Rocio Perez-Iglesias

Summary

Country: Spain

Publications

  1. ncbi Effect of FTO, SH2B1, LEP, and LEPR polymorphisms on weight gain associated with antipsychotic treatment
    Rocio Perez-Iglesias
    Department of Psychiatry, Marques de Valdecilla University Hospital, Planta 2 a, Edificio 2 de Noviembre, Avda Valdecilla s n, 39008 Santander, Spain
    J Clin Psychopharmacol 30:661-6. 2010
  2. doi White matter defects in first episode psychosis patients: a voxelwise analysis of diffusion tensor imaging
    Rocio Perez-Iglesias
    Department of Psychiatry, Marques de Valdecilla University Hospital, Avenida Valdecilla s n, University of Cantabria, Spain
    Neuroimage 49:199-204. 2010
  3. ncbi Lack of influence of COMT Val158Met genotype on cognition in first-episode non-affective psychosis
    Ignacio Mata
    University Hospital Marques de Valdecilla, Department of Psychiatry, Santander Cantabria, Spain
    Schizophr Res 102:206-9. 2008
  4. doi Predictors of neurocognitive impairment at 3 years after a first episode non-affective psychosis
    Rosa Ayesa-Arriola
    Department of Psychiatry, Marques de Valdecilla University Hospital, IFIMAV, School of Medicine, University of Cantabria, Santander, Spain
    Prog Neuropsychopharmacol Biol Psychiatry 43:23-8. 2013
  5. doi Effect of antipsychotics on peptides involved in energy balance in drug-naive psychotic patients after 1 year of treatment
    Rocio Perez-Iglesias
    Department of Psychiatry, Marques de Valdecilla University Hospital, University of Cantabria, Cantabria, Spain
    J Clin Psychopharmacol 28:289-95. 2008
  6. ncbi A 12-week randomized clinical trial to evaluate metabolic changes in drug-naive, first-episode psychosis patients treated with haloperidol, olanzapine, or risperidone
    Rocio Perez-Iglesias
    Department of Psychiatry, Marques de Valdecilla University Hospital, University of Cantabria, Santander, Spain
    J Clin Psychiatry 68:1733-40. 2007
  7. doi Catechol-O-methyltransferase Val158Met polymorphism and negative symptoms after acute antipsychotic treatment in first-episode non-affective psychosis
    Jose Maria Pelayo-Teran
    Department of Psychiatry, CIBERSAM, University Hospital Marqués de Valdecilla IFIMAV, School of Medicine, University of Cantabria, Santander, Spain
    Psychiatry Res 185:286-9. 2011
  8. doi Predictors of clinical remission following a first episode of non-affective psychosis: sociodemographics, premorbid and clinical variables
    Ignacio Diaz
    University Hospital La Fe, Department of Psychiatry, Valencia, Spain
    Psychiatry Res 206:181-7. 2013
  9. ncbi Predictors of acute treatment response in patients with a first episode of non-affective psychosis: sociodemographics, premorbid and clinical variables
    Benedicto Crespo-Facorro
    Hospital Universitario Marques de Valdecilla, Department of Psychiatry, School of Medicine, planta 2a, Edificio 2 de Noviembre, Avda Valdecilla s n, 39008, Santander, Spain
    J Psychiatr Res 41:659-66. 2007
  10. doi Insight dimensions in first-episode psychosis patients: clinical, cognitive, pre-morbid and socio-demographic correlates
    Rosa Ayesa-Arriola
    University Hospital Marqués de Valdecilla IFIMAV CIBERSAM, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
    Early Interv Psychiatry 5:140-9. 2011

Collaborators

Detail Information

Publications59

  1. ncbi Effect of FTO, SH2B1, LEP, and LEPR polymorphisms on weight gain associated with antipsychotic treatment
    Rocio Perez-Iglesias
    Department of Psychiatry, Marques de Valdecilla University Hospital, Planta 2 a, Edificio 2 de Noviembre, Avda Valdecilla s n, 39008 Santander, Spain
    J Clin Psychopharmacol 30:661-6. 2010
    ..None of the other single nucleotide polymorphisms evaluated were associated with weight gain during the first 12 months of antipsychotic therapy...
