Sonia Pascual

Summary

Country: Spain

Publications

  1. ncbi request reprint Comparison of staging systems to predict survival in hepatocellular carcinoma
    Sonia Pascual
    Liver Unit, Hospital General Universitario de Alicante, Alicante, Spain
    Liver Int 26:673-9. 2006
  2. doi request reprint Usefulness of surveillance programmes for early diagnosis of hepatocellular carcinoma in clinical practice
    Sonia Pascual
    Liver Unit, Hospital General Universitario de Alicante, Alicante, Spain
    Liver Int 28:682-9. 2008
  3. ncbi request reprint [Etiology of upper gastrointestinal bleeding of peptic origin: role of Helicobacter pylori and NSAIDs]
    S Pascual
    Unidad Hepática Servicio de Medicina Interna Hospital General Universitario Alicante Spain
    Gastroenterol Hepatol 26:630-4. 2003
  4. ncbi request reprint Intestinal permeability is increased in patients with advanced cirrhosis
    Sonia Pascual
    Liver Unit, Department of Internal Medicine, University General Hospital of Alicante C Pintor Baeza s n, Alicante 03010, Spain
    Hepatogastroenterology 50:1482-6. 2003
  5. doi request reprint Proteomic evidence of bacterial peptide translocation in afebrile patients with cirrhosis and ascites
    Rocío Caño
    Unidad Hepática, Hospital General Universitario, Avda Pintor Baeza 12, 03010, Alicante, Spain
    J Mol Med (Berl) 88:487-95. 2010
  6. doi request reprint Serum and ascitic fluid bacterial DNA: a new independent prognostic factor in noninfected patients with cirrhosis
    Pedro Zapater
    Unidad Hepática, Hospital General Universitario de Alicante, Universidad Miguel Hernandez, Elche, Alicante, Spain
    Hepatology 48:1924-31. 2008
  7. doi request reprint Norfloxacin modulates the inflammatory response and directly affects neutrophils in patients with decompensated cirrhosis
    Pedro Zapater
    Sección de Farmacología Clínica, Hospital General Universitario, Alicante, and Universidad Miguel Hernandez, Elche, Spain
    Gastroenterology 137:1669-79.e1. 2009
  8. doi request reprint Acute and chronic hemodynamic changes after propranolol in patients with cirrhosis under primary and secondary prophylaxis of variceal bleeding: a pilot study
    Enrique de-Madaria
    Unidad Hepática, Hospital General Universitario de Alicante, Alicante, Spain
    Eur J Gastroenterol Hepatol 22:507-12. 2010
  9. doi request reprint Interleukin-10-mediated heme oxygenase 1-induced underlying mechanism in inflammatory down-regulation by norfloxacin in cirrhosis
    Isabel Gómez-Hurtado
    Hepatic Unit and Clinical Pharmacology Service, Hospital General Universitario de Alicante, Universidad Miguel Hernandez, Elche, Alicante, Spain
    Hepatology 53:935-44. 2011
  10. ncbi request reprint The detection of bacterial DNA in blood of rats with CCl4-induced cirrhosis with ascites represents episodes of bacterial translocation
    Carlos Guarner
    Liver Section, Escuela de Patologia Digestiva, Hospital de la Sta Creu i St Pau, Barcelona, and Liver Unit, Hospital General Universitario, Alicante, Spain
    Hepatology 44:633-9. 2006

