Enrique Pérez-Payá

Summary

Country: Spain

Publications

  1. ncbi Molecules that modulate Apaf-1 activity
    Enrique Pérez-Payá
    Peptide and Protein Laboratory, Department of Medicinal Chemistry, Centro de Investigacion Principe Felipe, Avda Autopista del Saler, Valencia, Spain
    Med Res Rev 31:649-75. 2011
  2. ncbi The structural plasticity of the C terminus of p21Cip1 is a determinant for target protein recognition
    Vicent Esteve
    Dept Bioquimica i Biologia Molecular, Universitat de Valencia, 46100 Burjassot, Valencia, Spain
    Chembiochem 4:863-9. 2003
  3. ncbi Peptides in apoptosis research
    Jesús Salgado
    Departament de Bioquimica i Biologia Molecular, Universitat de Valencia, E 461 00 Burjassot, Valencia, Spain
    J Pept Sci 8:543-60. 2002
  4. ncbi Solvent-exposed residues located in the beta-sheet modulate the stability of the tetramerization domain of p53--a structural and combinatorial approach
    Puig Mora
    Department of Medicinal Chemistry, Centro de Investigacion Principe Felipe, E 46013 Valencia, Spain
    Proteins 71:1670-85. 2008
  5. ncbi Minocycline inhibits cell death and decreases mutant Huntingtin aggregation by targeting Apaf-1
    Mónica Sancho
    Laboratory of Peptide and Protein Chemistry, Centro de Investigacion Principe Felipe, E 46012 Valencia, Spain
    Hum Mol Genet 20:3545-53. 2011
  6. ncbi Polypeptide modulators of caspase recruitment domain (CARD)-CARD-mediated protein-protein interactions
    Yadira Palacios-Rodríguez
    Laboratory of Peptide and Protein Chemistry, Centro de Investigacion Principe Felipe, E 46012 Valencia, Spain
    J Biol Chem 286:44457-66. 2011
  7. ncbi Characterization of dequalinium as a XIAP antagonist that targets the BIR2 domain
    Mar Orzáez
    Laboratory of Peptide and Protein Chemistry, Centro de Investigacion Principe Felipe, Valencia, Spain
    Apoptosis 16:460-7. 2011
  8. ncbi ATP-noncompetitive inhibitors of CDK-cyclin complexes
    Mar Orzáez
    Department of Medicinal Chemistry, Centro de Investigacion Principe Felipe, Avda Autopista del Saler 16, 46012, Valencia, Spain
    ChemMedChem 4:19-24. 2009
  9. ncbi Poly-L-glutamic acid (PGA) aided inhibitors of apoptotic protease activating factor 1 (Apaf-1): an antiapoptotic polymeric nanomedicine
    Maria J Vicent
    Department of Medicinal Chemistry, Centro de Investigacion Principe Felipe, Avenida Autopista del Saler, and Instituto de Biomedicina de Valencia, CSIC, E 46010 Valencia, Spain
    J Med Chem 49:3763-5. 2006
  10. ncbi Ionic self-complementarity induces amyloid-like fibril formation in an isolated domain of a plant copper metallochaperone protein
    Helena Mira
    Departament de Bioquimica i Biologia Molecular, Universitat de Valencia, E 46100 Burjassot, Valencia, Spain
    BMC Struct Biol 4:7. 2004

