Mariano Rodriguez

Summary

Country: Spain

Publications

  1. pmc FGF23 fails to inhibit uremic parathyroid glands
    Rocio Canalejo
    Unidad de Investigacion, Servicio de Nefrologia, Departamento de Medicina, Red in ren, Instituto Maimó nides de Invstigación Biomédica de Córdoba, Hospital Universitario Reina Sofia, Cordoba, Spain
    J Am Soc Nephrol 21:1125-35. 2010
  2. doi request reprint Secondary hyperparathyroidism: pathogenesis, disease progression, and therapeutic options
    John Cunningham
    Centre for Nephrology, UCL Medical School, Royal Free Campus, London, United Kingdom
    Clin J Am Soc Nephrol 6:913-21. 2011
  3. doi request reprint Calcium-mediated parathyroid hormone suppression to assess progression of secondary hyperparathyroidism during treatment among incident dialysis patients
    M Rodriguez
    Hospital Universitario Reina Sofia M R, Instituto Maimonides de Investigacion Biomedica de Cordoba, Cordoba 14004, Spain
    J Clin Endocrinol Metab 98:618-25. 2013
  4. ncbi request reprint The calcium-sensing receptor: a key factor in the pathogenesis of secondary hyperparathyroidism
    Mariano Rodriguez
    Unidad de Investigacion, Servicio de Nefrologia, Hospital Universitario Reina Sofia, Avd Menendez Pidal s n, 14004 Cordoba, Spain
    Am J Physiol Renal Physiol 288:F253-64. 2005
  5. ncbi request reprint Regulation of parathyroid function in chronic renal failure
    Mariano Rodriguez
    Nephrology Service, Research Unit, Hospital Reina Sofia, Department of Medicine, Veterinary School, University of Cordoba, Cordoba, Spain
    J Bone Miner Metab 24:164-8. 2006
  6. doi request reprint Engineering parathyroid cells to treat secondary hyperparathyroidism
    Mariano Rodriguez
    Unidad de Investigacion, Servicio de Nefrologia, Hospital Universitario Reina Sofia, Cordoba, Spain
    Kidney Int 75:462-4. 2009
  7. doi request reprint Parathyroid hormone, a uremic toxin
    Mariano Rodriguez
    Unidad de Investigacion, Servicio de Nefrologia, Hospital Universitario Reina Sofia Cordoba, Universidad de Cordoba, Cordoba, Spain
    Semin Dial 22:363-8. 2009
  8. doi request reprint Vitamin D and vascular calcification in chronic kidney disease
    Mariano Rodriguez
    Unidad de Investigacion, Servicio de Nefrologia, Red in ren, Instituto Maimonides de Investigacion Biomedica de Cordoba, Departamento de Medicina, Hospital Universitario Reina Sofia, Cordoba, Espana
    Kidney Blood Press Res 34:261-8. 2011
  9. ncbi request reprint Calcium-sensing receptor expression and parathyroid hormone secretion in hyperplastic parathyroid glands from humans
    Sagrario Cañadillas
    Research Unit, Hospital Universitario Reina Sofia, Avd Menendez Pidal s n, Cordoba 14004, Spain
    J Am Soc Nephrol 16:2190-7. 2005
  10. doi request reprint Bacterial DNA and endothelial damage in haemodialysis patients
    Ana Merino
    Unidad de Investigacion, Hospital Universitario Reina Sofia, Cordoba 14004, Spain
    Nephrol Dial Transplant 23:3635-42. 2008

Collaborators

Detail Information

Publications63

  1. pmc FGF23 fails to inhibit uremic parathyroid glands
    Rocio Canalejo
    Unidad de Investigacion, Servicio de Nefrologia, Departamento de Medicina, Red in ren, Instituto Maimó nides de Invstigación Biomédica de Córdoba, Hospital Universitario Reina Sofia, Cordoba, Spain
    J Am Soc Nephrol 21:1125-35. 2010
    ..In conclusion, in hyperparathyroidism secondary to renal failure, the parathyroid cells resist the inhibitory effects of FGF23, perhaps as a result of the low expression of FGF23 receptor 1 and Klotho in this condition...
