Enrique Pérez-Payá

Summary

Country: Spain

Publications

  1. pmc Intrinsic caspase-8 activation mediates sensitization of erlotinib-resistant tumor cells to erlotinib/cell-cycle inhibitors combination treatment
    M Orzáez
    Laboratory of Peptide and Protein Chemistry, Centro de Investigacion Principe Felipe, Valencia, Spain
    Cell Death Dis 3:e415. 2012
  2. doi Molecules that modulate Apaf-1 activity
    Enrique Pérez-Payá
    Peptide and Protein Laboratory, Department of Medicinal Chemistry, Centro de Investigacion Principe Felipe, Avda Autopista del Saler, Valencia, Spain
    Med Res Rev 31:649-75. 2011
  3. ncbi The structural plasticity of the C terminus of p21Cip1 is a determinant for target protein recognition
    Vicent Esteve
    Dept Bioquimica i Biologia Molecular, Universitat de Valencia, 46100 Burjassot, Valencia, Spain
    Chembiochem 4:863-9. 2003
  4. ncbi Conjugation of a novel Apaf-1 inhibitor to peptide-based cell-membrane transporters: effective methods to improve inhibition of mitochondria-mediated apoptosis
    Mar Orzáez
    Department of Medicinal Chemistry, Centro de Investigacion Principe Felipe, Av Autopista del Saler 16, E 46013 Valencia, Spain
    Peptides 28:958-68. 2007
  5. ncbi Design of bioactive and structurally well-defined peptides from conformationally restricted libraries
    M Teresa Pastor
    Department de Bioquimica i Biologia Molecular, Universitat de Valencia, E 46100 Burjassot, Valencia, Spain
    Biopolymers 76:357-65. 2004
  6. pmc Combinatorial approaches: a new tool to search for highly structured beta-hairpin peptides
    Maria Teresa Pastor
    Department of Biochemistry and Molecular Biology, University of Valencia, Valencia, E 46100 Burjassot, Spain
    Proc Natl Acad Sci U S A 99:614-9. 2002
  7. ncbi Solvent-exposed residues located in the beta-sheet modulate the stability of the tetramerization domain of p53--a structural and combinatorial approach
    Puig Mora
    Department of Medicinal Chemistry, Centro de Investigacion Principe Felipe, E 46013 Valencia, Spain
    Proteins 71:1670-85. 2008
  8. ncbi Peptides in apoptosis research
    Jesús Salgado
    Departament de Bioquimica i Biologia Molecular, Universitat de Valencia, E 461 00 Burjassot, Valencia, Spain
    J Pept Sci 8:543-60. 2002
  9. pmc BH3-mimetics- and cisplatin-induced cell death proceeds through different pathways depending on the availability of death-related cellular components
    Vicente Andreu-Fernández
    Laboratory of Peptide and Protein Chemistry, Centro de Investigacion Principe Felipe, Valencia, Spain
    PLoS ONE 8:e56881. 2013
  10. doi Minocycline inhibits cell death and decreases mutant Huntingtin aggregation by targeting Apaf-1
    Mónica Sancho
    Laboratory of Peptide and Protein Chemistry, Centro de Investigacion Principe Felipe, E 46012 Valencia, Spain
    Hum Mol Genet 20:3545-53. 2011

