Francisco Perez Vizcaino

Summary

Country: Spain

Publications

  1. ncbi Postnatal maturation in nitric oxide-induced pulmonary artery relaxation involving cyclooxygenase-1 activity
    Francisco Perez-Vizcaino
    Department of Pharmacology, Institute of Pharmacology and Toxicology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Am J Physiol Lung Cell Mol Physiol 283:L839-48. 2002
  2. ncbi Chronic administration of genistein improves endothelial dysfunction in spontaneously hypertensive rats: involvement of eNOS, caveolin and calmodulin expression and NADPH oxidase activity
    Rocio Vera
    Department of Pharmacology, School of Pharmacy, University of Granada, 18071 Granada, Spain
    Clin Sci (Lond) 112:183-91. 2007
  3. ncbi Quercetin and isorhamnetin prevent endothelial dysfunction, superoxide production, and overexpression of p47phox induced by angiotensin II in rat aorta
    Manuel Sanchez
    Department of Pharmacology, School of Pharmacy, Universidad de Granada, 18071 Granada, Spain
    J Nutr 137:910-5. 2007
  4. ncbi The dietary flavonoid quercetin activates BKCa currents in coronary arteries via production of H2O2. Role in vasodilatation
    Angel Cogolludo
    Department of Pharmacology, School of Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain
    Cardiovasc Res 73:424-31. 2007
  5. ncbi Postnatal maturation of phosphodiesterase 5 (PDE5) in piglet pulmonary arteries: activity, expression, effects of PDE5 inhibitors, and role of the nitric oxide/cyclic GMP pathway
    Laura Moreno
    Department of Pharmacology, School of Medicine, University Complutense of Madrid, 28040 Madrid, Spain
    Pediatr Res 56:563-70. 2004
  6. ncbi Soluble guanylyl cyclase during postnatal porcine pulmonary maturation
    Laura Moreno
    Dept Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Am J Physiol Lung Cell Mol Physiol 288:L125-30. 2005
  7. ncbi Postnatal maturational shift from PKCzeta and voltage-gated K+ channels to RhoA/Rho kinase in pulmonary vasoconstriction
    Angel Cogolludo
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Cardiovasc Res 66:84-93. 2005
  8. ncbi Genistein restores caveolin-1 and AT-1 receptor expression and vascular function in large vessels of ovariectomized hypertensive rats
    Rocio Vera
    Department of Pharmacology, School of Pharmacy, University of Granada, Granada, Spain
    Menopause 14:933-40. 2007
  9. ncbi Nitric oxide (NO) scavenging and NO protecting effects of quercetin and their biological significance in vascular smooth muscle
    Gustavo Lopez-Lopez
    Department of Pharmacology, School of Medicine, University Complutense of Madrid, 28040 Madrid, Spain
    Mol Pharmacol 65:851-9. 2004
  10. doi Quercetin inhibits vascular superoxide production induced by endothelin-1: Role of NADPH oxidase, uncoupled eNOS and PKC
    Miguel Romero
    Department of Pharmacology, School of Pharmacy, University of Granada, 18071 Granada, Spain
    Atherosclerosis 202:58-67. 2009

Collaborators

  • Juan Duarte
  • Angel Cogolludo
  • Manuel Sanchez
  • Juan Tamargo
  • Francisco Perez-Vizcaino
  • Ana M Briones
  • Laura Moreno
  • Federica Lodi
  • Rosario Jimenez
  • Rocio Vera
  • Antonio Zarzuelo
  • Milagros Galisteo
  • Miguel Romero
  • Eduardo Villamor
  • Gustavo Lopez-Lopez
  • Maria José Zarzuelo
  • Francisco O'Valle
  • Rocío López-Sepúlveda
  • Carmen Menendez
  • Paul W Needs
  • Laura Cobeño
  • Inmaculada Concepcion Villar
  • Giovanna Frazziano
  • Gema Gonzalez-Luis
  • Antonio Lopez-Farre
  • Manuel Ibarra
  • Claire Lugnier
  • Begoña Losada
  • Manuel Moro