  2. doi White matter defects in first episode psychosis patients: a voxelwise analysis of diffusion tensor imaging
    Rocio Perez-Iglesias
    Department of Psychiatry, Marques de Valdecilla University Hospital, Avenida Valdecilla s n, University of Cantabria, Spain
    Neuroimage 49:199-204. 2010
    ....
  3. ncbi Lack of influence of COMT Val158Met genotype on cognition in first-episode non-affective psychosis
    Ignacio Mata
    University Hospital Marques de Valdecilla, Department of Psychiatry, Santander Cantabria, Spain
    Schizophr Res 102:206-9. 2008
    ..We found no significant differences in any cognitive measure according to COMT genotype. These findings, together with previously published research, put the relationship between COMT genotype and cognitive performance in doubt...
  4. doi Predictors of neurocognitive impairment at 3 years after a first episode non-affective psychosis
    Rosa Ayesa-Arriola
    Department of Psychiatry, Marques de Valdecilla University Hospital, IFIMAV, School of Medicine, University of Cantabria, Santander, Spain
    Prog Neuropsychopharmacol Biol Psychiatry 43:23-8. 2013
    ..However, patients show great variability in the level and course of deficits. The goal of the present longitudinal study was to identify predictors of neurocognitive impairment in first episode psychosis patients...
  5. doi Effect of antipsychotics on peptides involved in energy balance in drug-naive psychotic patients after 1 year of treatment
    Rocio Perez-Iglesias
    Department of Psychiatry, Marques de Valdecilla University Hospital, University of Cantabria, Cantabria, Spain
    J Clin Psychopharmacol 28:289-95. 2008
    ..The unexpected increase in ghrelin levels might be related with the causal mechanism of weight gain induced by antipsychotics. Finally, the 3 antipsychotics had similar effects in all parameters evaluated...
  6. ncbi A 12-week randomized clinical trial to evaluate metabolic changes in drug-naive, first-episode psychosis patients treated with haloperidol, olanzapine, or risperidone
    Rocio Perez-Iglesias
    Department of Psychiatry, Marques de Valdecilla University Hospital, University of Cantabria, Santander, Spain
    J Clin Psychiatry 68:1733-40. 2007
    ..This study examined the main metabolic side effects induced by antipsychotic treatment in a cohort of first-episode drug-naive subjects...
  7. doi Catechol-O-methyltransferase Val158Met polymorphism and negative symptoms after acute antipsychotic treatment in first-episode non-affective psychosis
    Jose Maria Pelayo-Teran
    Department of Psychiatry, CIBERSAM, University Hospital Marqués de Valdecilla IFIMAV, School of Medicine, University of Cantabria, Santander, Spain
    Psychiatry Res 185:286-9. 2011
    ..Val homozygote patients showed higher negative symptoms than Met homozygote patients. The COMT Val158 genotype seems to be related to the severity of negative symptoms rather than to clinical response...
  8. doi Predictors of clinical remission following a first episode of non-affective psychosis: sociodemographics, premorbid and clinical variables
    Ignacio Diaz
    University Hospital La Fe, Department of Psychiatry, Valencia, Spain
    Psychiatry Res 206:181-7. 2013
    ....
  9. ncbi Predictors of acute treatment response in patients with a first episode of non-affective psychosis: sociodemographics, premorbid and clinical variables
    Benedicto Crespo-Facorro
    Hospital Universitario Marques de Valdecilla, Department of Psychiatry, School of Medicine, planta 2a, Edificio 2 de Noviembre, Avda Valdecilla s n, 39008, Santander, Spain
    J Psychiatr Res 41:659-66. 2007
    ..Helping clinicians to identify non-responders is meant as a first step to optimise therapeutic effort to benefit individuals in this vulnerable group...
