Manuel Ramos-Casals

Summary

Country: Spain

Publications

  1. doi request reprint Primary Sjögren syndrome in Spain: clinical and immunologic expression in 1010 patients
    Manuel Ramos-Casals
    Department of Autoimmune Diseases, IDIBAPS, Hospital Clinic, Barcelona, Spain
    Medicine (Baltimore) 87:210-9. 2008
  2. ncbi request reprint Sarcoidosis or Sjögren syndrome? Clues to defining mimicry or coexistence in 59 cases
    Manuel Ramos-Casals
    Department of Autoimmune Diseases, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Hospital Clinic, Barcelona, Spain
    Medicine (Baltimore) 83:85-95. 2004
  3. ncbi request reprint Clinical features related to antiphospholipid syndrome in patients with chronic viral infections (hepatitis C virus/HIV infection): description of 82 cases
    Manuel Ramos-Casals
    Department of Autoimmune Diseases, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, School of Medicine, University of Barcelona, Spain
    Clin Infect Dis 38:1009-16. 2004
  4. ncbi request reprint Systemic autoimmune diseases co-existing with chronic hepatitis C virus infection (the HISPAMEC Registry): patterns of clinical and immunological expression in 180 cases
    M Ramos-Casals
    Department of Autoimmune Diseases, Institut d Investigacions Biomediques August Pi i Sunyer, School of Medicine, University of Barcelona, Hospital Clinic, Barcelona, Spain
    J Intern Med 257:549-57. 2005
  5. doi request reprint Hepatitis C virus and Sjögren's syndrome: trigger or mimic?
    Manuel Ramos-Casals
    Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases, C Villaroel 170, Hospital Clinic, Barcelona 08036, Spain
    Rheum Dis Clin North Am 34:869-84, vii. 2008
  6. ncbi request reprint Factors influencing dry mouth in patients with primary Sjögren syndrome: usefulness of the ESSPRI index
    Myriam Gandía
    Servei de Malalties Autoimmunes, Hospital Clinic, C Villarroel, 170, 08036 Barcelona, Spain, Tel 34 93 2275774 Fax 34 93 2271707 e mail
    Oral Health Dent Manag 13:402-7. 2014
  7. ncbi request reprint Systemic involvement in primary Sjogren's syndrome evaluated by the EULAR-SS disease activity index: analysis of 921 Spanish patients (GEAS-SS Registry)
    Manuel Ramos-Casals
    Servei de Malalties Autoimmunes Sistèmiques, Hospital Clinic, C Villarroel, 170, 08036 Barcelona, Spain
    Rheumatology (Oxford) 53:321-31. 2014
  8. ncbi request reprint [Recommendations on the use of belimumab in systemic lupus erythematosus. GEAS-SEMI Clinical Practice Guide]
    M Ramos-Casals
    Servicio de Enfermedades Autoinmunes, Laboratorio de Enfermedades Autoinmunes Josep Font, IDIBAPS, Hospital Clinic, Barcelona, Espana
    Rev Clin Esp (Barc) 213:42-58. 2013
  9. doi request reprint Primary Sjögren syndrome: an update on current pharmacotherapy options and future directions
    Pilar Brito-Zeron
    Servei de Malalties Autoimmunes, Hospital Clinic, Barcelona, Spain
    Expert Opin Pharmacother 14:279-89. 2013
  10. doi request reprint Topical and systemic medications for the treatment of primary Sjögren's syndrome
    Manuel Ramos-Casals
    Sjögren s Syndrome Research Group AGAUR, Laboratory of Autoimmune Diseases Josep Font, Department of Autoimmune Diseases, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
    Nat Rev Rheumatol 8:399-411. 2012

Detail Information

Publications90

  1. doi request reprint Primary Sjögren syndrome in Spain: clinical and immunologic expression in 1010 patients
    Manuel Ramos-Casals
    Department of Autoimmune Diseases, IDIBAPS, Hospital Clinic, Barcelona, Spain
    Medicine (Baltimore) 87:210-9. 2008
    ..Primary SS should be considered as a systemic autoimmune disease that can express in many guises beyond sicca involvement...
  2. ncbi request reprint Sarcoidosis or Sjögren syndrome? Clues to defining mimicry or coexistence in 59 cases
    Manuel Ramos-Casals
    Department of Autoimmune Diseases, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, University of Barcelona, Hospital Clinic, Barcelona, Spain
    Medicine (Baltimore) 83:85-95. 2004
    ....
  3. ncbi request reprint Clinical features related to antiphospholipid syndrome in patients with chronic viral infections (hepatitis C virus/HIV infection): description of 82 cases
    Manuel Ramos-Casals
    Department of Autoimmune Diseases, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, School of Medicine, University of Barcelona, Spain
    Clin Infect Dis 38:1009-16. 2004
    ..These viruses might act in some patients as chronic triggering agents that induce a heterogeneous, atypical presentation of APS...
  4. ncbi request reprint Systemic autoimmune diseases co-existing with chronic hepatitis C virus infection (the HISPAMEC Registry): patterns of clinical and immunological expression in 180 cases
    M Ramos-Casals
    Department of Autoimmune Diseases, Institut d Investigacions Biomediques August Pi i Sunyer, School of Medicine, University of Barcelona, Hospital Clinic, Barcelona, Spain
    J Intern Med 257:549-57. 2005
    ..To describe the clinical and immunologic characteristics of a large series of patients with systemic autoimmune diseases (SAD) associated with chronic hepatitis C virus (HCV) infection...
