X Navarro

Summary

Country: Spain

Publications

  1. ncbi request reprint Long term assessment of axonal regeneration through polyimide regenerative electrodes to interface the peripheral nerve
    Natalia Lago
    Department of Cell Biology, Physiology and Immunology, Institute of Neuroscience, Universitat Autonoma de Barcelona, Edif M, Campus UAB, E08193 Bellaterra, Spain
    Biomaterials 26:2021-31. 2005
  2. ncbi request reprint [Physiology of the autonomic nervous system]
    X Navarro
    Facultat de Medicina, Universitat Autònoma de Barcelona Bellaterra, Espana
    Rev Neurol 35:553-62. 2002
  3. ncbi request reprint A critical review of interfaces with the peripheral nervous system for the control of neuroprostheses and hybrid bionic systems
    Xavier Navarro
    Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, Bellaterra, Spain
    J Peripher Nerv Syst 10:229-58. 2005
  4. ncbi request reprint New silicones for the evaluation of sudomotor function with the impression mold technique
    Jorge Juan Vilches
    Unitat de Fisiologia, Facultat de Medicina, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Clin Auton Res 12:20-3. 2002
  5. ncbi request reprint Neural plasticity after peripheral nerve injury and regeneration
    X Navarro
    Group of Neuroplasticity and Regeneration, Institute of Neurosciences and Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, E 08193 Bellaterra, Spain
    Prog Neurobiol 82:163-201. 2007
  6. ncbi request reprint Effects of FK506 on nerve regeneration and reinnervation after graft or tube repair of long nerve gaps
    X Navarro
    Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, E 08193 Bellaterra, Spain
    Muscle Nerve 24:905-15. 2001
  7. ncbi request reprint Engineering an artificial nerve graft for the repair of severe nerve injuries
    X Navarro
    Group of Neuroplasticity and Regeneration, Institute of Neurosciences and Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Med Biol Eng Comput 41:220-6. 2003
  8. ncbi request reprint Superior muscle reinnervation after autologous nerve graft or poly-L-lactide-epsilon-caprolactone (PLC) tube implantation in comparison to silicone tube repair
    A Valero-Cabre
    Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, Spain
    J Neurosci Res 63:214-23. 2001
  9. ncbi request reprint Acute transplantation of olfactory ensheathing cells or Schwann cells promotes recovery after spinal cord injury in the rat
    Guillermo Garcia-Alias
    Institute of Neurosciences and Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, Bellaterra, Spain
    J Neurosci Res 75:632-41. 2004
  10. ncbi request reprint Increased expression of cyclo-oxygenase 2 and vascular endothelial growth factor in lesioned spinal cord by transplanted olfactory ensheathing cells
    Rubèn López-Vales
    Neuroplasticity and Regeneration Group, Institute of Neuroscience and Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, Bellaterra, Spain
    J Neurotrauma 21:1031-43. 2004

Collaborators

Detail Information

Publications70

  1. ncbi request reprint Long term assessment of axonal regeneration through polyimide regenerative electrodes to interface the peripheral nerve
    Natalia Lago
    Department of Cell Biology, Physiology and Immunology, Institute of Neuroscience, Universitat Autonoma de Barcelona, Edif M, Campus UAB, E08193 Bellaterra, Spain
    Biomaterials 26:2021-31. 2005
    ..The number of ChAT-positive axons was markedly lower distally than proximally to the sieve electrode...
  2. ncbi request reprint [Physiology of the autonomic nervous system]
    X Navarro
    Facultat de Medicina, Universitat Autònoma de Barcelona Bellaterra, Espana
    Rev Neurol 35:553-62. 2002
    ..Its overall function is that of maintaining a state of homeostasis in the organism and of performing the adaptation responses when faced with changes in the external and internal environment...
  3. ncbi request reprint A critical review of interfaces with the peripheral nervous system for the control of neuroprostheses and hybrid bionic systems
    Xavier Navarro
    Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, Bellaterra, Spain
    J Peripher Nerv Syst 10:229-58. 2005
    ..The last section reviews different strategies for the use of information recorded from peripheral interfaces and the current state of control neuroprostheses and hybrid bionic systems...
