Ana Navarro

Summary

Country: Spain

Publications

  1. doi request reprint Effects of rotenone and pyridaben on complex I electron transfer and on mitochondrial nitric oxide synthase functional activity
    Ana Navarro
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Cadiz, Plaza Fragela 9, 11003 Cadiz, Spain
    J Bioenerg Biomembr 42:405-12. 2010
  2. ncbi request reprint Hippocampal mitochondrial dysfunction in rat aging
    Ana Navarro
    Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Plaza Fragela 9, 11003 Cadiz, Spain
    Am J Physiol Regul Integr Comp Physiol 294:R501-9. 2008
  3. doi request reprint Human brain cortex: mitochondrial oxidative damage and adaptive response in Parkinson disease and in dementia with Lewy bodies
    Ana Navarro
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Cadiz, 11003 Cadiz, Spain
    Free Radic Biol Med 46:1574-80. 2009
  4. ncbi request reprint Age and exercise-related changes in lipid peroxidation and superoxide dismutase activity in liver and soleus muscle tissues of rats
    A Navarro-Arévalo
    Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Universidad de Cadiz, Spain
    Mech Ageing Dev 104:91-102. 1998
  5. ncbi request reprint Vitamin E at high doses improves survival, neurological performance, and brain mitochondrial function in aging male mice
    Ana Navarro
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Cadiz, Spain
    Am J Physiol Regul Integr Comp Physiol 289:R1392-9. 2005
  6. ncbi request reprint The mitochondrial energy transduction system and the aging process
    Ana Navarro
    Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Plaza Fragela 9, 11003 Cadiz, Spain
    Am J Physiol Cell Physiol 292:C670-86. 2007
  7. ncbi request reprint Dietary thioproline decreases spontaneous food intake and increases survival and neurological function in mice
    Ana Navarro
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Cadiz, Cadiz, Spain
    Antioxid Redox Signal 9:131-41. 2007
  8. ncbi request reprint Brain mitochondrial dysfunction in aging: conditions that improve survival, neurological performance and mitochondrial function
    Ana Navarro
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Cadiz, Spain
    Front Biosci 12:1154-63. 2007
  9. ncbi request reprint Role of nitric oxide on mitochondrial biogenesis during the ovarian cycle
    Ana Navarro
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Cadiz, Spain
    Front Biosci 12:1164-73. 2007
  10. doi request reprint Mitochondrial nitric oxide synthase, mitochondrial brain dysfunction in aging, and mitochondria-targeted antioxidants
    Ana Navarro
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Cadiz, 11003 Cadiz, Spain
    Adv Drug Deliv Rev 60:1534-44. 2008