  5. doi request reprint Hepatitis C virus and Sjögren's syndrome: trigger or mimic?
    Manuel Ramos-Casals
    Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases, C Villaroel 170, Hospital Clinic, Barcelona 08036, Spain
    Rheum Dis Clin North Am 34:869-84, vii. 2008
    ....
  6. ncbi request reprint Factors influencing dry mouth in patients with primary Sjögren syndrome: usefulness of the ESSPRI index
    Myriam Gandía
    Servei de Malalties Autoimmunes, Hospital Clinic, C Villarroel, 170, 08036 Barcelona, Spain, Tel 34 93 2275774 Fax 34 93 2271707 e mail
    Oral Health Dent Manag 13:402-7. 2014
    ....
  7. ncbi request reprint Systemic involvement in primary Sjogren's syndrome evaluated by the EULAR-SS disease activity index: analysis of 921 Spanish patients (GEAS-SS Registry)
    Manuel Ramos-Casals
    Servei de Malalties Autoimmunes Sistèmiques, Hospital Clinic, C Villarroel, 170, 08036 Barcelona, Spain
    Rheumatology (Oxford) 53:321-31. 2014
    ..To evaluate systemic involvement in primary SS in a large cohort of Spanish patients using the EULAR-SS disease activity index (ESSDAI) definitions...
  8. ncbi request reprint [Recommendations on the use of belimumab in systemic lupus erythematosus. GEAS-SEMI Clinical Practice Guide]
    M Ramos-Casals
    Servicio de Enfermedades Autoinmunes, Laboratorio de Enfermedades Autoinmunes Josep Font, IDIBAPS, Hospital Clinic, Barcelona, Espana
    Rev Clin Esp (Barc) 213:42-58. 2013
    ..These guidelines are based on the current scientific evidence on the use of belimumab in SLE patients in the clinical practice...
  9. doi request reprint Primary Sjögren syndrome: an update on current pharmacotherapy options and future directions
    Pilar Brito-Zeron
    Servei de Malalties Autoimmunes, Hospital Clinic, Barcelona, Spain
    Expert Opin Pharmacother 14:279-89. 2013
    ..Primary Sjögren syndrome (SS) is a chronic systemic autoimmune disease characterized by sicca features and systemic manifestations, and requires a multidisciplinary therapeutic approach...
  10. doi request reprint Topical and systemic medications for the treatment of primary Sjögren's syndrome
    Manuel Ramos-Casals
    Sjögren s Syndrome Research Group AGAUR, Laboratory of Autoimmune Diseases Josep Font, Department of Autoimmune Diseases, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
    Nat Rev Rheumatol 8:399-411. 2012
    ..On the basis of this evidence, we provide guidance on the use of these agents in different clinical scenarios...
  11. ncbi request reprint White matter abnormalities in primary Sjögren syndrome
    M Akasbi
    Sjögren Syndrome Research Group AGAUR, Laboratory of Autoimmune Diseases Josep Font, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Department of Autoimmune Diseases, Hospital do Meixoeiro, Vigo, Spain
    QJM 105:433-43. 2012
    ..To describe the main characteristics of patients with primary Sjögren syndrome (SS) and white matter abnormalities (WMA) seen by a specialist SS unit...
  12. pmc Rates of, and risk factors for, severe infections in patients with systemic autoimmune diseases receiving biological agents off-label
    Candido Diaz-Lagares
    Laboratorio de Enfermedades Autoinmunes Josep Font, IDIBAPS, Hospital Clinic, C Villarroel, Barcelona, 08036, Spain
    Arthritis Res Ther 13:R112. 2011
    ....
  13. ncbi request reprint Vasculitis induced by tumor necrosis factor-targeted therapies
    Manuel Ramos-Casals
    Servei de Malalties Autoimmunes, Hospital Clinic, C Villarroel, 170, 08036 Barcelona, Spain
    Curr Rheumatol Rep 10:442-8. 2008
    ..A total of 132 cases, identified up to July 2008, are included and analyzed in this review...
  14. doi request reprint Acute viral infections in patients with systemic lupus erythematosus: description of 23 cases and review of the literature
    Manuel Ramos-Casals
    Laboratory of Autoimmune Diseases Josep Font, Department of Autoimmune Diseases, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Barcelona, Spain
    Medicine (Baltimore) 87:311-8. 2008
    ..Physicians should examine the pharynx, eyes, skin, and genitalia and should conduct serologic and molecular studies to improve early detection of viral infection in patients with SLE...
  15. ncbi request reprint Lessons from diseases mimicking Sjögren's syndrome
    Manuel Ramos-Casals
    Servei de Malalties Autoimmunes, Hospital Clinic, C Villarroel, 170, 08036 Barcelona, Spain
    Clin Rev Allergy Immunol 32:275-83. 2007
    ..On the other hand, some processes may mimic the clinical picture of SS through nonlymphocytic infiltration of the exocrine glands. This review focuses on these two groups of diseases that mimic SS (infections and infiltrating processes)...
  16. ncbi request reprint Cryoglobulinaemia associated with hepatitis C virus: influence of HCV genotypes, HCV-RNA viraemia and HIV coinfection
    M Ramos-Casals
    Department of Autoimmune Diseases, Institut d Investigacions Biomédiques August Pi Sunyer IDIBAPS, Hospital Clinic, Barcelona, Spain
    J Viral Hepat 14:736-42. 2007
    ..Associated HIV infection significantly attenuated the clinical and immunological expression of cryoglobulinaemia, except in coinfected patients with high viral loads for the two viruses...
