X Pares

Summary

Country: Spain

Publications

  1. pmc Medium- and short-chain dehydrogenase/reductase gene and protein families : Medium-chain and short-chain dehydrogenases/reductases in retinoid metabolism
    X Pares
    Department of Biochemistry and Molecular Biology, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Cell Mol Life Sci 65:3936-49. 2008
  2. ncbi request reprint Characterization and functional role of Saccharomyces cerevisiae 2,3-butanediol dehydrogenase
    E Gonzalez
    Department of Biochemistry and Molecular Biology, Faculty of Sciences, Universitat Autonoma de Barcelona, E 08193 Bellaterra, Barcelona, Spain
    Chem Biol Interact 130:425-34. 2001
  3. ncbi request reprint Molecular basis for differential substrate specificity in class IV alcohol dehydrogenases: a conserved function in retinoid metabolism but not in ethanol oxidation
    B Crosas
    Department of Biochemistry and Molecular Biology, Universitat Autonoma de Barcelona, Bellaterra, Spain
    J Biol Chem 275:25180-7. 2000
  4. ncbi request reprint A vertebrate aldo-keto reductase active with retinoids and ethanol
    B Crosas
    Department of Biochemistry and Molecular Biology, Universitat Autonoma de Barcelona, E 08193 Bellaterra, Barcelona, Spain
    J Biol Chem 276:19132-40. 2001
  5. ncbi request reprint S-nitrosoglutathione reductase activity of human and yeast glutathione-dependent formaldehyde dehydrogenase and its nuclear and cytoplasmic localisation
    M R Fernandez
    Department of Biochemistry and Molecular Biology, Faculty of Sciences, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Cell Mol Life Sci 60:1013-8. 2003
  6. ncbi request reprint Retinoids, omega-hydroxyfatty acids and cytotoxic aldehydes as physiological substrates, and H2-receptor antagonists as pharmacological inhibitors, of human class IV alcohol dehydrogenase
    A Allali-Hassani
    Department of Biochemistry and Molecular Biology, Universitat Autonoma de Barcelona, Bellaterra, Spain
    FEBS Lett 426:362-6. 1998
  7. ncbi request reprint Distribution of alcohol dehydrogenase mRNA in the rat central nervous system. Consequences for brain ethanol and retinoid metabolism
    S E Martinez
    Department of Biochemistry and Molecular Biology, Universitat Autonoma de Barcelona, E 08193 Bellaterra Barcelona, Spain
    Eur J Biochem 268:5045-56. 2001
  8. ncbi request reprint Characterization of a (2R,3R)-2,3-butanediol dehydrogenase as the Saccharomyces cerevisiae YAL060W gene product. Disruption and induction of the gene
    E Gonzalez
    Department of Biochemistry and Molecular Biology, Faculty of Sciences, Universitat Autonoma de Barcelona, E 08193 Bellaterra Barcelona, and Spain
    J Biol Chem 275:35876-85. 2000
  9. ncbi request reprint Arabidopsis formaldehyde dehydrogenase. Molecular properties of plant class III alcohol dehydrogenase provide further insights into the origins, structure and function of plant class p and liver class I alcohol dehydrogenases
    M C Martinez
    Department of Biochemistry and Molecular Biology, Universitat Autonoma de Barcelona, Spain
    Eur J Biochem 241:849-57. 1996
  10. ncbi request reprint Human and yeast zeta-crystallins bind AU-rich elements in RNA
    M R Fernandez
    Department of Biochemistry and Molecular Biology, Faculty of Biosciences, Universitat Autonoma de Barcelona, Bellaterra, Barcelona, Spain
    Cell Mol Life Sci 64:1419-27. 2007