Collaborators

Detail Information

Publications40

  1. doi request reprint Effects of rotenone and pyridaben on complex I electron transfer and on mitochondrial nitric oxide synthase functional activity
    Ana Navarro
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Cadiz, Plaza Fragela 9, 11003 Cadiz, Spain
    J Bioenerg Biomembr 42:405-12. 2010
    ..This fact is interpreted as an indication of mtNOS being structurally adjacent to complex I with an intermolecular mtNOS-complex I hydrophobic bonding that is stronger at high Δψ and weaker at low Δψ...
  2. ncbi request reprint Hippocampal mitochondrial dysfunction in rat aging
    Ana Navarro
    Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Plaza Fragela 9, 11003 Cadiz, Spain
    Am J Physiol Regul Integr Comp Physiol 294:R501-9. 2008
    ..A significant statistical correlation was observed between mitochondrial oxidative damage and enzymatic activity. Mitochondrial dysfunction with shortage of energy supply is considered a likely cause of dysfunction in aged hippocampus...
  3. doi request reprint Human brain cortex: mitochondrial oxidative damage and adaptive response in Parkinson disease and in dementia with Lewy bodies
    Ana Navarro
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Cadiz, 11003 Cadiz, Spain
    Free Radic Biol Med 46:1574-80. 2009
    ..The adaptive response would partially compensate for mitochondrial dysfunction in these neurodegenerative diseases and would afford a human evolutionary response to shortage of ATP in the frontal cortex...
  4. ncbi request reprint Age and exercise-related changes in lipid peroxidation and superoxide dismutase activity in liver and soleus muscle tissues of rats
    A Navarro-Arévalo
    Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Universidad de Cadiz, Spain
    Mech Ageing Dev 104:91-102. 1998
    ..These findings suggest that free radicals play a role in aging and that the different type, intensity and duration of exercise modify the lipid peroxidation level and antioxidant enzyme activity...
  5. ncbi request reprint Vitamin E at high doses improves survival, neurological performance, and brain mitochondrial function in aging male mice
    Ana Navarro
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Cadiz, Spain
    Am J Physiol Regul Integr Comp Physiol 289:R1392-9. 2005
    ..58-0.99, P < 0.01), and the rates of respiration and of complex I and IV activities correlated positively (r2 = 0.74-0.80, P < 0.01) with success in the behavioral tests and with maximal life span...
  6. ncbi request reprint The mitochondrial energy transduction system and the aging process
    Ana Navarro
    Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Plaza Fragela 9, 11003 Cadiz, Spain
    Am J Physiol Cell Physiol 292:C670-86. 2007
    ..The pleiotropic signaling of mitochondrial H(2)O(2) and nitric oxide diffusion to the cytosol seems modified in aged animals and to contribute to the decreased mitochondrial biogenesis in old animals...
  7. ncbi request reprint Dietary thioproline decreases spontaneous food intake and increases survival and neurological function in mice
    Ana Navarro
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Cadiz, Cadiz, Spain
    Antioxid Redox Signal 9:131-41. 2007
    ..It is surmised that thioproline induces an anorexic effect associated with improved survival and neurological function through a decreased oxidative damage and regulation that may involve hypothalamic appetite centers...
  8. ncbi request reprint Brain mitochondrial dysfunction in aging: conditions that improve survival, neurological performance and mitochondrial function
    Ana Navarro
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Cadiz, Spain
    Front Biosci 12:1154-63. 2007
    ....
  9. ncbi request reprint Role of nitric oxide on mitochondrial biogenesis during the ovarian cycle
    Ana Navarro
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Cadiz, Spain
    Front Biosci 12:1164-73. 2007
    ..Relatively low levels of NO seem to drive the cell signaling for follicle proliferation, whereas relatively high NO levels trigger mitochondria-dependent follicle apoptosis...
  10. doi request reprint Mitochondrial nitric oxide synthase, mitochondrial brain dysfunction in aging, and mitochondria-targeted antioxidants
    Ana Navarro
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Cadiz, 11003 Cadiz, Spain
    Adv Drug Deliv Rev 60:1534-44. 2008
    ..Mitochondria-targeted antioxidants, phosphonium cation derivatives and antioxidant tetrapeptides, are reviewed in terms of structures and biological effects...
  11. doi request reprint Brain mitochondrial dysfunction and oxidative damage in Parkinson's disease
    Ana Navarro
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Cadiz, Plaza Fragela, 9, 11003, Cadiz, Spain
    J Bioenerg Biomembr 41:517-21. 2009
    ..Mitochondrial dysfunction in the human frontal cortex is to be considered a factor contributing to impaired cognition in PD...
  12. ncbi request reprint Mitochondrial function and mitochondria-induced apoptosis in an overstimulated rat ovarian cycle
    Ana Navarro
    Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, University Hospital of Puerto Real, Plaza Fragela 9, 11003 Cadiz, Spain
    Am J Physiol Endocrinol Metab 289:E1101-9. 2005
