- Prediction of cervical intraepithelial neoplasia grade 2+ (CIN2+) using HPV DNA testing after a diagnosis of atypical squamous cell of undetermined significance (ASC-US) in Catalonia, SpainRaquel Ibanez
Unit of Infections and Cancer, Cancer Epidemiology Research Programme, IDIBELL, Catalan Institute of Oncology, Av, Gran Via, 199 203L Hospitalet de Llobregat, 08907 Barcelona, Spain
BMC Infect Dis 12:25. 2012..We evaluated the implementation of the protocol and the prediction of HPV testing as a triage tool for cervical intraepithelial lesions grade two or worse (CIN2+) in women with a cytological diagnosis of ASC-US...
- Performance of the digene LQ, RH and PS HPVs genotyping systems on clinical samples and comparison with HC2 and PCR-based Linear ArrayJose M Godínez
Unit of Infections and Cancer UNIC, Cancer Epidemiology Research Program CERP, IDIBELL, Catalan Institute of Oncology ICO, Gran Via 199 203, L Hospitalet de Llobregat 08907, Barcelona, Spain
Infect Agent Cancer 6:23. 2011..abstract:..
- Human Papillomavirus (HPV) infection in pregnant women and mother-to-child transmission of genital HPV genotypes: a prospective study in SpainXavier Castellsague
Unit of Infections and Cancer UNIC, Cancer Epidemiology Research Program CERP, IDIBELL Institut Català d Oncologia ICO, Hospitalet de Llobregat, Barcelona, Spain
BMC Infect Dis 9:74. 2009..Studies on HPV infection in pregnant women and HPV transmission to the child have yielded inconsistent results...
- Human papillomavirus prevalence and type-specific relative contribution in invasive cervical cancer specimens from ItalyLuciano Mariani
Regina Elena National Cancer Institute, Dept Gynecologic Oncology, Roma, Italy
BMC Cancer 10:259. 2010..Human papillomavirus (HPV) infection is now well-established as a necessary cause of invasive cervical cancer (ICC) development. Only a few studies on HPV prevalence and type-specific distribution in ICC have been conducted in Italy...
- Age at sexual initiation and number of sexual partners in the female Spanish population Results from the AFRODITA surveySilvia de Sanjose
Unit of Infections and Cancer, Cancer Epidemiology Research Program, Catalan Institut of Oncology, Hospitalet del Llobregat, Spain
Eur J Obstet Gynecol Reprod Biol 140:234-40. 2008..The AFRODITA study was designed to describe patterns relating to the number of lifetime sexual partners (SP) and age at first sexual intercourse (AFSI) by geographic region in a representative sample of Spanish women...
- Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: a meta-analysisSilvia de Sanjose
Servei d Epidemiologia i Registre del Cancer, Institut Catala d Oncologia, Barcelona, Spain
Lancet Infect Dis 7:453-9. 2007..The HPV types most commonly detected are similar to those most commonly described in pre-neoplastic and cancer cases, although the relative contribution of HPV16 and HPV18 is substantially lower in cytologically normal women...
- Hepatitis C and non-Hodgkin lymphoma among 4784 cases and 6269 controls from the International Lymphoma Epidemiology ConsortiumSilvia de Sanjose
Unit of Infections and Cancer, Catalan Institute of Oncology, Institut d Investigacio Biomedica de Bellvitge, Centro de Investigación Biomédica en Red Epidemiología y Salud Pública, Barcelona, Spain
Clin Gastroenterol Hepatol 6:451-8. 2008..We pooled case-control study data to provide robust estimates of the risk of non-Hodgkin's lymphoma (NHL) subtypes after HCV infection...
- Association between personal use of hair dyes and lymphoid neoplasms in EuropeSilvia de Sanjose
Catalan Institute of Oncology, Barcelona, Spain
Am J Epidemiol 164:47-55. 2006..10, 2.40). Personal use of hair dyes is associated with a moderate increase in lymphoma risk, particularly among women and persons who used dyes before 1980. Specific compounds associated with this risk remain to be elucidated...