  4. ncbi request reprint New silicones for the evaluation of sudomotor function with the impression mold technique
    Jorge Juan Vilches
    Unitat de Fisiologia, Facultat de Medicina, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Clin Auton Res 12:20-3. 2002
    ..From these results we recommend Silasoft as a valid substitute of Elasticon for the evaluation of sudomotor function with the silicone impression technique...
  5. ncbi request reprint Neural plasticity after peripheral nerve injury and regeneration
    X Navarro
    Group of Neuroplasticity and Regeneration, Institute of Neurosciences and Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, E 08193 Bellaterra, Spain
    Prog Neurobiol 82:163-201. 2007
    ....
  6. ncbi request reprint Effects of FK506 on nerve regeneration and reinnervation after graft or tube repair of long nerve gaps
    X Navarro
    Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, E 08193 Bellaterra, Spain
    Muscle Nerve 24:905-15. 2001
    ..In conclusion, treatment with FK506 improved the rate of functional recovery after nerve resection and autograft repair...
  7. ncbi request reprint Engineering an artificial nerve graft for the repair of severe nerve injuries
    X Navarro
    Group of Neuroplasticity and Regeneration, Institute of Neurosciences and Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Med Biol Eng Comput 41:220-6. 2003
    ..Thus, by combined developments on nerve guides, extracellular matrix components and cell transplantation, an artificial graft has been designed that allows axonal regeneration across long gaps to levels comparable with an autograft...
  8. ncbi request reprint Superior muscle reinnervation after autologous nerve graft or poly-L-lactide-epsilon-caprolactone (PLC) tube implantation in comparison to silicone tube repair
    A Valero-Cabre
    Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, Spain
    J Neurosci Res 63:214-23. 2001
    ..Considering the higher CMAP amplitude and lower number of neurons with multiple projections, PLC nerve conduits seem superior to SIL tubes and a suitable alternative to autografts for the repair of long gaps...
  9. ncbi request reprint Acute transplantation of olfactory ensheathing cells or Schwann cells promotes recovery after spinal cord injury in the rat
    Guillermo Garcia-Alias
    Institute of Neurosciences and Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, Bellaterra, Spain
    J Neurosci Res 75:632-41. 2004
    ..Taken together, these results indicate that transplantation of both OEC and SC has potential for restoration of injured spinal cords. OEC grafts showed superior ability to reduce glial reactivity and to improve functional recovery...
  10. ncbi request reprint Increased expression of cyclo-oxygenase 2 and vascular endothelial growth factor in lesioned spinal cord by transplanted olfactory ensheathing cells
    Rubèn López-Vales
    Neuroplasticity and Regeneration Group, Institute of Neuroscience and Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, Bellaterra, Spain
    J Neurotrauma 21:1031-43. 2004
    ..Our results show that OECs promote functional and morphological preservation of the spinal cord after photochemical injury, increasing neoangiogenesis and up-regulation of COX-2 and VEGF expression in astrocytes...
  11. doi request reprint Valproate reduces CHOP levels and preserves oligodendrocytes and axons after spinal cord injury
    C Penas
    Group of Neuroplasticity and Regeneration, Institute of Neurosciences, Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Spain
    Neuroscience 178:33-44. 2011
    ..Since VPA is a drug already in clinical use, these results open the avenue for its therapeutical use in SCI as well as in demyelinating disorders...
  12. ncbi request reprint Functional and electrophysiological characterization of photochemical graded spinal cord injury in the rat
    Guillermo Garcia-Alias
    Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, Bellaterra, Spain
    J Neurotrauma 20:501-10. 2003
    ..A significant negative relationship was found between the area of cystic cavity of the spinal cord and the functional and electrophysiological impairment...
  13. ncbi request reprint Chronic transplantation of olfactory ensheathing cells promotes partial recovery after complete spinal cord transection in the rat
    Rubèn López-Vales
    Group of Neuroplasticity and Regeneration, Institute of Neuroscience and Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Glia 55:303-11. 2007
    ..However, delayed OEC grafts failed to reduce posttraumatic astrogliosis. In conclusion, the beneficial effects found in the present study further support the use of OECs for treating chronic spinal cord injuries...