  2. doi request reprint Secondary hyperparathyroidism: pathogenesis, disease progression, and therapeutic options
    John Cunningham
    Centre for Nephrology, UCL Medical School, Royal Free Campus, London, United Kingdom
    Clin J Am Soc Nephrol 6:913-21. 2011
    ..Future strategies may focus on the stimulation of apoptotic activity of hyperplastic parathyroid cells...
  3. doi request reprint Calcium-mediated parathyroid hormone suppression to assess progression of secondary hyperparathyroidism during treatment among incident dialysis patients
    M Rodriguez
    Hospital Universitario Reina Sofia M R, Instituto Maimonides de Investigacion Biomedica de Cordoba, Cordoba 14004, Spain
    J Clin Endocrinol Metab 98:618-25. 2013
    ..Parathyroid gland function is affected adversely by tissue hyperplasia and gland enlargement in hyperparathyroidism...
  4. ncbi request reprint The calcium-sensing receptor: a key factor in the pathogenesis of secondary hyperparathyroidism
    Mariano Rodriguez
    Unidad de Investigacion, Servicio de Nefrologia, Hospital Universitario Reina Sofia, Avd Menendez Pidal s n, 14004 Cordoba, Spain
    Am J Physiol Renal Physiol 288:F253-64. 2005
    ..Effective new treatments for SHPT that have a positive impact on mineral metabolism are clearly needed. Recent research shows that drugs that selectively target the CaR, calcimimetics, have the potential to meet these requirements...
  5. ncbi request reprint Regulation of parathyroid function in chronic renal failure
    Mariano Rodriguez
    Nephrology Service, Research Unit, Hospital Reina Sofia, Department of Medicine, Veterinary School, University of Cordoba, Cordoba, Spain
    J Bone Miner Metab 24:164-8. 2006
    ..However, low calcium, vitamin D deficiency, and an accumulation of phosphate due to the decrease in renal function are the main pathogenic factors involved in the pathogenesis of 2nd-HPTH in CKD patients...
  6. doi request reprint Engineering parathyroid cells to treat secondary hyperparathyroidism
    Mariano Rodriguez
    Unidad de Investigacion, Servicio de Nefrologia, Hospital Universitario Reina Sofia, Cordoba, Spain
    Kidney Int 75:462-4. 2009
    ....
  7. doi request reprint Parathyroid hormone, a uremic toxin
    Mariano Rodriguez
    Unidad de Investigacion, Servicio de Nefrologia, Hospital Universitario Reina Sofia Cordoba, Universidad de Cordoba, Cordoba, Spain
    Semin Dial 22:363-8. 2009
    ....
  8. doi request reprint Vitamin D and vascular calcification in chronic kidney disease
    Mariano Rodriguez
    Unidad de Investigacion, Servicio de Nefrologia, Red in ren, Instituto Maimonides de Investigacion Biomedica de Cordoba, Departamento de Medicina, Hospital Universitario Reina Sofia, Cordoba, Espana
    Kidney Blood Press Res 34:261-8. 2011
    ..Important issues regarding the role of vitamin D compounds on vascular calcification will be commented in this review...
  9. ncbi request reprint Calcium-sensing receptor expression and parathyroid hormone secretion in hyperplastic parathyroid glands from humans
    Sagrario Cañadillas
    Research Unit, Hospital Universitario Reina Sofia, Avd Menendez Pidal s n, Cordoba 14004, Spain
    J Am Soc Nephrol 16:2190-7. 2005
    ..These abnormalities in PTH regulation are related to low CaR expression...
  10. doi request reprint Bacterial DNA and endothelial damage in haemodialysis patients
    Ana Merino
    Unidad de Investigacion, Hospital Universitario Reina Sofia, Cordoba 14004, Spain
    Nephrol Dial Transplant 23:3635-42. 2008
    ....