- Epstein-Barr virus infection and risk of lymphoma: immunoblot analysis of antibody responses against EBV-related proteins in a large series of lymphoma subjects and matched controlsSilvia de Sanjose
Servei d Epidemiologia and Registre del Cancer, IDIBELL, Institut Catala d Oncologia, Gran Via Km 2 7, 08907 L Hospitalet, Barcelona, Spain
Int J Cancer 121:1806-12. 2007..Ab_EBV is a useful tool to explore EBV imbalances preceding or paralleling possible EBV associated oncogenic events...
- Human papillomavirus vaccines and vaccine implementationSilvia de Sanjose
Unit of Infections and Cancer UNIC, Cancer Epidemiology Research Programme, Catalan Institute of Oncology, IDIBELL and CIBER Epidemiología y Salud Pública CIBERESP, Barcelona, Spain
Womens Health (Lond Engl) 4:595-604. 2008..Finally, some major aspects that are likely to impact the introduction of these vaccines around the world are outlined, with particular emphasis on developing countries...
- Geographic variation in the prevalence of Kaposi sarcoma-associated herpesvirus and risk factors for transmissionSilvia de Sanjose
Institut Catala d Oncologia, and 2Centro de Investigación Biomédica en Red de Epidemiologia y Salud Pública, Barcelona, Spain
J Infect Dis 199:1449-56. 2009..The aim of the present study was to estimate the prevalence of Kaposi sarcoma-associated herpesvirus (KSHV) in the female general population, to define geographic variation in and heterosexual transmission of the virus...
- Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide studySilvia de Sanjose
IDIBELL, Institut Català d Oncologia Catalan Institute of Oncology, L Hospitalet de Llobregat, Barcelona, Spain
Lancet Oncol 11:1048-56. 2010..We aimed to provide novel and comprehensive data about the worldwide genotype distribution in patients with invasive cervical cancer...
- Reproductive factors and lymphoid neoplasms in Europe: findings from the EpiLymph case-control studyLaura Costas
Unit of Infections and Cancer, Cancer Epidemiology Research Programme, Institut Catala d Oncologia, IDIBELL, Av Gran Via de L Hospitalet 199 203, 08908, L Hospitalet de Llobregat, Barcelona, Spain
Cancer Causes Control 23:195-206. 2012..Higher incidence rates are observed for many lymphoma subtypes in men compared with women suggesting an underlying association. Our goal was to investigate the association between reproductive factors and lymphomas...
- Role of hepatitis C virus infection in malignant lymphoma in SpainSilvia de Sanjose
Servei d Epidemiologia i Registre del Cancer, Institut Catala d Oncologia, Barcelona, Spain
Int J Cancer 111:81-5. 2004..HCV infection is associated with an increased risk of a broad spectrum of lymphoid neoplasms among non severely immunocompromised subjects in Spain...
- Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymphDelphine Casabonne
Unit of Infections and Cancer UNIC, IDIBELL, Institut Catala d Oncologia, L Hospitalet de Llobregat, Barcelona, Spain
Haematologica 96:323-7. 2011..All interactions were additive and no main effect was observed. The strong interactions observed may be indicative of a specific pathway in cancer genesis. Confirmation of these results is warranted...
- The association of cyclin D1 G870A and E-cadherin C-160A polymorphisms with the risk of colorectal cancer in a case control study and meta-analysisXiang Lin Tan
Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
Int J Cancer 122:2573-80. 2008..However, the CCND1 G870A polymorphism may modify the protective effect of postmenopausal hormone use on the development of CRC...
- Occupational exposure to meat and risk of lymphoma: a multicenter case-control study from EuropeTina Moore
Department of Lifestyle, Environment and Cancer, International Agency for Research on Cancer, Lyon, France
Int J Cancer 121:2761-6. 2007..Occupational exposure to meat does not appear to represent an important risk factor of lymphoma, although an increased risk of specific types of non-Hodgkin lymphoma cannot be excluded...