  14. ncbi request reprint H reflex restitution and facilitation after different types of peripheral nerve injury and repair
    A Valero-Cabre
    Department of Cell Biology, Physiology and Immunology, Faculty of Medicine, Universitat Autonoma de Barcelona, 01893 Bellaterra, Spain
    Brain Res 919:302-12. 2001
    ..Changes in the H reflex circuitry and excitability correlated positively with the deficient recovery of walking pattern after severe nerve injury...
  15. ncbi request reprint Acute and delayed transplantation of olfactory ensheathing cells promote partial recovery after complete transection of the spinal cord
    Rubèn López-Vales
    Group of Neuroplasticity and Regeneration, Institute of Neuroscience and Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, E 08193 Bellaterra, Spain
    Neurobiol Dis 21:57-68. 2006
    ..The beneficial effects obtained with transplantation after transection are encouraging for the application of OECs in the human injured spinal cord...
  16. ncbi request reprint Olfactory ensheathing glia graft in combination with FK506 administration promote repair after spinal cord injury
    Rubèn López-Vales
    Group of Neuroplasticity and Regeneration, Institute of Neuroscience and Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, Spain
    Neurobiol Dis 24:443-54. 2006
    ....
  17. pmc Autophagy, and BiP level decrease are early key events in retrograde degeneration of motoneurons
    C Penas
    Group of Neuroplasticity and Regeneration, Institute of Neurosciences, Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Spain
    Cell Death Differ 18:1617-27. 2011
    ..Besides, Bcl2 is strongly implicated in the survival pathway activated by BiP overexpression...
  18. ncbi request reprint Role of metallothioneins in peripheral nerve function and regeneration
    D Ceballos
    Institute of Neurosciences and Department of Cellular Biology, Physiology and Immunology, Faculty of Medicine, Physiology Unit, Bellaterra, Barcelona 08193, Spain
    Cell Mol Life Sci 60:1209-16. 2003
    ..We conclude that Mt3 normally inhibits peripheral nerve regeneration...
  19. doi request reprint Selective sigma receptor agonist 2-(4-morpholinethyl)1-phenylcyclohexanecarboxylate (PRE084) promotes neuroprotection and neurite elongation through protein kinase C (PKC) signaling on motoneurons
    M S Guzmán-Lenis
    Group of Neuroplasticity and Regeneration, Institute of Neurosciences, Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Neuroscience 162:31-8. 2009
    ..These results suggest the use of PRE084 as a neuroprotective agent for spinal cord damage...
  20. ncbi request reprint Selective fascicular stimulation of the rat sciatic nerve with multipolar polyimide cuff electrodes
    X Navarro
    Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, E 08193 Bellaterra, Spain
    Restor Neurol Neurosci 18:9-21. 2001
    ..To assess a new flexible, multicontact spiral-cuff electrode made of polyimide with integrated platinum contacts for selective stimulation of nerve fascicles...
  21. doi request reprint Immediate electrical stimulation enhances regeneration and reinnervation and modulates spinal plastic changes after sciatic nerve injury and repair
    Meritxell Vivo
    Group of Neuroplasticity and Regeneration, Institute of Neurosciences, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Exp Neurol 211:180-93. 2008
    ..In conclusion, brief electrical stimulation applied after sciatic nerve injury promotes axonal regeneration over a long distance and reduces facilitation of spinal motor responses...
  22. ncbi request reprint Effects of ensheathing cells transplanted into photochemically damaged spinal cord
    E Verdu
    Neuroplasticity and Regeneration Group, Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, Edif M, E 08193 Bellaterra, Spain
    Neuroreport 12:2303-9. 2001
    ..These results indicate that OECs transplanted into damaged adult rat spinal cord exert a neuroprotective role by reducing astrocytic gliosis and cystic cavitation...
  23. doi request reprint Schwann cell targeting via intrasciatic injection of AAV8 as gene therapy strategy for peripheral nerve regeneration
    J Homs
    Center of Animal Biotechnology and Gene Therapy, Universitat Autonoma de Barcelona, Barcelona, Spain
    Gene Ther 18:622-30. 2011
    ..These results prove the utility of AAV8 as a gene therapy vector for Schwann cells to treat myelin disorders or to improve nerve regeneration...