  11. doi request reprint The effect of vitamin D derivatives on vascular calcification associated with inflammation
    Fatima Guerrero
    Department Medicina y Cirugia Animal, Universidad de Cordoba, Cordoba, Spain
    Nephrol Dial Transplant 27:2206-12. 2012
    ..Vitamin D sterols may modulate vascular response to inflammation and vascular calcification (VC)...
  12. doi request reprint Direct upregulation of parathyroid calcium-sensing receptor and vitamin D receptor by calcimimetics in uremic rats
    Francisco J Mendoza
    Departamento Medicina y Cirugia Animal, Universidad de Cordoba, Cordoba, Spain
    Am J Physiol Renal Physiol 296:F605-13. 2009
    ....
  13. ncbi request reprint Role of acidosis-induced increases in calcium on PTH secretion in acute metabolic and respiratory acidosis in the dog
    Ignacio Lopez
    Departamento de Medicina y Cirugia Animal, Universidad de Cordoba, 14014 Cordoba, Spain
    Am J Physiol Endocrinol Metab 286:E780-5. 2004
    ....
  14. doi request reprint Klotho modulates the stress response in human senescent endothelial cells
    Julia Carracedo
    Instituto Maimónides de Investigación Biomédica de Córdoba IMIBIC Fundación de Investigaciones Biomédicas de Córdoba FIBICO, Reina Sofia University Hospital, Cordoba, Spain
    Mech Ageing Dev 133:647-54. 2012
    ..Likewise exogenous Klotho prevented the increases in reactive oxygen species (ROS) activity, mitochondrial potential and cell apoptosis induced by TNFα...
  15. pmc Calcium deficiency reduces circulating levels of FGF23
    Maria E Rodriguez-Ortiz
    Research Unit, IMIBIC, Hospital Universitario Reina Sofia, Cordoba, Spain
    J Am Soc Nephrol 23:1190-7. 2012
    ..Taken together, these results suggest that hypocalcemia reduces the circulating concentrations of FGF23. This decrease in FGF23 could be a response to avoid a subsequent reduction in calcitriol, which could exacerbate hypocalcemia...
  16. ncbi request reprint Nutritional secondary hyperparathyroidism in rabbits
    Sonia Bas
    Dept Medicina y Cirugía Animal, Universidad de Cordoba, Campus Universitario de Rabanales, Ctra Madrid Cadiz km 396, 14014 Cordoba, Spain
    Domest Anim Endocrinol 28:380-90. 2005
    ..After 6 weeks on the LCaHPD rabbits develop parathyroid hyperplasia characterized by increases in PTH secretion, glandular weight and proliferation and by a decrease in CaRmRNA...
  17. ncbi request reprint The effect of LPS, uraemia, and haemodialysis membrane exposure on CD14 expression in mononuclear cells and its relation to apoptosis
    Julia Carracedo
    Unidad de Investigacion, Servicio de Nefrologia, Hospital Universitario Reina Sofia, Cordoba, Spain
    Nephrol Dial Transplant 17:428-34. 2002
    ..This study also investigated whether LPS affects mononuclear cell CD14 expression and the apoptosis induced by uraemia and exposure to Cuprophan (CU) membrane...
  18. pmc Cinacalcet reduces the set point of the PTH-calcium curve
    Casimiro Valle
    Nephrology Service and Research Unit, Hospital Universitario Reina Sofia, Cordoba, Spain
    J Am Soc Nephrol 19:2430-6. 2008
    ..In conclusion, cinacalcet increases the sensitivity of the parathyroids to calcium, causing a marked reduction in the set point of the PTH-calcium curve, in hemodialysis patients with secondary hyperparathyroidism...
  19. doi request reprint Carbamylated darbepoetin derivative prevents endothelial progenitor cell damage with no effect on angiogenesis
    Rafael Ramirez
    Unidad de Investigacion, Servicio de Nefrologia, Hospital Universitario Reina Sofia, Avda Menendez Pidal s n, Cordoba 14004, Spain
    J Mol Cell Cardiol 47:781-8. 2009
    ..By contrast, C-darbe failed to stimulate proliferation of EPCs. Both C-darbe and darbe equally reduced apoptosis and senescence. Thus, C-darbe protects EPCs from apoptosis and does not increase erythropoiesis...
