M Angela Nieto

Summary

Country: Spain

Publications

  1. doi request reprint Epithelial-Mesenchymal Transitions in development and disease: old views and new perspectives
    M Angela Nieto
    Instituto de Neurociencias, CSIC UMH, San Juan de Alicante, Spain
    Int J Dev Biol 53:1541-7. 2009
  2. pmc Reciprocal repression between Sox3 and snail transcription factors defines embryonic territories at gastrulation
    Hervé Acloque
    Instituto de Neurociencias, CSIC UMH, San Juan de Alicante 03550, Spain
    Dev Cell 21:546-58. 2011
  3. pmc Snail1 controls bone mass by regulating Runx2 and VDR expression during osteoblast differentiation
    Cristina A de Frutos
    Instituto de Neurociencias, CSIC UMH, San Juan de Alicante, Spain
    EMBO J 28:686-96. 2009
  4. pmc Inflammation and EMT: an alliance towards organ fibrosis and cancer progression
    Jose Miguel Lopez-Novoa
    Departamento de Fisiologia y Farmacologia, Universidad de Salamanca, Edificio Departamental, Campus Miguel de Unamuno, Salamanca, Spain
    EMBO Mol Med 1:303-14. 2009
  5. doi request reprint The epithelial-mesenchymal transition under control: global programs to regulate epithelial plasticity
    M Angela Nieto
    Instituto de Neurociencias, CSIC UMH Av Santiago Ramón y Cajal s n, 03550 San Juan de Alicante, Spain
    Semin Cancer Biol 22:361-8. 2012
  6. pmc The endogenous retrovirus ENS-1 provides active binding sites for transcription factors in embryonic stem cells that specify extra embryonic tissue
    Anne Mey
    Institut de Génomique Fonctionnelle de Lyon, Universite de Lyon, CNRS, INRA, Ecole Normale Superieure de Lyon, France
    Retrovirology 9:21. 2012
  7. doi request reprint The ins and outs of the epithelial to mesenchymal transition in health and disease
    M Angela Nieto
    Instituto de Neurociencias, Consejo Superior de Investigaciones Cientificas Universidad Miguel Hernandez, San Juan de Alicante 03550, Spain
    Annu Rev Cell Dev Biol 27:347-76. 2011
  8. doi request reprint Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1
    Oscar H Ocaña
    Instituto de Neurociencias CSIC UMH, Avda Ramon y Cajal s n, 03550 San Juan de Alicante, Spain
    Cancer Cell 22:709-24. 2012
  9. pmc A new regulatory loop in cancer-cell invasion
    Oscar H Ocaña
    Instituto de Neurociencias de Alicante, CSIC UMH, Apartado 18, San Juan de Alicante 03550, Spain
    EMBO Rep 9:521-2. 2008
  10. ncbi request reprint Snail1 is a transcriptional effector of FGFR3 signaling during chondrogenesis and achondroplasias
    Cristina A de Frutos
    Instituto de Neurociencias de Alicante, CSIC UMH, Apartado 18, San Juan de Alicante 03550, Spain
    Dev Cell 13:872-83. 2007