- Joint effect between regular use of non-steroidal anti-inflammatory drugs, variants in inflammatory genes and risk of lymphomaBirgit Hoeft
Molecular Tumour Epidemiology, Division of Cancer Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 280, Heidelberg, Germany
Cancer Causes Control 19:163-73. 2008..To further research in this area, we investigated the role of genetic variants in key inflammatory factors, non-steroidal anti-inflammatory drug [NSAID] use, and their joint effect in lymphomagenesis...
- A functional TNFRSF5 gene variant is associated with risk of lymphomaChristine F Skibola
Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, CA 94720 7360, USA
Blood 111:4348-54. 2008..These results suggest that the TNFRSF5 -1C>T polymorphism may increase FL susceptibility through mechanisms that hinder cellular immune responses. Further studies are needed to explore these findings...
- Anthropometric characteristics and non-Hodgkin's lymphoma and multiple myeloma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)Julie A Britton
Department of Epidemiology and Public Health, Imperial College London, Room 151, St Mary s Campus, Norfolk Place W2 1PG, London, UK
Haematologica 93:1666-77. 2008..It has been hypothesized that this may be due, in part, to the parallel rising prevalence of obesity. It is biologically plausible that anthropometric characteristics can infuence the risk of non-Hodgkin's lymphoma and multiple myeloma...
- Personal use of hair dye and the risk of certain subtypes of non-Hodgkin lymphomaYawei Zhang
Environmental Science Division, School of Public Health, Yale University, New Haven, CT, USA
Am J Epidemiol 167:1321-31. 2008..1, 2.0). These results indicate that personal hair-dye use may play a role in risks of FL and CLL/SLL in women who started use before 1980 and that increased risk of FL among women who started use during or after 1980 cannot be excluded...
- Vitamin D receptor gene polymorphisms and haplotypes and postmenopausal breast cancer riskSascha Abbas
Division of Cancer Epidemiology, German Cancer Research Center, Im Neuenheimer Feld, 69120 Heidelberg, Germany
Breast Cancer Res 10:R31. 2008..Effect modification by serum 25-hydroxyvitamin D (25 [OH]D), the biomarker for vitamin D status in humans, has rarely been examined...
- Exposure to ultraviolet radiation and risk of malignant lymphoma and multiple myeloma--a multicentre European case-control studyPaolo Boffetta
International Agency for Research on Cancer, Lyon, France
Int J Epidemiol 37:1080-94. 2008..Three recent studies have reported a decreased risk of non-Hodgkin lymphoma (NHL) for high ultraviolet (UV) radiation exposure...
- Polymorphisms in candidate obesity genes and their interaction with dietary intake of n-6 polyunsaturated fatty acids affect obesity risk in a sub-sample of the EPIC-Heidelberg cohortAlexandra Nieters
German Cancer Research Center, Division of Clinical Epidemiology, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
Eur J Nutr 41:210-21. 2002....
- Statin use and risk of lymphoid neoplasms: results from the European Case-Control Study EPILYMPHJoan Fortuny
, , Gran Via Km 2.7, 08907 L'Hospitalet de Llobregat, Autonomous University of Barcelona [corrected] Barcelona, Catalonia, Spain
Cancer Epidemiol Biomarkers Prev 15:921-5. 2006..These results are reassuring for the increasing number of patients taking statins on a regular basis...
- Influence of familial cancer history on lymphoid neoplasms risk validated in the large European case-control study epilymphRomain Casey
Registre des Hémopathies Malignes de Côte d Or, EA INSERM InVs 4T0003C, faculté de médecine de Dijon, 7 Boulevard Jeanne d Arc, 21 000 Dijon, France
Eur J Cancer 42:2570-6. 2006..Our study suggests familial aggregation of CLL with a family history of haematological cancer and of HL with a family history of lymphoma. The transmission pattern suggests a dominant model of heredity...
