J M Paramio

Summary

Country: Spain

Publications

  1. ncbi request reprint Keratin intermediate filament dynamics in cell heterokaryons reveals diverse behaviour of different keratins
    J M Paramio
    Department of Cell and Molecular Biology, CIEMAT, Madrid, Spain
    J Cell Sci 110:1099-111. 1997
  2. ncbi request reprint A role for phosphorylation in the dynamics of keratin intermediate filaments
    J M Paramio
    Cell and Molecular Biology Program, CIEMAT IMA, Madrid, Spain
    Eur J Cell Biol 78:33-43. 1999
  3. ncbi request reprint Regulation of the differentiation-related gene Drg-1 during mouse skin carcinogenesis
    E Gomez-Casero
    Centro de Investigaciones Energeticas, Medioambientales y Tecnologicas, Department of Cell and Molecular Biology and Gene Therapy, Madrid, Spain
    Mol Carcinog 32:100-9. 2001
  4. ncbi request reprint Molecular determinants of Akt-induced keratinocyte transformation
    C Segrelles
    Department of Cell and Molecular Biology, CIEMAT, Madrid, Spain
    Oncogene 25:1174-85. 2006
  5. pmc Inhibition of protein kinase B (PKB) and PKCzeta mediates keratin K10-induced cell cycle arrest
    J M Paramio
    Project on Cell and Molecular Biology and Gene Therapy, CIEMAT, E 28040 Madrid, Spain
    Mol Cell Biol 21:7449-59. 2001
  6. doi request reprint E2F1 loss induces spontaneous tumour development in Rb-deficient epidermis
    C Costa
    Department of Basic Research, Molecular Oncology Unit, CIEMAT Ed 70A, Madrid, Spain
    Oncogene 32:2937-51. 2013
  7. doi request reprint The orphan receptor GPR55 drives skin carcinogenesis and is upregulated in human squamous cell carcinomas
    E Pérez-Gómez
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    Oncogene 32:2534-42. 2013
  8. ncbi request reprint Akt pathway as a target for therapeutic intervention in HNSCC
    M Moral
    Molecular Oncology Unit, Division of Biomedicine, CIEMAT, Madrid, Spain
    Histol Histopathol 23:1269-78. 2008
  9. ncbi request reprint The ink4a/arf tumor suppressors cooperate with p21cip1/waf in the processes of mouse epidermal differentiation, senescence, and carcinogenesis
    J M Paramio
    Cell, Molecular Biology, and Gene Therapy Project, CIEMAT, Avenida Complutense 22, E 28040 Madrid, Spain
    J Biol Chem 276:44203-11. 2001
  10. ncbi request reprint Opposite functions for E2F1 and E2F4 in human epidermal keratinocyte differentiation
    J M Paramio
    Program on Cell and Molecular Biology, Centro de Investigaciones Energeticas, Medioambigentales y Tecnologicas Edificio 7, Av Complutense 22, Madrid E 28040, Spain
    J Biol Chem 275:41219-26. 2000

Collaborators

  • M Guzman
  • C Sanchez
  • A Alonso
  • J Martinez
  • D Lane
  • M Serrano
  • M Moral
  • E Pérez-Gómez
  • C Costa
  • M Santos
  • R García-Escudero
  • C Segrelles
  • C Lorz
  • M Duenas
  • C Andradas
  • M Quintanilla
  • M Martinez-Fernandez
  • J M Flores
  • E Gomez-Casero
  • M Fernanda Lara
  • J Martinez-Palacio
  • H Leis
  • P Hernandez
  • C Ballestin
  • A B Martínez-Cruz
  • S Ruiz
  • R Fahraeus
  • M L Rodriguez-Puebla
  • M Navarro
  • C J Conti
  • J L Jorcano
  • F Larcher
  • S Lain
  • K L Ball

