Sagrario Ortega

Summary

Country: Spain

Publications

  1. ncbi request reprint Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice
    Sagrario Ortega
    Molecular Oncology Program, Centro Nacional de Investigaciones Oncologicas, Melchor Fernandez Almagro 3, Madrid E 28029, Spain
    Nat Genet 35:25-31. 2003
  2. ncbi request reprint Cdk2 is dispensable for cell cycle inhibition and tumor suppression mediated by p27(Kip1) and p21(Cip1)
    Alberto Martin
    Molecular Oncology Program, Centro Nacional de Investigaciones Oncologicas CNIO, 28029 Madrid, Spain
    Cancer Cell 7:591-8. 2005
  3. doi request reprint Mice thrive without Cdk4 and Cdk2
    Cédric Barrière
    Molecular Oncology, Centro Nacional de Investigaciones Oncologicas, E 28029 Madrid, Spain
    Mol Oncol 1:72-83. 2007
  4. ncbi request reprint Cyclins and CDKS in development and cancer: lessons from genetically modified mice
    David Santamaria
    Molecular Oncology Program, Spanish National Cancer Centre CNIO, 28029 Madrid, Spain
    Front Biosci 11:1164-88. 2006
  5. ncbi request reprint Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6
    Marcos Malumbres
    Molecular Oncology Program, Centro Nacional de Investigaciones Oncologicas CNIO, E 28029 Madrid, Spain
    Cell 118:493-504. 2004
  6. doi request reprint Telomeres acquire embryonic stem cell characteristics in induced pluripotent stem cells
    Rosa M Marion
    Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre, Melchor Fernandez Almagro 3, Madrid, Spain
    Cell Stem Cell 4:141-54. 2009
  7. ncbi request reprint Driving the cell cycle to cancer
    Marcos Malumbres
    Molecular Oncology Programme, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Adv Exp Med Biol 532:1-11. 2003
  8. ncbi request reprint Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number
    Javier Martin
    Molecular Oncology Program, Centro Nacional de Investigaciones Oncologicas, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Oncogene 22:5261-9. 2003
  9. pmc A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity
    Rosa M Marion
    Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Research Centre CNIO, Melchor Fernandez Almagro 3, Madrid E 28029, Spain
    Nature 460:1149-53. 2009
  10. doi request reprint TRF1 is a stem cell marker and is essential for the generation of induced pluripotent stem cells
    Ralph P Schneider
    Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    Nat Commun 4:1946. 2013

Collaborators

  • Alberto Martin
  • Mariano Barbacid
  • Marcos Malumbres
  • Maria A Blasco
  • Manuel Serrano
  • Han Li
  • Manuel Collado
  • Gunnar Schotta
  • Matilde Murga
  • Oscar Fernandez-Capetillo
  • Xose R Bustelo
  • Charles Tease
  • Rosa M Marion
  • Ralph P Schneider
  • David Santamaria
  • Javier Martin
  • Maria Abad
  • Diego Megias
  • Marta Canamero
  • Jelena Urosevic
  • Elisa Varela
  • Rodrigo Diéguez-Hurtado
  • Katerina Strati
  • Nuria Marzo
  • Cédric Barrière
  • Pierre Dubus
  • Ignacio Prieto
  • Nathaniel Polnaszek
  • Orlando Dominguez
  • Ianire Garrobo
  • Teresa Rayon
  • Osvaldo Grana
  • Inmaculada Ors
  • Miguel Manzanares
  • Cristina Pantoja
  • Dolores Martinez
  • Jose A Palacios
  • Lluc Mosteiro
  • Ignacio Flores
  • Miguel Foronda
  • Santiago Reig
  • Francisca Mulero
  • Manuel Desco
  • Maria Dolores Martinez
  • Vincent Sauzeau
  • Inés Martínez-Corral
  • María L Soto-Montenegro
  • Emma M Burkitt Wright
  • David Olmeda
  • Stefan Schoeftner
  • Agueda Tejera
  • Raquel Blanco
  • América Giménez
  • Conchi Mora
  • Ainhoa García
  • Thomas Stratmann
  • Martin Rios
  • Ramon Gomis
  • Javier Galan
  • Antonio Cerqueira
  • Leonor Kremer
  • Maj A Hultén
  • Carlos Martinez-A
  • Alicia Martinez
  • Nieves Pezzi
  • Jose M Buesa
  • Jose L Barbero
  • Claudio Basilico
  • Sarah L Hunt
  • Michael Ittmann
  • Rocio Sotillo
  • Norman M Greenberg
  • Fanny Néhmé-Pélluard
  • Leif E Peterson
  • Albert F Parlow
  • Mustafa Ozen
  • Bernard Kwabi-Addo
  • Mark A Magnuson