Collaborators

Detail Information

Publications25

  1. doi request reprint Epithelial-Mesenchymal Transitions in development and disease: old views and new perspectives
    M Angela Nieto
    Instituto de Neurociencias, CSIC UMH, San Juan de Alicante, Spain
    Int J Dev Biol 53:1541-7. 2009
    ....
  2. pmc Reciprocal repression between Sox3 and snail transcription factors defines embryonic territories at gastrulation
    Hervé Acloque
    Instituto de Neurociencias, CSIC UMH, San Juan de Alicante 03550, Spain
    Dev Cell 21:546-58. 2011
    ..Thus, the subdivision of the early embryo into the two main territories, ectodermal and mesendodermal, is regulated by changes in cell behavior mediated by the antagonistic relationship between Sox3 and Snail transcription factors...
  3. pmc Snail1 controls bone mass by regulating Runx2 and VDR expression during osteoblast differentiation
    Cristina A de Frutos
    Instituto de Neurociencias, CSIC UMH, San Juan de Alicante, Spain
    EMBO J 28:686-96. 2009
    ..Our data show that the impact of Snail1 activity on the osteoblast population regulates the course of bone cells differentiation and ensures normal bone remodelling...
  4. pmc Inflammation and EMT: an alliance towards organ fibrosis and cancer progression
    Jose Miguel Lopez-Novoa
    Departamento de Fisiologia y Farmacologia, Universidad de Salamanca, Edificio Departamental, Campus Miguel de Unamuno, Salamanca, Spain
    EMBO Mol Med 1:303-14. 2009
    ..Importantly, the chronic inflammatory microenvironment common to fibrotic and cancer cells emerges as a decisive factor in the induction of the pathological EMT...
  5. doi request reprint The epithelial-mesenchymal transition under control: global programs to regulate epithelial plasticity
    M Angela Nieto
    Instituto de Neurociencias, CSIC UMH Av Santiago Ramón y Cajal s n, 03550 San Juan de Alicante, Spain
    Semin Cancer Biol 22:361-8. 2012
    ....
  6. pmc The endogenous retrovirus ENS-1 provides active binding sites for transcription factors in embryonic stem cells that specify extra embryonic tissue
    Anne Mey
    Institut de Génomique Fonctionnelle de Lyon, Universite de Lyon, CNRS, INRA, Ecole Normale Superieure de Lyon, France
    Retrovirology 9:21. 2012
    ....
  7. doi request reprint The ins and outs of the epithelial to mesenchymal transition in health and disease
    M Angela Nieto
    Instituto de Neurociencias, Consejo Superior de Investigaciones Cientificas Universidad Miguel Hernandez, San Juan de Alicante 03550, Spain
    Annu Rev Cell Dev Biol 27:347-76. 2011
    ..In addition, the EMT now constitutes a promising target for the treatment of cancer and organ-degenerative diseases...
  8. doi request reprint Metastatic colonization requires the repression of the epithelial-mesenchymal transition inducer Prrx1
    Oscar H Ocaña
    Instituto de Neurociencias CSIC UMH, Avda Ramon y Cajal s n, 03550 San Juan de Alicante, Spain
    Cancer Cell 22:709-24. 2012
    ..Thus, unlike the classical EMT transcription factors, Prrx1 uncouples EMT and stemness, and is a biomarker associated with patient survival and lack of metastasis...
  9. pmc A new regulatory loop in cancer-cell invasion
    Oscar H Ocaña
    Instituto de Neurociencias de Alicante, CSIC UMH, Apartado 18, San Juan de Alicante 03550, Spain
    EMBO Rep 9:521-2. 2008
  10. ncbi request reprint Snail1 is a transcriptional effector of FGFR3 signaling during chondrogenesis and achondroplasias
    Cristina A de Frutos
    Instituto de Neurociencias de Alicante, CSIC UMH, Apartado 18, San Juan de Alicante 03550, Spain
    Dev Cell 13:872-83. 2007
    ..Significantly, Snail1 is aberrantly upregulated in thanatophoric versus normal cartilages from stillborns. Thus, Snail activity may likely be considered a target for achondroplasia therapies...
  11. pmc Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney
    Agnes Boutet
    Instituto de Neurociencias de Alicante, CSIC UMH, Sant Joan d Alacant, Alicante, Spain
    EMBO J 25:5603-13. 2006
    ..Significantly, Snail is also activated in patients with renal fibrosis. Thus, Snail expression is suppressed during renal development and it must remain silent in the mature kidney where its aberrant activation leads to fibrosis...
  12. doi request reprint Scratch2 prevents cell cycle re-entry by repressing miR-25 in postmitotic primary neurons
    Eva Rodriguez-Aznar
    Instituto de Neurociencias, CSIC UMH, San Juan de Alicante 03550, Spain
    J Neurosci 33:5095-105. 2013
    ..Thus, Scratch2 appears to safeguard the homeostasis of postmitotic primary neurons by preventing cell cycle re-entry...
  13. ncbi request reprint Reactivation of Snail genes in renal fibrosis and carcinomas: a process of reversed embryogenesis?
    Agnes Boutet
    Instituto de Neurociencias de Alicante, CSIC UMH, Sant Joan d Alacant, Spain