Detail Information

Publications12

  1. ncbi request reprint Keratin intermediate filament dynamics in cell heterokaryons reveals diverse behaviour of different keratins
    J M Paramio
    Department of Cell and Molecular Biology, CIEMAT, Madrid, Spain
    J Cell Sci 110:1099-111. 1997
    ..In summary, our results demonstrate that, following fusion, the keratin intermediate filament network reshapes rather rapidly and that keratins are highly dynamic proteins, although this mobility depends on each particular polypeptide...
  2. ncbi request reprint A role for phosphorylation in the dynamics of keratin intermediate filaments
    J M Paramio
    Cell and Molecular Biology Program, CIEMAT IMA, Madrid, Spain
    Eur J Cell Biol 78:33-43. 1999
    ..As a whole, present results indicate that the highly dynamic properties of the keratin polypeptides can be modulated by phosphorylation...
  3. ncbi request reprint Regulation of the differentiation-related gene Drg-1 during mouse skin carcinogenesis
    E Gomez-Casero
    Centro de Investigaciones Energeticas, Medioambientales y Tecnologicas, Department of Cell and Molecular Biology and Gene Therapy, Madrid, Spain
    Mol Carcinog 32:100-9. 2001
    ..These results suggest that, in addition to being upregulated during keratinocyte differentiation, the Drg-1 gene might have a complex function in skin tumorigenesis...
  4. ncbi request reprint Molecular determinants of Akt-induced keratinocyte transformation
    C Segrelles
    Department of Cell and Molecular Biology, CIEMAT, Madrid, Spain
    Oncogene 25:1174-85. 2006
    ..Collectively, these results demonstrate that Akt is able to transform keratinocytes by specific mechanisms involving transcriptional and post-transcriptional processes...
  5. pmc Inhibition of protein kinase B (PKB) and PKCzeta mediates keratin K10-induced cell cycle arrest
    J M Paramio
    Project on Cell and Molecular Biology and Gene Therapy, CIEMAT, E 28040 Madrid, Spain
    Mol Cell Biol 21:7449-59. 2001
    ..Together, these results suggest new and essential roles for the keratins as modulators of specific signal transduction pathways...
  6. doi request reprint E2F1 loss induces spontaneous tumour development in Rb-deficient epidermis
    C Costa
    Department of Basic Research, Molecular Oncology Unit, CIEMAT Ed 70A, Madrid, Spain
    Oncogene 32:2937-51. 2013
    ....
  7. doi request reprint The orphan receptor GPR55 drives skin carcinogenesis and is upregulated in human squamous cell carcinomas
    E Pérez-Gómez
    Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain
    Oncogene 32:2534-42. 2013
    ..Altogether, these findings reveal the pivotal importance of GPR55 in skin tumor development, and suggest that this receptor may be used as a new biomarker and therapeutic target in squamous cell carcinomas...
  8. ncbi request reprint Akt pathway as a target for therapeutic intervention in HNSCC
    M Moral
    Molecular Oncology Unit, Division of Biomedicine, CIEMAT, Madrid, Spain
    Histol Histopathol 23:1269-78. 2008
    ....
  9. ncbi request reprint The ink4a/arf tumor suppressors cooperate with p21cip1/waf in the processes of mouse epidermal differentiation, senescence, and carcinogenesis
    J M Paramio
    Cell, Molecular Biology, and Gene Therapy Project, CIEMAT, Avenida Complutense 22, E 28040 Madrid, Spain
    J Biol Chem 276:44203-11. 2001
    ..These results indicate that ink4a/arf and cip1/waf genes cooperate to allow normal keratinocyte differentiation and that the absence of both favors malignant transformation...
  10. ncbi request reprint Opposite functions for E2F1 and E2F4 in human epidermal keratinocyte differentiation
    J M Paramio
    Program on Cell and Molecular Biology, Centro de Investigaciones Energeticas, Medioambigentales y Tecnologicas Edificio 7, Av Complutense 22, Madrid E 28040, Spain
    J Biol Chem 275:41219-26. 2000
    ....
  11. ncbi request reprint Differential expression and functionally co-operative roles for the retinoblastoma family of proteins in epidermal differentiation
    J M Paramio
    Cell and Molecular Biology Program, CIEMAT, Madrid, Spain
    Oncogene 17:949-57. 1998
    ....
  12. ncbi request reprint Inhibition of pRb phosphorylation and cell-cycle progression by a 20-residue peptide derived from p16CDKN2/INK4A
    R Fahraeus
    Cell Transformation Group, University of Dundee, UK RFAHRAES bad dundee ac uk
    Curr Biol 6:84-91. 1996
    ..Reconstitution of p16 function in transformed cells is therefore an attractive target for anti-cancer drug design...