  17. ncbi request reprint Autoimmune diseases induced by TNF-targeted therapies: analysis of 233 cases
    Manuel Ramos-Casals
    Department of Autoimmune Diseases, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Hospital Clinic, Barcelona, Spain
    Medicine (Baltimore) 86:242-51. 2007
    ..In conclusion, the use of anti-TNF agents has been associated with an increasing number of cases of autoimmune diseases, principally cutaneous vasculitis, lupus-like syndrome, SLE, and interstitial lung disease...
  18. ncbi request reprint Emerging biological therapies in primary Sjogren's syndrome
    M Ramos-Casals
    Department of Autoimmune Diseases, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Barcelona, Spain
    Rheumatology (Oxford) 46:1389-96. 2007
    ..The use of biological agents targeting molecules and receptors involved in the aetiopathogenesis of primary SS opens a new era in the therapeutic management of patients with primary SS...
  19. ncbi request reprint High prevalence of serum metabolic alterations in primary Sjögren's syndrome: influence on clinical and immunological expression
    Manuel Ramos-Casals
    Department of Autoimmune Diseases and the Lipid Unit, School of Medicine, University of Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Spain
    J Rheumatol 34:754-61. 2007
    ..To analyze the prevalence and clinical significance of associated metabolic alterations [dyslipidemia, diabetes mellitus (DM), and hyperuricemia] in a large series of unselected patients with primary Sjögren's syndrome (SS)...
  20. ncbi request reprint Characterization of B cell lymphoma in patients with Sjögren's syndrome and hepatitis C virus infection
    Manuel Ramos-Casals
    Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, School of Medicine, University of Barcelona, Barcelona, Spain
    Arthritis Rheum 57:161-70. 2007
    ..To characterize the clinical and immunologic patterns of expression, response to therapy, and outcome of patients with Sjögren's syndrome (SS) and associated hepatitis C virus (HCV) infection who developed B cell lymphoma...
  21. ncbi request reprint The overlap of Sjögren's syndrome with other systemic autoimmune diseases
    Manuel Ramos-Casals
    Department of Autoimmune Diseases, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    Semin Arthritis Rheum 36:246-55. 2007
    ..To analyze the main diagnostic problems caused by the overlap between Sjögren's syndrome (SS) and other systemic autoimmune diseases (SAD)...
  22. ncbi request reprint Life-threatening cryoglobulinemia: clinical and immunological characterization of 29 cases
    Manuel Ramos-Casals
    Department of Autoimmune Diseases, School of Medicine, University of Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, Barcelona, Spain
    Semin Arthritis Rheum 36:189-96. 2006
    ..To analyze the etiology, clinical presentation, and outcomes of patients with life-threatening cryoglobulinemic vasculitis...
  23. doi request reprint A systematic review of the off-label use of biological therapies in systemic autoimmune diseases
    Manuel Ramos-Casals
    Laboratory of Autoimmune Diseases Josep Font, Department of Autoimmune Diseases, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Barcelona, Spain
    Medicine (Baltimore) 87:345-64. 2008
    ..Future controlled trials are needed to confirm the potential use of biological therapies in patients with SAD...
  24. doi request reprint Autoimmune diseases induced by TNF-targeted therapies
    Manuel Ramos-Casals
    Laboratory of Autoimmune Diseases Josep Font, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Spain
    Best Pract Res Clin Rheumatol 22:847-61. 2008
    ..Large, prospective, postmarketing studies are required to evaluate the risk of developing autoimmune diseases in patients receiving TNF-targeted therapies...
  25. doi request reprint Therapy: Are TNF blockers safe for patients with hepatitis B virus infection?
    Manuel Ramos-Casals
    Institut d Investigacions Biomediques August Pi i Sunyer, Department of Autoimmune Diseases, Laboratory of Autoimmune Diseases Josep Font, Villarroel 170, Barcelona 08036, Spain
    Nat Rev Rheumatol 6:618-20. 2010
    ..a prospective study has concluded that it is safe to use anti-tumor-necrosis-factor agents in patients with chronic hepatitis B virus infection receiving antiviral prophylaxis. Is there sufficient evidence to back up this conclusion?..
  26. ncbi request reprint Treatment of primary Sjögren syndrome: a systematic review
    Manuel Ramos-Casals
    Sjögren Syndrome Research Group AGAUR, Josep Font Laboratory of Autoimmune Diseases, IDIBAPS, Department of Autoimmune Diseases, Hospital Clinic, C Villarroel, 170, 08036 Barcelona, Spain
    JAMA 304:452-60. 2010
    ..A variety of topical and systemic drugs are available to treat primary Sjögren syndrome, although no evidence-based therapeutic guidelines are currently available...
  27. ncbi request reprint Off-label use of rituximab in 196 patients with severe, refractory systemic autoimmune diseases
    M Ramos-Casals
    Laboratorio de Enfermedades Autoinmunes Josep Font, IDIBAPS, Hospital Clinic, Barcelona Spain
    Clin Exp Rheumatol 28:468-76. 2010
    ..To analyse the safety and efficacy of the off-label use of rituximab in patients with severe, refractory systemic autoimmune diseases...
  28. ncbi request reprint New approaches in Sjögren's syndrome therapy
    Manuel Ramos Casals
    , Department of Autoimmune Diseases, , C Villarroel, 170, 08036 Barcelona, Spain
    Expert Rev Clin Immunol 3:195-204. 2007
    ....
