Matilde Murga

Summary

Country: Spain

Publications

  1. ncbi Genomic instability: on the birth and death of cancer
    M Murga
    Genomic Instability Group, Molecular Oncology Programme, Spanish National Cancer Center CNIO, Madrid, Spain
    Clin Transl Oncol 9:216-20. 2007
  2. ncbi A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging
    Matilde Murga
    Genomic Instability Group, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    Nat Genet 41:891-8. 2009
  3. ncbi Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors
    Matilde Murga
    Genomic Instability Group, Spanish National Cancer Research Centre, Madrid, Spain
    Nat Struct Mol Biol 18:1331-5. 2011
  4. ncbi ATR signaling can drive cells into senescence in the absence of DNA breaks
    Luis I Toledo
    Genomic Instability Group, Spanish National Cancer Research Center CNIO, Madrid 28029, Spain
    Genes Dev 22:297-302. 2008
  5. ncbi Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression
    Alejo Efeyan
    Tumor Suppression Group, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    PLoS ONE 4:e5475. 2009
  6. ncbi A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations
    Luis I Toledo
    Genomic Instability Group, Spanish National Cancer Research Centre, Madrid, Spain
    Nat Struct Mol Biol 18:721-7. 2011
  7. ncbi ATM regulates ATR chromatin loading in response to DNA double-strand breaks
    Myriam Cuadrado
    Genomic Instability Group, Spanish National Cancer Center, Madrid 28029, Spain
    J Exp Med 203:297-303. 2006
  8. ncbi Targeting ATR and Chk1 kinases for cancer treatment: a new model for new (and old) drugs
    Luis I Toledo
    Genomic Instability Group, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    Mol Oncol 5:368-73. 2011
  9. ncbi Global chromatin compaction limits the strength of the DNA damage response
    Matilde Murga
    Genomic Instability Group, Molecular Oncology Programme, Spanish National Cancer Center, Madrid 28029, Spain
    J Cell Biol 178:1101-8. 2007
  10. ncbi A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity
    Rosa M Marion
    Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Research Centre CNIO, Melchor Fernandez Almagro 3, Madrid E 28029, Spain
    Nature 460:1149-53. 2009

Collaborators

Detail Information

Publications11

  1. ncbi Genomic instability: on the birth and death of cancer
    M Murga
    Genomic Instability Group, Molecular Oncology Programme, Spanish National Cancer Center CNIO, Madrid, Spain
    Clin Transl Oncol 9:216-20. 2007
    ..The review will end up presenting suggestive evidence which proposes that genomic instability might turn out to be not just the driving force but also the Achilles' heel of cancer...
  2. ncbi A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging
    Matilde Murga
    Genomic Instability Group, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    Nat Genet 41:891-8. 2009
    ....
  3. ncbi Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors
    Matilde Murga
    Genomic Instability Group, Spanish National Cancer Research Centre, Madrid, Spain
    Nat Struct Mol Biol 18:1331-5. 2011
    ..Besides its impact on cancer, Myc overexpression aggravated the phenotypes of Atr-Seckel mice, revealing that oncogenes can modulate the severity of replicative stress-associated diseases...
  4. ncbi ATR signaling can drive cells into senescence in the absence of DNA breaks
    Luis I Toledo
    Genomic Instability Group, Spanish National Cancer Research Center CNIO, Madrid 28029, Spain
    Genes Dev 22:297-302. 2008
    ..Our system provides a novel platform for the study of the specific functions of ATR signaling and adds evidence for the tumor-suppressive potential of the DNA damage response...
  5. ncbi Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression
    Alejo Efeyan
    Tumor Suppression Group, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    PLoS ONE 4:e5475. 2009
    ..Regarding murine Atm, our data suggest that it plays a minor role in oncogene-induced senescence or in p53-dependent tumor suppression, being its tumor suppressive activity probably limited to the maintenance of genomic stability...
  6. ncbi A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations
    Luis I Toledo
    Genomic Instability Group, Spanish National Cancer Research Centre, Madrid, Spain
    Nat Struct Mol Biol 18:721-7. 2011
    ....
  7. ncbi ATM regulates ATR chromatin loading in response to DNA double-strand breaks
    Myriam Cuadrado
    Genomic Instability Group, Spanish National Cancer Center, Madrid 28029, Spain
    J Exp Med 203:297-303. 2006
    ..These data provide experimental evidence of an active cross talk between ATM and ATR signaling pathways in response to DNA damage...
  8. ncbi Targeting ATR and Chk1 kinases for cancer treatment: a new model for new (and old) drugs
    Luis I Toledo
    Genomic Instability Group, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    Mol Oncol 5:368-73. 2011
    ..In addition, this rationale also implies that the same effect should also be observed for other molecules that target the RS-response (RSR), such as inhibitors of the Chk1-activating kinase ATR...
  9. ncbi Global chromatin compaction limits the strength of the DNA damage response
    Matilde Murga
    Genomic Instability Group, Molecular Oncology Programme, Spanish National Cancer Center, Madrid 28029, Spain
    J Cell Biol 178:1101-8. 2007
    ..We propose that slight differences in the epigenetic configuration might account for the cell-to-cell variation in the strength of the DDR observed when groups of cells are challenged with DNA breaks...
  10. ncbi A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity
    Rosa M Marion
    Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Research Centre CNIO, Melchor Fernandez Almagro 3, Madrid E 28029, Spain
    Nature 460:1149-53. 2009
    ....
  11. ncbi Why cells respond differently to DNA damage: a chromatin perspective
    Oscar Fernandez-Capetillo
    Genomic Instability Group, Molecular Oncology Programme, Spanish National Cancer Research Centre, Madrid, Spain
    Cell Cycle 7:980-3. 2008
    ..We here provide an overview of the available data, including our own, that would be supportive of such a model and discuss how this perspective might be used to explain previous observations...