Detail Information

Publications20

  1. ncbi request reprint Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice
    Sagrario Ortega
    Molecular Oncology Program, Centro Nacional de Investigaciones Oncologicas, Melchor Fernandez Almagro 3, Madrid E 28029, Spain
    Nat Genet 35:25-31. 2003
    ..But CDK2 is essential for completion of prophase I during meiotic cell division in male and female germ cells, an unforeseen role for this cell cycle kinase...
  2. ncbi request reprint Cdk2 is dispensable for cell cycle inhibition and tumor suppression mediated by p27(Kip1) and p21(Cip1)
    Alberto Martin
    Molecular Oncology Program, Centro Nacional de Investigaciones Oncologicas CNIO, 28029 Madrid, Spain
    Cancer Cell 7:591-8. 2005
    ..These results indicate that Cdk2 is not an essential target for p27(Kip1) and p21(Cip1) in cell cycle inhibition and tumor suppression...
  3. doi request reprint Mice thrive without Cdk4 and Cdk2
    Cédric Barrière
    Molecular Oncology, Centro Nacional de Investigaciones Oncologicas, E 28029 Madrid, Spain
    Mol Oncol 1:72-83. 2007
    ..These observations indicate that Cdk4 and Cdk2 are dispensable for the mammalian cell cycle and for adult homeostasis...
  4. ncbi request reprint Cyclins and CDKS in development and cancer: lessons from genetically modified mice
    David Santamaria
    Molecular Oncology Program, Spanish National Cancer Centre CNIO, 28029 Madrid, Spain
    Front Biosci 11:1164-88. 2006
    ..This review will discuss these new findings and their implications for cancer therapy...
  5. ncbi request reprint Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6
    Marcos Malumbres
    Molecular Oncology Program, Centro Nacional de Investigaciones Oncologicas CNIO, E 28029 Madrid, Spain
    Cell 118:493-504. 2004
    ..These results indicate that D-type cyclin-dependent kinases are not essential for cell cycle entry and suggest the existence of alternative mechanisms to initiate cell proliferation upon mitogenic stimulation...
  6. doi request reprint Telomeres acquire embryonic stem cell characteristics in induced pluripotent stem cells
    Rosa M Marion
    Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre, Melchor Fernandez Almagro 3, Madrid, Spain
    Cell Stem Cell 4:141-54. 2009
    ..Together, these results highlight the importance of telomere biology for iPS cell generation and functionality...
  7. ncbi request reprint Driving the cell cycle to cancer
    Marcos Malumbres
    Molecular Oncology Programme, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Adv Exp Med Biol 532:1-11. 2003
    ..These models are being used now to understand how deregulation of these Cdks leads to cancer development and will be a valuable tool to design and validate new therapeutic strategies against tumour development...
  8. ncbi request reprint Genetic rescue of Cdk4 null mice restores pancreatic beta-cell proliferation but not homeostatic cell number
    Javier Martin
    Molecular Oncology Program, Centro Nacional de Investigaciones Oncologicas, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Oncogene 22:5261-9. 2003
    ..Thus, mammalian Cdk4 is not only involved in controlling proliferation of specific cell types but may play a wider role in establishing homeostatic cell numbers...
  9. pmc A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity
    Rosa M Marion
    Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Research Centre CNIO, Melchor Fernandez Almagro 3, Madrid E 28029, Spain
    Nature 460:1149-53. 2009
    ....
  10. doi request reprint TRF1 is a stem cell marker and is essential for the generation of induced pluripotent stem cells
    Ralph P Schneider
    Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    Nat Commun 4:1946. 2013
    ..We further show that TRF1 is necessary for both induction and maintenance of pluripotency, and that TRF1 is a direct transcriptional target of Oct3/4...
  11. pmc Suv4-20h abrogation enhances telomere elongation during reprogramming and confers a higher tumorigenic potential to iPS cells