  29. doi request reprint Rituximab therapy in lupus nephritis: current clinical evidence
    Manuel Ramos-Casals
    Laboratory of Autoimmune Diseases Josep Font, Department of Autoimmune Diseases, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, Barcelona, Spain
    Clin Rev Allergy Immunol 40:159-69. 2011
    ..Although it is not yet possible to make definite recommendations, the global analysis of these cases supports the off-label use of rituximab in severe, refractory LN cases...
  30. doi request reprint Targeted therapy for systemic sclerosis: how close are we?
    Manuel Ramos-Casals
    Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Barcelona, Spain
    Nat Rev Rheumatol 6:269-78. 2010
    ..In the future, it is hoped that the simultaneous or sequential use of different drugs will provide better results than currently available monotherapies in patients with systemic sclerosis...
  31. doi request reprint Clinical and prognostic significance of parotid scintigraphy in 405 patients with primary Sjogren's syndrome
    Manuel Ramos-Casals
    Sjögren Syndrome Research Group, Laboratory of Autoimmune Diseases Josep Font, IDIBAPS, Department of Autoimmune Diseases, GESCLINIC, Hospital Clinic, Barcelona, Spain
    J Rheumatol 37:585-90. 2010
    ..To evaluate the association between the degree of involvement shown by parotid scintigraphy at diagnosis and the disease expression, outcomes, and prognosis of primary Sjögren's syndrome (SS)...
  32. ncbi request reprint Clinical guidelines for the management of acute viral infections in patients with systemic lupus erythematosus
    M Ramos-Casals
    Department of Autoimmune Diseases, Laboratory of Autoimmune Diseases Josep Font, Institut d Investigacions Biomédiques, August Pi i Sunyer IDIBAPS, Hospital Clinic, Barcelona, Spain
    Minerva Med 100:437-46. 2009
    ..We also propose clinical guidelines for the management of these infections in patients with SLE...
  33. ncbi request reprint Sjögren syndrome or sjögren disease? The histological and immunological bias caused by the 2002 criteria
    Manuel Ramos-Casals
    Department of Autoimmune Diseases, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Barcelona, Spain
    Clin Rev Allergy Immunol 38:178-85. 2010
    ..In contrast, etiopathogenic mechanisms other than lymphocytic-mediated epithelial damage could be involved in patients with negative Ro and negative biopsy, in whom the term Sjögren "syndrome" seems more adequate...
  34. ncbi request reprint Rituximab in systemic lupus erythematosus: A systematic review of off-label use in 188 cases
    Manuel Ramos-Casals
    Laboratory of Autoimmune Diseases Josep Font, Department of Autoimmune Diseases, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, Barcelona, Spain
    Lupus 18:767-76. 2009
    ....
  35. ncbi request reprint Systemic autoimmune diseases in patients with hepatitis C virus infection: characterization of 1020 cases (The HISPAMEC Registry)
    Manuel Ramos-Casals
    Laboratory of Autoimmune Diseases Josep Font, Department of Autoimmune Diseases, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, 08036 Barcelona, Spain
    J Rheumatol 36:1442-8. 2009
    ..To describe the clinical and immunologic characteristics of a large series of patients with systemic autoimmune diseases (SAD) associated with chronic hepatitis C virus (HCV) infection...
  36. doi request reprint Mannose-binding lectin-low genotypes are associated with milder systemic and immunological disease expression in primary Sjögren's syndrome
    M Ramos-Casals
    Department of Autoimmune Diseases, Laboratory of Autoimmune Diseases Josep Font, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    Rheumatology (Oxford) 48:65-9. 2009
    ..To investigate the association of mannose-binding lectin (MBL)-low genotypes with the clinical and immunological expression of primary SS...
  37. ncbi request reprint Atypical autoantibodies in patients with primary Sjögren syndrome: clinical characteristics and follow-up of 82 cases
    Manuel Ramos-Casals
    Department of Autoimmune Diseases, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, School of Medicine, University of Barcelona, Barcelona, Spain
    Semin Arthritis Rheum 35:312-21. 2006
    ..To analyze the clinical characteristics, follow-up, and fulfillment of classification criteria for other systemic autoimmune diseases (SAD) in patients with primary Sjögren syndrome (SS) and atypical autoantibodies...
  38. ncbi request reprint Viral etiopathogenesis of Sjögren's syndrome: role of the hepatitis C virus
    Manuel Ramos-Casals
    Department of Autoimmune Diseases, C Villaroel 170, Hospital Clinic, Institut Clinic d Infeccions i Immunologia, 08036 Barcelona, Catalonia, Spain
    Autoimmun Rev 1:238-43. 2002
    ..Thus, HCV patients with sicca symptomatology and positive autoantibodies could be misdiagnosed as a 'primary' SS. Nevertheless, there are several clinical and immunologic features that could help us differentiate both processes...
  39. ncbi request reprint Mycophenolate mofetil in patients with hepatitis C virus infection
    M Ramos-Casals
    Department of Autoimmune Diseases, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, School of Medicine, University of Barcelona, Hospital Clinic, Barcelona, Spain
    Lupus 14:s64-72. 2005
    ....
  40. doi request reprint Autoimmune diseases induced by biological agents: a double-edged sword?
    Manuel Ramos-Casals
    Laboratory of Autoimmune Diseases Josep Font, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Spain
    Autoimmun Rev 9:188-93. 2010
    ..The induced autoimmune diseases with the poorest outcomes were interstitial lung disease, inflammatory ocular disease and central nervous system demyelinating diseases...
