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Genomes and GenesSpecies | Rocio Perez-IglesiasSummaryCountry: Spain Publications
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Publications
Effect of FTO, SH2B1, LEP, and LEPR polymorphisms on weight gain associated with antipsychotic treatmentRocio Perez-Iglesias
Department of Psychiatry, Marques de Valdecilla University Hospital, Planta 2 a, Edificio 2 de Noviembre, Avda Valdecilla s n, 39008 Santander, Spain
J Clin Psychopharmacol 30:661-6. 2010..None of the other single nucleotide polymorphisms evaluated were associated with weight gain during the first 12 months of antipsychotic therapy...
White matter defects in first episode psychosis patients: a voxelwise analysis of diffusion tensor imagingRocio Perez-Iglesias
Department of Psychiatry, Marques de Valdecilla University Hospital, Avenida Valdecilla s n, University of Cantabria, Spain
Neuroimage 49:199-204. 2010....- Lack of influence of COMT Val158Met genotype on cognition in first-episode non-affective psychosisIgnacio Mata
University Hospital Marques de Valdecilla, Department of Psychiatry, Santander Cantabria, Spain
Schizophr Res 102:206-9. 2008..We found no significant differences in any cognitive measure according to COMT genotype. These findings, together with previously published research, put the relationship between COMT genotype and cognitive performance in doubt... - Effect of antipsychotics on peptides involved in energy balance in drug-naive psychotic patients after 1 year of treatmentRocio Perez-Iglesias
Department of Psychiatry, Marques de Valdecilla University Hospital, University of Cantabria, Cantabria, Spain
J Clin Psychopharmacol 28:289-95. 2008..The unexpected increase in ghrelin levels might be related with the causal mechanism of weight gain induced by antipsychotics. Finally, the 3 antipsychotics had similar effects in all parameters evaluated... - Catechol-O-methyltransferase Val158Met polymorphism and negative symptoms after acute antipsychotic treatment in first-episode non-affective psychosisJose Maria Pelayo-Teran
Department of Psychiatry, CIBERSAM, University Hospital Marqués de Valdecilla IFIMAV, School of Medicine, University of Cantabria, Santander, Spain
Psychiatry Res 185:286-9. 2011..Val homozygote patients showed higher negative symptoms than Met homozygote patients. The COMT Val158 genotype seems to be related to the severity of negative symptoms rather than to clinical response... - A practical clinical trial comparing haloperidol, risperidone, and olanzapine for the acute treatment of first-episode nonaffective psychosisBenedicto Crespo-Facorro
University Hospital Marques de Valdecilla, Department of Psychiatry, Santander, Spain
J Clin Psychiatry 67:1511-21. 2006.... - Predictors of acute treatment response in patients with a first episode of non-affective psychosis: sociodemographics, premorbid and clinical variablesBenedicto Crespo-Facorro
Hospital Universitario Marques de Valdecilla, Department of Psychiatry, School of Medicine, planta 2a, Edificio 2 de Noviembre, Avda Valdecilla s n, 39008, Santander, Spain
J Psychiatr Res 41:659-66. 2007..Helping clinicians to identify non-responders is meant as a first step to optimise therapeutic effort to benefit individuals in this vulnerable group... - Association between the interleukin-1 receptor antagonist gene and negative symptom improvement during antipsychotic treatmentIgnacio Mata
Department of Psychiatry, University Hospital Marques de Valdecilla, School of Medicine, University of Cantabria, Santander, Spain
Am J Med Genet B Neuropsychiatr Genet 141:939-43. 2006..These results suggest that the VNTR polymorphism in the IL-1RN gene may be a useful predictor of negative symptom improvement in schizophrenic patients treated with antipsychotic drugs... - Insight dimensions in first-episode psychosis patients: clinical, cognitive, pre-morbid and socio-demographic correlatesRosa Ayesa-Arriola
University Hospital Marqués de Valdecilla IFIMAV CIBERSAM, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
Early Interv Psychiatry 5:140-9. 2011..To investigate pre-morbid, socio-demographic, clinical and cognitive variables as predictors of insight in a large and representative sample of first-episode psychosis patients... - Weight gain induced by haloperidol, risperidone and olanzapine after 1 year: findings of a randomized clinical trial in a drug-naïve populationRocio Perez-Iglesias
Department of Psychiatry, Marques de Valdecilla University Hospital, Avda Valdecilla s n, 39008, University of Cantabria, Spain
Schizophr Res 99:13-22. 2008..There is little information about weight gain induced by antipsychotics at long-term... - Lack of association between clinical and cognitive change in first-episode psychosis: the first 6 weeks of treatmentCesar Gonzalez-Blanch
Mental Health Centre, University Hospital Marques de Valdecilla, University of Cantabria, Santander, Spain