  24. ncbi request reprint Influence of aging on peripheral nerve function and regeneration
    E Verdu
    Department of Cell Biology, Physiology and Immunology, Faculty of Medicine, Universitat Autonoma de Barcelona, Bellaterra, Spain
    J Peripher Nerv Syst 5:191-208. 2000
    ..These age-related changes are not linearly progressive with age; the capabilities for axonal regeneration and reinnervation are maintained throughout life, but tend to be delayed and less effective with aging...
  25. ncbi request reprint Effects of COX-2 and iNOS inhibitors alone or in combination with olfactory ensheathing cell grafts after spinal cord injury
    Rubèn López-Vales
    Group of Neuroplasticity and Regeneration Group, Institute of Neuroscience and Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, Bellaterra, Barcelona, Spain
    Spine (Phila Pa 1976) 31:1100-6. 2006
    ..We studied the effects of inhibitors of COX-2 (NS398) and iNOS (aminoguanidine) alone or in combination with olfactory ensheathing cell (OEC) grafts after spinal cord injury in the rat...
  26. ncbi request reprint Neurobiological assessment of regenerative electrodes for bidirectional interfacing injured peripheral nerves
    Natalia Lago
    Institute of Neurosciences, Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, E 08193 Bellaterra, Spain
    IEEE Trans Biomed Eng 54:1129-37. 2007
    ..Difficulties for recording impulses with regenerative electrodes include the small size of regenerated axons, changes in membrane excitability and in target reconnection...
  27. ncbi request reprint Morphological characterization of photochemical graded spinal cord injury in the rat
    Enrique Verdú
    Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, Bellaterra, Spain
    J Neurotrauma 20:483-99. 2003
    ..In spinal cord sections from animals illuminated for 5 min and perfused 60 min postillumination, light and electron microscopy showed cytotoxic edema with astrocytic swelling, red blood cell extravasation, and myelin degradation...
  28. ncbi request reprint Olfactory ensheathing cells transplanted in lesioned spinal cord prevent loss of spinal cord parenchyma and promote functional recovery
    Enrique Verdú
    Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Glia 42:275-86. 2003
    ..These results indicate that OECs promote functional and morphological preservation of the spinal cord after photochemical injury...
  29. ncbi request reprint [Immunophilins: neuroprotective agents and promoters of neural regeneration]
    E Udina
    Grupo de Neuroplasticidad y Regeneración, Departamento de Biologia Celular, Fisiologia e Inmunologia, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Neurologia 17:200-13. 2002
    ..The development of new agents that selectively bind to immunophilins opens new interesting perspectives for the therapy of degenerative diseases and injuries of the nervous system...
  30. ncbi request reprint Integrated CMOS amplifier for ENG signal recording
    A Uranga
    Electronic Engineering Department, Universitat Autonoma de Barcelona, 08193 Bellaterra, Spain
    IEEE Trans Biomed Eng 51:2188-94. 2004
    ..Compound muscle action potentials, motor unit action potentials, and compound nerve action potentials have been recorded in acute experiments with rats, in order to validate the amplifier...
  31. doi request reprint Analysis of FK506-mediated protection in an organotypic model of spinal cord damage: heat shock protein 70 levels are modulated in microglial cells
    M S Guzmán-Lenis
    Group of Neuroplasticity and Regeneration, Institute of Neurosciences and Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, Bellaterra, Barcelona, Spain
    Neuroscience 155:104-13. 2008
    ..These observations suggest that FK506 might protect spinal cord tissue by targeting on microglial cells and that transient downregulation of Hsp70 on these cells after excitotoxicity is a relevant mechanism of action of FK506...
  32. ncbi request reprint FK506 enhances regeneration of axons across long peripheral nerve gaps repaired with collagen guides seeded with allogeneic Schwann cells
    Esther Udina
    Department of Cell Biology, Group of Neuroplasticity and Regeneration, Institute of Neurosciences and Physiology and Immunology, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Glia 47:120-9. 2004
    ..Thus, FK506 should be considered as adjunct therapy for various types of tubulization repair...
  33. doi request reprint Chapter 6: Methods and protocols in peripheral nerve regeneration experimental research: part III-electrophysiological evaluation
    Xavier Navarro
    Institute of Neurosciences and Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, E 08193 Bellaterra, Spain
    Int Rev Neurobiol 87:105-26. 2009
    ..This chapter gives a brief review of the most useful electrophysiological methods, their values, and limitations...
