M A Nieto

Summary

Country: Spain

Publications

  1. ncbi Overexpression of Snail family members highlights their ability to promote chick neural crest formation
    Marta G del Barrio
    Instituto Cajal, CSIC, Doctor Arce, 37 28002 Madrid, Spain
    Development 129:1583-93. 2002
  2. ncbi The snail superfamily of zinc-finger transcription factors
    M Angela Nieto
    Instituto Cajal, Doctor Arce, 37, 28002 Madrid, Spain
    Nat Rev Mol Cell Biol 3:155-66. 2002
  3. ncbi The early steps of neural crest development
    M A Nieto
    Instituto Cajal, CSIC, Doctor Arce, 37, 28002, Madrid, Spain
    Mech Dev 105:27-35. 2001
  4. ncbi Conserved and divergent roles for members of the Snail family of transcription factors in the chick and mouse embryo
    M Sefton
    Instituto Cajal, CSIC, Avenida Doctor Arce, 28002 Madrid, Spain
    Development 125:3111-21. 1998
  5. ncbi The expression and regulation of chick EphA7 suggests roles in limb patterning and innervation
    M Araujo
    Instituto Cajal, CSIC, Doctor Arce, 28002 Madrid, Spain
    Development 125:4195-204. 1998
  6. ncbi Novel expression gradients of Eph-like receptor tyrosine kinases in the developing chick retina
    M Sefton
    Instituto Cajal, CSIC, Avenida Doctor Arce 37, Madrid, 28002, Spain
    Dev Biol 188:363-8. 1997
  7. ncbi The increasing complexity of the Snail gene superfamily in metazoan evolution
    M Manzanares
    Department of Developmental Neurobiology, Instituto Cajal, CSIC, Av Doctor Arce 37, 28002, Madrid, Spain
    Trends Genet 17:178-81. 2001
  8. ncbi Control of cell behavior during vertebrate development by Slug, a zinc finger gene
    M A Nieto
    Instituto Cajal, Madrid, Spain
    Science 264:835-9. 1994
  9. ncbi Differential expression of Eph receptors and ephrins correlates with the formation of topographic projections in primary and secondary visual circuits of the embryonic chick forebrain
    O Marin
    Instituto Cajal, CSIC, Doctor Arce 37, Madrid, 28002, Spain
    Dev Biol 234:289-303. 2001
  10. ncbi The expression of chick EphA7 during segmentation of the central and peripheral nervous system
    M Araujo
    Instituto Cajal, CSIC, Madrid, Spain
    Mech Dev 68:173-7. 1997