  20. ncbi request reprint Calcimimetics normalize the phosphate-induced stimulation of PTH secretion in vivo and in vitro
    Yolanda Almaden
    Unidad de Investigación and Department Medicina, Servicio de Nefrologia, Hospital Universitario Reina Sofia, and Department Medicina y Cirugia Animal, Universidad de Cordoba, Cordoba, Spain
    J Nephrol 22:281-8. 2009
    ..The aim of this study was to assess whether calcimimetics are able to normalize the phosphate-induced stimulation of PTH secretion...
  21. ncbi request reprint On-line hemodiafiltration reduces the proinflammatory CD14+CD16+ monocyte-derived dendritic cells: A prospective, crossover study
    Julia Carracedo
    Unidad de Investigacion, Servicio de Nefrologia, Hospital Universitario Reina Sofia, Cordoba, Spain
    J Am Soc Nephrol 17:2315-21. 2006
    ..Future studies are needed to assess the possible therapeutic effect of convective transport on chronic inflammation that is associated with HD...
  22. ncbi request reprint Bacterial DNA prolongs the survival of inflamed mononuclear cells in haemodialysis patients
    Maria Dolores Navarro
    Servicio de Nefrologia, Hospital Universitario Reina Sofia, Avda Menendez Pidal s n, Cordoba 14004 Spain
    Nephrol Dial Transplant 22:3580-5. 2007
    ..The aim of this study was to evaluate whether DNAb contamination may have an effect on apoptosis of activated monocytes from CKD-5 patients...
  23. ncbi request reprint Monocytes from dialysis patients exhibit characteristics of senescent cells: does it really mean inflammation?
    Julia Carracedo
    Unidad de Investigacion, Servicio de Nefrologia, Hospital Universitario Reina Sofia, Cordoba, Spain
    Contrib Nephrol 149:208-18. 2005
    ....
  24. ncbi request reprint Dynamics of secretion and metabolism of PTH during hypo- and hypercalcaemia in the dog as determined by the 'intact' and 'whole' PTH assays
    Jose C Estepa
    Department of Medicina y Cirugia Animal, Universidad de Cordoba, Campus Rabanales, Ctra Madrid Cadiz km 396, 14014 Cordoba, Spain
    Nephrol Dial Transplant 18:1101-7. 2003
    ....
  25. ncbi request reprint Regulation of arachidonic acid production by intracellular calcium in parathyroid cells: effect of extracellular phosphate
    Yolanda Almaden
    Research Unit and Nephrology Service, Reina Sofia University Hospital, Cordoba, Spain
    J Am Soc Nephrol 13:693-8. 2002
    ..The stimulation of PTH secretion by high phosphate levels can be prevented by increases in intracellular calcium levels...
  26. doi request reprint Effect of calcium and the calcimimetic AMG 641 on matrix-Gla protein in vascular smooth muscle cells
    Francisco J Mendoza
    Departamento de Medicina y Cirugia Animal, Universidad de Cordoba, Campus Universitario Rabanales, Spain
    Calcif Tissue Int 88:169-78. 2011
    ..This local upregulation of MGP expression provides one potential mechanism by which calcimimetics prevent VC...
  27. doi request reprint The calcimimetic AMG 641 accelerates regression of extraosseous calcification in uremic rats
    Ignacio Lopez
    Departmento de Medicina y Cirugia Animal, Universidad de Cordoba, Campus Universitario Rabanales, Ctra Madrid Cadiz km 396, 14014 Cordoba, Spain
    Am J Physiol Renal Physiol 296:F1376-85. 2009
    ....
  28. ncbi request reprint Microinflammation in hemodialysis is related to a preactivated subset of monocytes
    Rafael Ramirez
    Unidad de Investigacion, Servicio de Nefrologia, Hospital Universitario Reina Sofia, Cordoba, Spain
    Hemodial Int 10:S24-7. 2006
    ..These results support that CD14+/CD16+ monocytes from HD patients evidence characteristics of primed prestimulated proinflammatory cells, similar to data observed in SLE and HIV...