  34. ncbi request reprint Peripheral and spinal motor reorganization after nerve injury and repair
    Antoni Valero-Cabre
    Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, Spain
    J Neurotrauma 21:95-108. 2004
    ..5%) or straight suture (2.2%) than following crossed suture (5%) or silicone tube (6%). In conclusion, nerve repair with a silicone tube leaving a short gap does not increase accuracy of reinnervation...
  35. ncbi request reprint FK506 enhances reinnervation by regeneration and by collateral sprouting of peripheral nerve fibers
    Esther Udina
    Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, E 08193 Bellaterra, Spain
    Exp Neurol 183:220-31. 2003
    ..Taken together, our findings indicate that, in addition to an effect on rate of axonal elongation, FK506 improves functional recovery of denervated targets by increasing both regenerative and collateral reinnervation...
  36. ncbi request reprint Effects of motor and sensory nerve transplants on amount and specificity of sciatic nerve regeneration
    Natalia Lago
    Group of Neuroplasticity and Regeneration, Department of Cell Biology, Physiology and Immunology, and Institute of Neuroscience, Universitat Autonoma de Barcelona, Bellaterra, Spain
    J Neurosci Res 85:2800-12. 2007
    ..Although there is not clear preferential reinnervation, regeneration of motor axons is promoted at early times by a motor graft, whereas reinnervation of sensory pathways is increased by a sensory graft...
  37. doi request reprint Electrical stimulation combined with exercise increase axonal regeneration after peripheral nerve injury
    Elena Asensio-Pinilla
    Group of Neuroplasticity and Regeneration, Institute of Neurosciences and Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Exp Neurol 219:258-65. 2009
    ..The facilitation of the monosynaptic H reflex in the injured limb was reduced in all treated groups, suggesting that the maintenance of activity helps to prevent the development of hyperreflexia...
  38. ncbi request reprint Alignment of collagen and laminin-containing gels improve nerve regeneration within silicone tubes
    Enrique Verdú
    Group of Neuroplasticity and Regeneration, Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, E 08193 Bellaterra, Spain
    Restor Neurol Neurosci 20:169-79. 2002
    ..Placement of extracellular matrix components has been used as a mean to enhance axonal growth across nerve long gaps repaired by tubulization. However, such matrices may impede axonal regeneration depending on its density and microgeometry...
  39. ncbi request reprint Early social isolation decreases the expression of calbindin D-28k in rat cerebellar Purkinje cells
    R Pascual
    Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, Spain
    Neurosci Lett 272:171-4. 1999
    ....
  40. ncbi request reprint Differential motor and electrophysiological outcome in rats with mid-thoracic or high lumbar incomplete spinal cord injuries
    Guillermo Garcia-Alias
    Neuroplasticity and Regeneration Group, Institute of Neurosciences and Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, E 08193, Bellaterra, Spain
    Brain Res 1108:195-204. 2006
    ..The causes of this anatomical difference may be attributed to damage inflicted on the central pattern generator of locomotion resulting in dysfunction of lumbar motoneurons and altered spinal reflexes modulation...
  41. doi request reprint Chapter 27: Neural plasticity after nerve injury and regeneration
    Xavier Navarro
    Institute of Neurosciences and Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, E 08193 Bellaterra, Spain
    Int Rev Neurobiol 87:483-505. 2009
    ....
  42. ncbi request reprint Spinal cord injury induces endoplasmic reticulum stress with different cell-type dependent response
    Clara Penas
    Group of Neuroplasticity and Regeneration, Institute of Neurosciences and Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, Bellaterra, Barcelona, Spain
    J Neurochem 102:1242-55. 2007
    ..Considering the pro-apoptotic action attributed to this transcription factor, this phenomenon might account for the different susceptibility of cell types to dye after SCI...
  43. ncbi request reprint Evaluation of the long-term regenerative potential in an experimental nerve amputee model
    Natalia Lago
    Group of Neuroplasticity and Regeneration, Department of Cell Biology, Physiology and Immunology, Institute of Neuroscience, Universitat Autonoma de Barcelona, Bellaterra, Spain
    J Peripher Nerv Syst 12:108-20. 2007
    ..These results indicate that axons regenerated may be eventually interfaced with external input-output systems over long time, even if ending in the absence of distal targets as will occur in amputee limbs...