Can J Psychiatry 53:839-47. 2008.... - Cognitive dimensions in first-episode schizophrenia spectrum disordersCesar Gonzalez-Blanch
Hospital Universitario Marques de Valdecilla, Department of Psychiatry, School of Medicine, Santander, Spain
J Psychiatr Res 41:968-77. 2007..We aimed to characterize the basic cognitive functioning of a representative sample of patients with a first-episode schizophrenia spectrum disorders... - Specific brain structural abnormalities in first-episode schizophrenia. A comparative study with patients with schizophreniform disorder, non-schizophrenic non-affective psychoses and healthy volunteersBenedicto Crespo-Facorro
Department of Psychiatry, University Hospital Marques de Valdecilla, CIBERSAM, School of Medicine, University of Cantabria, Santander, Spain
Schizophr Res 115:191-201. 2009..The brain changes found in patients with a first episode of schizophrenia spectrum disorders are robustly associated with the diagnoses of schizophrenia and schizophreniform disorder and are independent of relevant intervening variables... - Effectiveness of haloperidol, risperidone and olanzapine in the treatment of first-episode non-affective psychosis: results of a randomized, flexible-dose, open-label 1-year follow-up comparisonBenedicto Crespo-Facorro
University Hospital Marques de Valdecilla, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
J Psychopharmacol 25:744-54. 2011..Specific clinical programmes and the use of second-generation antipsychotics may enhance the effectiveness of antipsychotic treatments... - Low-activity allele of Catechol-O-Methyltransferase (COMTL) is associated with increased lateral ventricles in patients with first episode non-affective psychosisBenedicto Crespo-Facorro
University Hospital Marques de Valdecilla, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
Prog Neuropsychopharmacol Biol Psychiatry 31:1514-8. 2007..We hypothesized that the low activity-COMT (COMT(L)) allele would be associated with the presence of structural brain changes as assessed by quantitative magnetic resonance imaging (MRI)... - Interleukin-1 receptor antagonist genotype and brain morphometry in first-episode non-affective psychosisRoberto Roiz-Santiáñez
University Hospital Marques de Valdecilla, Department of Psychiatry School of Medicine, University of Cantabria, Santander, Spain
Psychiatry Res 162:167-71. 2008..We did not find evidence for association between genetic variation in the IL-1RN gene and brain morphometry at early phases of the illness... - Reduced thalamic volume in first-episode non-affective psychosis: correlations with clinical variables, symptomatology and cognitive functioningBenedicto Crespo-Facorro
University Hospital Marques de Valdecilla, Department of Psychiatry, Planta 2 a, Edificio 2 de Noviembre Avda, Valdecilla s n, 39008, Santander, Spain
Neuroimage 35:1613-23. 2007..However, further investigations are warranted to fully clarify the relationship between those structural anomalies and clinical and cognitive outcomes... - Cognitive functioning and negative symptoms in first episode schizophrenia: different patterns of correlatesJose Manuel Rodríguez-Sánchez
University Hospital Marques de Valdecilla, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
Neurotox Res 14:227-35. 2008..The widely described relationship between negative symptoms and executive impairments in schizophrenia appears to be mediated by likely dysfunctions in the speed of processing instead of by working memory impairment... - Caudate nucleus volume and its clinical and cognitive correlations in first episode schizophreniaBenedicto Crespo-Facorro
University Hospital Marques de Valdecilla, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
Schizophr Res 91:87-96. 2007..The purpose of this study is to examine the relationship between caudate nucleus volumes and clinical and cognitive features of schizophrenic patients in an early phase of their illness... - Insular cortex thinning in first episode schizophrenia patientsRoberto Roiz-Santiáñez
University Hospital Marques de Valdecilla, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
Psychiatry Res 182:216-22. 2010..The fact that insular thinning is already present at early phases of the illness and is independent of intervening variables offers evidence for the potential of these changes to be a biological marker of the illness... - Interleukin-12 plasma levels in drug-naïve patients with a first episode of psychosis: effects of antipsychotic drugsBenedicto Crespo-Facorro
University Hospital Marques de Valdecilla, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
Psychiatry Res 158:206-16. 2008..Thus, patients with a first episode of psychosis have inflammatory-like immunological function during early phases of the illness that it is independent of the antipsychotic treatment used... - Predicting relapse after a first episode of non-affective psychosis: a three-year follow-up studyOlalla Caseiro