Collaborators

Detail Information

Publications27

  1. ncbi request reprint Comparison of staging systems to predict survival in hepatocellular carcinoma
    Sonia Pascual
    Liver Unit, Hospital General Universitario de Alicante, Alicante, Spain
    Liver Int 26:673-9. 2006
    ..Some new staging systems in hepatocellular carcinoma (HCC) have been described in the last years. The aim of this study was to compare the survival-predicting capacity of some variables and the prognostic classifications...
  2. doi request reprint Usefulness of surveillance programmes for early diagnosis of hepatocellular carcinoma in clinical practice
    Sonia Pascual
    Liver Unit, Hospital General Universitario de Alicante, Alicante, Spain
    Liver Int 28:682-9. 2008
    ..The aims of this study have been to compare the survival of patients with HCC being diagnosed or not in SPs, and to establish a more accurate profile of the best target population...
  3. ncbi request reprint [Etiology of upper gastrointestinal bleeding of peptic origin: role of Helicobacter pylori and NSAIDs]
    S Pascual
    Unidad Hepática Servicio de Medicina Interna Hospital General Universitario Alicante Spain
    Gastroenterol Hepatol 26:630-4. 2003
    ..Upper gastrointestinal bleeding continues to be a severe and frequent complication in ulcerative disease. Etiologic diagnosis in these patients is highly important in order to initiate appropriate treatment and prevent bleeding recurrence...
  4. ncbi request reprint Intestinal permeability is increased in patients with advanced cirrhosis
    Sonia Pascual
    Liver Unit, Department of Internal Medicine, University General Hospital of Alicante C Pintor Baeza s n, Alicante 03010, Spain
    Hepatogastroenterology 50:1482-6. 2003
    ..The aim of this study was to investigate if the alterations of the intestinal barrier in cirrhosis are related with the degree of liver failure and associated with other clinical complications...
  5. doi request reprint Proteomic evidence of bacterial peptide translocation in afebrile patients with cirrhosis and ascites
    Rocío Caño
    Unidad Hepática, Hospital General Universitario, Avda Pintor Baeza 12, 03010, Alicante, Spain
    J Mol Med (Berl) 88:487-95. 2010
    ..Bacterial peptide translocation is present in the ascitic fluid of a subgroup of patients with advanced cirrhosis and is associated with an increased immune response...
  6. doi request reprint Serum and ascitic fluid bacterial DNA: a new independent prognostic factor in noninfected patients with cirrhosis
    Pedro Zapater
    Unidad Hepática, Hospital General Universitario de Alicante, Universidad Miguel Hernandez, Elche, Alicante, Spain
    Hepatology 48:1924-31. 2008
    ..This fact may be related to the development of acute-on-chronic liver failure at short term and does not predict the development of spontaneous bacterial peritonitis...
  7. doi request reprint Norfloxacin modulates the inflammatory response and directly affects neutrophils in patients with decompensated cirrhosis
    Pedro Zapater
    Sección de Farmacología Clínica, Hospital General Universitario, Alicante, and Universidad Miguel Hernandez, Elche, Spain
    Gastroenterology 137:1669-79.e1. 2009
    ..Patients with cirrhosis undergoing selective intestinal decontamination with norfloxacin show a reduction in serum cytokine levels, probably because of a combined effect of norfloxacin on bowel flora and neutrophils...
  8. doi request reprint Acute and chronic hemodynamic changes after propranolol in patients with cirrhosis under primary and secondary prophylaxis of variceal bleeding: a pilot study
    Enrique de-Madaria
    Unidad Hepática, Hospital General Universitario de Alicante, Alicante, Spain
    Eur J Gastroenterol Hepatol 22:507-12. 2010
    ..Our aim was to determine whether the response of the hepatic venous pressure gradient (HVPG) to the intravenous administration of propranolol predicts the response after chronic oral propranolol treatment...
  9. doi request reprint Interleukin-10-mediated heme oxygenase 1-induced underlying mechanism in inflammatory down-regulation by norfloxacin in cirrhosis