Collaborators

Detail Information

Publications43

  1. ncbi Overexpression of Snail family members highlights their ability to promote chick neural crest formation
    Marta G del Barrio
    Instituto Cajal, CSIC, Doctor Arce, 37 28002 Madrid, Spain
    Development 129:1583-93. 2002
    ..We observe that both genes elicit the same responses in the neural tube. Our results indicate that they can be functionally equivalent, although the embryos show a higher response to the endogenous gene, chick Slug...
  2. ncbi The snail superfamily of zinc-finger transcription factors
    M Angela Nieto
    Instituto Cajal, Doctor Arce, 37, 28002 Madrid, Spain
    Nat Rev Mol Cell Biol 3:155-66. 2002
    ..Different family members have also been implicated in the signalling cascade that confers left right identity, as well as in the formation of appendages, neural differentiation, cell division and cell survival...
  3. ncbi The early steps of neural crest development
    M A Nieto
    Instituto Cajal, CSIC, Doctor Arce, 37, 28002, Madrid, Spain
    Mech Dev 105:27-35. 2001
    ..As such, the neural crest constitutes an excellent model to study cell migration...
  4. ncbi Conserved and divergent roles for members of the Snail family of transcription factors in the chick and mouse embryo
    M Sefton
    Instituto Cajal, CSIC, Avenida Doctor Arce, 28002 Madrid, Spain
    Development 125:3111-21. 1998
    ..Furthermore, several early sites of Slu and Sna expression have been swapped in the avian lineage. Our analysis of the Snail family may also shed new light on the origin of the neural crest...
  5. ncbi The expression and regulation of chick EphA7 suggests roles in limb patterning and innervation
    M Araujo
    Instituto Cajal, CSIC, Doctor Arce, 28002 Madrid, Spain
    Development 125:4195-204. 1998
    ..Moreover, they implicate the Eph receptor family in the patterning and innervation of the developing limb, extending its role in axon pathfinding to the distal periphery...
  6. ncbi Novel expression gradients of Eph-like receptor tyrosine kinases in the developing chick retina
    M Sefton
    Instituto Cajal, CSIC, Avenida Doctor Arce 37, Madrid, 28002, Spain
    Dev Biol 188:363-8. 1997
    ..We also demonstrate a dorsal to ventral expression gradient for Cek11, an Eck-like receptor, the Eph subclass previously suggested to specify positional information along the temporonasal axis...
  7. ncbi The increasing complexity of the Snail gene superfamily in metazoan evolution
    M Manzanares
    Department of Developmental Neurobiology, Instituto Cajal, CSIC, Av Doctor Arce 37, 28002, Madrid, Spain
    Trends Genet 17:178-81. 2001
    ..We discuss the implications of the distinct duplication events on the acquisition of new functions...
  8. ncbi Control of cell behavior during vertebrate development by Slug, a zinc finger gene
    M A Nieto
    Instituto Cajal, Madrid, Spain
    Science 264:835-9. 1994
    ..This change, which is the transition from epithelial to mesenchymal character, occurs at the formation of mesoderm during gastrulation and on emigration of the neutral crest from the neural tube...
  9. ncbi Differential expression of Eph receptors and ephrins correlates with the formation of topographic projections in primary and secondary visual circuits of the embryonic chick forebrain
    O Marin
    Instituto Cajal, CSIC, Doctor Arce 37, Madrid, 28002, Spain
    Dev Biol 234:289-303. 2001
    ..These results suggest a conserved function for EphA receptors and their ligands in the elaboration of topographic maps at multiple levels of the visual pathway...
  10. ncbi The expression of chick EphA7 during segmentation of the central and peripheral nervous system
    M Araujo
    Instituto Cajal, CSIC, Madrid, Spain
    Mech Dev 68:173-7. 1997
    ..In the somitic mesoderm, the expression correlates with segmentation and the guidance of both neural crest and motor axons through the sclerotomes...
  11. ncbi Expression of chicken slug and snail in mesenchymal components of the developing central nervous system
    Faustino Marin
    Instituto Cajal, CSIC, Madrid, Spain
    Dev Dyn 230:144-8. 2004
    ....
  12. pmc Modularity and reshuffling of Snail and Slug expression during vertebrate evolution
    Annamaria Locascio
    Department of Developmental Neurobiology, Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Avenida Doctor Arce 37, 28002 Madrid, Spain
    Proc Natl Acad Sci U S A 99:16841-6. 2002
    ..Because these changes do not fit easily into current models, we need to invoke additional mechanisms acting on enhancer elements to distribute expression domains and functions of duplicated genes unequally during evolution...
  13. ncbi Expression of the G protein-coupled receptor kinase 2 during early mouse embryogenesis
    M Sefton
    Instituto Cajal, CSIC, Av Doctor Arce, 37, E 28002, Madrid, Spain
    Mech Dev 98:127-31. 2000
    ..In the limb bud, GRK2 transcripts were observed in cells of the progress zone and in the interdigital areas. At later stages, the expression in the heart is compatible with the phenotype observed in the GRK2 deficient mice...