  41. ncbi request reprint Triple association between hepatitis C virus infection, systemic autoimmune diseases, and B cell lymphoma
    Manuel Ramos-Casals
    Departments of Autoimmune Diseases and Hematology, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, University of Barcelona, Barcelona, Spain
    J Rheumatol 31:495-9. 2004
    ..To analyze the clinical characteristics of patients from a Department of Autoimmune Diseases presenting chronic hepatitis C virus (HCV) infection, systemic autoimmune disease, and B cell lymphoma...
  42. ncbi request reprint Cutaneous vasculitis in primary Sjögren syndrome: classification and clinical significance of 52 patients
    Manuel Ramos-Casals
    Department of Autoimmune Diseases, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, School of Medicine, University of Barcelona, Barcelona, Spain
    Medicine (Baltimore) 83:96-106. 2004
    ..Life-threatening vasculitis was closely related to cryoglobulinemia...
  43. ncbi request reprint Sjögren syndrome associated with hepatitis C virus: a multicenter analysis of 137 cases
    Manuel Ramos-Casals
    Department of Autoimmune Diseases, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, School of Medicine, University of Barcelona, Barcelona, Spain
    Medicine (Baltimore) 84:81-9. 2005
    ..We propose the term "SS secondary to HCV" when these patients fulfill the 2002 classification criteria for SS...
  44. ncbi request reprint Sarcoidosis in patients with chronic hepatitis C virus infection: analysis of 68 cases
    Manuel Ramos-Casals
    Department of Autoimmune Diseases, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, School of Medicine, University of Barcelona, Barcelona, Spain
    Medicine (Baltimore) 84:69-80. 2005
    ..Clinicians should be aware of the possibility that sarcoidosis may initially manifest or be reactivated during or shortly after treatment with antiviral therapy in patients with chronic HCV infection...
  45. ncbi request reprint Hepatitis C virus, Sjögren's syndrome and B-cell lymphoma: linking infection, autoimmunity and cancer
    Manuel Ramos-Casals
    Department of Autoimmune Diseases, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, School of Medicine, University of Barcelona, Barcelona, Spain
    Autoimmun Rev 4:8-15. 2005
    ....
  46. ncbi request reprint Hypocomplementaemia as an immunological marker of morbidity and mortality in patients with primary Sjogren's syndrome
    M Ramos-Casals
    Department of Autoimmune Diseases, Institut d Investigacions Biomédiques Augst Pi i Sunyer IDIBAPS Hospital Clinic, School of Medicine, Univesity of Barcelona, Spain
    Rheumatology (Oxford) 44:89-94. 2005
    ....
  47. ncbi request reprint Primary Sjögren's syndrome: current and emergent aetiopathogenic concepts
    M Ramos-Casals
    Department of Autoimmune Diseases, Hospital Clinic, C Villarroel, 170, 08036 Barcelona, Spain
    Rheumatology (Oxford) 44:1354-67. 2005
  48. ncbi request reprint Autoimmunity and geriatrics: clinical significance of autoimmune manifestations in the elderly
    M Ramos-Casals
    Department of Autoimmune Diseases, Clinical Institute of Infections and Immunology, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    Lupus 12:341-55. 2003
    ..This review analyses the main immune disorders associated with immunosenescence, the prevalence and clinical significance of autoantibodies in the elderly and the clinical expression of the main autoimmune diseases in older patients...
  49. ncbi request reprint [Sjögren syndrome. New therapeutic approaches]
    Manuel Ramos-Casals
    Servicio de Enfermedades Autoinmunes Sistémicas, Hospital Clinic de Barcelona, Barcelona, Spain
    Med Clin (Barc) 124:111-5. 2005
  50. ncbi request reprint Primary Sjögren syndrome: hematologic patterns of disease expression
    Manuel Ramos-Casals
    Department of Autoimmune Diseases, Clinical Institute of Infections and Immunology, Barcelona, Spain
    Medicine (Baltimore) 81:281-92. 2002
  51. ncbi request reprint Antimitochondrial antibodies in patients with chronic hepatitis C virus infection: description of 18 cases and review of the literature
    M Ramos-Casals
    Department of Autoimmune Diseases, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, School of Medicine, University of Barcelona, Barcelona, Spain
    J Viral Hepat 12:648-54. 2005
    ..Two-thirds of these patients presented an associated SAD, mainly Sjögren's syndrome or systemic sclerosis, together with a high frequency of multiple autoantibodies and an increased prevalence of cirrhosis and neoplasia...
  52. ncbi request reprint Th1/Th2 cytokine imbalance in patients with Sjögren syndrome secondary to hepatitis C virus infection
    Manuel Ramos-Casals
    Department of Autoimmune Diseases, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, School of Medicine, University of Barcelona, Barcelona, Catalonia, Spain
    Semin Arthritis Rheum 32:56-63. 2002
    ..To investigate if the serum immunologic profile, as delineated by serum circulating levels of Th1/Th2 cytokines and autoantibodies, is different in patients with Sjögren syndrome (SS) with and without hepatitis C virus (HCV) infection...
