Miguel Quintanilla

Summary

Country: Spain

Publications

  1. doi request reprint Functional blockade of Smad4 leads to a decrease in beta-catenin levels and signaling activity in human pancreatic carcinoma cells
    Diana Romero
    Instituto de Investigaciones Biomedicas Alberto Sols, Arturo Duperier 4, 28029 Madrid, Spain
    Carcinogenesis 29:1070-6. 2008
  2. ncbi request reprint Uveal vs. cutaneous melanoma. Origins and causes of the differences
    Carolina Belmar-Lopez
    Universidad Francisco de Vitoria, Facultad de Ciencias Biosanitarias, Dpto Biotecnología, Pozuelo de Alarcon, Madrid, Spain
    Clin Transl Oncol 10:137-42. 2008
  3. pmc Tissue-derived mesenchymal stromal cells used as vehicles for anti-tumor therapy exert different in vivo effects on migration capacity and tumor growth
    Carolina Belmar-Lopez
    Instituto Aragones de Ciencias de la Salud IIS Aragon, Zaragoza, Spain
    BMC Med 11:139. 2013
  4. ncbi request reprint Expression of the TGF-beta coreceptor endoglin in epidermal keratinocytes and its dual role in multistage mouse skin carcinogenesis
    Miguel Quintanilla
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Arturo Duperier 4, Madrid 28029, Spain
    Oncogene 22:5976-85. 2003
  5. ncbi request reprint Impaired wound repair in adult endoglin heterozygous mice associated with lower NO bioavailability
    Eduardo Pérez-Gómez
    Instituto de Investigaciones Biomedicas Alberto Sols, Spanish National Research Council CSIC, Autonomous University of Madrid UAM, Madrid, Spain
    J Invest Dermatol 134:247-55. 2014
  6. ncbi request reprint A role for endoglin as a suppressor of malignancy during mouse skin carcinogenesis
    Eduardo Pérez-Gómez
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Madrid, Spain
    Cancer Res 67:10268-77. 2007
  7. doi request reprint The transmembrane domain of podoplanin is required for its association with lipid rafts and the induction of epithelial-mesenchymal transition
    Beatriz Fernández-Muñoz
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Científicas CSIC Universidad autónoma de Madrid UAM, Madrid, Spain
    Int J Biochem Cell Biol 43:886-96. 2011
  8. doi request reprint The role of the TGF-β coreceptor endoglin in cancer
    Eduardo Pérez-Gómez
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Científicas CSIC Universidad Autónoma de Madrid, Madrid, Spain
    ScientificWorldJournal 10:2367-84. 2010
  9. ncbi request reprint Lysyl oxidase-like 2 as a new poor prognosis marker of squamous cell carcinomas
    Hector Peinado
    Departamento de Bioquimica, Instituto de Investigaciones Biomédicas Alberto Sols Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid, Universidad Autonoma de Madrid, Madrid, Spain
    Cancer Res 68:4541-50. 2008
  10. ncbi request reprint S-endoglin expression is induced in senescent endothelial cells and contributes to vascular pathology
    Francisco J Blanco
    Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Circ Res 103:1383-92. 2008

