Garaulet G, Perez Chacon G, Alarcón H, Alfranca A, Mulero F, Martinez Torrecuadrada J, et al
. Intratumoral expression using a NFkB-based promoter enhances IL12 antitumor efficacy. Cancer Gene Ther. 2019;: pubmed publisher
..In summary, this new inflammation-regulated expression system might be useful for the development of new IL12 delivery systems with improved anti-tumor activity and limited toxicity. ..
Rodriguez A, Roy J, Martínez Martínez S, López Maderuelo M, Niño Moreno P, Ortí L, et al
. A conserved docking surface on calcineurin mediates interaction with substrates and immunosuppressants. Mol Cell. 2009;33:616-26 pubmed publisher
..These studies suggest that LxVP-type sites are a common feature of calcineurin substrates, and that immunosuppressant-immunophilin complexes inhibit calcineurin by interfering with this mode of substrate recognition. ..
Garaulet G, Lazcano J, Alarcón H, de Frutos S, Martínez Torrecuadrada J, Rodriguez A. Display of the Albumin-Binding Domain in the Envelope Improves Lentiviral Vector Bioavailability. Hum Gene Ther Methods. 2017;28:340-351 pubmed publisher
..Therefore, the use of ABD represents an improvement for in vivo gene therapy applications. The results strongly point to ABD display as a universal strategy to increase the in vivo efficacy of different viral vectors. ..