Marques de Valdecilla University Hospital, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
J Psychiatr Res 46:1099-105. 2012..A better understanding and improvement in factors which influence relapse should diminish the risk of relapse and consequently improve the outcome of the illness... - Attenuation of antipsychotic-induced weight gain with early behavioral intervention in drug-naive first-episode psychosis patients: A randomized controlled trialMario Alvarez-Jimenez
University Hospital Marqués de Valdecilla Clinical and Social Psychiatry Research Unit, Department of Psychiatry, Santander, Spain
J Clin Psychiatry 67:1253-60. 2006.... - Prefrontal cognitive functions in stabilized first-episode patients with schizophrenia spectrum disorders: a dissociation between dorsolateral and orbitofrontal functioningJose Manuel Rodríguez-Sánchez
Hospital Universitario Marques de Valdecilla, Department of Psychiatry, School of Medicine, University of Cantabria, Planta 2 a, Edificio 2 de Noviembre Avda Valdecilla s n, 39008 Santander, Spain
Schizophr Res 77:279-88. 2005..The OFC functions are unimpaired at the early phases of psychosis and in contrast there is a significant deficit in DLPFC functions in first-episode of schizophrenia... - One year longitudinal study of the straight gyrus morphometry in first-episode schizophrenia-spectrum patientsRoberto Roiz-Santiáñez
Department of Psychiatry, University of Cantabria, Santander, Spain
Psychiatry Res 202:80-3. 2012..We did not find a differential pattern of volumetric change between the two groups... - Catechol-O-Methyltransferase (COMT) Val158Met variations and cannabis use in first-episode non-affective psychosis: clinical-onset implicationsJose Maria Pelayo-Teran
Department of Psychiatry, University Hospital Marques de Valdecilla, School of Medicine, University of Cantabria, Santander, Spain
Psychiatry Res 179:291-6. 2010..Based on these results, the use of cannabis could exert a modulator effect on the genotype, suppressing the delay effect for the age of onset in the case of the Met allele patients... - Cannabis use and cognitive functioning in first-episode schizophrenia patientsJose Manuel Rodríguez-Sánchez
Department of Psychiatry, CIBERSAM, University Hospital Marques de Valdecilla, IFIMAV, Santander, Spain
Schizophr Res 124:142-51. 2010..Cannabis user patients appear to comprise a subgroup of patients with a better premorbid adjustment and premorbid frontal cognitive functions... - Straight gyrus morphology in first-episode schizophrenia-spectrum patientsRoberto Roiz-Santiáñez
Department of Psychiatry, School of Medicine, University of Cantabria, University Hospital Marques de Valdecilla, IFIMAV, Santander, Spain
Prog Neuropsychopharmacol Biol Psychiatry 35:84-90. 2011..Our results, based on a large and representative sample, do not confirm the presence of significant straight gyrus morphometric anomalies in schizophrenia-spectrum disorders, after controlling for potential confounding variables... - Relapse prevention and remission attainment in first-episode non-affective psychosis. A randomized, controlled 1-year follow-up comparison of haloperidol, risperidone and olanzapineBenedicto Crespo-Facorro
Department of Psychiatry, University of Cantabria IFIMAV, Santander 39008, Spain
J Psychiatr Res 45:763-9. 2011..We conclude that haloperidol, olanzapine and risperidone show a similar effectiveness in relapse prevention or in remission attainment during the first year of treatment... - White matter integrity and cognitive impairment in first-episode psychosisRocio Perez-Iglesias
Department of Psychiatry, Marques de Valdecilla University Hospital, Spain
Am J Psychiatry 167:451-8. 2010..However, a significant proportion of patients do not show any cognitive deficits. The aim of this study was to assess if there were differences in white matter integrity between patients with and without cognitive impairment... - Additive effect of NRG1 and DISC1 genes on lateral ventricle enlargement in first episode schizophreniaIgnacio Mata
Department of Psychiatry, University Hospital Marques de Valdecilla, School of Medicine, University of Cantabria, Santander, Spain, CIBERSAM
Neuroimage 53:1016-22. 2010..Our findings suggest that NRG1 and DISC1 genes may be associated with brain abnormalities in schizophrenia through their influence on related pathways of brain development... - Glucose and lipid disturbances after 1 year of antipsychotic treatment in a drug-naïve populationRocio Perez-Iglesias
Department of Psychiatry, Marques de Valdecilla University Hospital, Avda Valdecilla s n, 39008, University of Cantabria, Spain
Schizophr Res 107:115-21. 2009..This study examined the main metabolic side effects induced by antipsychotic treatment in a cohort of first episode drug-naïve subjects after the first year of treatment... - Neurocognitive effectiveness of haloperidol, risperidone, and olanzapine in first-episode psychosis: a randomized, controlled 1-year follow-up comparisonBenedicto Crespo-Facorro
