M Rodriguez-Concepcion

Summary

Country: Spain

Publications

  1. ncbi request reprint Bioinformatic and molecular analysis of hydroxymethylbutenyl diphosphate synthase (GCPE) gene expression during carotenoid accumulation in ripening tomato fruit
    Manuel Rodriguez-Concepcion
    Departament de Bioquimica i Biologia Molecular, Facultat de Quimica, Universitat de Barcelona, Martí i Franquès 1 7, 08028 Barcelona, Spain
    Planta 217:476-82. 2003
  2. ncbi request reprint The MEP pathway: a new target for the development of herbicides, antibiotics and antimalarial drugs
    M Rodriguez-Concepcion
    Department de Bioquimica i Biologia Molecular, Facultat de Quimica, Universidad de Barcelona, Barcelona, Spain
    Curr Pharm Des 10:2391-400. 2004
  3. ncbi request reprint Carboxyl-methylation of prenylated calmodulin CaM53 is required for efficient plasma membrane targeting of the protein
    M Rodriguez-Concepcion
    Department Bioquímica i Biologia Molecular, Universitat de Barcelona, Martí i Franquès 1 7, 08028 Barcelona, Spain
    Plant J 24:775-84. 2000
  4. pmc Distinct light-mediated pathways regulate the biosynthesis and exchange of isoprenoid precursors during Arabidopsis seedling development
    Manuel Rodriguez-Concepcion
    Departament de Bioquimica i Biologia Molecular, Facultat de Quimica, Universitat de Barcelona, 08028 Barcelona, Spain
    Plant Cell 16:144-56. 2004
  5. ncbi request reprint 1-Deoxy-D-xylulose 5-phosphate reductoisomerase and plastid isoprenoid biosynthesis during tomato fruit ripening
    M Rodriguez-Concepcion
    Departament de Bioquimica i Biologia Molecular, Facultat de Quimica, Universitat de Barcelona, Martí i Franquès 1 7, 08028 Barcelona, Spain
    Plant J 27:213-22. 2001
  6. pmc Elucidation of the methylerythritol phosphate pathway for isoprenoid biosynthesis in bacteria and plastids. A metabolic milestone achieved through genomics
    Manuel Rodriguez-Concepcion
    Departament de Bioquimica i Biologia Molecular, Facultat de Quimica, Universitat de Barcelona, Martí i Franquès 1 7, 08028 Barcelona, Spain
    Plant Physiol 130:1079-89. 2002
  7. pmc Escherichia coli engineered to synthesize isopentenyl diphosphate and dimethylallyl diphosphate from mevalonate: a novel system for the genetic analysis of the 2-C-methyl-d-erythritol 4-phosphate pathway for isoprenoid biosynthesis
    N Campos
    Department de Bioquimica i Biologia Molecular, Facultat de Quimica, Universitat de Barcelona, c Marti i Franques 1, 08028 Barcelona, Spain
    Biochem J 353:59-67. 2001
  8. ncbi request reprint Genetic evidence of branching in the isoprenoid pathway for the production of isopentenyl diphosphate and dimethylallyl diphosphate in Escherichia coli
    M Rodriguez-Concepcion
    Department de Bioquimica i Biologia Molecular, Facultat de Quimica, Universitat de Barcelona, Martí i Franquès 1 7, Barcelona, Spain
    FEBS Lett 473:328-32. 2000
  9. ncbi request reprint Carotenoid biosynthesis during tomato fruit development: regulatory role of 1-deoxy-D-xylulose 5-phosphate synthase
    L M Lois
    Departament de Bioquimica i Biologia Molecular, Facultat de Quimica, Universitat de Barcelona, Barcelona, Spain
    Plant J 22:503-13. 2000
  10. ncbi request reprint Identification of gcpE as a novel gene of the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis in Escherichia coli
    N Campos
    Department de Bioquimica i Biologia Molecular, Universitat de Barcelona, Spain
    FEBS Lett 488:170-3. 2001

Collaborators

  • N Campos
  • M Rohmer
  • Victor Gonzalez
  • Michael A Phillips
  • Albert Boronat
  • Susanna Sauret-Güeto
  • Lorenzo Carretero-Paulet
  • Patricia Botella-Pavía
  • Oscar Besumbes
  • Antía Rodríguez-Villalón
  • Irma Roig-Villanova
  • Jaime F Martinez-Garcia
  • Ester Ibáñez
  • Santiago Imperial
  • Jordi Querol
  • J Querol
  • A Boronat
  • L M Lois
  • Jordi Perez-Gil
  • Anahit Galstyan
  • Sergi Portolés
  • Jordi Bou-Torrent
  • Eva Maria Urós
  • Ursula Flores-Pérez
  • Carolina San Román
  • Patricia Leon
  • Albert Cairó
  • Ana Ramos-Valdivia
  • Iván Ahumada
  • Nuria Cunillera
  • Albert Ferrer
  • S Imperial
  • F Gallego