Detail Information

Publications16

  1. ncbi Postnatal maturation in nitric oxide-induced pulmonary artery relaxation involving cyclooxygenase-1 activity
    Francisco Perez-Vizcaino
    Department of Pharmacology, Institute of Pharmacology and Toxicology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Am J Physiol Lung Cell Mol Physiol 283:L839-48. 2002
    ..Therefore, the present data suggest that the maturational increase in the vasodilatation of NO in the pulmonary arteries during the first days of extrauterine life involves a cycloxygenase-dependent inhibition of neonatal NO activity...
  2. ncbi Chronic administration of genistein improves endothelial dysfunction in spontaneously hypertensive rats: involvement of eNOS, caveolin and calmodulin expression and NADPH oxidase activity
    Rocio Vera
    Department of Pharmacology, School of Pharmacy, University of Granada, 18071 Granada, Spain
    Clin Sci (Lond) 112:183-91. 2007
    ..This latter effect appears to be related to increased eNOS activity associated with increased calmodulin-1 expression and decreased O(2)(-) generation...
  3. ncbi Quercetin and isorhamnetin prevent endothelial dysfunction, superoxide production, and overexpression of p47phox induced by angiotensin II in rat aorta
    Manuel Sanchez
    Department of Pharmacology, School of Pharmacy, Universidad de Granada, 18071 Granada, Spain
    J Nutr 137:910-5. 2007
    ....
  4. ncbi The dietary flavonoid quercetin activates BKCa currents in coronary arteries via production of H2O2. Role in vasodilatation
    Angel Cogolludo
    Department of Pharmacology, School of Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain
    Cardiovasc Res 73:424-31. 2007
    ..We hypothesized that quercetin might activate BKCa channel in isolated myocytes from rat coronary arteries and that this mechanism might be involved in its coronary artery relaxant effects...
  5. ncbi Postnatal maturation of phosphodiesterase 5 (PDE5) in piglet pulmonary arteries: activity, expression, effects of PDE5 inhibitors, and role of the nitric oxide/cyclic GMP pathway
    Laura Moreno
    Department of Pharmacology, School of Medicine, University Complutense of Madrid, 28040 Madrid, Spain
    Pediatr Res 56:563-70. 2004
    ..However, PDE5 is not responsible for the maturational increase of NO bioactivity during the first days of extrauterine life...
  6. ncbi Soluble guanylyl cyclase during postnatal porcine pulmonary maturation
    Laura Moreno
    Dept Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Am J Physiol Lung Cell Mol Physiol 288:L125-30. 2005
    ..In conclusion, an increased expression of sGC in pulmonary conduit arteries from 2-wk-old compared with newborn piglets explains, at least partly, the age-dependent increase in the vasorelaxant response of NO and other activators of sGC...
  7. ncbi Postnatal maturational shift from PKCzeta and voltage-gated K+ channels to RhoA/Rho kinase in pulmonary vasoconstriction
    Angel Cogolludo
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Cardiovasc Res 66:84-93. 2005
    ..We therefore investigated the role of L-type Ca(2+) channels, protein kinase C (PKC) zeta, voltage-gated K(+) channels (K(V)), and RhoA/Rho kinase in TXA(2)-induced pulmonary vasoconstriction during postnatal maturation...
  8. ncbi Genistein restores caveolin-1 and AT-1 receptor expression and vascular function in large vessels of ovariectomized hypertensive rats
    Rocio Vera
    Department of Pharmacology, School of Pharmacy, University of Granada, Granada, Spain
    Menopause 14:933-40. 2007
    ....
  9. ncbi Nitric oxide (NO) scavenging and NO protecting effects of quercetin and their biological significance in vascular smooth muscle
    Gustavo Lopez-Lopez
    Department of Pharmacology, School of Medicine, University Complutense of Madrid, 28040 Madrid, Spain
    Mol Pharmacol 65:851-9. 2004
    ..When the extracellular NO scavenging effect was prevented, quercetin increased the biological activity of NO, an effect related to its O(2)(.) scavenger properties and/or its inhibitory effect on tissue O(2)(.) generation...
  10. doi Quercetin inhibits vascular superoxide production induced by endothelin-1: Role of NADPH oxidase, uncoupled eNOS and PKC
    Miguel Romero
    Department of Pharmacology, School of Pharmacy, University of Granada, 18071 Granada, Spain
    Atherosclerosis 202:58-67. 2009
    ..Taken together these results indicate that ET-1-induced NADPH oxidase up-regulation and eNOS uncoupling via PKC leading to endothelial dysfunction and these effects were prevented by quercetin and isorhamnetin...
  11. ncbi Protective effects of the flavonoid quercetin in chronic nitric oxide deficient rats
    Juan Duarte
    University of Granada, Department of Pharmacology, School of Pharmacy, Granada, Spain
    J Hypertens 20:1843-54. 2002
    ..The present study analysed, for the first time, the effects of the flavonoid quercetin in rats after chronic inhibition of nitric oxide (NO) synthesis with Nomega-nitro-L-arginine methyl ester (L-NAME)...
  12. ncbi Role of protein kinase Czeta and its adaptor protein p62 in voltage-gated potassium channel modulation in pulmonary arteries
    Laura Moreno
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Mol Pharmacol 72:1301-9. 2007
    ..These observations identify PKCzeta and/or p62 as potential therapeutic targets for the treatment of pulmonary hypertension...
  13. ncbi Endothelium-independent vasodilator effects of the flavonoid quercetin and its methylated metabolites in rat conductance and resistance arteries
    Francisco Perez-Vizcaino
    Department of Pharmacology, Institute of Pharmacology and Toxicology, School of Medicine, University Complutense of Madrid, 28040 Madrid, Spain
    J Pharmacol Exp Ther 302:66-72. 2002
    ..In conclusion, quercetin and its metabolites showed vasodilator effects with selectivity toward the resistance vessels. These effects are not due to or modulated by endothelial factors and are unrelated to changes in cytosolic Ca(2+)...
  14. ncbi Serotonin inhibits voltage-gated K+ currents in pulmonary artery smooth muscle cells: role of 5-HT2A receptors, caveolin-1, and KV1.5 channel internalization
    Angel Cogolludo
    Department Pharmacology, School Medicine, Universidad Complutense, Madrid, Spain
    Circ Res 98:931-8. 2006
    ..5 currents via phospholipase C, protein kinase C, tyrosine kinase, and a caveolae pathway. KV channel inhibition accounts, at least partly, for 5-HT-induced pulmonary vasoconstriction and might play a role in PH...
  15. ncbi Thromboxane A2-induced inhibition of voltage-gated K+ channels and pulmonary vasoconstriction: role of protein kinase Czeta
    Angel Cogolludo
    Department of Pharmacology, School of Medicine, Universidad Complutense, 28040 Madrid, Spain
    Circ Res 93:656-63. 2003
    ..We propose PKCzeta as a link between TP receptor activation and KV channel inhibition...
  16. doi Glucuronidated metabolites of the flavonoid quercetin do not auto-oxidise, do not generate free radicals and do not decrease nitric oxide bioavailability
    Federica Lodi
    Department of Pharmacology, School of Medicine, Universidad Complutense de Madrid, Spain
    Planta Med 74:741-6. 2008
    ..Quercetin, but not quercetin 3-glucuronide, inhibited the biological activity of NO. These data indicate that, in contrast to quercetin, its main circulating forms, i. e., the glucuronides, do not exert pro-oxidant effects...