  10. doi Insight dimensions in first-episode psychosis patients: clinical, cognitive, pre-morbid and socio-demographic correlates
    Rosa Ayesa-Arriola
    University Hospital Marqués de Valdecilla IFIMAV CIBERSAM, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
    Early Interv Psychiatry 5:140-9. 2011
    ..To investigate pre-morbid, socio-demographic, clinical and cognitive variables as predictors of insight in a large and representative sample of first-episode psychosis patients...
  11. ncbi Association between the interleukin-1 receptor antagonist gene and negative symptom improvement during antipsychotic treatment
    Ignacio Mata
    Department of Psychiatry, University Hospital Marques de Valdecilla, School of Medicine, University of Cantabria, Santander, Spain
    Am J Med Genet B Neuropsychiatr Genet 141:939-43. 2006
    ..These results suggest that the VNTR polymorphism in the IL-1RN gene may be a useful predictor of negative symptom improvement in schizophrenic patients treated with antipsychotic drugs...
  12. ncbi Course of cognitive deficits in first episode of non-affective psychosis: a 3-year follow-up study
    Jose Manuel Rodríguez-Sánchez
    University Hospital Marques de Valdecilla, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Madrid, Spain Electronic address
    Schizophr Res 150:121-8. 2013
    ..However, patients whose cognitive performance demonstrated a declining trend may present with a poorer progression in terms of clinical and disability variables...
  13. ncbi The relevance of cognitive, clinical and premorbid variables in predicting functional outcome for individuals with first-episode psychosis: a 3 year longitudinal study
    Rosa Ayesa-Arriola
    Department of Psychiatry, Marques de Valdecilla University Hospital, IFIMAV, School of Medicine, University of Cantabria, Santander, Spain CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Madrid, Spain Electronic address
    Psychiatry Res 209:302-8. 2013
    ..The data support the notion that premorbid social adjustment is an important aspect in functional outcome over the course of the illness. ..
  14. ncbi Weight gain induced by haloperidol, risperidone and olanzapine after 1 year: findings of a randomized clinical trial in a drug-naïve population
    Rocio Perez-Iglesias
    Department of Psychiatry, Marques de Valdecilla University Hospital, Avda Valdecilla s n, 39008, University of Cantabria, Spain
    Schizophr Res 99:13-22. 2008
    ..There is little information about weight gain induced by antipsychotics at long-term...
  15. doi Aripiprazole, Ziprasidone and Quetiapine in the treatment of first-episode nonaffective psychosis: a 12-week randomized, flexible-dose, open-label trial
    Benedicto Crespo-Facorro
    University Hospital Marques de Valdecilla, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
    Schizophr Res 147:375-82. 2013
    ..We aimed to compare the clinical effectiveness in the short-term of Aripiprazole, Ziprasidone and Quetiapine in the treatment of first-episode schizophrenia-spectrum disorders...
  16. ncbi A practical clinical trial comparing haloperidol, risperidone, and olanzapine for the acute treatment of first-episode nonaffective psychosis
    Benedicto Crespo-Facorro
    University Hospital Marques de Valdecilla, Department of Psychiatry, Santander, Spain
    J Clin Psychiatry 67:1511-21. 2006
    ....
  17. doi Specific brain structural abnormalities in first-episode schizophrenia. A comparative study with patients with schizophreniform disorder, non-schizophrenic non-affective psychoses and healthy volunteers
    Benedicto Crespo-Facorro
    Department of Psychiatry, University Hospital Marques de Valdecilla, CIBERSAM, School of Medicine, University of Cantabria, Santander, Spain
    Schizophr Res 115:191-201. 2009
    ..The brain changes found in patients with a first episode of schizophrenia spectrum disorders are robustly associated with the diagnoses of schizophrenia and schizophreniform disorder and are independent of relevant intervening variables...