  29. ncbi request reprint Effects of uremic ultrafiltrate on the regulation of the parathyroid cell cycle by calcitriol
    Antonio Canalejo
    Unidad de Investigacion, Servicio de Nefrologia, Hospital Universitario Reina Sofia, Cordoba, Spain
    Kidney Int 63:732-7. 2003
    ..We questioned whether the uremic milieu interferes with the inhibition of parathyroid cell proliferation by CTR...
  30. doi request reprint Upregulation of parathyroid VDR expression by extracellular calcium is mediated by ERK1/2-MAPK signaling pathway
    Sagrario Cañadillas
    Unidad de Investigacion, Servicio de Nefrologia, Red in ren, Instituto Maimonides de Investigacion Biomedica de Cordoba IMIBIC, Hospital Universitario Reina Sofia, Cordoba, Spain
    Am J Physiol Renal Physiol 298:F1197-204. 2010
    ..Furthermore, the transcription factor Sp1 mediates this effect...
  31. ncbi request reprint Coupling of endothelial injury and repair: an analysis using an in vivo experimental model
    Sonia Nogueras
    Research Unit, Nephrology Service, Reina Sofia University Hospital, ES 14004 Cordova, Spain
    Am J Physiol Heart Circ Physiol 294:H708-13. 2008
    ..Inflammation without endothelial injury does not trigger the mobilization of circulating angiogenic cells...
  32. doi request reprint Carbamylated low-density lipoprotein induces oxidative stress and accelerated senescence in human endothelial progenitor cells
    Julia Carracedo
    Instituto Maimónides de Investigación Biomédica de Córdoba Fundación de Investigaciones Biomédicas de Córdoba, Cordoba, Spain
    FASEB J 25:1314-22. 2011
    ..This study supports the hypothesis that cLDL triggers genomic damage in EPCs, resulting in premature senescence. We can, therefore, hypothesize that EPCs injury by cLDL contributes to an increase in atherosclerotic disease in CKD...
  33. ncbi request reprint Assessment of calcitonin response to experimentally induced hypercalcemia in cats
    Carmen Pineda
    Departamento de Medicina y Cirugia Animal, Universidad de Cordoba, Cordoba, Spain
    Am J Vet Res 74:1514-21. 2013
    ..To characterize the dynamics of calcitonin secretion in response to experimentally induced hypercalcemia in cats...
  34. ncbi request reprint Direct and indirect effects of parathyroid hormone on circulating levels of fibroblast growth factor 23 in vivo
    Ignacio Lopez
    Department of Medicina y Cirugia Animal, Universidad de Cordoba, and Unidad de Investigacion, Servicio de Nefrología Red in Ren, Hospital Universitario Reina Sofia IMIBIC, Cordoba, Spain
    Kidney Int 80:475-82. 2011
    ..Hence, our results show a direct and an indirect effect of PTH on FGF23 secretion, the latter through changes in calcitriol concentrations...
  35. doi request reprint In vascular smooth muscle cells paricalcitol prevents phosphate-induced Wnt/β-catenin activation
    Julio M Martinez-Moreno
    Unidad de Investigacion, IMIBIC, Hospital Reina Sofia, Avda Menendez Pidal s n, Cordoba, Spain
    Am J Physiol Renal Physiol 303:F1136-44. 2012
    ..In conclusion, the differential effect of calcitriol and paricalcitol on vascular calcification appears to be mediated by a distinct regulation of the BMP and Wnt/β-catenin signaling pathways...
  36. ncbi request reprint Proliferation in hyperplastic human and normal rat parathyroid glands: role of phosphate, calcitriol, and gender
    Yolanda Almaden
    Unit of Investigation, Hospital Universitario Reina Sofia, Cordoba, Spain
    Kidney Int 64:2311-7. 2003
    ....