    Cell Cycle 6:638-42. 2007
    ..Thus, Snail genes illustrate a paradigm whereby reactivation of crucial embryonic genes in adult tissues provokes the onset of devastating diseases...
  14. pmc The physiology and pathology of the EMT. Meeting on the epithelial-mesenchymal transition
    Hervé Acloque
    Instituto de Neurociencias de Alicante, CSIC UMH, Apartado 18, San Juan de Alicante, 03550 Spain
    EMBO Rep 9:322-6. 2008
  15. doi request reprint Deletion of H-Ras decreases renal fibrosis and myofibroblast activation following ureteral obstruction in mice
    M Teresa Grande
    Departamento de Fisiologia y Farmacologia, Instituto Reina Sofia de Investigacion Nefrologica, Universidad de Salamanca, Salamanca 37007, Spain
    Kidney Int 77:509-18. 2010
    ..As expected, we found lower levels of activated Akt in the kidneys and cultured fibroblasts of the knockout. Whether Ras inhibition will turn out to prevent progression of renal fibrosis will require more direct studies...
  16. doi request reprint Attenuation of Notch signalling by the Down-syndrome-associated kinase DYRK1A
    Javier Fernandez-Martinez
    Instituto de Neurociencias, CSIC UMH, Sant Joan d Alacant, Alicante, Spain
    J Cell Sci 122:1574-83. 2009
    ....
  17. pmc Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease
    Hervé Acloque
    Instituto de Neurociencias CSIC UMH, San Juan de Alicante, Spain
    J Clin Invest 119:1438-49. 2009
    ..Cells undergo EMT to migrate and colonize distant territories. Not surprisingly, this is also the mechanism used by cancer cells to disperse throughout the body...
  18. doi request reprint Snail1 suppresses TGF-beta-induced apoptosis and is sufficient to trigger EMT in hepatocytes
    D Lorena Franco
    Instituto de Neurociencias CSIC UMH, 03550 San Juan de Alicante, Spain
    J Cell Sci 123:3467-77. 2010
    ..As Snail1 is a known target of TGF-β signalling, our data indicate that Snail1 might transduce the tumour-promoting effects of TGF-β, namely the EMT concomitant with the resistance to cell death...
  19. doi request reprint Epithelial plasticity: a common theme in embryonic and cancer cells
    M Angela Nieto
    Instituto de Neurociencias Consejo Superior de Investigaciones Científicas CSIC Universidad Miguel Hernández UMH, Avenida Ramon y Cajal s n, 03550 San Juan de Alicante, Spain
    Science 342:1234850. 2013
    ..The parallels in phenotypic plasticity in normal morphogenesis and cancer highlight the importance of studying the embryo to understand tumor progression and to aid in the design of improved therapeutic strategies. ..
  20. doi request reprint eEF1A mediates the nuclear export of SNAG-containing proteins via the Exportin5-aminoacyl-tRNA complex
    José Manuel Mingot
    Instituto de Neurociencias, CSIC UMH, Avda Ramon y Cajal s n, 03550 San Juan de Alicante, Spain Electronic address
    Cell Rep 5:727-37. 2013
    ..Thus, we describe a nuclear role for eEF1A and provide a mechanism for protein nuclear export that attenuates the activity of SNAG-containing transcription factors. ..
  21. doi request reprint Characterization of Snail nuclear import pathways as representatives of C2H2 zinc finger transcription factors
    José Manuel Mingot
    Instituto de Neurociencias, CSIC UMH, Avda Ramon y Cajal s n, San Juan de Alicante, Spain
    J Cell Sci 122:1452-60. 2009
    ..Importantly, the identified basic residues are also conserved in other families of C(2)H(2) transcription factors whose nuclear localization requires the zinc finger region...
  22. ncbi request reprint An Epigenetic Mark that Protects the Epithelial Phenotype in Health and Disease
    Fabiana Heredia
    Instituto de Neurociencias CSIC UMH, Avda Ramon y Cajal s n, 03550 San Juan de Alicante, Spain
    Cell Stem Cell 8:462-3. 2011
    ..Their findings also suggest that under conditions where EMT and stemness coexist, they can be independently regulated...
  23. doi request reprint Evolutionary history of the Snail/Scratch superfamily
    Alejandro Barrallo-Gimeno
    Instituto de Neurociencias, Consejo Superior de Investigaciones Cientificas Universidad Miguel Hernandez, San Juan de Alicante 03550 Spain
    Trends Genet 25:248-52. 2009
    ....
  24. ncbi request reprint The expression of Scratch genes in the developing and adult brain
    Faustino Marin
    Instituto de Neurociencias, CSIC UMH, San Juan de Alicante, Spain
    Dev Dyn 235:2586-91. 2006
    ..Nevertheless, strong expression of Scratch2 is retained in the postnatal cortical subventricular zone, in the inner part of the cerebellar external granular layer, and in the glial cells of the adult vomeronasal nerve...
  25. ncbi request reprint Evolution of the neural crest
    Alejandro Barrallo-Gimeno
    Instituto de Neurociencias de Alicante CSIC UMH, San Juan de Alicante, Spain
    Adv Exp Med Biol 589:235-44. 2006
    ....