  18. ncbi Lack of association between clinical and cognitive change in first-episode psychosis: the first 6 weeks of treatment
    Cesar Gonzalez-Blanch
    Mental Health Centre, University Hospital Marques de Valdecilla, University of Cantabria, Santander, Spain
    Can J Psychiatry 53:839-47. 2008
    ....
  19. doi Effectiveness of haloperidol, risperidone and olanzapine in the treatment of first-episode non-affective psychosis: results of a randomized, flexible-dose, open-label 1-year follow-up comparison
    Benedicto Crespo-Facorro
    University Hospital Marques de Valdecilla, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
    J Psychopharmacol 25:744-54. 2011
    ..Specific clinical programmes and the use of second-generation antipsychotics may enhance the effectiveness of antipsychotic treatments...
  20. ncbi Low-activity allele of Catechol-O-Methyltransferase (COMTL) is associated with increased lateral ventricles in patients with first episode non-affective psychosis
    Benedicto Crespo-Facorro
    University Hospital Marques de Valdecilla, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
    Prog Neuropsychopharmacol Biol Psychiatry 31:1514-8. 2007
    ..We hypothesized that the low activity-COMT (COMT(L)) allele would be associated with the presence of structural brain changes as assessed by quantitative magnetic resonance imaging (MRI)...
  21. doi Long-term (3-year) neurocognitive effectiveness of antipsychotic medications in first-episode non-affective psychosis: a randomized comparison of haloperidol, olanzapine, and risperidone
    Rosa Ayesa-Arriola
    Department of Psychiatry, Marques de Valdecilla University Hospital, IFIMAV, School of Medicine, University of Cantabria, Avda Valdecilla s n, 39008 Santander, Spain
    Psychopharmacology (Berl) 227:615-25. 2013
    ..The initially postulated superior neurocognitive effectiveness of second-generation antipsychotics is currently under debate...
  22. doi Insular cortex thinning in first episode schizophrenia patients
    Roberto Roiz-Santiáñez
    University Hospital Marques de Valdecilla, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
    Psychiatry Res 182:216-22. 2010
    ..The fact that insular thinning is already present at early phases of the illness and is independent of intervening variables offers evidence for the potential of these changes to be a biological marker of the illness...
  23. ncbi Cognitive functioning and negative symptoms in first episode schizophrenia: different patterns of correlates
    Jose Manuel Rodríguez-Sánchez
    University Hospital Marques de Valdecilla, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
    Neurotox Res 14:227-35. 2008
    ..The widely described relationship between negative symptoms and executive impairments in schizophrenia appears to be mediated by likely dysfunctions in the speed of processing instead of by working memory impairment...
  24. doi Prediction of acute clinical response following a first episode of non affective psychosis: results of a cohort of 375 patients from the Spanish PAFIP study
    Benedicto Crespo-Facorro
    University Hospital Marques de Valdecilla, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
    Prog Neuropsychopharmacol Biol Psychiatry 44:162-7. 2013
    ..We aimed to investigate sociodemographic, premorbid and clinical predictors of response to antipsychotic treatment after a first episode of non-affective psychosis...
  25. ncbi Caudate nucleus volume and its clinical and cognitive correlations in first episode schizophrenia
    Benedicto Crespo-Facorro
    University Hospital Marques de Valdecilla, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
    Schizophr Res 91:87-96. 2007
    ..The purpose of this study is to examine the relationship between caudate nucleus volumes and clinical and cognitive features of schizophrenic patients in an early phase of their illness...
  26. ncbi Reduced thalamic volume in first-episode non-affective psychosis: correlations with clinical variables, symptomatology and cognitive functioning
    Benedicto Crespo-Facorro
    University Hospital Marques de Valdecilla, Department of Psychiatry, Planta 2 a, Edificio 2 de Noviembre Avda, Valdecilla s n, 39008, Santander, Spain
    Neuroimage 35:1613-23. 2007
    ..However, further investigations are warranted to fully clarify the relationship between those structural anomalies and clinical and cognitive outcomes...