  37. ncbi request reprint Serum concentrations of calcium, phosphorus, magnesium and calciotropic hormones in donkeys
    Ignacio Lopez
    Department of Medicina y Cirugia Animal, Universidad de Cordoba, Campus Universitario Rabanales, Ctra Madrid Cadiz km 396, 14014 Cordoba, Spain
    Am J Vet Res 67:1333-6. 2006
    ..To provide reference values for serum biochemical variables that are used for evaluation of mineral metabolism in donkeys and compare values with those in horses...
  38. ncbi request reprint Direct suppressive effect of acute metabolic and respiratory alkalosis on parathyroid hormone secretion in the dog
    Ignacio Lopez
    Departamento de Medicina y Cirugia Animal, Universidad de Cordoba, Cordoba, Spain
    J Bone Miner Res 18:1478-85. 2003
    ..8 pg/ml) and respiratory (1.8 +/- 0.6 pg/ml) alkalosis groups than in the control group (27 +/- 5 pg/ml). Acute alkalosis is an independent factor that decreases PTH values during normocalcemia and delays the PTH response to hypocalcemia...
  39. ncbi request reprint Regulation of parathyroid vitamin D receptor expression by extracellular calcium
    Bartolome Garfia
    Departamento de Medicina y Cirugia Animal, Universidad de Cordoba, 14004 Cordoba, Spain
    J Am Soc Nephrol 13:2945-52. 2002
    ..In conclusion, our study shows that extracellular Ca regulates VDR expression by parathyroid cells independently of CTR and that by this mechanism hypocalcemia may prevent the feedback of CTR on the parathyroids...
  40. doi request reprint Mineral metabolism in growing cats: changes in the values of blood parameters with age
    Carmen Pineda
    1Department of Animal Medicine and Surgery, University of Cordoba, Cordoba, Spain
    J Feline Med Surg 15:866-71. 2013
    ..Our results, showing changes in most parameters of mineral metabolism during growth, reinforce the need to use adequate age-related reference values for diagnostic purposes. ..
  41. ncbi request reprint Dynamics of PTH secretion in hemodialysis patients as determined by the intact and whole PTH assays
    Rafael Santamaria
    Nephrology Service, Reina Sofia University Hospital, Cordoba, Spain
    Kidney Int 64:1867-73. 2003
    ..These large circulating PTH fragments may exert a hypocalcemic effect by contributing to skeletal resistance to 1-84 PTH...
  42. ncbi request reprint Lymphocyte apoptosis: role of uremia and permeability of dialysis membrane
    Sagrario Soriano
    Servicio de Nefrologia, Hospital Universitario Reina Sofia, Cordoba, Spain
    Nephron Clin Pract 100:c71-7. 2005
    ..The aim of the present study was to determine if, in addition to uremia, dialysis membranes with different biocompatibility and permeability have an effect on lymphocyte apoptosis...
  43. pmc TGF-β prevents phosphate-induced osteogenesis through inhibition of BMP and Wnt/β-catenin pathways
    Fatima Guerrero
    Instituto Maimónides para la Investigación Biomédica IMIBIC Hospital Reina Sofía Universidad de Córdoba, Cordoba, Spain
    PLoS ONE 9:e89179. 2014
    ..This study was aimed to evaluate signaling pathways involved during VSMC differentiation of MSC in presence or not of high phosphate...
  44. pmc Magnesium inhibits Wnt/β-catenin activity and reverses the osteogenic transformation of vascular smooth muscle cells
    Addy Montes de Oca
    IMIBIC, Hospital Univ Reina Sofia, REDinREN, Cordoba, Spain Depto Medicina y Cirugía Animal, University of Cordoba, Cordoba, Spain
    PLoS ONE 9:e89525. 2014
    ..Inhibition of Wnt/β-catenin by magnesium is one potential intracellular mechanism by which this anti-calcifying effect is achieved. ..