  53. ncbi request reprint Systemic autoimmune diseases in elderly patients: atypical presentation and association with neoplasia
    Manuel Ramos-Casals
    Department of Autoimmune Diseases, Institut d lnvestigacions Biomèdiques August Pi i Sunyer IDIBAPS, University of Barcelona, Hospital Clinic, Barcelona, Spain
    Autoimmun Rev 3:376-82. 2004
    ..The study of autoimmune manifestations in elderly populations should be considered a priority for future medical research because of increasing life expectation, especially in developed countries...
  54. ncbi request reprint Severe autoimmune cytopenias in treatment-naive hepatitis C virus infection: clinical description of 35 cases
    Manuel Ramos-Casals
    Department of Autoimmune Diseases, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, School of Medicine, University of Barcelona, Spain
    Medicine (Baltimore) 82:87-96. 2003
    ..Hemolytic anemia and severe thrombocytopenia were the most frequent cytopenias observed. Most patients responded well to corticosteroids, although a higher rate of mortality was observed in those with liver cirrhosis...
  55. ncbi request reprint Therapeutic management of extrahepatic manifestations in patients with chronic hepatitis C virus infection
    M Ramos-Casals
    Department of Autoimmune Diseases, Clinical Institutes of Infection and Immunology, Insitut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Department of Medicine, School of Medicine, University of Barcelona, Spain
    Rheumatology (Oxford) 42:818-28. 2003
  56. pmc Primary Sjögren's syndrome: new clinical and therapeutic concepts
    M Ramos-Casals
    Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Spain
    Ann Rheum Dis 64:347-54. 2005
    ..In coming years treatment will be based on muscarinic agonists for sicca features and immunosuppressive/biological agents for extraglandular features...
  57. ncbi request reprint Raynaud's phenomenon in primary Sjögren's syndrome. Prevalence and clinical characteristics in a series of 320 patients
    Mario Garcia-Carrasco
    Department of Systemic Autoimmune Diseases, Hospital Clinic, Barcelona, Spain
    J Rheumatol 29:726-30. 2002
    ..To determine the prevalence of Raynaud's phenomenon (RP) in a large series of patients with primary Sjögren's syndrome (SS) and to identify the clinical and immunological features related to its presence...
  58. ncbi request reprint Anti-Ro52 antibody testing influences the classification and clinical characterisation of primary Sjögren's syndrome
    Soledad Retamozo
    Department Autoimmune Diseases, Hospital Clinic, Barcelona, Spain
    Clin Exp Rheumatol 30:686-92. 2012
    ..To evaluate how determination of antibodies against the Ro52 antigen influences the classification and clinical characterisation of patients with suspected primary Sjögren's syndrome (SS)...
  59. ncbi request reprint Classification and characterisation of peripheral neuropathies in 102 patients with primary Sjögren's syndrome
    Pilar Brito-Zeron
    Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Spain
    Clin Exp Rheumatol 31:103-10. 2013
    ....
  60. doi request reprint Monoclonal gammopathy related to Sjögren syndrome: a key marker of disease prognosis and outcomes
    Pilar Brito-Zeron
    Sjögren Syndrome Research Group AGAUR, Laboratory of Autoimmune Diseases Josep Font, Institut d Investigacions Biomediques August Pi i Sunyer, Department of Autoimmune Diseases, ICMiD, Hospital Clinic, Barcelona, Spain
    J Autoimmun 39:43-8. 2012
    ....
  61. ncbi request reprint Vasculitis in systemic lupus erythematosus: prevalence and clinical characteristics in 670 patients
    Manuel Ramos-Casals
    Department of Autoimmune Diseases, Hospital Clinic, Barcelona, IDIBAPS Institut d Investigacions Biomèdiques August Pi i Sunyer, School of Medicine, University of Barcelona, Barcelona, Spain
    Medicine (Baltimore) 85:95-104. 2006
    ..The presence of vasculitis in our patients with SLE was associated with a higher ECLAM score, livedo reticularis, hematologic parameters (anemia, high ESR), and anti-La/SS-B antibodies...
  62. ncbi request reprint Characterization and differentiation of autoimmune versus viral liver involvement in patients with Sjögren's syndrome
    Manuel Ramos-Casals
    Department of Autoimmune Diseases and Hepatology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, IDIBAPS, School of Medicine, University of Barcelona, Barcelona, Spain
    J Rheumatol 33:1593-9. 2006
    ..To analyze the prevalence and clinical significance of liver involvement in patients with Sjögren's syndrome (SS), focusing on the characterization and differentiation of autoimmune versus chronic viral liver disease...
  63. ncbi request reprint Outcomes in biopsy-proven lupus nephritis: evaluation of 190 white patients from a single center
    Antoni Siso
    Laboratory of Autoimmune Diseases Josep Font, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Department of Autoimmune Diseases, and Hypertension Unit, Department of Internal Medicine AC, Institut Clinic de Medicina i Dermatologia, Hospital Clinic, Barcelona, Spain
    Medicine (Baltimore) 89:300-7. 2010
    ..Our results suggest that biopsy-proven LN in white patients has an excellent prognosis. Ethnicity should be considered a key factor when evaluating the prognosis and therapeutic response to different agents in patients with LN...
  64. doi request reprint Chronic hepatitis B virus infection in Sjögren's syndrome. Prevalence and clinical significance in 603 patients
    Miguel Marcos
    Department of Autoimmune Diseases, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, Barcelona, Spain
    Autoimmun Rev 8:616-20. 2009
    ..To analyze the prevalence and clinical characteristics of chronic hepatitis B virus (HBV) infection in a large series of patients with Sjögren syndrome (SS)...