  27. doi Interleukin-1 receptor antagonist genotype and brain morphometry in first-episode non-affective psychosis
    Roberto Roiz-Santiáñez
    University Hospital Marques de Valdecilla, Department of Psychiatry School of Medicine, University of Cantabria, Santander, Spain
    Psychiatry Res 162:167-71. 2008
    ..We did not find evidence for association between genetic variation in the IL-1RN gene and brain morphometry at early phases of the illness...
  28. doi Predicting relapse after a first episode of non-affective psychosis: a three-year follow-up study
    Olalla Caseiro
    Marques de Valdecilla University Hospital, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
    J Psychiatr Res 46:1099-105. 2012
    ..A better understanding and improvement in factors which influence relapse should diminish the risk of relapse and consequently improve the outcome of the illness...
  29. ncbi Prefrontal cognitive functions in stabilized first-episode patients with schizophrenia spectrum disorders: a dissociation between dorsolateral and orbitofrontal functioning
    Jose Manuel Rodríguez-Sánchez
    Hospital Universitario Marques de Valdecilla, Department of Psychiatry, School of Medicine, University of Cantabria, Planta 2 a, Edificio 2 de Noviembre Avda Valdecilla s n, 39008 Santander, Spain
    Schizophr Res 77:279-88. 2005
    ..The OFC functions are unimpaired at the early phases of psychosis and in contrast there is a significant deficit in DLPFC functions in first-episode of schizophrenia...
  30. doi One year longitudinal study of the straight gyrus morphometry in first-episode schizophrenia-spectrum patients
    Roberto Roiz-Santiáñez
    Department of Psychiatry, University of Cantabria, Santander, Spain
    Psychiatry Res 202:80-3. 2012
    ..We did not find a differential pattern of volumetric change between the two groups...
  31. ncbi Additive effect of NRG1 and DISC1 genes on lateral ventricle enlargement in first episode schizophrenia
    Ignacio Mata
    Department of Psychiatry, University Hospital Marques de Valdecilla, School of Medicine, University of Cantabria, Santander, Spain, CIBERSAM
    Neuroimage 53:1016-22. 2010
    ..Our findings suggest that NRG1 and DISC1 genes may be associated with brain abnormalities in schizophrenia through their influence on related pathways of brain development...
  32. doi Relapse prevention and remission attainment in first-episode non-affective psychosis. A randomized, controlled 1-year follow-up comparison of haloperidol, risperidone and olanzapine
    Benedicto Crespo-Facorro
    Department of Psychiatry, University of Cantabria IFIMAV, Santander 39008, Spain
    J Psychiatr Res 45:763-9. 2011
    ..We conclude that haloperidol, olanzapine and risperidone show a similar effectiveness in relapse prevention or in remission attainment during the first year of treatment...
  33. doi Straight gyrus morphology in first-episode schizophrenia-spectrum patients
    Roberto Roiz-Santiáñez
    Department of Psychiatry, School of Medicine, University of Cantabria, University Hospital Marques de Valdecilla, IFIMAV, Santander, Spain
    Prog Neuropsychopharmacol Biol Psychiatry 35:84-90. 2011
    ..Our results, based on a large and representative sample, do not confirm the presence of significant straight gyrus morphometric anomalies in schizophrenia-spectrum disorders, after controlling for potential confounding variables...
  34. doi Catechol-O-Methyltransferase (COMT) Val158Met variations and cannabis use in first-episode non-affective psychosis: clinical-onset implications
    Jose Maria Pelayo-Teran
    Department of Psychiatry, University Hospital Marques de Valdecilla, School of Medicine, University of Cantabria, Santander, Spain
    Psychiatry Res 179:291-6. 2010
    ..Based on these results, the use of cannabis could exert a modulator effect on the genotype, suppressing the delay effect for the age of onset in the case of the Met allele patients...