  44. doi request reprint Effects of Schwann cell transplants in an experimental nerve amputee model
    Natalia Lago
    Department of Cell Biology, Physiology and Immunology, and Institute of Neurosciences, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Restor Neurol Neurosci 27:67-78. 2009
    ....
  45. ncbi request reprint FK 506 reduces tissue damage and prevents functional deficit after spinal cord injury in the rat
    Rubèn López-Vales
    Group of Neuroplasticity and Regeneration, Institute of Neuroscience and Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, Bellaterra, Spain
    J Neurosci Res 81:827-36. 2005
    ..The results indicate that FK 506 administration protects the damaged spinal cord and should be considered as potential therapy for treating spinal cord injuries...
  46. ncbi request reprint Assessment of biocompatibility of chronically implanted polyimide and platinum intrafascicular electrodes
    Natalia Lago
    Institute of Neurosciences and Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, E08193 Bellaterra, Spain
    IEEE Trans Biomed Eng 54:281-90. 2007
    ..Both types of LIFEs can be considered biocompatible and cause reversible, minimal nerve damage...
  47. doi request reprint Cytoskeletal and activity-related changes in spinal motoneurons after root avulsion
    Clara Penas
    Group of Neuroplasticity and Regeneration, Institute of Neurosciences, Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, Bellaterra, Spain
    J Neurotrauma 26:763-79. 2009
    ..This study presents a detailed description of motoneuron reaction after root avulsion, which suggests an early time-window during the first 2 weeks for attempts to repair the injury and promote motoneuron survival and regeneration...
  48. doi request reprint Drug screening of neuroprotective agents on an organotypic-based model of spinal cord excitotoxic damage
    Mónica Sofía Guzmán-Lenis
    Group of Neuroplasticity and Regeneration, Institute of Neurosciences, Department of Cell Biology, Physiology and Immunology, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Restor Neurol Neurosci 27:335-49. 2009
    ..Due to the lack of effective treatments for such conditions, new alternatives need to be explored...
  49. doi request reprint Nociceptive responses and spinal plastic changes of afferent C-fibers in three neuropathic pain models induced by sciatic nerve injury in the rat
    Laura Casals-Díaz
    Department of Cell Biology, Group of Neuroplasticity and Regeneration, Institute of Neurosciences, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Exp Neurol 217:84-95. 2009
    ..Although signs of neuropathic pain appear in all three lesion models, nociceptive responses and central plasticity patterns differ between them...
  50. ncbi request reprint Changes in mouse sudomotor function and sweat gland innervation with ageing
    Jorge J Vilches
    Department of Cell Biology, Physiology and Immunology, Faculty of Medicine, Universitat Autonoma de Barcelona, Spain
    Auton Neurosci 95:80-7. 2002
    ..A reduction of sweat glands size in aged mice was also found, suggesting that the diminished sweat gland responsiveness with ageing may be attributed to sweat gland atrophy as well as to loss of innervation...
  51. ncbi request reprint Morphologic and functional evaluation of peripheral nerve fibers regenerated through polyimide sieve electrodes over long-term implantation
    Dolores Ceballos
    Department of Cell Biology, Physiology and Immunology, Faculty of Medicine, Universitat Autonoma de Barcelona, E 08193 Bellaterra, Spain
    J Biomed Mater Res 60:517-28. 2002
    ..Stimulation through different active electrodes excited nerve bundles, evoking compound muscle action potentials of varying shape and amplitude, indicative of selective axonal stimulation...
  52. ncbi request reprint Comparative dose-dependence study of FK506 on transected mouse sciatic nerve repaired by allograft or xenograft
    Esther Udina
    Group of Neuroplasticity and Regeneration, Institute of Neurosciences and Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, Bellaterra, Spain
    J Peripher Nerv Syst 8:145-54. 2003
    ..In conclusion, effective axonal regeneration is achieved with FK506 administration at doses of 5 mg/kg/day through allografts and, partially, through xenografts...