  65. doi request reprint Prevalence and clinical relevance of autoimmune neutropenia in patients with primary Sjögren's syndrome
    Pilar Brito-Zeron
    Laboratory of Autoimmune Diseases Josep Font, Department of Autoimmune Diseases, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, Barcelona, Spain
    Semin Arthritis Rheum 38:389-95. 2009
    ..To analyze the prevalence of neutropenia in a large cohort of patients with primary Sjögren's syndrome (SS) and its association with clinical and immunological disease expression and adverse outcomes...
  66. ncbi request reprint Clusters of clinical and immunologic features in systemic lupus erythematosus: analysis of 600 patients from a single center
    Josep Font
    Department of Autoimmune Diseases, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, School of Medicine, University of Barcelona, Spain
    Semin Arthritis Rheum 33:217-30. 2004
    ....
  67. ncbi request reprint Circulating auto-antibodies against nuclear and non-nuclear antigens in primary Sjögren's syndrome: prevalence and clinical significance in 335 patients
    Norma Nardi
    Department of Autoimmune Diseases, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, School of Medicine, University of Barcelona, C Villaroel 170, 08036 Barcelona, Spain
    Clin Rheumatol 25:341-6. 2006
    ....
  68. ncbi request reprint Circulating monoclonal immunoglobulins in Sjögren syndrome: prevalence and clinical significance in 237 patients
    Pilar Brito-Zeron
    Department of Autoimmune Diseases, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, Facultad de Medicina, Universitat de Barcelona, Barcelona, Spain
    Medicine (Baltimore) 84:90-7. 2005
    ..SS-HCV patients presented a more restrictive monoclonal expression (limited to either monoclonal IgMkappa or monoclonal IgGlambda) than primary SS patients, who showed all types of heavy and light chains...
  69. doi request reprint Pulmonary disorders induced by monoclonal antibodies in patients with rheumatologic autoimmune diseases
    Manuel Ramos-Casals
    Department of Autoimmune Diseases, Laboratory of Autoimmune Diseases Josep Font, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Spain
    Am J Med 124:386-94. 2011
    ..Large, prospective, postmarketing studies including nonbiological agents as controls may help elucidate the real risk of pulmonary disease in patients with rheumatologic autoimmune diseases receiving monoclonal antibodies...
  70. ncbi request reprint Mortality in the catastrophic antiphospholipid syndrome: causes of death and prognostic factors in a series of 250 patients
    Silvia Bucciarelli
    Institut Clinic de Medicina i Dermatologia, Hospital Clinic, Barcelona, Catalonia, Spain
    Arthritis Rheum 54:2568-76. 2006
    ..To assess the main causes of death and the prognostic factors that influence mortality in patients with the catastrophic antiphospholipid syndrome (CAPS)...
  71. ncbi request reprint Primary Sjögren syndrome: clinical and immunologic disease patterns in a cohort of 400 patients
    Mario Garcia-Carrasco
    Department of Autoimmune Diseases, Clinical Institute of Infections and Immunology, Barcelona, Spain
    Medicine (Baltimore) 81:270-80. 2002
  72. ncbi request reprint [Prognosis of patients with primary Sjögren's syndrome]
    Pilar Brito-Zeron
    Laboratorio de Enfermedades Autoinmunes Josep Font, Instituto de Investigaciones Biomédicas August Pi i Sunyer IDIBAPS, Barcelona, Espana
    Med Clin (Barc) 130:109-15. 2008
    ..These features identify a specific subset of patients diagnosed with primary Sjögren's syndrome in whom a closer follow-up, and probably an earlier and more robust therapeutic management, should be mandatory...
  73. ncbi request reprint Hematologic malignancies in patients with cryoglobulinemia: association with autoimmune and chronic viral diseases
    Olga Trejo
    Department of Autoimmune Diseases, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, School of Medicine, University of Barcelona, Barcelona, Spain
    Semin Arthritis Rheum 33:19-28. 2003
    ....
  74. ncbi request reprint Mortality in the catastrophic antiphospholipid syndrome: causes of death and prognostic factors
    Silvia Bucciarelli
    Department of Autoimmune Diseases, Institut Clinic de Medicina i Dermatologia, Hospital Clinic, Barcelona, Catalonia, Spain
    Autoimmun Rev 6:72-5. 2006
    ..According to the results of this analysis, anticoagulation plus steroids plus plasma exchange should be the first line of therapy in patients with catastrophic APS...
  75. ncbi request reprint Pure sensory neuropathy in primary Sjögren's syndrome. Longterm prospective followup and review of the literature
    Josep Font
    Department of Autoimmune Diseases, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Barcelona, Spain
    J Rheumatol 30:1552-7. 2003
    ..To study the clinical course, response to therapy, and longterm outcome of pure sensory neuropathy (PSN) in a series of patients with primary Sjögren's syndrome (SS) followed prospectively in our referral centers...
  76. ncbi request reprint Intestinal involvement secondary to the antiphospholipid syndrome (APS): clinical and immunologic characteristics of 97 patients: comparison of classic and catastrophic APS
    Ricard Cervera
    Department of Autoimmune Diseases, Institut Clinic de Medicina i Dermatologia, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Catalonia, Spain
    Semin Arthritis Rheum 36:287-96. 2007
    ..To analyze the clinical and laboratory characteristics of 97 patients with intestinal involvement secondary to the antiphospholipid syndrome (APS) (37 patients with classic APS and 60 with catastrophic APS)...