  35. ncbi Cannabis use and cognitive functioning in first-episode schizophrenia patients
    Jose Manuel Rodríguez-Sánchez
    Department of Psychiatry, CIBERSAM, University Hospital Marques de Valdecilla, IFIMAV, Santander, Spain
    Schizophr Res 124:142-51. 2010
    ..Cannabis user patients appear to comprise a subgroup of patients with a better premorbid adjustment and premorbid frontal cognitive functions...
  36. ncbi White matter integrity and cognitive impairment in first-episode psychosis
    Rocio Perez-Iglesias
    Department of Psychiatry, Marques de Valdecilla University Hospital, Spain
    Am J Psychiatry 167:451-8. 2010
    ..However, a significant proportion of patients do not show any cognitive deficits. The aim of this study was to assess if there were differences in white matter integrity between patients with and without cognitive impairment...
  37. ncbi Attenuation of antipsychotic-induced weight gain with early behavioral intervention in drug-naive first-episode psychosis patients: A randomized controlled trial
    Mario Alvarez-Jimenez
    University Hospital Marqués de Valdecilla Clinical and Social Psychiatry Research Unit, Department of Psychiatry, Santander, Spain
    J Clin Psychiatry 67:1253-60. 2006
    ....
  38. ncbi Cognitive dimensions in first-episode schizophrenia spectrum disorders
    Cesar Gonzalez-Blanch
    Hospital Universitario Marques de Valdecilla, Department of Psychiatry, School of Medicine, Santander, Spain
    J Psychiatr Res 41:968-77. 2007
    ..We aimed to characterize the basic cognitive functioning of a representative sample of patients with a first-episode schizophrenia spectrum disorders...
  39. doi Glucose and lipid disturbances after 1 year of antipsychotic treatment in a drug-naïve population
    Rocio Perez-Iglesias
    Department of Psychiatry, Marques de Valdecilla University Hospital, Avda Valdecilla s n, 39008, University of Cantabria, Spain
    Schizophr Res 107:115-21. 2009
    ..This study examined the main metabolic side effects induced by antipsychotic treatment in a cohort of first episode drug-naïve subjects after the first year of treatment...
  40. doi Homocysteine and cognition in first-episode psychosis patients
    Rosa Ayesa-Arriola
    Department of Psychiatry, Marques de Valdecilla University Hospital, IFIMAV, School of Medicine, University of Cantabria, Santander, Spain
    Eur Arch Psychiatry Clin Neurosci 262:557-64. 2012
    ..However, no relationship between homocysteine levels and cognitive impairment was detected. These results suggest the need for further studies to clarify the role of homocysteine in the etiology and prognosis of psychosis...
  41. doi Insular cortex morphometry in first-episode schizophrenia-spectrum patients: Diagnostic specificity and clinical correlations
    Benedicto Crespo-Facorro
    University Hospital Marques de Valdecilla, CIBERSAM, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
    J Psychiatr Res 44:314-20. 2010
    ..Contrary to our initial hypotheses, we were unable to demonstrate significant morphometric anomalies in a large and heterogeneous sample of patients with a first-episode of schizophrenia-spectrum disorders...
  42. doi Effect of antipsychotic drugs on brain morphometry. A randomized controlled one-year follow-up study of haloperidol, risperidone and olanzapine
    Benedicto Crespo-Facorro
    University Hospital Marques de Valdecilla, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
    Prog Neuropsychopharmacol Biol Psychiatry 32:1936-43. 2008
    ..Here we investigate the effects of risperidone, olanzapine and low doses of haloperidol on cortical and subcortical morphometry in first episode drug naïve patients with non-affective psychosis...