Collaborators

Detail Information

Publications24

  1. pmc Intrinsic caspase-8 activation mediates sensitization of erlotinib-resistant tumor cells to erlotinib/cell-cycle inhibitors combination treatment
    M Orzáez
    Laboratory of Peptide and Protein Chemistry, Centro de Investigacion Principe Felipe, Valencia, Spain
    Cell Death Dis 3:e415. 2012
    ..This finding could have significant implications for future treatment strategies in clinical settings...
  2. doi Molecules that modulate Apaf-1 activity
    Enrique Pérez-Payá
    Peptide and Protein Laboratory, Department of Medicinal Chemistry, Centro de Investigacion Principe Felipe, Avda Autopista del Saler, Valencia, Spain
    Med Res Rev 31:649-75. 2011
    ....
  3. ncbi The structural plasticity of the C terminus of p21Cip1 is a determinant for target protein recognition
    Vicent Esteve
    Dept Bioquimica i Biologia Molecular, Universitat de Valencia, 46100 Burjassot, Valencia, Spain
    Chembiochem 4:863-9. 2003
    ..Our results suggest that the C-terminal domain of p21(Cip1) adopts an extended structure when bound to PCNA and probably when bound to the oncoprotein SET, but an alpha helix when bound to CaM...
  4. ncbi Conjugation of a novel Apaf-1 inhibitor to peptide-based cell-membrane transporters: effective methods to improve inhibition of mitochondria-mediated apoptosis
    Mar Orzáez
    Department of Medicinal Chemistry, Centro de Investigacion Principe Felipe, Av Autopista del Saler 16, E 46013 Valencia, Spain
    Peptides 28:958-68. 2007
    ..Finally, the influence of the cargo (peptoid) molecules on the conformational behavior of the CPP in buffers and in membrane mimetic environments was analyzed using circular dichroism (CD) spectroscopy...
  5. ncbi Design of bioactive and structurally well-defined peptides from conformationally restricted libraries
    M Teresa Pastor
    Department de Bioquimica i Biologia Molecular, Universitat de Valencia, E 46100 Burjassot, Valencia, Spain
    Biopolymers 76:357-65. 2004
    ....
  6. pmc Combinatorial approaches: a new tool to search for highly structured beta-hairpin peptides
    Maria Teresa Pastor
    Department of Biochemistry and Molecular Biology, University of Valencia, Valencia, E 46100 Burjassot, Spain
    Proc Natl Acad Sci U S A 99:614-9. 2002
    ..Our results show how combinatorial approaches can be used to obtain highly structured peptide sequences that could be used as templates in which functionality can be introduced...
  7. ncbi Solvent-exposed residues located in the beta-sheet modulate the stability of the tetramerization domain of p53--a structural and combinatorial approach
    Puig Mora
    Department of Medicinal Chemistry, Centro de Investigacion Principe Felipe, E 46013 Valencia, Spain
    Proteins 71:1670-85. 2008
    ..We propose that stabilization through hydrophobic interactions of key secondary structure elements might be the underlying mechanism for the strong influence of solvent-exposed residues in the stability of p53TD...
  8. ncbi Peptides in apoptosis research
    Jesús Salgado
    Departament de Bioquimica i Biologia Molecular, Universitat de Valencia, E 461 00 Burjassot, Valencia, Spain
    J Pept Sci 8:543-60. 2002
    ..Additionally, important perspectives are open to other systems, such as the macromolecular assemblies that are responsible for the activation of initiator caspases...
  9. pmc BH3-mimetics- and cisplatin-induced cell death proceeds through different pathways depending on the availability of death-related cellular components
    Vicente Andreu-Fernández
    Laboratory of Peptide and Protein Chemistry, Centro de Investigacion Principe Felipe, Valencia, Spain
    PLoS ONE 8:e56881. 2013
    ..Such undesirable effects would probably be ameliorated by selectively and locally inhibiting apoptosis in defined sensitive cells...
  10. doi Minocycline inhibits cell death and decreases mutant Huntingtin aggregation by targeting Apaf-1
    Mónica Sancho
    Laboratory of Peptide and Protein Chemistry, Centro de Investigacion Principe Felipe, E 46012 Valencia, Spain
    Hum Mol Genet 20:3545-53. 2011
    ..As a consequence, minocycline-treated cells as well as Apaf-1 knock-out cells are resistant to the development of mutant huntingtin-dependent protein aggregation...
  11. doi ATP-noncompetitive inhibitors of CDK-cyclin complexes
    Mar Orzáez
    Department of Medicinal Chemistry, Centro de Investigacion Principe Felipe, Avda Autopista del Saler 16, 46012, Valencia, Spain
    ChemMedChem 4:19-24. 2009
    ..Herein we review the progress made in the development of ATP-noncompetitive CDK-cyclin inhibitors...
  12. ncbi Poly-L-glutamic acid (PGA) aided inhibitors of apoptotic protease activating factor 1 (Apaf-1): an antiapoptotic polymeric nanomedicine
    Maria J Vicent
    Department of Medicinal Chemistry, Centro de Investigacion Principe Felipe, Avenida Autopista del Saler, and Instituto de Biomedicina de Valencia, CSIC, E 46010 Valencia, Spain
    J Med Chem 49:3763-5. 2006