  45. ncbi request reprint Stress-induced premature senescence in mononuclear cells from patients on long-term hemodialysis
    Rafael Ramirez
    Unidad de Investigacion, Servicio de Nefrologia, Hospital Universitario Reina Sofia, Cordoba, Spain
    Am J Kidney Dis 45:353-9. 2005
    ..Characteristics of senescent mononuclear cells include telomere length shortening, increased p53 expression, CD14dim/CD16bright expression, and interleukin overproduction...
  46. ncbi request reprint The imbalance in the ratio of Th1 and Th2 helper lymphocytes in uraemia is mediated by an increased apoptosis of Th1 subset
    Maria Antonia Alvarez-Lara
    Nephrology Service, Reina Sofia University Hospital, 14004 Cordoba, Spain
    Nephrol Dial Transplant 19:3084-90. 2004
    ..The aims of the present study were to assess the Th1/Th2 pattern in uraemia and to evaluate whether a relative increase in Th1 apoptosis may explain the Th1/Th2 imbalance observed in uraemic patients...
  47. ncbi request reprint Reversibility of calcitriol-induced medial artery calcification in rats with intact renal function
    Alicia Bas
    Department of Medicina y Cirugia Animal, Universidad de Cordoba, Cordoba, Spain
    J Bone Miner Res 21:484-90. 2006
    ..Induction and regression of calcitriol-induced VC was studied in 47 rats. After calcitriol withdrawal, there was a relatively rapid regression of VC mediated by an active cellular process...
  48. ncbi request reprint Calcimimetic R-568 decreases extraosseous calcifications in uremic rats treated with calcitriol
    Ignacio Lopez
    Department of Medicina y Cirugia Animal, Universidad de Cordoba, Campus Universitario Rabanales, Ctra Madrid Cadiz km 396, 14014 Cordoba, Spain
    J Am Soc Nephrol 17:795-804. 2006
    ..01) by concurrent treatment with R-568. In uremic rats, R-568 reduces elevated PTH levels without inducing vascular calcification, prevents calcitriol-induced vascular calcification, and decreases mortality...
  49. ncbi request reprint Effect of changes in ionized calcium concentration in arterial blood and metabolic acidosis on the arterial partial pressure of oxygen in dogs
    Ignacio Lopez
    Departmento de Medicina y Cirugia Animal, Universidad de Cordoba, Ctra Madrid Cadiz, Km 396, 14014 Cordoba, Spain
    Am J Vet Res 67:801-8. 2006
    ..To evaluate the effects of metabolic acidosis and changes in ionized calcium (Ca2+) concentration on PaO2 in dogs...
  50. doi request reprint High-phosphate-induced calcification is related to SM22α promoter methylation in vascular smooth muscle cells
    Addy Montes de Oca
    Department of Medicina y Cirugia Animal, Universidad de Cordoba, Cordoba, Spain
    J Bone Miner Res 25:1996-2005. 2010
    ..These findings uncover a new insight into mechanisms by which high phosphate concentration promotes vascular calcification...
  51. ncbi request reprint Direct effect of acute metabolic and respiratory acidosis on parathyroid hormone secretion in the dog
    Ignacio Lopez
    Departamento de Medicina y Cirugia Animal, Universidad de Cordoba, Spain
    J Bone Miner Res 17:1691-700. 2002
    ....
  52. doi request reprint Pharmacodynamics of cinacalcet over 48 hours in patients with controlled secondary hyperparathyroidism: useful data in clinical practice
    M Dolores Arenas
    Nephrology Service, Hospital Perpetuo Socorro, ES 03013 Alicante, Spain
    J Clin Endocrinol Metab 98:1718-25. 2013
    ..Also, in patients with reduced PTH, it is unknown what happens in the first 24 hours after withdrawal...
  53. doi request reprint Localization, distribution, and function of the calcium-sensing receptor in sperm
    Francisco J Mendoza
    Dept Medicina y Cirugía Animal, Universidad de Cordoba, Campus Universitario Rabanales, Ctra Madrid Cadiz km 396, Cordoba, Spain
    J Androl 33:96-104. 2012
    ..In conclusion, our results demonstrate the expression of functional CaSR in testicular tissue and sperm, which can be activated by calcimimetic AMG 641...