- Meat, fish, and colorectal cancer risk: the European Prospective Investigation into cancer and nutritionTeresa Norat
International Agency for Research on Cancer, 150 cours Albert Thomas, 69 372 Lyon cedex 08, France
J Natl Cancer Inst 97:906-16. 2005..CONCLUSIONS: Our data confirm that colorectal cancer risk is positively associated with high consumption of red and processed meat and support an inverse association with fish intake...
- Hepatitis C and risk of lymphoma: results of the European multicenter case-control study EPILYMPHAlexandra Nieters
German Cancer Research Center, Heidelberg, Germany
Gastroenterology 131:1879-86. 2006..However, previous epidemiologic studies were limited in size to establish an association between HCV infection and specific lymphoma subtypes. We performed a large, multicenter, case-control study to address this question...
- Tobacco and alcohol consumption and risk of lymphoma: results of a population-based case-control study in GermanyAlexandra Nieters
Division of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany
Int J Cancer 118:422-30. 2006..In conclusion, this investigation suggests a positive association between tobacco smoking and lymphoma risk and finds decreased odds ratios among consumers of alcohol...
- Medical history and risk for lymphoma: results of a population-based case-control study in GermanyNikolaus Becker
German Cancer Research Center, Division of Clinical Epidemiology, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
Eur J Cancer 41:133-42. 2005..These results are compatible with the notion that persistent immunological alterations contribute to the aetiology of lymphoma, but partially inconsistent with the Th1/Th2-shift paradigm...
- Population-based study of lymphoma in Germany: rationale, study design and first resultsNikolaus Becker
Deutsches Krebsforschungszentrum, Abteilung Klinische Epidemiologie, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
Leuk Res 28:713-24. 2004..The inconsistencies of some of the findings with an explanation by the Th1/Th2 paradigm, however, warrant further research and may indicate that broader explanatory concepts are needed...
- Sun exposure and malignant lymphoma: a population-based case-control study in GermanyThomas Weihkopf
Institute of Medical Biostatistics, Epidemiology and Informatics, Johannes Gutenberg University, Mainz, Germany
Int J Cancer 120:2445-51. 2007..This data suggest that exposure to natural and artificial ultraviolet radiation may reduce the OR for lymphoma in this study population...
- Serum C-peptide, IGFBP-1 and IGFBP-2 and risk of colon and rectal cancers in the European Prospective Investigation into Cancer and NutritionMazda Jenab
Nutrition and Hormones Group, IARC WHO, Lyon, France
Int J Cancer 121:368-76. 2007..No clear colorectal cancer risk associations were observed for IGFBP-1 or -2. This large prospective study confirms that hyperinsulinemia, as determined by C-peptide levels, is associated with an increased colorectal cancer risk...
- Fruit and vegetable consumption and lymphoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)Sabine Rohrmann
Division of Clinical Epidemiology C020, German Cancer Research Centre, Im Neuenheimer Feld 280, Heidelberg, 69120, Germany
Cancer Causes Control 18:537-49. 2007..The best-established risk factors are related to dys-regulation of immune function, and evidence suggests that factors such as dietary or lifestyle habits may be involved in the etiology...
- Single nucleotide polymorphism--disease relationships: statistical issues for the performance of association studiesNikolaus Becker
Deutsches Krebsforschungszentrum, Division of Clinical Epidemiology, Im Neuenheimer Feld 280, Heidelberg 69120, Germany
Mutat Res 525:11-8. 2003..Additionally, minimal information is proposed which should be presented in publications about association studies in order to facilitate reproducibility studies by other authors...