    Isabel Gómez-Hurtado
    Hepatic Unit and Clinical Pharmacology Service, Hospital General Universitario de Alicante, Universidad Miguel Hernandez, Elche, Alicante, Spain
    Hepatology 53:935-44. 2011
    ..Unblocking IL-10 restored proinflammatory mediator and HO-1 expression to previously observed levels in response to LPS stimulation...
  10. ncbi request reprint The detection of bacterial DNA in blood of rats with CCl4-induced cirrhosis with ascites represents episodes of bacterial translocation
    Carlos Guarner
    Liver Section, Escuela de Patologia Digestiva, Hospital de la Sta Creu i St Pau, Barcelona, and Liver Unit, Hospital General Universitario, Alicante, Spain
    Hepatology 44:633-9. 2006
    ..In conclusion, the presence of bactDNA in biological fluids in rats with cirrhosis constitutes a marker of BT, and it is associated with a marked inflammatory response, independent of the result of the culture...
  11. ncbi request reprint Clinical significance of extrapyramidal signs in patients with cirrhosis
    Rodrigo Jover
    Department of Gastroenterology Liver Unit, Hospital General Universitario de Alicante, C Pintor Baeza, sn, E 03010 Alicante, Spain
    J Hepatol 42:659-65. 2005
    ..The aims of this study have been to investigate the relationship between extrapyramidal signs and cognitive impairment, and what is their influence on quality of life...
  12. ncbi request reprint Comparison of stool immunoassay with standard methods for detection of Helicobacter pylori infection in patients with upper-gastrointestinal bleeding of peptic origin
    Pilar Griñó
    Gastroenterology Unit, Department of Internal Medicine, University General Hospital, Miguel Hernandez University, Alicante, Spain
    Eur J Gastroenterol Hepatol 15:525-9. 2003
    ....
  13. ncbi request reprint A sequential study of serum bacterial DNA in patients with advanced cirrhosis and ascites
    Rubén Francés
    Unidad Hepática Sección de Inmunología, Alicante, Spain
    Hepatology 39:484-91. 2004
    ..In conclusion, bacterial translocation is a single-species, dynamic process that appears to develop in a subgroup of patients with advanced cirrhosis...
  14. ncbi request reprint Comparison of diagnostic methods for Helicobacter pylori infection in patients with upper gastrointestinal bleeding
    P Grino
    Dept of Internal Medicine, University General Hospital, Universidad Miguel Hernandez, Alicante, Spain
    Scand J Gastroenterol 36:1254-8. 2001
    ..Accuracy of the most frequently used tests for diagnosing Helicobacter pylori infection in patients with upper gastrointestinal bleeding of peptic origin is determined...
  15. doi request reprint Causality assessment of liver injury after chronic oral amiodarone intake
    Lucía Llanos
    Clinical Pharmacology Section, University General Hospital, Alicante, Spain
    Pharmacoepidemiol Drug Saf 18:291-300. 2009
    ..As clinically significant hepatotoxicity associated with oral amiodarone is infrequent and difficult to predict, a new Bayesian-developed model is proposed to help in the causality assessment of amiodarone-induced liver injury...
  16. ncbi request reprint Ultrastructural characteristics of distal duodenum mucosa in patients with cirrhosis
    Jose Such
    Liver Unit, University General Hospital of Alicante, Miguel Hernandez University, 03010 Alicante, Spain
    Eur J Gastroenterol Hepatol 14:371-6. 2002
    ..The aim of this observational study was to investigate the ultrastructural characteristics of the intestinal epithelial layer of duodenum mucosa in patients with cirrhosis...
  17. ncbi request reprint Randomized trial comparing albumin and saline in the prevention of paracentesis-induced circulatory dysfunction in cirrhotic patients with ascites
    Javier Sola-Vera
    Liver Unit, Internal Medicine Department, Hospital General Universitario de Alicante, Spain
    Hepatology 37:1147-53. 2003