Collaborators

Detail Information

Publications13

  1. ncbi Molecules that modulate Apaf-1 activity
    Enrique Pérez-Payá
    Peptide and Protein Laboratory, Department of Medicinal Chemistry, Centro de Investigacion Principe Felipe, Avda Autopista del Saler, Valencia, Spain
    Med Res Rev 31:649-75. 2011
    ....
  2. ncbi The structural plasticity of the C terminus of p21Cip1 is a determinant for target protein recognition
    Vicent Esteve
    Dept Bioquimica i Biologia Molecular, Universitat de Valencia, 46100 Burjassot, Valencia, Spain
    Chembiochem 4:863-9. 2003
    ..Our results suggest that the C-terminal domain of p21(Cip1) adopts an extended structure when bound to PCNA and probably when bound to the oncoprotein SET, but an alpha helix when bound to CaM...
  3. ncbi Peptides in apoptosis research
    Jesús Salgado
    Departament de Bioquimica i Biologia Molecular, Universitat de Valencia, E 461 00 Burjassot, Valencia, Spain
    J Pept Sci 8:543-60. 2002
    ..Additionally, important perspectives are open to other systems, such as the macromolecular assemblies that are responsible for the activation of initiator caspases...
  4. ncbi Solvent-exposed residues located in the beta-sheet modulate the stability of the tetramerization domain of p53--a structural and combinatorial approach
    Puig Mora
    Department of Medicinal Chemistry, Centro de Investigacion Principe Felipe, E 46013 Valencia, Spain
    Proteins 71:1670-85. 2008
    ..We propose that stabilization through hydrophobic interactions of key secondary structure elements might be the underlying mechanism for the strong influence of solvent-exposed residues in the stability of p53TD...
  5. ncbi Minocycline inhibits cell death and decreases mutant Huntingtin aggregation by targeting Apaf-1
    Mónica Sancho
    Laboratory of Peptide and Protein Chemistry, Centro de Investigacion Principe Felipe, E 46012 Valencia, Spain
    Hum Mol Genet 20:3545-53. 2011
    ..As a consequence, minocycline-treated cells as well as Apaf-1 knock-out cells are resistant to the development of mutant huntingtin-dependent protein aggregation...
  6. ncbi Polypeptide modulators of caspase recruitment domain (CARD)-CARD-mediated protein-protein interactions
    Yadira Palacios-Rodríguez
    Laboratory of Peptide and Protein Chemistry, Centro de Investigacion Principe Felipe, E 46012 Valencia, Spain
    J Biol Chem 286:44457-66. 2011
    ..To this end, we analyzed the activity of individual recombinant CARDs, rationally designed CARD-derived peptides, and peptides derived from phage display...
  7. ncbi Characterization of dequalinium as a XIAP antagonist that targets the BIR2 domain
    Mar Orzáez
    Laboratory of Peptide and Protein Chemistry, Centro de Investigacion Principe Felipe, Valencia, Spain
    Apoptosis 16:460-7. 2011
    ..In this sense, we have identified dequalinium hydrochloride (Dq) as an inhibitor of the XIAP/caspase-3 interaction both in vitro and in cellular assays...
  8. ncbi ATP-noncompetitive inhibitors of CDK-cyclin complexes
    Mar Orzáez
    Department of Medicinal Chemistry, Centro de Investigacion Principe Felipe, Avda Autopista del Saler 16, 46012, Valencia, Spain
    ChemMedChem 4:19-24. 2009
    ..Herein we review the progress made in the development of ATP-noncompetitive CDK-cyclin inhibitors...
  9. ncbi Poly-L-glutamic acid (PGA) aided inhibitors of apoptotic protease activating factor 1 (Apaf-1): an antiapoptotic polymeric nanomedicine
    Maria J Vicent
    Department of Medicinal Chemistry, Centro de Investigacion Principe Felipe, Avenida Autopista del Saler, and Instituto de Biomedicina de Valencia, CSIC, E 46010 Valencia, Spain
    J Med Chem 49:3763-5. 2006
    ..Full structural and biophysical characterization of the conjugate by different techniques has been accomplished. This macromolecule clearly enhances the antiapoptotic activity of peptoid 1 in different cell models...
  10. ncbi Ionic self-complementarity induces amyloid-like fibril formation in an isolated domain of a plant copper metallochaperone protein
    Helena Mira
    Departament de Bioquimica i Biologia Molecular, Universitat de Valencia, E 46100 Burjassot, Valencia, Spain
    BMC Struct Biol 4:7. 2004
    ..The aim of the present study was the biochemical and biophysical characterisation of the C-terminal domain of the copper metallochaperone CCH...
  11. ncbi Effects of mutagenesis in the switch I region and conserved arginines of Escherichia coli MnmE protein, a GTPase involved in tRNA modification
    Marta Martinez-Vicente
    Laboratorio de Genetica Molecular, Centro de Investigacion Principe Felipe, Valencia, Spain
    J Biol Chem 280:30660-70. 2005
    ..This behavior is reminiscent to that found in yeast and stresses the importance of tRNA modification for gene expression...
  12. ncbi Peptides and peptide mimics as modulators of apoptotic pathways
    Mar Orzáez
    Department of Medicinal Chemistry, Centro de Investigacion Principe Felipe, Valencia, Spain
    ChemMedChem 4:146-60. 2009
    ..Peptides are essential tools for drug discovery, as well as preclinical and pharmaceutical drug development...
  13. ncbi Design of a bivalent peptide with two independent elements of secondary structure able to fold autonomously
    David Pantoja-Uceda
    Department of Medicinal Chemistry, Centro de Investigacion Principe Felipe, Avda Autopista del Saler, 16 Valencia, Spain
    J Pept Sci 14:845-54. 2008
    ..These results suggest that the two elements of secondary structure are stable and well folded...