Detail Information

Publications21

  1. ncbi request reprint Bioinformatic and molecular analysis of hydroxymethylbutenyl diphosphate synthase (GCPE) gene expression during carotenoid accumulation in ripening tomato fruit
    Manuel Rodriguez-Concepcion
    Departament de Bioquimica i Biologia Molecular, Facultat de Quimica, Universitat de Barcelona, Martí i Franquès 1 7, 08028 Barcelona, Spain
    Planta 217:476-82. 2003
    ..Together, our results are consistent with a non-limiting role for HDS in carotenoid biosynthesis during tomato fruit ripening...
  2. ncbi request reprint The MEP pathway: a new target for the development of herbicides, antibiotics and antimalarial drugs
    M Rodriguez-Concepcion
    Department de Bioquimica i Biologia Molecular, Facultat de Quimica, Universidad de Barcelona, Barcelona, Spain
    Curr Pharm Des 10:2391-400. 2004
    ..Current efforts should eventually contribute to an effective drug designed to fight against microbial pathogens that show resistance to currently available agents...
  3. ncbi request reprint Carboxyl-methylation of prenylated calmodulin CaM53 is required for efficient plasma membrane targeting of the protein
    M Rodriguez-Concepcion
    Department Bioquímica i Biologia Molecular, Universitat de Barcelona, Martí i Franquès 1 7, 08028 Barcelona, Spain
    Plant J 24:775-84. 2000
    ....
  4. pmc Distinct light-mediated pathways regulate the biosynthesis and exchange of isoprenoid precursors during Arabidopsis seedling development
    Manuel Rodriguez-Concepcion
    Departament de Bioquimica i Biologia Molecular, Facultat de Quimica, Universitat de Barcelona, 08028 Barcelona, Spain
    Plant Cell 16:144-56. 2004
    ....
  5. ncbi request reprint 1-Deoxy-D-xylulose 5-phosphate reductoisomerase and plastid isoprenoid biosynthesis during tomato fruit ripening
    M Rodriguez-Concepcion
    Departament de Bioquimica i Biologia Molecular, Facultat de Quimica, Universitat de Barcelona, Martí i Franquès 1 7, 08028 Barcelona, Spain
    Plant J 27:213-22. 2001
    ..Furthermore, the complete arrest of tomato seedling development using fosmidomycin confirms a key role of the MEP pathway in plant development...
  6. pmc Elucidation of the methylerythritol phosphate pathway for isoprenoid biosynthesis in bacteria and plastids. A metabolic milestone achieved through genomics
    Manuel Rodriguez-Concepcion
    Departament de Bioquimica i Biologia Molecular, Facultat de Quimica, Universitat de Barcelona, Martí i Franquès 1 7, 08028 Barcelona, Spain
    Plant Physiol 130:1079-89. 2002
  7. pmc Escherichia coli engineered to synthesize isopentenyl diphosphate and dimethylallyl diphosphate from mevalonate: a novel system for the genetic analysis of the 2-C-methyl-d-erythritol 4-phosphate pathway for isoprenoid biosynthesis
    N Campos
    Department de Bioquimica i Biologia Molecular, Facultat de Quimica, Universitat de Barcelona, c Marti i Franques 1, 08028 Barcelona, Spain
    Biochem J 353:59-67. 2001
    ..We used this system to show that the ygbP, ychB and ygbB genes are essential in E. coli and that the steps catalysed by the products of these genes belong to the trunk line of the MEP pathway...
  8. ncbi request reprint Genetic evidence of branching in the isoprenoid pathway for the production of isopentenyl diphosphate and dimethylallyl diphosphate in Escherichia coli
    M Rodriguez-Concepcion
    Department de Bioquimica i Biologia Molecular, Facultat de Quimica, Universitat de Barcelona, Martí i Franquès 1 7, Barcelona, Spain
    FEBS Lett 473:328-32. 2000
    ..In addition, the IPP isomerase encoded by the idi gene was shown to be functional in vivo and to represent the only possibility for interconverting IPP and DMAPP in this bacterium...
  9. ncbi request reprint Carotenoid biosynthesis during tomato fruit development: regulatory role of 1-deoxy-D-xylulose 5-phosphate synthase
    L M Lois
    Departament de Bioquimica i Biologia Molecular, Facultat de Quimica, Universitat de Barcelona, Barcelona, Spain
    Plant J 22:503-13. 2000
    ..Our results change the current view that PSY1 is the only regulatory enzyme in tomato fruit carotenogenesis, and point towards a coordinated role of both DXS and PSY1 in the control of fruit carotenoid synthesis...
  10. ncbi request reprint Identification of gcpE as a novel gene of the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid biosynthesis in Escherichia coli
    N Campos
    Department de Bioquimica i Biologia Molecular, Universitat de Barcelona, Spain
    FEBS Lett 488:170-3. 2001
    ..Our data demonstrate that the gcpE gene is essential for the MEP pathway in Escherichia coli and indicate that this gene is required for the trunk line of the isoprenoid biosynthetic route...
  11. ncbi request reprint Regulation of carotenoid biosynthesis in plants: evidence for a key role of hydroxymethylbutenyl diphosphate reductase in controlling the supply of plastidial isoprenoid precursors