Collaborators

Detail Information

Publications12

  1. pmc Medium- and short-chain dehydrogenase/reductase gene and protein families : Medium-chain and short-chain dehydrogenases/reductases in retinoid metabolism
    X Pares
    Department of Biochemistry and Molecular Biology, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Cell Mol Life Sci 65:3936-49. 2008
    ..The large number of enzymes involved in the two directions of this step, also including aldo-keto reductases, suggests that retinaldehyde levels are strictly regulated...
  2. ncbi request reprint Characterization and functional role of Saccharomyces cerevisiae 2,3-butanediol dehydrogenase
    E Gonzalez
    Department of Biochemistry and Molecular Biology, Faculty of Sciences, Universitat Autonoma de Barcelona, E 08193 Bellaterra, Barcelona, Spain
    Chem Biol Interact 130:425-34. 2001
    ..This suggests that other enzymes, in addition to BDH, can also metabolize 2,3-butanediol in yeast...
  3. ncbi request reprint Molecular basis for differential substrate specificity in class IV alcohol dehydrogenases: a conserved function in retinoid metabolism but not in ethanol oxidation
    B Crosas
    Department of Biochemistry and Molecular Biology, Universitat Autonoma de Barcelona, Bellaterra, Spain
    J Biol Chem 275:25180-7. 2000
    ..In contrast, the kinetics toward retinoids was only slightly affected by the mutations at position 294, compatible with a more conserved function of mammalian class IV alcohol dehydrogenase in retinoid metabolism...
  4. ncbi request reprint A vertebrate aldo-keto reductase active with retinoids and ethanol
    B Crosas
    Department of Biochemistry and Molecular Biology, Universitat Autonoma de Barcelona, E 08193 Bellaterra, Barcelona, Spain
    J Biol Chem 276:19132-40. 2001
    ....
  5. ncbi request reprint S-nitrosoglutathione reductase activity of human and yeast glutathione-dependent formaldehyde dehydrogenase and its nuclear and cytoplasmic localisation
    M R Fernandez
    Department of Biochemistry and Molecular Biology, Faculty of Sciences, Universitat Autonoma de Barcelona, 08193 Bellaterra, Barcelona, Spain
    Cell Mol Life Sci 60:1013-8. 2003
    ..This agrees with previous results in rat, and suggests a role in the regulation of GSNO levels in the cytoplasmic and nuclear compartments of the eukaryotic cell...
  6. ncbi request reprint Retinoids, omega-hydroxyfatty acids and cytotoxic aldehydes as physiological substrates, and H2-receptor antagonists as pharmacological inhibitors, of human class IV alcohol dehydrogenase
    A Allali-Hassani
    Department of Biochemistry and Molecular Biology, Universitat Autonoma de Barcelona, Bellaterra, Spain
    FEBS Lett 426:362-6. 1998
    ..H2-receptor antagonists are poor inhibitors of human and rat classes I and IV (Ki > 0.3 mM) suggesting a small interference in ethanol metabolism at the pharmacological doses of these common drugs...
  7. ncbi request reprint Distribution of alcohol dehydrogenase mRNA in the rat central nervous system. Consequences for brain ethanol and retinoid metabolism
    S E Martinez
    Department of Biochemistry and Molecular Biology, Universitat Autonoma de Barcelona, E 08193 Bellaterra Barcelona, Spain
    Eur J Biochem 268:5045-56. 2001
    ..The impairment of retinol oxidation by competitive inhibition of ADH in the presence of ethanol may be an additional origin of CNS abnormalities caused by ethanol...
  8. ncbi request reprint Characterization of a (2R,3R)-2,3-butanediol dehydrogenase as the Saccharomyces cerevisiae YAL060W gene product. Disruption and induction of the gene
    E Gonzalez
    Department of Biochemistry and Molecular Biology, Faculty of Sciences, Universitat Autonoma de Barcelona, E 08193 Bellaterra Barcelona, and Spain
    J Biol Chem 275:35876-85. 2000
    ..The corresponding enzyme is the first eukaryotic (2R, 3R)-2,3-butanediol dehydrogenase characterized of the medium-chain dehydrogenase/reductase family...
  9. ncbi request reprint Arabidopsis formaldehyde dehydrogenase. Molecular properties of plant class III alcohol dehydrogenase provide further insights into the origins, structure and function of plant class p and liver class I alcohol dehydrogenases
    M C Martinez
    Department of Biochemistry and Molecular Biology, Universitat Autonoma de Barcelona, Spain
    Eur J Biochem 241:849-57. 1996
    ..A sequence motif, Pro-Xaa-Ile/Val-Xaa-Gly-His-Glu-Xaa-Xaa-Gly, common to all medium-chain alcohol dehydrogenases is defined...
  10. ncbi request reprint Human and yeast zeta-crystallins bind AU-rich elements in RNA
    M R Fernandez
    Department of Biochemistry and Molecular Biology, Faculty of Biosciences, Universitat Autonoma de Barcelona, Bellaterra, Barcelona, Spain
    Cell Mol Life Sci 64:1419-27. 2007
    ..This supports a role for zeta-crystallins as trans-acting factors that could regulate the turnover of certain mRNAs...
  11. ncbi request reprint Genetic polymorphism of alcohol dehydrogenase in europeans: the ADH2*2 allele decreases the risk for alcoholism and is associated with ADH3*1
    E Borras
    Department of Biochemistry and Molecular Biology, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Hepatology 31:984-9. 2000
    ..In conclusion, the ADH2*2 allele decreases the risk for alcoholism, whereas the ADH2*2 and ADH3*1 alleles are found to be associated in the European population...
  12. ncbi request reprint Alcohol dehydrogenase of class IV (sigma sigma-ADH) from human stomach. cDNA sequence and structure/function relationships
    J Farres
    Department of Biochemistry and Molecular Biology, Faculty of Sciences, Universitat Autonoma de Barcelona, Spain
    Eur J Biochem 224:549-57. 1994
    ..An important change at position 294, with Val in human and Ala in rat class IV, is probably responsible for the dramatic difference in Km values for ethanol between human (37 mM) and rat (2.4 M) class IV enzymes...