Department of Psychiatry, CIBERSAM, School of Medicine, University Hospital Marques de Valdecilla, University of Cantabria, Santander, Spain
J Clin Psychiatry 70:717-29. 2009..To investigate the neurocognitive effectiveness of haloperidol, risperidone, and olanzapine in first-episode schizophrenia-spectrum disorders... - Homocysteine and cognition in first-episode psychosis patientsRosa Ayesa-Arriola
Department of Psychiatry, Marques de Valdecilla University Hospital, IFIMAV, School of Medicine, University of Cantabria, Santander, Spain
Eur Arch Psychiatry Clin Neurosci 262:557-64. 2012..However, no relationship between homocysteine levels and cognitive impairment was detected. These results suggest the need for further studies to clarify the role of homocysteine in the etiology and prognosis of psychosis... - Serotonin transporter polymorphisms and early response to antipsychotic treatment in first episode of psychosisJavier Vázquez-Bourgon
Department of Psychiatry, University Hospital Marques de Valdecilla, School of Medicine, University of Cantabria, Santander, Spain
Psychiatry Res 175:189-94. 2010..Our results suggest a minor contribution to antipsychotic drug response of genetic alterations in the 5-HTT gene... - Insular cortex morphometry in first-episode schizophrenia-spectrum patients: Diagnostic specificity and clinical correlationsBenedicto Crespo-Facorro
University Hospital Marques de Valdecilla, CIBERSAM, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
J Psychiatr Res 44:314-20. 2010..Contrary to our initial hypotheses, we were unable to demonstrate significant morphometric anomalies in a large and heterogeneous sample of patients with a first-episode of schizophrenia-spectrum disorders... - Effect of antipsychotic drugs on brain morphometry. A randomized controlled one-year follow-up study of haloperidol, risperidone and olanzapineBenedicto Crespo-Facorro
University Hospital Marques de Valdecilla, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
Prog Neuropsychopharmacol Biol Psychiatry 32:1936-43. 2008..Here we investigate the effects of risperidone, olanzapine and low doses of haloperidol on cortical and subcortical morphometry in first episode drug naïve patients with non-affective psychosis... - Long-term (3-year) effectiveness of haloperidol, risperidone and olanzapine: results of a randomized, flexible-dose, open-label comparison in first-episode nonaffective psychosisBenedicto Crespo-Facorro
University Hospital Marques de Valdecilla, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Planta 2ª, Edificio 2 de Noviembre Avda Valdecilla s n, 39008 Santander, Spain
Psychopharmacology (Berl) 219:225-33. 2012..To enhance the effectiveness of antipsychotics in first-episode psychosis is crucial in order to achieve the most favourable prognosis. Difference in effectiveness between antipsychotics is still under debate... - Sex-specific variation of MRI-based cortical morphometry in adult healthy volunteers: the effect on cognitive functioningBenedicto Crespo-Facorro
University Hospital Marques de Valdecilla, CIBERSAM, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
Prog Neuropsychopharmacol Biol Psychiatry 35:616-23. 2011..In conclusion, our findings do not support the notion of sexual dimorphism in cortical mantle morphology. The results also suggest that variability in cortical thickness may affect cognitive functioning in females but not in males... - Temporal pole morphology in first-episode schizophrenia patients: clinical correlationsRoberto Roiz-Santiáñez
University Hospital Marques de Valdecilla, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
Psychiatry Res 184:189-91. 2010..Patients did not significantly differ from controls in the TP morphometric variables evaluated. Clinical variables were not significantly related to the TP... - Epidemiological factors associated with treated incidence of first-episode non-affective psychosis in Cantabria: insights from the Clinical Programme on Early Phases of PsychosisJose M Pelayo-Teran
Department of Psychiatry, University Hospital Marques de Valdecilla, School of Medicine, University of Cantabria, Santander, Spain
Early Interv Psychiatry 2:178-87. 2008..The aim of the study was to analyse the treated incidence of schizophrenia in Cantabria (Northern Spain) and the sociodemographic risk factors associated with the illness onset... - Gyrification brain abnormalities associated with adolescence and early-adulthood cannabis useIgnacio Mata
Department of Psychiatry, University Hospital Marques de Valdecilla, School of Medicine, University of Cantabria, IFIMAV, Santander, Spain
Brain Res 1317:297-304. 2010.... - Catechol-O-methyltransferase Val158Met polymorphism and clinical characteristics in first episode non-affective psychosisJose Maria Pelayo-Teran