Collaborators

Detail Information

Publications25

  1. doi request reprint Functional blockade of Smad4 leads to a decrease in beta-catenin levels and signaling activity in human pancreatic carcinoma cells
    Diana Romero
    Instituto de Investigaciones Biomedicas Alberto Sols, Arturo Duperier 4, 28029 Madrid, Spain
    Carcinogenesis 29:1070-6. 2008
    ..These findings provide evidence for a cross talk between Smad4 and the Wnt/beta-catenin pathway in pancreatic carcinoma cells, suggesting a new role for Smad4 as an attenuator of beta-catenin proteasomal degradation...
  2. ncbi request reprint Uveal vs. cutaneous melanoma. Origins and causes of the differences
    Carolina Belmar-Lopez
    Universidad Francisco de Vitoria, Facultad de Ciencias Biosanitarias, Dpto Biotecnología, Pozuelo de Alarcon, Madrid, Spain
    Clin Transl Oncol 10:137-42. 2008
    ..Despite the common origin, both melanomas show extreme differences in their metastatic potential, clinical response to treatments, immune response and genetic alterations. We will describe some of those differences in this review...
  3. pmc Tissue-derived mesenchymal stromal cells used as vehicles for anti-tumor therapy exert different in vivo effects on migration capacity and tumor growth
    Carolina Belmar-Lopez
    Instituto Aragones de Ciencias de la Salud IIS Aragon, Zaragoza, Spain
    BMC Med 11:139. 2013
    ....
  4. ncbi request reprint Expression of the TGF-beta coreceptor endoglin in epidermal keratinocytes and its dual role in multistage mouse skin carcinogenesis
    Miguel Quintanilla
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Arturo Duperier 4, Madrid 28029, Spain
    Oncogene 22:5976-85. 2003
    ..These data suggest that endoglin might attenuate TGF-beta(1) signaling in normal epidermis and interfere with progression of skin carcinogenesis...
  5. ncbi request reprint Impaired wound repair in adult endoglin heterozygous mice associated with lower NO bioavailability
    Eduardo Pérez-Gómez
    Instituto de Investigaciones Biomedicas Alberto Sols, Spanish National Research Council CSIC, Autonomous University of Madrid UAM, Madrid, Spain
    J Invest Dermatol 134:247-55. 2014
    ..Similarly, the skin of Eng(+/-) mice failed to mount a hyperplastic response to acute stimulation with TPA. These results demonstrate an important involvement of Eng in wound healing that is associated with NO bioavailability. ..
  6. ncbi request reprint A role for endoglin as a suppressor of malignancy during mouse skin carcinogenesis
    Eduardo Pérez-Gómez
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Madrid, Spain
    Cancer Res 67:10268-77. 2007
    ..Our results show that endoglin behaves as a suppressor of malignancy during the late stages of carcinogenesis. Therefore, disruption of membrane endoglin emerges as a crucial event for progression to spindle cell carcinomas...
  7. doi request reprint The transmembrane domain of podoplanin is required for its association with lipid rafts and the induction of epithelial-mesenchymal transition
    Beatriz Fernández-Muñoz
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Científicas CSIC Universidad autónoma de Madrid UAM, Madrid, Spain
    Int J Biochem Cell Biol 43:886-96. 2011
    ..Together, these data suggest that both the CT and TM domains are required for podoplanin localization in raft platforms, and that this association appears to be necessary for podoplanin-mediated EMT and cell migration...
  8. doi request reprint The role of the TGF-β coreceptor endoglin in cancer
    Eduardo Pérez-Gómez
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Científicas CSIC Universidad Autónoma de Madrid, Madrid, Spain
    ScientificWorldJournal 10:2367-84. 2010
    ..In this review, we evaluate the implication of endoglin in tumor development underlying studies developed in our laboratories in recent years...
  9. ncbi request reprint Lysyl oxidase-like 2 as a new poor prognosis marker of squamous cell carcinomas
    Hector Peinado
    Departamento de Bioquimica, Instituto de Investigaciones Biomédicas Alberto Sols Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid, Universidad Autonoma de Madrid, Madrid, Spain
    Cancer Res 68:4541-50. 2008
    ..Altogether, our results show that LOXL2 can be used as a new poor prognosis indicator in human squamous cell carcinomas promoting malignant transformation by both SNAI1-dependent and SNAI1-independent pathways...
  10. ncbi request reprint S-endoglin expression is induced in senescent endothelial cells and contributes to vascular pathology
    Francisco J Blanco
    Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Circ Res 103:1383-92. 2008
    ..Taken together, these results suggest that S-endoglin is induced during endothelial senescence and may contribute to age-dependent vascular pathology...
  11. ncbi request reprint Characterization of murine S-endoglin isoform and its effects on tumor development
    Eduardo Pérez-Gómez
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Científicas CSIC Universidad autónoma de Madrid UAM, Arturo Duperier 4, 28029 Madrid, Spain
    Oncogene 24:4450-61. 2005
    ..These results point to S-endoglin as an antiangiogenic molecule, in contrast to L-endoglin which is proangiogenic. Oncogene (2005) 24, 4450-4461. doi:10.1038/sj.onc.1208644 Published online 4 April 2005...
  12. ncbi request reprint The genetics of malignant melanoma
    Jesus Lomas
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Spain
    Front Biosci 13:5071-93. 2008
    ..A consequence of all these studies is the emergence of potential new strategies that could improve the still inadequate arsenal of therapeutic tools to fight against this fatal disease...
  13. doi request reprint Podoplanin is a substrate of presenilin-1/γ-secretase
    Maria M Yurrita
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Científicas CSIC Universidad autónoma de Madrid UAM, 28029 Madrid, Spain
    Int J Biochem Cell Biol 46:68-75. 2014