    ..01] without significant variations after albumin). In conclusion, albumin is more effective than saline in the prevention of PICD. Saline is a valid alternative to albumin when less than 6 L of ascitic fluid is evacuated...
  18. ncbi request reprint Detection and identification of bacterial DNA in patients with cirrhosis and culture-negative, nonneutrocytic ascites
    Jose Such
    Unidad Hepática, Hospital General Universitario, Universidad Miguel Hernandez, Campus de San Juan, San Juan de Alicante, c Pintor Baeza s n, 03010 Alicante, Spain
    Hepatology 36:135-41. 2002
    ..In conclusion, we have detected bactDNA in serum and AF in 32% of all patients studied, and this likely represents single clone episodes of translocation and systemic seeding. E. coli is the most frequently identified bacteria...
  19. ncbi request reprint Assessing the short- and long-term prognosis of patients with cirrhosis and acute variceal bleeding
    L Sempere
    Epidemiology Service, Hospital General Universitario, Alicante, Spain
    Rev Esp Enferm Dig 101:236-48. 2009
    ..to evaluate the efficacy of various indicators in predicting short- and long-term survival in patients with cirrhosis and acute variceal bleeding...
  20. ncbi request reprint A comparison of two different dosages of somatostatin combined with sclerotherapy for the treatment of acute esophageal variceal bleeding: a prospective randomized trial
    J M Palazon
    Liver Unit, Hospital General Universitario, Alicante, Spain
    Rev Esp Enferm Dig 98:249-54. 2006
    ....
  21. ncbi request reprint Pharmacokinetic variations of acetaminophen according to liver dysfunction and portal hypertension status
    P Zapater
    Unidad de Farmacología Clínica, Hospital General Universitario, y Departamento de Farmacología y Terapéutica, Facultad de Medicina, Universidad Miguel Hernandez, San Juan de Alicante, Spain
    Aliment Pharmacol Ther 20:29-36. 2004
    ..To study the pharmacokinetic and metabolism profiles of a single dose of acetaminophen in patients with cirrhosis...
  22. doi request reprint Occupational exposures and risk of oesophageal cancer by histological type: a case-control study in eastern Spain
    M Santibanez
    Occupational Health Unit, Public Health Center, Elche, Alicante, Spain
    Occup Environ Med 65:774-81. 2008
    ..To explore the relationship between occupations and specific occupational exposures and oesophageal cancer (OC) by histological type...
  23. pmc Bacterial DNA activates cell mediated immune response and nitric oxide overproduction in peritoneal macrophages from patients with cirrhosis and ascites
    R Frances
    Department of Immunology, Hospital General Universitario, Pintor Baeza s n, Alicante, Spain
    Gut 53:860-4. 2004
    ....
  24. pmc Translocation of bacterial DNA from Gram-positive microorganisms is associated with a species-specific inflammatory response in serum and ascitic fluid of patients with cirrhosis
    R Frances
    CIBERehd, Instituto de Salud Carlos III, Madrid, Spain, and Liver Unit, Hospital General Universitario, Alicante, Spain
    Clin Exp Immunol 150:230-7. 2007
    ..Therefore, the host's immune response to bacterial-DNA translocation constitutes a species-specific phenomenon...
  25. doi request reprint Bacterial DNA in patients with cirrhosis and noninfected ascites mimics the soluble immune response established in patients with spontaneous bacterial peritonitis
    Rubén Francés
    CIBERehd, Instituto de Salud Carlos III, Madrid, Spain
    Hepatology 47:978-85. 2008
    ..Norfloxacin abrogates bactDNA translocation and cytokine response...
  26. ncbi request reprint Presence of bacterial-DNA in cirrhosis identifies a subgroup of patients with marked inflammatory response not related to endotoxin
    Jose M Gonzalez-Navajas
    CIBERehd, Instituto de Salud Carlos III, Madrid, Spain
    J Hepatol 48:61-7. 2008
    ....
  27. ncbi request reprint Bacterial DNA induces the complement system activation in serum and ascitic fluid from patients with advanced cirrhosis
    Rubén Francés
    CIBERehd, Instituto de Salud Carlos III, Madrid, Spain
    J Clin Immunol 27:438-44. 2007
    ....