  54. doi request reprint Darbepoetin-α treatment enhances glomerular regenerative process in the Thy-1 glomerulonephritis model
    Sagrario Cañadillas
    Research Unit, Hospital Universitario Reina Sofia, Cordoba, Spain
    Am J Physiol Renal Physiol 299:F1278-87. 2010
    ..The results indicate that darbepoetin-α treatment promotes glomerular recovery...
  55. ncbi request reprint Mild hyperphosphatemia and mortality in hemodialysis patients
    Alberto Rodriguez-Benot
    Division of Nephrology, Hospital Universitario Reina Sofia, Cordoba, Spain
    Am J Kidney Dis 46:68-77. 2005
    ..0 to 5.0 mg/dL [0.97 to 1.61 mmol/L]). However, mild hyperphosphatemia (phosphate, 5.01 to 6.5 mg/dL [1.62 to 2.10 mmol/L]) is still to be addressed as an independent mortality risk factor in HD patients...
  56. ncbi request reprint Magnesium - its role in CKD
    Angel L M de Francisco
    Servicio de Nefrologia, Hospital Universitario Marques de Valdecilla, Santander, Spain
    Nefrologia 33:389-99. 2013
    ....
  57. ncbi request reprint Simultaneous pancreas-kidney transplant: a single-center long-term outcome
    María Luisa Aguera
    Department of Nephrology, University Hospital Reina Sofia, Cordoba, Spain
    J Nephrol 20:173-6. 2007
    ..We consider that the analysis of our long-term program (based in a single center) of simultaneous pancreas-kidney transplantation would provide valuable information for this therapeutic approach regarding patient and organ survival...
  58. ncbi request reprint Caspase-3-dependent pathway mediates apoptosis of human mononuclear cells induced by cellulosic haemodialysis membranes
    Julia Carracedo
    Unidad de Investigacion, Servicio de Nefrologia, Hospital Universitario Reina Sofia, Cordoba, Spain
    Nephrol Dial Transplant 17:1971-7. 2002
    ..Thus, we determined whether apoptosis is dependent on caspase-3 activity and is inhibited by lipopolysaccharide (LPS), which are two features of spontaneous apoptosis in normal monocytes...
  59. doi request reprint New insights in regulation of calcium homeostasis
    Arnold Felsenfeld
    Department of Medicine, VA Greater Los Angeles Healthcare System and the David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Curr Opin Nephrol Hypertens 22:371-6. 2013
    ..Perturbations can result in hypocalcemia or hypercalcemia and adaptations in calcium handling must occur during growth and aging...
  60. ncbi request reprint Persistent downregulation of calcium-sensing receptor mRNA in rat parathyroids when severe secondary hyperparathyroidism is reversed by an isogenic kidney transplantation
    Ewa Lewin
    Nephrological Department P, Rigshospitalet, University of Copenhagen, Denmark
    J Am Soc Nephrol 13:2110-6. 2002
    ..This indicates that upregulation of CaR mRNA and VDR mRNA is not necessary to induce the rapid normalization of PTH secretion from hyperplastic parathyroid glands...
  61. ncbi request reprint Autoregulation in the parathyroid glands by PTH/PTHrP receptor ligands in normal and uremic rats
    Ewa Lewin
    Nephrological Department B, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark
    Kidney Int 64:63-70. 2003
    ..Our aim was to search for the PTH/PTHrP receptor in rat parathyroid glands and to examine the effects of PTHrP 1-40 on PTH secretion in in vivo models of secondary hyperparathyroidism (HPT) in uremic rats...
  62. ncbi request reprint Can calcimimetics inhibit parathyroid hyperplasia? Evidence from preclinical studies
    Tilman Drueke
    Nephrol Dial Transplant 22:1828-39. 2007
  63. ncbi request reprint Osteoporosis in chronic kidney disease
    John Cunningham
    Middlesex Hospital, University College London Hospitals, London, England UK
    Am J Kidney Dis 43:566-71. 2004