    ..We found that podoplanin CTFs are also generated in cells expressing podoplanin mutants harboring heterologous transmembrane regions. Taken together, these results indicate that podoplanin is a novel substrate for PS1/γ-secretase. ..
  14. ncbi request reprint Regulation of podoplanin/PA2.26 antigen expression in tumour cells. Involvement of calpain-mediated proteolysis
    Ester Martín-Villar
    Instituto de Investigaciones Biomedicas Alberto Sols, CSIC UAM Arturo Duperier, 4, 28029 Madrid, Spain
    Int J Biochem Cell Biol 41:1421-9. 2009
    ..YS dipeptide is highly conserved across species, suggesting that it might be functionally relevant...
  15. doi request reprint Molecular biology of malignant melanoma
    Mar Pons
    Instituto de Investigaciones Biomedicas Alberto Sols, Departamento de Biotecnologia, Universidad Francisco de Vitoria, CSIC UAM, Arturo Duperier 4, 28029 Madrid, Spain
    Adv Exp Med Biol 624:252-64. 2008
    ..Hopefully, the understanding generated by all these studies will contribute to develop new therapeutic strategies to handle this fatal malignancy...
  16. ncbi request reprint Role of intratumoral lymphatic vessels in the lymph node dissemination of laryngopharyngeal squamous cell carcinoma
    Adolfo Hinojar-Gutiérrez
    Department of Otorhinolaryngology, Hospital Universitario de la Princesa, Universidad Autonoma de Madrid, Madrid, Spain
    Head Neck 32:757-62. 2010
    ..The development of new markers for lymphatic endothelium allowed the study of intratumoral lymphatic microcirculation, as well as its association with lymph node metastasis...
  17. ncbi request reprint A role for the Fas/FasL system in modulating genetic susceptibility to T-cell lymphoblastic lymphomas
    María Villa-Morales
    Laboratorio de Genetica Molecular Humana, Departamento de Biologia, Universidad Autonoma de Madrid, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid, Spain
    Cancer Res 67:5107-16. 2007
    ....
  18. ncbi request reprint The role of the TGF-beta coreceptor endoglin in cancer
    Eduardo Pérez-Gómez
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Científicas CSIC Universidad Autónoma de Madrid, Madrid, Spain
    ScientificWorldJournal 10:2367-84. 2010
    ..In this review, we evaluate the implication of endoglin in tumor development underlying studies developed in our laboratories in recent years...
  19. doi request reprint Evaluation of mitochondrial function and metabolic reprogramming during tumor progression in a cell model of skin carcinogenesis
    Carmen G Vallejo
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Científicas CSIC Universidad autónoma de Madrid UAM, Madrid, Spain
    Biochimie 95:1171-6. 2013
    ..This result indicates that oxidative stress is an early event during tumor progression...
  20. ncbi request reprint Podoplanin binds ERM proteins to activate RhoA and promote epithelial-mesenchymal transition
    Ester Martín-Villar
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Científicas CSIC Universidad autónoma de Madrid UAM, 28029 Madrid, Spain
    J Cell Sci 119:4541-53. 2006
    ..These results provide a mechanistic basis to understand the role of podoplanin in cell migration or invasiveness...
  21. ncbi request reprint Chromosomal instability and phenotypic plasticity during the squamous-spindle carcinoma transition: association of a specific T(14;15) with malignant progression
    Mar Pons
    Instituto de Investigaciones Biomedicas, Alberto Sols, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Arturo Duperier 4, Madrid 28029, Spain
    Oncogene 24:7608-18. 2005
    ..9%) of CarC-R cells, but it was widely spread in CarC-RT and its derived cell clones, regardless of their epithelial or fibroblastic phenotype, indicating that T(14;15) segregates with malignancy...
  22. ncbi request reprint Soluble MMP-14 produced by bone marrow-derived stromal cells sheds epithelial endoglin modulating the migratory properties of human breast cancer cells
    Nicolas Tobar
    Laboratorio de Biologia Celular, INTA, Universidad de Chile, Santiago 7830490, Chile, Laboratorio de Fisiología Periodontal, Facultad de Medicina, Pontificia Universidad Catolica de Chile, Santiago 8331150, Chile, Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas CSIC, Madrid, Spain, Centro de Investigación Biomédica en Red de Enfermedades Raras CIBERER, 28040 Madrid, Spain and Instituto de Investigaciones Biomédicas Alberto Sols, CSIC, 28029 Madrid, Spain
    Carcinogenesis 35:1770-9. 2014
    ....
  23. ncbi request reprint Transforming growth factor beta-1 induces snail transcription factor in epithelial cell lines: mechanisms for epithelial mesenchymal transitions
    Hector Peinado
    Instituto de Investigaciones Biomédicas Alberto Sols CSIC UAM and Departamento de Bioquímica UAM, Arturo Duperier 4, 28029 Madrid, Spain
    J Biol Chem 278:21113-23. 2003
    ..These data support that MAPK and phosphatidylinositol 3-kinase signaling pathways are implicated in TGFbeta1-mediated induction of Snail promoter, probably through Ras activation and its downstream effectors...
  24. ncbi request reprint Transforming growth factor-beta1 modulates matrix metalloproteinase-9 production through the Ras/MAPK signaling pathway in transformed keratinocytes
    Juan Francisco Santibanez
    Laboratorio de Biologia Celular, INTA, Universidad de Chile Casilla 138, Santiago, Chile
    Biochem Biophys Res Commun 296:267-73. 2002
    ....
  25. ncbi request reprint TGF-beta(1) and Smad4 overexpression induce a less invasive phenotype in highly invasive spindle carcinoma cells
    Juan Francisco Santibanez
    Laboratorio de Biologia Celular, INTA, Universidad de Chile, Casilla 138, Santiago 11, Chile
    FEBS Lett 520:171-6. 2002
    ..This activation was abolished with a dominant-negative Smad4 construct. These results lead us to conclude that both TGF-beta(1) and Smad4 overexpression reduce the invasive potential of Car C cells, probably via the Smad pathway...