Department of Psychiatry, University Hospital Marques de Valdecilla, School of Medicine, University of Cantabria, Santander, Spain
Am J Med Genet B Neuropsychiatr Genet 147:550-6. 2008..These data would indicate that COMT genotype may have a role in the etiological model for schizophrenia and other psychotic disorders... - 1-year follow-up study of cognitive function in first-episode non-affective psychosisJosé M Rodríguez-Sánchez
University Hospital Marques de Valdecilla, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
Schizophr Res 104:165-74. 2008..Further investigations are warranted to discern the variability in patterns of specific cognitive deficits over time... - A neuregulin 1 variant is associated with increased lateral ventricle volume in patients with first-episode schizophreniaIgnacio Mata
Department of Psychiatry, School of Medicine, University of Cantabria, University Hospital Marques de Valdecilla, CIBERSAM, Santander, Spain
Biol Psychiatry 65:535-40. 2009..We examined whether variations in this polymorphism influence brain volumes in first-episode schizophrenia subjects... - Prediction of acute clinical response following a first episode of non affective psychosis: Results of a cohort of 375 patients from the Spanish PAFIP studyBenedicto Crespo-Facorro
University Hospital Marques de Valdecilla, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain CIBERSAM, Centro Investigación Biomédica en Red Salud Mental, Madrid, Spain Electronic address
Prog Neuropsychopharmacol Biol Psychiatry 44:162-7. 2013..We aimed to investigate sociodemographic, premorbid and clinical predictors of response to antipsychotic treatment after a first episode of non-affective psychosis... - Predictors of neurocognitive impairment at 3 years after a first episode non-affective psychosisRosa Ayesa-Arriola
Department of Psychiatry, Marques de Valdecilla University Hospital, IFIMAV, School of Medicine, University of Cantabria, Santander, Spain
Prog Neuropsychopharmacol Biol Psychiatry 43:23-8. 2013..However, patients show great variability in the level and course of deficits. The goal of the present longitudinal study was to identify predictors of neurocognitive impairment in first episode psychosis patients... - Aripiprazole, ziprasidone, and quetiapine in the treatment of first-episode nonaffective psychosis: results of a 6-week, randomized, flexible-dose, open-label comparisonBenedicto Crespo-Facorro
University Hospital Marques de Valdecilla, IFIMAV, Department of Psychiatry, School of Medicine, University of Cantabria, Santander, Spain
J Clin Psychopharmacol 33:215-20. 2013..Differences in effectiveness between second-generation antipsychotics would determine their position in everyday clinical practice and could help physicians choose the more efficacious antipsychotics... - Treatment of the first episode of schizophrenia: an update on pharmacologic and psychological interventionsBenedicto Crespo-Facorro
Department of Psychiatry, Hospital Universitario Marques de Valdecilla, Avda Valdecilla s n 39008, Santander, Spain
Curr Psychiatry Rep 10:202-9. 2008..Cognitive-behavioral therapy and family interventions seem to be effective adjunctive treatments in early phases of schizophrenia in some patients... - A 12-week randomized clinical trial to evaluate metabolic changes in drug-naive, first-episode psychosis patients treated with haloperidol, olanzapine, or risperidoneRocio Perez Iglesias
Department of Psychiatry, Marques de Valdecilla University Hospital, University of Cantabria, Santander, Spain
J Clin Psychiatry 68:1733-40. 2007..This study examined the main metabolic side effects induced by antipsychotic treatment in a cohort of first-episode drug-naive subjects... - Cognitive functioning in the early course of first-episode schizophrenia spectrum disorders: timing and patternsCesar Gonzalez-Blanch
Hospital Universitario Marques de Valdecilla, Department of Psychiatry, planta 2a, Edificio 2 de Noviembre, Avda Valdecilla s n, 39008, Santander, Spain
Eur Arch Psychiatry Clin Neurosci 256:364-71. 2006..The aim of this study was to examine possible cognitive changes throughout the early course of schizophrenia spectrum disorders... - Predictors of clinical remission following a first episode of non-affective psychosis: sociodemographics, premorbid and clinical variablesIgnacio Diaz
University Hospital La Fe, Department of Psychiatry, Valencia, Spain
Psychiatry Res 206:181-7. 2013.... - Long-term effect of haloperidol, olanzapine, and risperidone on plasma prolactin levels in patients with first-episode psychosisRocio Perez-Iglesias
Department of Psychiatry, Marques de Valdecilla University Hospital, University of Cantabria, Spain
J Clin Psychopharmacol 32:804-8. 2012..The main goal of this study was to assess the long-term effect of haloperidol, olanzapine, and risperidone on serum prolactin levels in a naturalistically treated first-episode psychosis population...