- The fibroblast growth factor receptor gene Arg388 allele is not associated with early lymph node metastasis of breast cancerNikolaus Becker
Deutsches Krebsforschungszentrum, Division of Clinical Epidemiology, 69120 Heidelberg, Germany
Cancer Epidemiol Biomarkers Prev 12:582-3. 2003
- Polymorphisms in the estrogen receptor 1 and vitamin C and matrix metalloproteinase gene families are associated with susceptibility to lymphomaChristine F Skibola
School of Public Health, Division of Environmental Health Sciences, University of California Berkeley, Berkeley, California, USA
PLoS ONE 3:e2816. 2008..Non-Hodgkin lymphoma (NHL) is the fifth most common cancer in the U.S. and few causes have been identified. Genetic association studies may help identify environmental risk factors and enhance our understanding of disease mechanisms...
- Reproductive and dietary determinants of the age at menopause in EPIC-HeidelbergGabriele Nagel
Division of Clinical Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120 Heidelberg, Germany
Maturitas 52:337-47. 2005..The aim of the study was to explore the influence of reproductive and dietary factors on the age at menopause...
- Dietary fibre in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC): an observational studySheila A Bingham
MRC Dunn Human Nutrition Unit, Cambridge, UK
Lancet 361:1496-501. 2003..INTERPRETATION: In populations with low average intake of dietary fibre, an approximate doubling of total fibre intake from foods could reduce the risk of colorectal cancer by 40%...
- Effect of cytokine genotypes on the hepatitis B virus-hepatocellular carcinoma associationAlexandra Nieters
Department of Clinical Epidemiology, German Cancer Research Center, Heidelberg, Germany
Cancer 103:740-8. 2005..However, only a minority of HBV carriers eventually develop hepatocellular carcinoma. The authors hypothesized that cytokine genotypes may be important codeterminants of the risk of HBV-related hepatocellular carcinoma...
- [Dietary fibers in food and protection against colorectal cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) study]Anne M Tjønneland
Kraeftens Bekaempelse, Institut for Epidemiologisk Kraeftforskning, København
Ugeskr Laeger 166:2458-60. 2004
- Genetic variation in TNF and IL10 and risk of non-Hodgkin lymphoma: a report from the InterLymph ConsortiumNathaniel Rothman
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, MD 20892, USA
Lancet Oncol 7:27-38. 2006..We aimed to test this hypothesis using previously unpublished data from eight European, Canadian, and US case-control studies of the International Lymphoma Epidemiology Consortium (InterLymph)...
- Risk of malignant lymphoma following viral hepatitis infectionPierluigi Cocco
Department of Public Health, Occupational Health Section, University of Cagliari, Asse Didattico, Policlinico Universitario, SS 554, Km 4, 500, 09042, Monserrato, Cagliari, Italy
Int J Hematol 87:474-83. 2008..Our results confirm a role of either acute or chronic active HCV infection in lymphomagenesis. Further studies are warranted to test the hypothesis that acute infection from other hepatitis viruses might also increase lymphoma risk...
- Fruit and vegetable consumption and lung cancer risk: updated information from the European Prospective Investigation into Cancer and Nutrition (EPIC)Jakob Linseisen
Division of Clinical Epidemiology, German Cancer Research Centre, Heidelberg, Germany
Int J Cancer 121:1103-14. 2007..In addition to an overall inverse association with fruit intake, the results of this evaluation add evidence for a significant inverse association of vegetable consumption and lung cancer incidence in smokers...
- Helicobacter pylori infection, interleukin-1 gene polymorphisms and the risk of colorectal cancer: evidence from a case-control study in GermanyNatalia Zumkeller
Division of Clinical Epidemiology and Aging Research, German Cancer Research Centre, Bergheimer Str 20, D 69115 Heidelberg, Germany
Eur J Cancer 43:1283-9. 2007..Additionally, a pro-inflammatory genotype did not increase the colorectal cancer risk associated with H. pylori infection. H. pylori positive subjects carrying the pro-inflammatory genotypes even had a lower risk...