  14. ncbi Cell movements during vertebrate development: integrated tissue behaviour versus individual cell migration
    A Locascio
    Instituto Cajal, CSIC, Avda Doctor Arce 37, 28002, Madrid, Spain
    Curr Opin Genet Dev 11:464-9. 2001
    ....
  15. pmc Snail genes at the crossroads of symmetric and asymmetric processes in the developing mesoderm
    Aixa V Morales
    Instituto Cajal, CSIC, Doctor Arce 37, 28002 Madrid, Spain
    EMBO Rep 8:104-9. 2007
    ..Thus, Snail1 is the first cue corrected by RA in the PSM to ensure synchronized bilateral segmentation...
  16. pmc Snail blocks the cell cycle and confers resistance to cell death
    Sonia Vega
    Instituto Cajal, Consejo Superior de Investigaciones Cieutificas, 28002 Madrid, Spain
    Genes Dev 18:1131-43. 2004
    ....
  17. ncbi LSox5 regulates RhoB expression in the neural tube and promotes generation of the neural crest
    Siro Perez-Alcala
    Instituto Cajal CSIC, Doctor Arce 37, 28002 Madrid, Spain
    Development 131:4455-65. 2004
    ....
  18. ncbi Biological potential of a functional human SNAIL retrogene
    Annamaria Locascio
    Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Av Doctor Arce 37, 28002 Madrid, Spain
    J Biol Chem 277:38803-9. 2002
    ..In light of this data, we have renamed it SNAIL-like, a new player that must be considered in both physiological and pathological studies of SNAIL function in humans...
  19. ncbi The epithelial mesenchymal transition confers resistance to the apoptotic effects of transforming growth factor Beta in fetal rat hepatocytes
    Francisco Valdés
    Departamento de Bioquimica y Biologia Molecular, Instituto de Bioquimica, Centro Mixto CSIC UCM, Facultad de Farmacia, Universidad Complutense de Madrid, Madrid, Spain
    Mol Cancer Res 1:68-78. 2002
    ..In summary, these cells are refractory to the apoptotic effects of TGF-beta, showing characteristics of liver progenitors and of some hepatocellular carcinoma cells...
  20. ncbi Snail1a and Snail1b cooperate in the anterior migration of the axial mesendoderm in the zebrafish embryo
    Maria J Blanco
    Instituto Cajal, CSIC, Doctor Arce 37, 28002 Madrid, Spain
    Development 134:4073-81. 2007
    ....
  21. ncbi Relative expression of Slug, RhoB, and HNK-1 in the cranial neural crest of the early chicken embryo
    Marta G del Barrio
    Instituto Cajal, CSIC, Madrid, Spain
    Dev Dyn 229:136-9. 2004
    ..The existence of these crest subpopulations should be considered when analyzing both wild-type embryos and the phenotype of experimentally manipulated chick embryos. Developmental Dynamics 229:136-139, 2004...
  22. doi Thanatophoric dysplasia type II with encephalocele and semilobar holoprosencephaly: Insights into its pathogenesis
    M L Martinez-Frias
    ECEMC, Centro de Investigación de Anomalías Congénitas, Instituto de Salud Carlos III, Madrid, Spain
    Am J Med Genet A 155:197-202. 2011
    ..In addition, we evaluated recent observations that FGF ligands and receptors (including FGFR3) act in concert to organize the whole telencephalon activity, rather than independently patterning different areas...
  23. ncbi GluR5 and GluR6 kainate receptor subunits coexist in hippocampal neurons and coassemble to form functional receptors
    A V Paternain
    Department of Neural Plasticity, Instituto Cajal, Consejo Superior de Investigaciones Cientificas, 28002 Madrid, Spain
    J Neurosci 20:196-205. 2000
    ....
  24. ncbi How to become neural crest: from segregation to delamination
    Aixa V Morales
    Instituto Cajal, CSIC, Doctor Arce 37, 28002 Madrid, Spain
    Semin Cell Dev Biol 16:655-62. 2005
    ..In addition, striking rostrocaudal differences unveil how the regulatory cascades are somehow different but still can lead to the production of bona fide neural crest cells...
  25. ncbi Correlation of Snail expression with histological grade and lymph node status in breast carcinomas
    Maria J Blanco
    Instituto Cajal, CSIC, Doctor Arce 37, 28002 Madrid, Spain
    Oncogene 21:3241-6. 2002
    ....
  26. ncbi Expression of EphA receptors and ligands during chick cerebellar development
    Maria J Blanco
    Instituto Cajal, CSIC, Doctor Arce, 37, 28002 Madrid, Spain
    Mech Dev 114:225-9. 2002
    ....
  27. pmc Snail activation disrupts tissue homeostasis and induces fibrosis in the adult kidney
    Agnes Boutet
    Instituto de Neurociencias de Alicante, CSIC UMH, Sant Joan d Alacant, Alicante, Spain
    EMBO J 25:5603-13. 2006
    ..Significantly, Snail is also activated in patients with renal fibrosis. Thus, Snail expression is suppressed during renal development and it must remain silent in the mature kidney where its aberrant activation leads to fibrosis...
  28. ncbi Snail1 is a transcriptional effector of FGFR3 signaling during chondrogenesis and achondroplasias
    Cristina A de Frutos
    Instituto de Neurociencias de Alicante, CSIC UMH, Apartado 18, San Juan de Alicante 03550, Spain