    Rosa M Marion
    Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Centre, Melchor Fernandez Almagro 3, Madrid, Spain
    PLoS ONE 6:e25680. 2011
    ....
  12. doi request reprint Reprogramming in vivo produces teratomas and iPS cells with totipotency features
    Maria Abad
    Tumour Suppression Group, Spanish National Cancer Research Centre CNIO, Madrid E 28029, Spain
    Nature 502:340-5. 2013
    ..We conclude that reprogramming in vivo is feasible and confers totipotency features absent in standard iPS or ES cells. These discoveries could be relevant for future applications of reprogramming in regenerative medicine. ..
  13. pmc Different telomere-length dynamics at the inner cell mass versus established embryonic stem (ES) cells
    Elisa Varela
    Telomeres and Telomerase Group, Spanish National Cancer Research Centre, Madrid E 28029, Spain
    Proc Natl Acad Sci U S A 108:15207-12. 2011
    ....
  14. pmc The Ink4/Arf locus is a barrier for iPS cell reprogramming
    Han Li
    Tumor Suppression Group, Spanish National Cancer Research Centre CNIO, 3 Melchor Fernandez Almagro Street, Madrid E 28029, Spain
    Nature 460:1136-9. 2009
    ..All together, we conclude that the silencing of Ink4/Arf locus is rate-limiting for reprogramming, and its transient inhibition may significantly improve the generation of iPS cells...
  15. pmc Constitutive activation of B-Raf in the mouse germ line provides a model for human cardio-facio-cutaneous syndrome
    Jelena Urosevic
    Molecular Oncology Program, Centro Nacional de Investigaciones Oncologicas CNIO, E 28029 Madrid, Spain
    Proc Natl Acad Sci U S A 108:5015-20. 2011
    ..Moreover, they may serve as a tool to evaluate the potential therapeutic efficacy of B-RAF inhibitors and establish the precise window at which they could be effective against this congenital syndrome...
  16. ncbi request reprint Cyclin D-dependent kinases, INK4 inhibitors and cancer
    Sagrario Ortega
    Molecular Oncology Program, Centro Nacional de Investigaciones Oncologicas, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Biochim Biophys Acta 1602:73-87. 2002
    ..As a consequence, some of these molecules are currently being considered as targets for cancer therapy, and several novel molecules, such as Cdk inhibitors, are under development as potential anti-cancer drugs...
  17. doi request reprint A Cre-reporter transgenic mouse expressing the far-red fluorescent protein Katushka
    Rodrigo Diéguez-Hurtado
    Biotechnology Program, Spanish National Cancer Research Centre CNIO, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Genesis 49:36-45. 2011
    ..Thus, this reporter model enables early, widespread, and sensitive in vivo detection of Cre activity and should provide a versatile tool for a wide spectrum of fluorescence and live-imaging applications...
  18. ncbi request reprint Cyclin-dependent kinase 4 hyperactivity promotes autoreactivity in the immune system but protects pancreatic cell mass from autoimmune destruction in the nonobese diabetic mouse model
    Nuria Marzo
    Institut d Investigacions Biomèdiques August Pi i Sunyer and University of Barcelona, Barcelona, Spain
    J Immunol 180:1189-98. 2008
    ....
  19. ncbi request reprint Cohesin component dynamics during meiotic prophase I in mammalian oocytes
    Ignacio Prieto
    Department of Immunology and Oncology, Centro Nacional de Biotecnologia CSIC, UAM Campus de Cantoblanco, Madrid E 28049, Spain
    Chromosome Res 12:197-213. 2004
    ....
  20. ncbi request reprint Fibroblast growth factor 2 promotes tumor progression in an autochthonous mouse model of prostate cancer
    Nathaniel Polnaszek
    Department of Pathology, Baylor College of Medicine and Houston Department of Veterans Affairs Medical Center, Houston, Texas 77030, USA
    Cancer Res 63:5754-60. 2003
    ..These findings suggest that both FGF2-mediated angiogenesis and intranuclear FGF2 activities may promote tumor progression and support the hypothesis that FGF2 plays a significant role in prostate cancer progression in vivo...