  53. ncbi request reprint Comparison of continuous and discontinuous FK506 administration on autograft or allograft repair of sciatic nerve resection
    Esther Udina
    Neuroplasticity and Regeneration Group, and Department of Cell Biology, Physiology and Immunology, Autonomous University of Barcelona, E 08193 Bellaterra, Spain
    Muscle Nerve 29:812-22. 2004
    ..In allograft repair, FK506 significantly enhanced both the rate and degree of regeneration and recovery, but its withdrawal resulted in graft rejection, a marked deterioration in function, and loss of regenerating fibers...
  54. ncbi request reprint Changes in crossed spinal reflexes after peripheral nerve injury and repair
    Antoni Valero-Cabre
    Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, E 08193 Bellaterra, Spain
    J Neurophysiol 87:1763-71. 2002
    ..These changes tended to decline toward baseline values with progressive reinnervation but still remained significant 3 mo after injury...
  55. ncbi request reprint Correlation between target reinnervation and distribution of motor axons in the injured rat sciatic nerve
    Natalia Lago
    Group of Neuroplasticity and Regeneration, Department of Cell Biology, Physiology and Immunology, and Institute of Neuroscience, Universitat Autonoma de Barcelona, Bellaterra, Spain
    J Neurotrauma 23:227-40. 2006
    ..Thus, labeling of motor axons by ChAT immunohistochemistry provides useful information for the study of the degree and specificity of nerve regeneration...
  56. doi request reprint Neurophysiological, histological and immunohistochemical characterization of bortezomib-induced neuropathy in mice
    Jordi Bruna
    Group of Neuroplasticity and Regeneration, Institute of Neurosciences and Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, Bellaterra, Spain
    Exp Neurol 223:599-608. 2010
    ..After washout, partial recovery was observed in functional, electrophysiological and histological analyses. These results suggest that axon and myelin changes might be secondary to an initial dysfunctional neuronopathy...
  57. ncbi request reprint Effects of the immunophilin ligand FK506 on nerve regeneration in collagen guides seeded with Schwann cells in rats
    Esther Udina
    Group of Neuroplasticity and Regeneration, Institute of Neurosciences and Department of Cell Biology, Physiology and Immunology, Facultat de Medicina, Universitat Autonoma de Barcelona, E 08193 Bellaterra, Spain
    Neurosci Lett 357:99-102. 2004
    ..The numbers of myelinated fibers in the distal regenerated nerve were similar between treated and control groups. In conclusion, FK506 improves functional recovery after repair with collagen guides seeded with syngeneic Schwann cells...
  58. ncbi request reprint Bimodal dose-dependence of FK506 on the rate of axonal regeneration in mouse peripheral nerve
    Esther Udina
    Department of Cell Biology, Physiology, and Immunology, Facultat de Medecina, Universitat Autonoma de Barcelona, E 8193 Bellaterra, Spain
    Muscle Nerve 26:348-55. 2002
    ..These results have clinical implications for the pharmacological treatment of nerve injuries while avoiding immunosuppressive effects and for the design of related drugs with more specific activities...
  59. ncbi request reprint Functional impact of axonal misdirection after peripheral nerve injuries followed by graft or tube repair
    Antoni Valero-Cabre
    Department of Cell Biology, Physiology and Immunology, Universitat Autonoma de Barcelona, Bellaterra, Spain
    J Neurotrauma 19:1475-85. 2002
    ....
  60. ncbi request reprint Neuroregenerative and neuroprotective actions of neuroimmunophilin compounds in traumatic and inflammatory neuropathies
    Bruce G Gold
    Center for Research on Occupational and Environmental Toxicology CROET, Oregon Health and Science University, Portland, OR 97201 3098, USA
    Neurol Res 26:371-80. 2004
    ..Moreover, these studies have led to the discovery of a novel mechanism whereby these compounds activate intrinsic neuroregenerative and neuroprotective pathways in the neuron...
  61. ncbi request reprint Design, in vitro and in vivo assessment of a multi-channel sieve electrode with integrated multiplexer
    Anup Ramachandran
    Department of Medical Engineering and Neuroprosthetics, Fraunhofer IBMT, Ensheimer Str 48, 66386 St Ingbert, Germany
    J Neural Eng 3:114-24. 2006
    ..Initial experiments showed that axons regenerated through the holes of the sieve and reinnervated distal target organs. Nerve signals were recorded in preliminary tests after 3-7 months post-implantation...