    Patricia Botella-Pavía
    Departament de Bioquimica i Biologia Molecular, Facultat de Quimica, Universitat de Barcelona, Martí i Franquès 1 7, 08028 Barcelona, Spain
    Plant J 40:188-99. 2004
    ..Together, the data support a major role for HDR in controlling the production of MEP-derived precursors for plastid isoprenoid biosynthesis...
  12. pmc Expression and molecular analysis of the Arabidopsis DXR gene encoding 1-deoxy-D-xylulose 5-phosphate reductoisomerase, the first committed enzyme of the 2-C-methyl-D-erythritol 4-phosphate pathway
    Lorenzo Carretero-Paulet
    Departament de Bioquimica i Biologia Molecular, Facultat de Quimica, Universitat de Barcelona, c Marti i Franques 1, 08028 Barcelona, Spain
    Plant Physiol 129:1581-91. 2002
    ..Our results are consistent with the participation of the Arabidopsis DXR gene in the control of the 2-C-methyl-D-erythritol 4-phosphate pathway...
  13. ncbi request reprint Essential role of residue H49 for activity of Escherichia coli 1-deoxy-D-xylulose 5-phosphate synthase, the enzyme catalyzing the first step of the 2-C-methyl-D-erythritol 4-phosphate pathway for isoprenoid Synthesis
    J Querol
    Departament de Bioquimica i Biologia Molecular, Universitat de Barcelona, Martí i Franquès 1 7, 08028 Barcelona, Spain
    Biochem Biophys Res Commun 289:155-60. 2001
    ..These findings are consistent with those obtained for yeast TK and demonstrate a key role of H49 for DXS activity...
  14. pmc Plastid cues posttranscriptionally regulate the accumulation of key enzymes of the methylerythritol phosphate pathway in Arabidopsis
    Susanna Sauret-Güeto
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, 08028 Barcelona, Spain
    Plant Physiol 141:75-84. 2006
    ..Regulation of the MEP pathway by a mechanism dependent on plastid cues might function under physiological conditions to finely adjust plastidial isoprenoid biosynthesis to the metabolic capabilities or requirements of plastids...
  15. ncbi request reprint Functional analysis of the Arabidopsis thaliana GCPE protein involved in plastid isoprenoid biosynthesis
    Jordi Querol
    Departament de Bioquimica i Biologia Molecular, Facultat de Quimica, Universitat de Barcelona, Martí i Franquès 1 7, 08028 Barcelona, Spain
    FEBS Lett 514:343-6. 2002
    ..coli strain, indicating the plant protein is a true functional homologue of the bacterial gcpE gene product...
  16. ncbi request reprint Enhanced flux through the methylerythritol 4-phosphate pathway in Arabidopsis plants overexpressing deoxyxylulose 5-phosphate reductoisomerase
    Lorenzo Carretero-Paulet
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Av Diagonal 645, 08028 Barcelona, Spain
    Plant Mol Biol 62:683-95. 2006
    ....
  17. ncbi request reprint Metabolic engineering of isoprenoid biosynthesis in Arabidopsis for the production of taxadiene, the first committed precursor of Taxol
    Oscar Besumbes
    Departament de Bioquimica i Biologia Molecular, Facultat de Quimica, Universitat de Barcelona, Martí i Franquès 1 7, 08028 Barcelona, Spain
    Biotechnol Bioeng 88:168-75. 2004
    ....
  18. ncbi request reprint A mutant pyruvate dehydrogenase E1 subunit allows survival of Escherichia coli strains defective in 1-deoxy-D-xylulose 5-phosphate synthase
    Susanna Sauret-Güeto
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona Av Diagonal 645, 08028 Barcelona, Spain
    FEBS Lett 580:736-40. 2006
    ....
  19. pmc Interaction of shade avoidance and auxin responses: a role for two novel atypical bHLH proteins
    Irma Roig-Villanova
    Laboratori de Genètica Molecular Vegetal Consorci CSIC IRTA, Departament de Genetica Molecular, Barcelona, Spain
    EMBO J 26:4756-67. 2007
    ..Additional results support that PAR1 and PAR2 function in integrating shade and hormone transcriptional networks, rapidly connecting phytochrome-sensed light changes with auxin responsiveness...
  20. ncbi request reprint Identification of lethal mutations in Escherichia coli genes encoding enzymes of the methylerythritol phosphate pathway
    Susanna Sauret-Güeto
    Departament de Bioquimica i Biologia Molecular, Facultat de Quimica, Universitat de Barcelona, Spain
    Biochem Biophys Res Commun 307:408-15. 2003
    ..Besides confirming the role of residues involved in catalysis, our results define regions within several of the proteins with a potential key role for enzyme function...
  21. doi request reprint Carotenoid accumulation in bacteria with enhanced supply of isoprenoid precursors by upregulation of exogenous or endogenous pathways
    Antía Rodríguez-Villalón
    Departament de Bioquimica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona, Av Diagonal 645, 08028 Barcelona, Spain
    J Biotechnol 135:78-84. 2008
    ..coli but that factors other than precursor supply should be considered for high pigment accumulation levels...