  43. doi Serotonin transporter polymorphisms and early response to antipsychotic treatment in first episode of psychosis
    Javier Vázquez-Bourgon
    Department of Psychiatry, University Hospital Marques de Valdecilla, School of Medicine, University of Cantabria, Santander, Spain
    Psychiatry Res 175:189-94. 2010
    ..Our results suggest a minor contribution to antipsychotic drug response of genetic alterations in the 5-HTT gene...
  44. doi Epidemiological factors associated with treated incidence of first-episode non-affective psychosis in Cantabria: insights from the Clinical Programme on Early Phases of Psychosis
    Jose M Pelayo-Teran
    Department of Psychiatry, University Hospital Marques de Valdecilla, School of Medicine, University of Cantabria, Santander, Spain
    Early Interv Psychiatry 2:178-87. 2008
    ..The aim of the study was to analyse the treated incidence of schizophrenia in Cantabria (Northern Spain) and the sociodemographic risk factors associated with the illness onset...
  45. ncbi Interleukin-12 plasma levels in drug-naïve patients with a first episode of psychosis: effects of antipsychotic drugs
    Benedicto Crespo-Facorro
    University Hospital Marques de Valdecilla, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
    Psychiatry Res 158:206-16. 2008
    ..Thus, patients with a first episode of psychosis have inflammatory-like immunological function during early phases of the illness that it is independent of the antipsychotic treatment used...
  46. ncbi Temporal pole morphology in first-episode schizophrenia patients: clinical correlations
    Roberto Roiz-Santiáñez
    University Hospital Marques de Valdecilla, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
    Psychiatry Res 184:189-91. 2010
    ..Patients did not significantly differ from controls in the TP morphometric variables evaluated. Clinical variables were not significantly related to the TP...
  47. doi Long-term (3-year) effectiveness of haloperidol, risperidone and olanzapine: results of a randomized, flexible-dose, open-label comparison in first-episode nonaffective psychosis
    Benedicto Crespo-Facorro
    University Hospital Marques de Valdecilla, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Planta 2ª, Edificio 2 de Noviembre Avda Valdecilla s n, 39008 Santander, Spain
    Psychopharmacology (Berl) 219:225-33. 2012
    ..To enhance the effectiveness of antipsychotics in first-episode psychosis is crucial in order to achieve the most favourable prognosis. Difference in effectiveness between antipsychotics is still under debate...
  48. pmc Sex-specific variation of MRI-based cortical morphometry in adult healthy volunteers: the effect on cognitive functioning
    Benedicto Crespo-Facorro
    University Hospital Marques de Valdecilla, CIBERSAM, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
    Prog Neuropsychopharmacol Biol Psychiatry 35:616-23. 2011
    ..In conclusion, our findings do not support the notion of sexual dimorphism in cortical mantle morphology. The results also suggest that variability in cortical thickness may affect cognitive functioning in females but not in males...
  49. doi Aripiprazole, ziprasidone, and quetiapine in the treatment of first-episode nonaffective psychosis: results of a 6-week, randomized, flexible-dose, open-label comparison
    Benedicto Crespo-Facorro
    University Hospital Marques de Valdecilla, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
    J Clin Psychopharmacol 33:215-20. 2013
    ..Differences in effectiveness between second-generation antipsychotics would determine their position in everyday clinical practice and could help physicians choose the more efficacious antipsychotics...
  50. doi Long-term effect of haloperidol, olanzapine, and risperidone on plasma prolactin levels in patients with first-episode psychosis
    Rocio Perez-Iglesias
    Department of Psychiatry, Marques de Valdecilla University Hospital, University of Cantabria, Spain
    J Clin Psychopharmacol 32:804-8. 2012
    ..The main goal of this study was to assess the long-term effect of haloperidol, olanzapine, and risperidone on serum prolactin levels in a naturalistically treated first-episode psychosis population...