    ....
  13. ncbi request reprint Rat brain and liver mitochondria develop oxidative stress and lose enzymatic activities on aging
    Ana Navarro
    Department of Biochemistry and Molecular Biology, University of Cadiz, Spain
    Am J Physiol Regul Integr Comp Physiol 287:R1244-9. 2004
    ..A subpopulation of brain mitochondria with increased size and fragility was differentiated in aging rats, whereas liver showed a homogeneous mitochondrial population...
  14. ncbi request reprint Behavioral dysfunction, brain oxidative stress, and impaired mitochondrial electron transfer in aging mice
    Ana Navarro
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Cadiz, 11003 Cadiz, Spain
    Am J Physiol Regul Integr Comp Physiol 282:R985-92. 2002
    ..The cumulative toxic effects of oxyradicals are considered the molecular mechanism of the behavioral deficits observed on aging...
  15. ncbi request reprint Beneficial effects of moderate exercise on mice aging: survival, behavior, oxidative stress, and mitochondrial electron transfer
    Ana Navarro
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Cadiz, 11003 Cadiz, Spain
    Am J Physiol Regul Integr Comp Physiol 286:R505-11. 2004
    ..Moderate exercise, started at young age in mice, increased life span, decreased oxidative stress, and prevented the decline of cytochrome oxidase activity and behavioral performance at middle age but not at old age...
  16. ncbi request reprint Myocardial and skeletal muscle aging and changes in oxidative stress in relationship to rigorous exercise training
    A Navarro-Arévalo
    Departamento de Bioquimica y Biologia Molecular, Facultad de Medicina, Universidad de Cadiz, Spain
    Mech Ageing Dev 108:207-17. 1999
    ..In the skeletal muscle in old animals, the Cu, ZnSOD isoenzyme pattern was modified. The rigorous exercise did not change this pattern. The pattern of MnSOD isoenzyme was not varied in either tissue, age nor and exercise...
  17. ncbi request reprint Skeletal muscle and aging
    A Navarro
    Department of Biochemistry and Molecular Biology, Faculty of Medicine University of Cádiz Plaza Fragela No 9 11003 Cadiz Spain
    Front Biosci 6:D26-44. 2001
    ..The effect of skeletal muscle cell senescence on the cellular response to exercise, and the effect of dietary restriction on muscle cell senescence can also be explored from this perspective...
  18. pmc High doses of vitamin E improve mitochondrial dysfunction in rat hippocampus and frontal cortex upon aging
    Ana Navarro
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Cadiz, Cadiz, Spain
    Am J Physiol Regul Integr Comp Physiol 300:R827-34. 2011
    ..Aging decreased (19%) hippocampus mitochondrial mass, an effect that was restored by vitamin E. High doses of vitamin E seem to sustain mitochondrial biogenesis in synaptic areas...
  19. ncbi request reprint Pesticides and impairment of mitochondrial function in relation with the parkinsonian syndrome
    Carmen Gomez
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Cadiz, 11003 Cadiz, Spain
    Front Biosci 12:1079-93. 2007
    ..This regulation and the role of mitochondrial NO diffusion as a signal for mitochondrial biogenesis could have a role in the etiopathology of Parkinson's disease...
  20. pmc Reduced antioxidant defense in early onset first-episode psychosis: a case-control study
    Juan Antonio Mico
    Department of Neuroscience, Pharmacology and Psychiatry, School of Medicine, CIBERSAM, Centro de Investigación Biomédica en Red de Salud Mental University of Cádiz, Spain
    BMC Psychiatry 11:26. 2011
    ..Our objective is to determine the activity of the antioxidant defense system at admission in patients with early onset first psychotic episodes compared with a control group...
  21. ncbi request reprint Mitochondrial dysfunction in human colorectal cancer progression
    María Jesús Sánchez-Pino
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Cadiz, Spain
    Front Biosci 12:1190-9. 2007
    ....
  22. doi request reprint Mitochondria and calcium flux as targets of neuroprotection caused by minocycline in cerebellar granule cells
    Eva Maria Garcia-Martinez
    Neurofarmacologia, Dpto Ciencias Médicas, Facultad de Medicina, UCLM, Albacete, Spain
    Biochem Pharmacol 79:239-50. 2010
    ..Taken together, our results indicate that mitochondria are a critical factor in minocycline-mediated neuroprotection...
  23. ncbi request reprint Mitochondrial enzyme activities as biochemical markers of aging
    Ana Navarro
    Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Cadiz, 11003 Cadiz, Spain
    Mol Aspects Med 25:37-48. 2004
    ..The activities of mtNOS, NADH dehydrogenase and cytochrome oxidase may be used as indicators of the effectiveness of antiaging treatments...
  24. ncbi request reprint The role of mitochondrial nitric oxide synthase in inflammation and septic shock
    Alberto Boveris
    Laboratory of Free Radical Biology, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina
    Free Radic Biol Med 33:1186-93. 2002
    ....
  25. doi request reprint Brain mitochondrial dysfunction in aging
    Alberto Boveris
    Laboratory of Free Radical Biology, School of Pharmacy and Biochemistry, University of Buenos Aires, C1113AAD Buenos Aires, Argentina
    IUBMB Life 60:308-14. 2008
