez Pidal s n, 14004 Cordoba, Spain
    J Clin Oncol 21:1472-9. 2003
    ..Although defective progenitor-stromal adhesion is a well-recognized feature of chronic myeloid leukemia (CML), the role of CDH13 abnormalities has not been evaluated in this disease...
  18. ncbi The role of DNA hypermethylation in the pathogenesis and prognosis of acute lymphoblastic leukemia
    Jose Roman-Gomez
    Department of Hematology, Reina Sofia Hospital, 14004 Cordoba, Spain
    Leuk Lymphoma 44:1855-64. 2003
    ....
  19. ncbi The suppressor of cytokine signaling-1 is constitutively expressed in chronic myeloid leukemia and correlates with poor cytogenetic response to interferon-alpha
    Jose Roman-Gomez
    Hematology Department, Reina Sofia Hospital, Cordoba, Spain
    Haematologica 89:42-8. 2004
    ..Because suppressor of cytokine signaling (SOCS) proteins are negative regulators of cytokine-induced signaling, it has been hypothesized that aberrant SOCS expression could confer resistance against cytokine therapy...
  20. ncbi Promoter hypermethylation of cancer-related genes: a strong independent prognostic factor in acute lymphoblastic leukemia
    Jose Roman-Gomez
    Hematology Department, Reina Sofia Hospital, Avda Menendez Pidal s n, 14004 Cordoba, Spain
    Blood 104:2492-8. 2004
    ..0001) and OS (P = .003). Our results suggest that the methylation profile may be a potential new biomarker of risk prediction in ALL...
  21. pmc Transcriptional silencing of the Dickkopfs-3 (Dkk-3) gene by CpG hypermethylation in acute lymphoblastic leukaemia
    J Roman-Gomez
    1Hematology Department, Molecular Biology Unit, Reina Sofia Hospital, 14004 Cordoba, Spain
    Br J Cancer 91:707-13. 2004
    ..0009). Our data suggest that Dkk-3 methylation occurs at an early stage in ALL pathogenesis and probably influences the clinical behaviour of the disease...
  22. ncbi Unusual and aggressive thrombotic onset in two children with antiphospholipid-antibody syndrome and systemic lupus erythematosus
    Rosa Roldan-Molina
    Rheumatology Department, Reina Sofia Hospital, Cordoba 14004, Spain
    Joint Bone Spine 71:327-30. 2004
    ..However, there is no consensus regarding the duration and intensity of oral anticoagulation in children with antiphospholipid antibody syndrome...
  23. ncbi [The monitoring of BCR-ABL mRNA by reverse transcription PCR in patients undergoing allogeneic bone marrow transplantation for acute lymphoblastic leukemia with a positive Philadelphia chromosome]
    J Roman
    Servicio de Hematologia, Hospital Reina Sofia, Cordoba
    Med Clin (Barc) 113:779-82. 1999
    ..However, the clinical significance of the residual BCR-ABL-positive clones after BMT is still controversial...