  77. doi request reprint Monoclonal antibody therapy-associated neurological disorders
    Xavier Bosch
    Department of Internal Medicine, University of Barcelona, Villarroel 170, 08036 Barcelona, Spain
    Nat Rev Neurol 7:165-72. 2011
    ....
  78. ncbi request reprint Catastrophic antiphospholipid syndrome: lessons from the "CAPS Registry"--a tribute to the late Josep Font
    Ricard Cervera
    Department of Autoimmune Diseases, Hospital Clinic, Barcelona, Catalonia, Spain
    Ann N Y Acad Sci 1108:448-56. 2007
    ..This registry can be freely consulted at the Internet (www.med.ub.es/MIMMUN/FORUM/CAPS.HTM) and it is expected that the periodical analysis of these data will allow us to increase our knowledge of this condition...
  79. doi request reprint Therapeutic targeting of B cells for rheumatic autoimmune diseases
    Pablo Engel
    Immunology Unit, Department of Cell Biology, Immunology and Neuroscience, Faculty of Medicine, University of Barcelona, Barcelona, Spain
    Pharmacol Rev 63:127-56. 2011
    ....
  80. ncbi request reprint [Current therapy of lupus nephritis]
    Josep Font
    Servicio de Enfermedades Autoinmunes Instituto Clínico de Infecciones e Inmunología Hospital Clínic Barcelona España
    Med Clin (Barc) 119:738-42. 2002
  81. pmc Catastrophic antiphospholipid syndrome during pregnancy and puerperium: maternal and fetal characteristics of 15 cases
    José A Gómez-Puerta
    Servei de Malalties Autoimmunes, Hospital Clinic, Villarroel 170, 08036 Barcelona, Catalonia, Spain
    Ann Rheum Dis 66:740-6. 2007
    ..The catastrophic variant of the antiphospholipid syndrome (APS) is a life-threatening form of presentation of this syndrome that can be triggered by several factors...
  82. ncbi request reprint Morbidity and mortality in systemic lupus erythematosus during a 10-year period: a comparison of early and late manifestations in a cohort of 1,000 patients
    Ricard Cervera
    Department of Autoimmune Diseases, Institut Clinic d Infeccions i Immunologia, IDIBAPS Institut d Investigacions Biomèdiques August Pi i Sunyer, Hospital Clinic, University of Barcelona, Barcelona, Catalonia, Spain
    Medicine (Baltimore) 82:299-308. 2003
    ..Meanwhile, a more prominent role of thrombotic events is becoming evident, affecting both morbidity and mortality in SLE...
  83. ncbi request reprint [Central nervous system involvement in primary Sjögren syndrome]
    Marta Ramírez
    Laboratorio de Enfermedades Autoinmunes Josep Font, Servicio de Enfermedades Autoinmunes, IDIBAPS, Barcelona, Spain
    Med Clin (Barc) 133:349-59. 2009
    ..Differential diagnosis includes the coexistence of other systemic autoimmune diseases (lupus, antiphospholipid syndrome, vasculitis), cerebrovascular disease and multiple sclerosis...
  84. ncbi request reprint Antiphospholipid antibodies associated with malignancies: clinical and pathological characteristics of 120 patients
    José A Gómez-Puerta
    Department of Autoimmune Diseases, Institut Clínic de Medicina i Dermatologia ICMiD, Hospital Clinic, Barcelona, Catalonia, Spain
    Semin Arthritis Rheum 35:322-32. 2006
    ..To describe the different types of malignancies associated with antiphospholipid antibodies (aPL)...
  85. ncbi request reprint Extrahepatic manifestations in patients with chronic hepatitis C virus infection
    Manuel Ramos-Casals
    Department of Autoimmune Diseases, Institut d Investigacions Biomediques August Pi i Sunyer, School of Medicine, University of Barcelona, Hospital Clinic, Barcelona, Spain
    Curr Opin Rheumatol 17:447-55. 2005
    ..Chronic hepatitis C virus infection often has autoimmune clinical and analytic features. This review analyzes recent data on the close association of chronic hepatitis C virus infection with autoimmune and lymphoproliferative processes...
  86. ncbi request reprint Advances in lupus and Sjögren's syndrome: a tribute to Josep Font
    Manuel Ramos-Casals
    Department ofAutoimmune Diseases, IDIBAPS Hospital Clinic, Barcelona, Spain
    Ann N Y Acad Sci 1108:51-63. 2007
    ....
  87. ncbi request reprint Treatment of B-cell lymphoma with rituximab in two patients with Sjögren's syndrome associated with hepatitis C virus infection
    Manuel Ramos-Casals
    Lupus 13:969-71. 2004
  88. ncbi request reprint Do male patients with primary Sjögren's syndrome have a higher frequency of autoantibodies?
    Manuel Ramos-Casals
    J Rheumatol 32:1634-5; author reply 1635-6. 2005
  89. ncbi request reprint [Results of the treatment with oral pilocarpine in 100 patients with primary Sjögrens syndrome]
    Pilar Brito-Zeron
    Med Clin (Barc) 126:637. 2006
  90. ncbi request reprint Thyroid disease in Sjögren's syndrome
    Luis J Jara
    Direction of Education and Research, Hospital de Especialidades, Centro Medico La Raza, IMSS, Seris y Zaachila s n C P, 02990, Mexico City, Mexico
    Clin Rheumatol 26:1601-6. 2007
    ..Other studies are necessary to clarify the shared pathogenesis mechanism in SS and autoimmune thyroid disease and to understand this fascinating autoimmune association...