    ..The diffusion of mitochondrial NO and H2O2 to the cytosol is decreased in the aged brain and may be a factor for reduced mitochondrial biogenesis...
  26. doi request reprint Systemic and mitochondrial adaptive responses to moderate exercise in rodents
    Alberto Boveris
    School of Pharmacy and Biochemistry, University of Buenos Aires, C1113AAD Buenos Aires, Argentina
    Free Radic Biol Med 44:224-9. 2008
    ....
  27. ncbi request reprint Endogenous dopamine enhances the neurotoxicity of 3-nitropropionic acid in the striatum through the increase of mitochondrial respiratory inhibition and free radicals production
    Ruth F Villarán
    Departamento de Bioquimica, Bromatologia, Toxicologia y Medicina Legal, Facultad de Farmacia, Universidad de Sevilla, C Profesor García González, 2, 41012 Sevilla, Spain
    Neurotoxicology 29:244-58. 2008
    ....
  28. ncbi request reprint Pharmacological regulation of mitochondrial nitric oxide synthase
    Alberto Boveris
    Laboratory of Free Radical Biology, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
    Methods Enzymol 359:328-39. 2002
  29. ncbi request reprint Hypoxia exacerbates macrophage mitochondrial damage in endotoxic shock
    Ana Navarro
    Am J Physiol Regul Integr Comp Physiol 288:R354-5. 2005
  30. ncbi request reprint UVB irradiation-induced impairment of keratinocytes and adaptive responses to oxidative stress
    Ingrid Wiswedel
    Department of Pathological Biochemistry, Institute of Clinical Chemistry and Pathological Biochemistry, Germany
    Free Radic Res 41:1017-27. 2007
    ..From the data it can be concluded that keratinocytes are sufficiently protected at low UVB doses, whereas higher doses lead to irreversible cell damage...
  31. ncbi request reprint Kidney mitochondrial nitric oxide synthase
    Alberto Boveris
    Laboratory of Free Radical Biology, School of Pharmacy and Biochemistry, University of Buenos Aires, Buenos Aires, Argentina
    Antioxid Redox Signal 5:265-71. 2003
    ..The enzymatic activity of kidney mtNOS generates intramitochondrial NO concentrations that regulate mitochondrial functions: state 3 respiration was decreased by 12-28%, and state 4 hydrogen peroxide production was increased 12-35%...
  32. ncbi request reprint Premature roll-off in radiofrequency ablation using bipolar saline-enhanced electrodes
    Fernando Burdio
    Eur Radiol 15:1495-6; author reply 1497-8. 2005
  33. ncbi request reprint Evolving technology in bipolar perfused radiofrequency ablation: assessment of efficacy, predictability and safety in a pig liver model
    Fernando Burdio
    Department of Surgery A, Hospital Clinico Universitario Lozano Blesa, Zaragoza, Spain
    Eur Radiol 16:1826-34. 2006
    ..This method has been shown to determine: (1) the relative control of impedance during the procedure; (2) ovoid and relatively large thermal lesions with less dependence upon closest vessels...
  34. ncbi request reprint Does thermal ablation promote liver metastases progression more than resection?
    Fernando Burdio
    Surgery 140:479-80; author reply 480. 2006
  35. ncbi request reprint Bipolar saline-enhanced electrode for radiofrequency ablation: results of experimental study of in vivo porcine liver
    Fernando Burdio
    Department of Surgery A, Hospital Clinico Universitario Lozano Blesa, Zaragoza, Spain
    Radiology 229:447-56. 2003
    ....
  36. ncbi request reprint Apolipoprotein D expression in human brain reactive astrocytes
    Eva Del Valle
    Departamento de Morfologia y Biologia Celular, Facultad de Biología y Medicina, Universidad de Oviedo, Espana
    J Histochem Cytochem 51:1285-90. 2003
    ..The possible significance of this increased synthesis of apo D in reactive astrocytes is discussed in relation to the role of apo D in aging and in glial function...
  37. ncbi request reprint Apolipoprotein D expression absence in degenerating neurons of human central nervous system
    Ana Navarro
    Department of Morphology and Cellular Biology, University of Oviedo, Asturias, Spain
    Histol Histopathol 23:995-1001. 2008
    ..These findings are in accordance with the role possibly played by apo D in the neuroprotection of the nervous system...
  38. doi request reprint Mitochondrial nitric oxide synthase and the regulation of heart rate
    Ana Navarro
    Am J Hypertens 21:485. 2008
  39. ncbi request reprint Large hepatic ablation with bipolar saline-enhanced radiofrequency: an experimental study in in vivo porcine liver with a novel approach
    Fernando Burdio
    Department of Surgery A, Hospital Cli nico Universitario Lozano Blesa, Zaragoza, Spain
    J Surg Res 110:193-201. 2003
    ..Nevertheless, treating liver tumors larger than 2.5 cm in diameter often requires multiple overlapping ablations to encompass the tumor and the surrounding healthy tissue rim with an increasing risk of local recurrence...
  40. ncbi request reprint Chronic estradiol treatment improves brain homeostasis during aging in female rats
    Ana Alonso
    Department of Functional Biology, University of Oviedo, Oviedo, Spain
    Endocrinology 149:57-72. 2008
    ..Additional animal studies are required to clarify the neuroprotective role of estradiol in relation to other important molecules involved in the IRS-1-phosphatidylinositol-3 kinase signaling pathway...