    ..Full structural and biophysical characterization of the conjugate by different techniques has been accomplished. This macromolecule clearly enhances the antiapoptotic activity of peptoid 1 in different cell models...
  13. pmc Altered mitochondria morphology and cell metabolism in Apaf1-deficient cells
    Mónica Sancho
    Laboratory of Peptide and Protein Chemistry, Centro de Investigacion Principe Felipe, Valencia, Spain
    PLoS ONE 9:e84666. 2014
    ..Other cellular roles, including a pro-survival role, have also been described for Apaf1, while the relative contribution of each function to cell death, but also to cell homeostatic conditions, remain to be clarified...
  14. ncbi Prevention of in vivo excitotoxicity by a family of trialkylglycines, a novel class of neuroprotectants
    Carmina Montoliu
    Laboratory of Neurobiology, Instituto de Investigaciones Citologicas, Fundacion Valenciana de Investigaciones Biomedicas, Valencia, Spain
    J Pharmacol Exp Ther 301:29-36. 2002
    ..These lead compounds may become tolerated drugs for the treatment of acute and chronic neurodegenerative diseases with fewer side effects than NMDA receptor antagonists...
  15. ncbi Combinatorial chemistry of beta-hairpins
    M Teresa Pastor
    Departament de Bioquimica i Biologia Molecular, Universitat de Valencia, Burjassot, Valencia, Spain
    Mol Divers 6:149-55. 2003
    ..In particular, the use of conformationally restricted peptide libraries has allowed the identification of linear peptides that are folded in a beta-hairpin structure in plain aqueous solutions...
  16. pmc Polypeptide modulators of caspase recruitment domain (CARD)-CARD-mediated protein-protein interactions
    Yadira Palacios-Rodríguez
    Laboratory of Peptide and Protein Chemistry, Centro de Investigacion Principe Felipe, E 46012 Valencia, Spain
    J Biol Chem 286:44457-66. 2011
    ..To this end, we analyzed the activity of individual recombinant CARDs, rationally designed CARD-derived peptides, and peptides derived from phage display...
  17. doi Characterization of dequalinium as a XIAP antagonist that targets the BIR2 domain
    Mar Orzáez
    Laboratory of Peptide and Protein Chemistry, Centro de Investigacion Principe Felipe, Valencia, Spain
    Apoptosis 16:460-7. 2011
    ..In this sense, we have identified dequalinium hydrochloride (Dq) as an inhibitor of the XIAP/caspase-3 interaction both in vitro and in cellular assays...
  18. ncbi Design of a minimized cyclic tetrapeptide that neutralizes bacterial endotoxins
    Puig Mora
    Department of Medicinal Chemistry, Centro de Investigaciones Principe Felipe, Avda Autopista del Saler, 16 46013 Valencia, Spain
    J Pept Sci 12:491-6. 2006
    ..After inserting this sequence in a Cys cyclic peptide, it showed the same biological activity as the parent peptide. This sequence could provide the basis for the design of small molecules with LPS-binding properties...
  19. ncbi Discovery of inhibitors of protein-protein interactions from combinatorial libraries
    Maria J Vicent
    Dept Química Médica, Centro de Investigacion Principe Felipe, E 46013 Valencia, Spain
    Curr Top Med Chem 7:83-95. 2007
    ....
  20. ncbi Effects of mutagenesis in the switch I region and conserved arginines of Escherichia coli MnmE protein, a GTPase involved in tRNA modification
    Marta Martinez-Vicente
    Laboratorio de Genetica Molecular, Centro de Investigacion Principe Felipe, Valencia, Spain
    J Biol Chem 280:30660-70. 2005
    ..This behavior is reminiscent to that found in yeast and stresses the importance of tRNA modification for gene expression...
  21. pmc Ionic self-complementarity induces amyloid-like fibril formation in an isolated domain of a plant copper metallochaperone protein
    Helena Mira
    Departament de Bioquimica i Biologia Molecular, Universitat de Valencia, E 46100 Burjassot, Valencia, Spain
    BMC Struct Biol 4:7. 2004
    ..The aim of the present study was the biochemical and biophysical characterisation of the C-terminal domain of the copper metallochaperone CCH...
  22. ncbi Conformational diversity of the Goodpasture antigen, the noncollagenous-1 domain of the alpha3 chain of collagen IV
    Juan J Calvete
    Consejo Superior de Investigaciones Cientificas, Instituto de Biomedicina de Valencia, Valencia, Spain
    Proteomics 6:S237-44. 2006
    ..The hitherto unrecognized conformational diversification of the Goodpasture autoantigen may be of relevance in pathogenesis...
  23. doi Design of a bivalent peptide with two independent elements of secondary structure able to fold autonomously
    David Pantoja-Uceda
    Department of Medicinal Chemistry, Centro de Investigacion Principe Felipe, Avda Autopista del Saler, 16 Valencia, Spain
    J Pept Sci 14:845-54. 2008
    ..These results suggest that the two elements of secondary structure are stable and well folded...
  24. doi Peptides and peptide mimics as modulators of apoptotic pathways
    Mar Orzáez
    Department of Medicinal Chemistry, Centro de Investigacion Principe Felipe, Valencia, Spain
    ChemMedChem 4:146-60. 2009
    ..Peptides are essential tools for drug discovery, as well as preclinical and pharmaceutical drug development...