J M Paramio

Summary

Country: Spain

Publications

  1. ncbi Keratin intermediate filament dynamics in cell heterokaryons reveals diverse behaviour of different keratins
    J M Paramio
    Department of Cell and Molecular Biology, CIEMAT, Madrid, Spain
    J Cell Sci 110:1099-111. 1997
  2. ncbi A role for phosphorylation in the dynamics of keratin intermediate filaments
    J M Paramio
    Cell and Molecular Biology Program, CIEMAT IMA, Madrid, Spain
    Eur J Cell Biol 78:33-43. 1999
  3. ncbi Molecular determinants of Akt-induced keratinocyte transformation
    C Segrelles
    Department of Cell and Molecular Biology, CIEMAT, Madrid, Spain
    Oncogene 25:1174-85. 2006
  4. ncbi Regulation of the differentiation-related gene Drg-1 during mouse skin carcinogenesis
    E Gomez-Casero
    Centro de Investigaciones Energeticas, Medioambientales y Tecnologicas, Department of Cell and Molecular Biology and Gene Therapy, Madrid, Spain
    Mol Carcinog 32:100-9. 2001
  5. ncbi Inhibition of protein kinase B (PKB) and PKCzeta mediates keratin K10-induced cell cycle arrest
    J M Paramio
    Project on Cell and Molecular Biology and Gene Therapy, CIEMAT, E 28040 Madrid, Spain
    Mol Cell Biol 21:7449-59. 2001
  6. ncbi Akt pathway as a target for therapeutic intervention in HNSCC
    M Moral
    Molecular Oncology Unit, Division of Biomedicine, CIEMAT, Madrid, Spain
    Histol Histopathol 23:1269-78. 2008
  7. ncbi The ink4a/arf tumor suppressors cooperate with p21cip1/waf in the processes of mouse epidermal differentiation, senescence, and carcinogenesis
    J M Paramio
    Cell, Molecular Biology, and Gene Therapy Project, CIEMAT, Avenida Complutense 22, E 28040 Madrid, Spain
    J Biol Chem 276:44203-11. 2001
  8. ncbi Opposite functions for E2F1 and E2F4 in human epidermal keratinocyte differentiation
    J M Paramio
    Program on Cell and Molecular Biology, Centro de Investigaciones Energeticas, Medioambigentales y Tecnologicas Edificio 7, Av Complutense 22, Madrid E 28040, Spain
    J Biol Chem 275:41219-26. 2000
  9. ncbi Differential expression and functionally co-operative roles for the retinoblastoma family of proteins in epidermal differentiation
    J M Paramio
    Cell and Molecular Biology Program, CIEMAT, Madrid, Spain
    Oncogene 17:949-57. 1998
  10. ncbi Inhibition of pRb phosphorylation and cell-cycle progression by a 20-residue peptide derived from p16CDKN2/INK4A
    R Fahraeus
    Cell Transformation Group, University of Dundee, UK RFAHRAES bad dundee ac uk
    Curr Biol 6:84-91. 1996

Collaborators

  • J Martinez
  • A Alonso
  • M Serrano
  • D Lane
  • M Moral
  • C Segrelles
  • E Gomez-Casero
  • M Santos
  • H Leis
  • M Fernanda Lara
  • S Ruiz
  • R Fahraeus
  • J L Jorcano
  • M L Rodriguez-Puebla
  • M Navarro
  • F Larcher
  • C J Conti
  • S Lain
  • K L Ball

Detail Information

Publications10

  1. ncbi Keratin intermediate filament dynamics in cell heterokaryons reveals diverse behaviour of different keratins
    J M Paramio
    Department of Cell and Molecular Biology, CIEMAT, Madrid, Spain
    J Cell Sci 110:1099-111. 1997
    ..In summary, our results demonstrate that, following fusion, the keratin intermediate filament network reshapes rather rapidly and that keratins are highly dynamic proteins, although this mobility depends on each particular polypeptide...
  2. ncbi A role for phosphorylation in the dynamics of keratin intermediate filaments
    J M Paramio
    Cell and Molecular Biology Program, CIEMAT IMA, Madrid, Spain
    Eur J Cell Biol 78:33-43. 1999
    ..As a whole, present results indicate that the highly dynamic properties of the keratin polypeptides can be modulated by phosphorylation...
  3. ncbi Molecular determinants of Akt-induced keratinocyte transformation
    C Segrelles
    Department of Cell and Molecular Biology, CIEMAT, Madrid, Spain
    Oncogene 25:1174-85. 2006
    ..Collectively, these results demonstrate that Akt is able to transform keratinocytes by specific mechanisms involving transcriptional and post-transcriptional processes...
  4. ncbi Regulation of the differentiation-related gene Drg-1 during mouse skin carcinogenesis
    E Gomez-Casero
    Centro de Investigaciones Energeticas, Medioambientales y Tecnologicas, Department of Cell and Molecular Biology and Gene Therapy, Madrid, Spain
    Mol Carcinog 32:100-9. 2001
    ..These results suggest that, in addition to being upregulated during keratinocyte differentiation, the Drg-1 gene might have a complex function in skin tumorigenesis...
  5. ncbi Inhibition of protein kinase B (PKB) and PKCzeta mediates keratin K10-induced cell cycle arrest
    J M Paramio
    Project on Cell and Molecular Biology and Gene Therapy, CIEMAT, E 28040 Madrid, Spain
    Mol Cell Biol 21:7449-59. 2001
    ..Together, these results suggest new and essential roles for the keratins as modulators of specific signal transduction pathways...
  6. ncbi Akt pathway as a target for therapeutic intervention in HNSCC
    M Moral
    Molecular Oncology Unit, Division of Biomedicine, CIEMAT, Madrid, Spain
    Histol Histopathol 23:1269-78. 2008
    ....
  7. ncbi The ink4a/arf tumor suppressors cooperate with p21cip1/waf in the processes of mouse epidermal differentiation, senescence, and carcinogenesis
    J M Paramio
    Cell, Molecular Biology, and Gene Therapy Project, CIEMAT, Avenida Complutense 22, E 28040 Madrid, Spain
    J Biol Chem 276:44203-11. 2001
    ..These results indicate that ink4a/arf and cip1/waf genes cooperate to allow normal keratinocyte differentiation and that the absence of both favors malignant transformation...
  8. ncbi Opposite functions for E2F1 and E2F4 in human epidermal keratinocyte differentiation
    J M Paramio
    Program on Cell and Molecular Biology, Centro de Investigaciones Energeticas, Medioambigentales y Tecnologicas Edificio 7, Av Complutense 22, Madrid E 28040, Spain
    J Biol Chem 275:41219-26. 2000
    ....
  9. ncbi Differential expression and functionally co-operative roles for the retinoblastoma family of proteins in epidermal differentiation
    J M Paramio
    Cell and Molecular Biology Program, CIEMAT, Madrid, Spain
    Oncogene 17:949-57. 1998
    ....
  10. ncbi Inhibition of pRb phosphorylation and cell-cycle progression by a 20-residue peptide derived from p16CDKN2/INK4A
    R Fahraeus
    Cell Transformation Group, University of Dundee, UK RFAHRAES bad dundee ac uk
    Curr Biol 6:84-91. 1996
    ..Reconstitution of p16 function in transformed cells is therefore an attractive target for anti-cancer drug design...