    Dev Cell 13:872-83. 2007
    ..Significantly, Snail1 is aberrantly upregulated in thanatophoric versus normal cartilages from stillborns. Thus, Snail activity may likely be considered a target for achondroplasia therapies...
  29. doi [The "Snail" genes and renal diseases: what we learn from organogenesis]
    Agnes Boutet
    Med Sci (Paris) 24:238-40. 2008
  30. doi Non-coding RNAs take centre stage in epithelial-to-mesenchymal transition
    Amparo Cano
    Departamento de Bioquimica UAM, Instituto de Investigaciones Biomédicas Alberto Sols CSIC UAM Arturo Duperier 4, 28029 Madrid, Spain
    Trends Cell Biol 18:357-9. 2008
    ..These findings open new avenues for understanding the modulation of the epithelial-to-mesenchymal transition in physiological and pathological situations...
  31. ncbi Snail precedes slug in the genetic cascade required for the specification and migration of the Xenopus neural crest
    Manuel J Aybar
    Millennium Nucleus in Developmental Biology, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago, Chile
    Development 130:483-94. 2003
    ....
  32. ncbi Snail and E47 repressors of E-cadherin induce distinct invasive and angiogenic properties in vivo
    Hector Peinado
    Departamento de Bioquimica, UAM Instituto de Investigaciones Biomédicas Alberto Sols CSIC UAM, Arturo Duperier 4, 28029 Madrid, Spain
    J Cell Sci 117:2827-39. 2004
    ....
  33. ncbi The expression of Scratch genes in the developing and adult brain
    Faustino Marin
    Instituto de Neurociencias, CSIC UMH, San Juan de Alicante, Spain
    Dev Dyn 235:2586-91. 2006
    ..Nevertheless, strong expression of Scratch2 is retained in the postnatal cortical subventricular zone, in the inner part of the cerebellar external granular layer, and in the glial cells of the adult vomeronasal nerve...
  34. ncbi The Snail genes as inducers of cell movement and survival: implications in development and cancer
    Alejandro Barrallo-Gimeno
    Instituto de Neurociencias de Alicante CSIC UMH, Apartado 18, Sant Joan d Alacant, 03550, Spain
    Development 132:3151-61. 2005
    ..From these findings, we propose that Snail genes act primarily as survival factors and inducers of cell movement, rather than as inducers of EMT or cell fate...
  35. ncbi Snail family members and cell survival in physiological and pathological cleft palates
    Concepción Martínez-Álvarez
    Departamento de Anatomía y Embriología Humana I, Facultad de Medicina, Universidad Complutense de Madrid, 28040 Madrid, Spain
    Dev Biol 265:207-18. 2004
    ....
  36. ncbi Snail3 orthologues in vertebrates: divergent members of the Snail zinc-finger gene family
    Miguel Manzanares
    Instituto de Investigaciones Biomedicas, CSIC UAM, Arturo Duperier 4, 28029 Madrid, Spain
    Dev Genes Evol 214:47-53. 2004
    ..We further show that all three Snail genes lie in regions of extensive paralogy, revealing their common origin through segmental or chromosomal duplication...
  37. ncbi Jawsfest: new perspectives on neural crest lineages and morphogenesis
    Paul Trainor
    Stowers Institute for Medical Research, 1000 E 50th Street, Kansas City, MO 64110, USA
    Development 130:5059-63. 2003
    ..These aspects of the field were revisited and discussed in a recent meeting organized to honour the retirement of Jim Weston and his contribution to the field...
  38. doi In situ hybridization analysis of chick embryos in whole-mount and tissue sections
    Hervé Acloque
    Instituto de Neurociencias de Alicante CSIC UMH, Apartado 18, San Juan de Alicante, 03550 Spain
    Methods Cell Biol 87:169-85. 2008
  39. pmc A new regulatory loop in cancer-cell invasion
    Oscar H Ocaña
    Instituto de Neurociencias de Alicante, CSIC UMH, Apartado 18, San Juan de Alicante 03550, Spain
    EMBO Rep 9:521-2. 2008
  40. ncbi Evolution of the neural crest
    Alejandro Barrallo-Gimeno
    Instituto de Neurociencias de Alicante CSIC UMH, San Juan de Alicante, Spain
    Adv Exp Med Biol 589:235-44. 2006
    ....
  41. ncbi Reactivation of Snail genes in renal fibrosis and carcinomas: a process of reversed embryogenesis?
    Agnes Boutet
    Instituto de Neurociencias de Alicante, CSIC UMH, Sant Joan d Alacant, Spain
    Cell Cycle 6:638-42. 2007
    ..Thus, Snail genes illustrate a paradigm whereby reactivation of crucial embryonic genes in adult tissues provokes the onset of devastating diseases...
  42. pmc Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability
    Derek C Radisky
    Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720, USA
    Nature 436:123-7. 2005
    ..These findings identify a previously undescribed pathway in which a component of the breast tumour microenvironment alters cellular structure in culture and tissue structure in vivo, leading to malignant transformation...
  43. pmc The physiology and pathology of the EMT. Meeting on the epithelial-mesenchymal transition
    Hervé Acloque
    Instituto de Neurociencias de Alicante, CSIC UMH, Apartado 18, San Juan de Alicante, 03550 Spain
    EMBO Rep 9:322-6. 2008