  62. ncbi request reprint Classification of afferent signals recorded with a single cuff electrode
    Changmok Choi
    Biorobotics Lab, Department of Mechanical Engineering, Korea Advanced Institute of Science and Technology, South Korea
    Conf Proc IEEE Eng Med Biol Soc 2007:2385-8. 2007
    ..In the future, the possibility of discriminating additional stimuli using additional channels and more advanced classification techniques will be investigated...
  63. ncbi request reprint Reorganization of reflex responses mediated by different afferent sensory fibers after spinal cord transection
    Antoni Valero-Cabre
    Laboratory for Magnetic Brain Stimulation, Department of Neurology, Harvard Medical School Beth Israel Deaconess Medical Center, 330 Brookline Avenue, KS 452, Boston, MA 02215, USA
    J Neurophysiol 91:2838-48. 2004
    ....
  64. ncbi request reprint On the use of fast blue, fluoro-gold and diamidino yellow for retrograde tracing after peripheral nerve injury: uptake, fading, dye interactions, and toxicity
    Anna Puigdellívol-Sánchez
    Department of Human Anatomy and Embryology, Faculty of Medicine, University of Barcelona, c Casanova no 143, 08036, Barcelona, Spain
    J Neurosci Methods 115:115-27. 2002
    ..The contributions of cell death as well as different optional tracer combinations for studies of nerve regeneration are discussed...
  65. ncbi request reprint Mechanism of syncope in patients with heart disease and negative electrophysiologic test
    Carlo Menozzi
    Department of Cardiology, Ospedale S Maria Nuova, Reggio Emilia, Italy
    Circulation 105:2741-5. 2002
    ..In patients with syncope and structural heart disease, syncope is suspected to be attributable to a primary cardiac arrhythmia, but little is known of its mechanism when electrophysiologic study is unremarkable...
  66. ncbi request reprint Olfactory ensheathing glia and Schwann cells: two of a kind?
    Konstantin Wewetzer
    Hannover Medical School, Center of Anatomy Neuroanatomy OE4140, Carl Neuberg Strasse 1, 30625 Hannover, Germany
    Cell Tissue Res 309:337-45. 2002
    ..The present review summarizes recent data on the in vitro and in vivo properties of OECs and critically compares the analogies and differences in the biology of both cell types relevant in the above-mentioned context...
  67. doi request reprint Dual-chamber defibrillators reduce clinically significant adverse events compared with single-chamber devices: results from the DATAS (Dual chamber and Atrial Tachyarrhythmias Adverse events Study) trial
    Jesus Almendral
    Cardiology Department, Hospital General Universitario Gregorio Maranon, Madrid, Spain
    Europace 10:528-35. 2008
    ..single-chamber (SC) implantable cardioverter defibrillator (ICD). DC-ICD had atrial tachyarrhythmia (AT) therapy capabilities. Strict programming recommendations were reinforced...
  68. ncbi request reprint Nonarrhythmic syncope documented by an implantable loop recorder (an ISSUE substudy)
    Michele Brignole
    Department of Cardiology, Ospedali Riuniti, Lavagna, Italy
    Am J Cardiol 90:654-7. 2002
  69. ncbi request reprint The DATAS rationale and design: a controlled, randomized trial to assess the clinical benefit of dual chamber (DDED) defibrillator
    Aurelio Quesada
    Cardiology Department, Hospital General Universitario, Valencia, Spain
    Europace 6:142-50. 2004
    ..To date (June 2003) there have been 343 patients enroled from 947 screened patients. The projected enrollment includes 360 patients and the conclusion of the study is expected at the beginning of 2005...
  70. ncbi request reprint Noninvasive measurement of torque development in the rat foot: measurement setup and results from stimulation of the sciatic nerve with polyimide-based cuff electrodes
    Thomas Stieglitz
    Fraunhofer Institute for Biomedical Engineering, Neural Prosthetics Group, D 66386 Sankt Ingbert, Germany
    IEEE Trans Neural Syst Rehabil Eng 11:427-37. 2003
    ..Using one cuff around the nerve, electrical stimulation on different electrode tripoles led to plantarflexion and dorsiflexion of the foot without an a priori alignment of the cuff...