- Variation in DNA repair genes XRCC3, XRCC4, XRCC5 and susceptibility to myelomaPatrick J Hayden
Durkan Leukaemia Laboratories, Department of Haematology, Institute of Molecular Medicine, Trinity College Dublin, Ireland
Hum Mol Genet 16:3117-27. 2007..015). This SNP is located in the 3'-UTR of XRCC5. Overall, these data provide support for the hypothesis that common variation in the genes encoding DNA repair proteins contributes to susceptibility to myeloma...
- Family history of hematopoietic malignancies and risk of non-Hodgkin lymphoma (NHL): a pooled analysis of 10 211 cases and 11 905 controls from the International Lymphoma Epidemiology Consortium (InterLymph)Sophia S Wang
Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, 6120 Executive Boulevard, Bethesda, MD 20892, USA
Blood 109:3479-88. 2007..0; 95% CI = 1.6-5.6). The pattern of NHL heritability appeared to be uniform across NHL subtypes, but risk patterns differed by specific hematopoietic malignancies and the sex of the relative, revealing critical clues to disease etiology...
- Interleukin-2, interleukin-12, and interferon-gamma levels and risk of young adult Hodgkin lymphomaWendy Cozen
Department of Preventive Medicine, Keck School of Medicine and Norris Comprehensive Cancer Center, University of Southern California, Los Angeles 90089 9175, USA
Blood 111:3377-82. 2008..8-fold (P=.03) increase in YAHL risk. Thus, both case-twins and their unaffected cotwins had a decreased ability to produce IL-12, which may contribute to YAHL susceptibility...
- Non-Hodgkin lymphoma and obesity: a pooled analysis from the InterLymph ConsortiumEleanor V Willett
Epidemiology and Genetics Unit, Department of Health Sciences, University of York, Heslington, York YO10 5DD, United Kingdom
Int J Cancer 122:2062-70. 2008....
- Genetic susceptibility to lymphomaChristine F Skibola
Division of Environmental Health Sciences, School of Public Health, 140 Warren Hall, University of California, Berkeley, CA 94720 7360, USA
Haematologica 92:960-9. 2007..Numerous studies suggest that common genetic variants with low penetrance influence lymphoma risk, though replication studies will be needed to eliminate false positive associations...
- Smoking and lymphoma risk in the European prospective investigation into cancer and nutritionAlexandra Nieters
Division of Cancer Epidemiology, Deutsches Krebsforschungszentrum, Heidelberg, Germany
Am J Epidemiol 167:1081-9. 2008..Future analysis should involve viral biomarkers and genetic susceptibility markers to elucidate potential mechanisms of smoking-induced carcinogenesis, particularly for Hodgkin's lymphoma...
- Tobacco smoking, alcohol drinking and non-Hodgkin's lymphoma: A European multicenter case-control study (Epilymph)Herve Besson
International Agency for Research on Cancer, Lyon, France
Int J Cancer 119:901-8. 2006..The results of this large-scale European study did not support an association between tobacco and NHL and suggested a protective effect of alcohol on development of NHL for men and in non-Mediterranean countries...
- Diabetes and the risk of non-Hodgkin's lymphoma and multiple myeloma in the European Prospective Investigation into Cancer and NutritionAneire E Khan
Department of Epidemiology and Public Health, Division of Epidemiology, Public Health and Primary Care, Imperial College London, St Mary s Campus, Variety Wing, Norfolk Place, Paddington, London W2 1PG
Haematologica 93:842-50. 2008..Increases in the incidence of non-Hodgkin's lymphoma and multiple myeloma in the past implicate environmental factors as potential causal agents...
- Birth order, allergies and lymphoma risk: results of the European collaborative research project EpilymphNikolaus Becker
Division of Cancer Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 280, D 69120 Heidelberg, Germany
Leuk Res 31:1365-72. 2007..Our findings on birth order and lymphoma increase the inconsistency of findings across studies and suggest a critical reappraisal of potential underlying mechanisms...