Research Topics
Genomes and Genes | Beatriz RicoSummaryCountry: Spain Publications
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Publications
Control of axonal branching and synapse formation by focal adhesion kinaseBeatriz Rico
Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco, California 94143, USA
Nat Neurosci 7:1059-69. 2004..Thus, FAK functions as a negative regulator of axonal branching and synapse formation, and it seems to exert its actions, in part, through Rho family GTPases...
Neuregulin signaling, cortical circuitry development and schizophreniaBeatriz Rico
Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
Curr Opin Genet Dev 21:262-70. 2011..We will also discuss how this basic knowledge may help us to understand the etiology of schizophrenia, and eventually lead to the development of novel therapies for treating the disorder...
Control of cortical GABA circuitry development by Nrg1 and ErbB4 signallingPietro Fazzari
Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
Nature 464:1376-80. 2010....
Focal adhesion kinase regulates actin nucleation and neuronal filopodia formation during axonal growthMariola R Chacón
Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Alicante, Spain
Development 139:3200-10. 2012..Our study reveals a novel mechanism through which FAK controls filopodia formation and actin nucleation during axonal development...
Transneuronal tracing of diverse CNS circuits by Cre-mediated induction of wheat germ agglutinin in transgenic miceJoao M Braz
Department of Anatomy and Physiology and W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco 94143, USA
Proc Natl Acad Sci U S A 99:15148-53. 2002..Because the lectin can be induced in developing and adult animals, and in all regions of the brain and spinal cord, these ZW may prove extremely valuable for numerous studies of CNS circuit analysis...
Focal adhesion kinase modulates radial glia-dependent neuronal migration through connexin-26Manuel Valiente
Instituto de Neurociencias, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
J Neurosci 31:11678-91. 2011..These results indicate that FAK plays a fundamental role in the dynamic regulation of Gap-mediated adhesions during glial-guided neuronal migration in the mouse...
BDNF mobilizes synaptic vesicles and enhances synapse formation by disrupting cadherin-beta-catenin interactionsShernaz X Bamji
Neuroscience Program, Howard Hughes Medical Institute, and Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
J Cell Biol 174:289-99. 2006..Together, this data demonstrates that the disruption of cadherin-beta-catenin complexes is an important molecular event through which BDNF increases synapse density in cultured hippocampal neurons...
Focal adhesion kinase functions downstream of Sema3A signaling during axonal remodelingMariola R Chacón
Instituto de Neurociencias de Alicante, CSIC and Universidad Miguel Hernandez, 03550 Sant Joan d Alacant, Spain
Mol Cell Neurosci 44:30-42. 2010..Altogether, our results provide novel insights into the spatiotemporal dynamics of FAK activation mediated by Sema3A and on its interaction with its downstream effectors: Paxillin and alpha-actinin in neurons...
CREB-Dependent Regulation of GAD65 Transcription by BDNF/TrkB in Cortical InterneuronsCarlos Sánchez-Huertas
Instituto de Neurociencias de Alicante, Consejo Superior de Investigaciones Científicas and Universidad Miguel Hernández, 03550 Sant Joan d Alacant, Spain
Cereb Cortex 21:777-88. 2011..Our study reveals a novel molecular mechanism through which BDNF/TrkB signaling may modulate the maturation and function of cortical inhibitory circuits...
TrkB receptor signaling is required for establishment of GABAergic synapses in the cerebellumBeatriz Rico
Howard Hughes Medical Institute and Department of Physiology, University of California, San Francisco, California 94143, USA
Nat Neurosci 5:225-33. 2002..Thus, TrkB is essential to the development of GABAergic neurons and regulates synapse formation in addition to its role in the development of axon terminals...
Critical role of integrin-linked kinase in granule cell precursor proliferation and cerebellar developmentJulia Mills
Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, V6T 1Z4, Canada
J Neurosci 26:830-40. 2006..Together, these results implicate ILK as a critical effector in a signaling pathway necessary for granule cell proliferation and cerebellar development...
The primate thalamus is a key target for brain dopamineMiguel Ángel Sánchez-González
Departamento de Anatomia, Histologia y Neurociencia, Facultad de Medicina, Universidad Autonoma de Madrid, 28029 Madrid, Spain
J Neurosci 25:6076-83. 2005..Investigating this "thalamic dopaminergic system" should further our understanding of higher brain functions and conditions such as Parkinson's disease, schizophrenia, and drug addiction...
Distribution of the dopamine innervation in the macaque and human thalamusMiguel Angel Garcia Cabezas
Departamento de Anatomia, Histologia y Neurociencia, Facultad de Medicina, Universidad Autonoma de Madrid, C Arzobispo Morcillo s n, 28029 Madrid, Spain
Neuroimage 34:965-84. 2007....