  51. ncbi Neurocognitive effectiveness of haloperidol, risperidone, and olanzapine in first-episode psychosis: a randomized, controlled 1-year follow-up comparison
    Benedicto Crespo-Facorro
    Department of Psychiatry, CIBERSAM, School of Medicine, University Hospital Marques de Valdecilla, University of Cantabria, Santander, Spain
    J Clin Psychiatry 70:717-29. 2009
    ..To investigate the neurocognitive effectiveness of haloperidol, risperidone, and olanzapine in first-episode schizophrenia-spectrum disorders...
  52. ncbi Catechol-O-methyltransferase Val158Met polymorphism and clinical characteristics in first episode non-affective psychosis
    Jose Maria Pelayo-Teran
    Department of Psychiatry, University Hospital Marques de Valdecilla, School of Medicine, University of Cantabria, Santander, Spain
    Am J Med Genet B Neuropsychiatr Genet 147:550-6. 2008
    ..These data would indicate that COMT genotype may have a role in the etiological model for schizophrenia and other psychotic disorders...
  53. doi Gyrification brain abnormalities associated with adolescence and early-adulthood cannabis use
    Ignacio Mata
    Department of Psychiatry, University Hospital Marques de Valdecilla, School of Medicine, University of Cantabria, IFIMAV, Santander, Spain
    Brain Res 1317:297-304. 2010
    ....
  54. doi Cognitive dysfunction in first-episode psychosis: the processing speed hypothesis
    Jose Manuel Rodríguez-Sánchez
    Department of Psychiatry, School of Medicine, Hospital Universitario Marques de Valdecilla, University of Cantabria, planta 2a, Edificio 2 de Noviembre, Avda, Valdecilla s n, 39008, Santander, Spain
    Br J Psychiatry Suppl 51:s107-10. 2007
    ..Speed of processing is a cognitive process underlying cognitive dysfunction in people with chronic schizophrenia...
  55. ncbi A neuregulin 1 variant is associated with increased lateral ventricle volume in patients with first-episode schizophrenia
    Ignacio Mata
    Department of Psychiatry, School of Medicine, University of Cantabria, University Hospital Marques de Valdecilla, CIBERSAM, Santander, Spain
    Biol Psychiatry 65:535-40. 2009
    ..We examined whether variations in this polymorphism influence brain volumes in first-episode schizophrenia subjects...
  56. ncbi Cognitive functioning in the early course of first-episode schizophrenia spectrum disorders: timing and patterns
    Cesar Gonzalez-Blanch
    Hospital Universitario Marques de Valdecilla, Department of Psychiatry, planta 2a, Edificio 2 de Noviembre, Avda Valdecilla s n, 39008, Santander, Spain
    Eur Arch Psychiatry Clin Neurosci 256:364-71. 2006
    ..The aim of this study was to examine possible cognitive changes throughout the early course of schizophrenia spectrum disorders...
  57. ncbi Treatment of the first episode of schizophrenia: an update on pharmacologic and psychological interventions
    Benedicto Crespo-Facorro
    Department of Psychiatry, Hospital Universitario Marques de Valdecilla, Avda Valdecilla s n 39008, Santander, Spain
    Curr Psychiatry Rep 10:202-9. 2008
    ..Cognitive-behavioral therapy and family interventions seem to be effective adjunctive treatments in early phases of schizophrenia in some patients...
  58. ncbi 1-year follow-up study of cognitive function in first-episode non-affective psychosis
    José M Rodríguez-Sánchez
    University Hospital Marques de Valdecilla, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
    Schizophr Res 104:165-74. 2008
    ..Further investigations are warranted to discern the variability in patterns of specific cognitive deficits over time...
  59. ncbi Lack of insight 3years after first-episode psychosis: An unchangeable illness trait determined from first presentation?
    Rosa Ayesa-Arriola
    Department of Psychiatry, Marques de Valdecilla University Hospital, IFIMAV, School of Medicine, University of Cantabria, Santander, Spain CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Madrid, Spain Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, UK Electronic address
    Schizophr Res 157:271-7. 2014
    ..This study aimed to explore baseline predictors of disturbances on insight at follow-up...