Matilde Murga

Summary

Country: Spain

Publications

  1. pmc A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging
    Matilde Murga
    Genomic Instability Group, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    Nat Genet 41:891-8. 2009
  2. ncbi request reprint Genomic instability: on the birth and death of cancer
    M Murga
    Genomic Instability Group, Molecular Oncology Programme, Spanish National Cancer Center CNIO, Madrid, Spain
    Clin Transl Oncol 9:216-20. 2007
  3. doi request reprint Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors
    Matilde Murga
    Genomic Instability Group, Spanish National Cancer Research Centre, Madrid, Spain
    Nat Struct Mol Biol 18:1331-5. 2011
  4. pmc ATR signaling can drive cells into senescence in the absence of DNA breaks
    Luis I Toledo
    Genomic Instability Group, Spanish National Cancer Research Center CNIO, Madrid 28029, Spain
    Genes Dev 22:297-302. 2008
  5. pmc Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression
    Alejo Efeyan
    Tumor Suppression Group, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    PLoS ONE 4:e5475. 2009
  6. pmc A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity
    Rosa M Marion
    Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Research Centre CNIO, Melchor Fernandez Almagro 3, Madrid E 28029, Spain
    Nature 460:1149-53. 2009
  7. doi request reprint A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations
    Luis I Toledo
    Genomic Instability Group, Spanish National Cancer Research Centre, Madrid, Spain
    Nat Struct Mol Biol 18:721-7. 2011
  8. pmc ATM regulates ATR chromatin loading in response to DNA double-strand breaks
    Myriam Cuadrado
    Genomic Instability Group, Spanish National Cancer Center, Madrid 28029, Spain
    J Exp Med 203:297-303. 2006
  9. pmc Targeting ATR and Chk1 kinases for cancer treatment: a new model for new (and old) drugs
    Luis I Toledo
    Genomic Instability Group, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    Mol Oncol 5:368-73. 2011
  10. pmc Global chromatin compaction limits the strength of the DNA damage response
    Matilde Murga
    Genomic Instability Group, Molecular Oncology Programme, Spanish National Cancer Center, Madrid 28029, Spain
    J Cell Biol 178:1101-8. 2007

Collaborators

Detail Information

Publications13

  1. pmc A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging
    Matilde Murga
    Genomic Instability Group, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    Nat Genet 41:891-8. 2009
    ....
  2. ncbi request reprint Genomic instability: on the birth and death of cancer
    M Murga
    Genomic Instability Group, Molecular Oncology Programme, Spanish National Cancer Center CNIO, Madrid, Spain
    Clin Transl Oncol 9:216-20. 2007
    ..The review will end up presenting suggestive evidence which proposes that genomic instability might turn out to be not just the driving force but also the Achilles' heel of cancer...
  3. doi request reprint Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors
    Matilde Murga
    Genomic Instability Group, Spanish National Cancer Research Centre, Madrid, Spain
    Nat Struct Mol Biol 18:1331-5. 2011
    ..Besides its impact on cancer, Myc overexpression aggravated the phenotypes of Atr-Seckel mice, revealing that oncogenes can modulate the severity of replicative stress-associated diseases...
  4. pmc ATR signaling can drive cells into senescence in the absence of DNA breaks
    Luis I Toledo
    Genomic Instability Group, Spanish National Cancer Research Center CNIO, Madrid 28029, Spain
    Genes Dev 22:297-302. 2008
    ..Our system provides a novel platform for the study of the specific functions of ATR signaling and adds evidence for the tumor-suppressive potential of the DNA damage response...
  5. pmc Limited role of murine ATM in oncogene-induced senescence and p53-dependent tumor suppression
    Alejo Efeyan
    Tumor Suppression Group, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    PLoS ONE 4:e5475. 2009
    ..Regarding murine Atm, our data suggest that it plays a minor role in oncogene-induced senescence or in p53-dependent tumor suppression, being its tumor suppressive activity probably limited to the maintenance of genomic stability...
  6. pmc A p53-mediated DNA damage response limits reprogramming to ensure iPS cell genomic integrity
    Rosa M Marion
    Telomeres and Telomerase Group, Molecular Oncology Program, Spanish National Cancer Research Centre CNIO, Melchor Fernandez Almagro 3, Madrid E 28029, Spain
    Nature 460:1149-53. 2009
    ....
  7. doi request reprint A cell-based screen identifies ATR inhibitors with synthetic lethal properties for cancer-associated mutations
    Luis I Toledo
    Genomic Instability Group, Spanish National Cancer Research Centre, Madrid, Spain
    Nat Struct Mol Biol 18:721-7. 2011
    ....
  8. pmc ATM regulates ATR chromatin loading in response to DNA double-strand breaks
    Myriam Cuadrado
    Genomic Instability Group, Spanish National Cancer Center, Madrid 28029, Spain
    J Exp Med 203:297-303. 2006
    ..These data provide experimental evidence of an active cross talk between ATM and ATR signaling pathways in response to DNA damage...
  9. pmc Targeting ATR and Chk1 kinases for cancer treatment: a new model for new (and old) drugs
    Luis I Toledo
    Genomic Instability Group, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    Mol Oncol 5:368-73. 2011
    ..In addition, this rationale also implies that the same effect should also be observed for other molecules that target the RS-response (RSR), such as inhibitors of the Chk1-activating kinase ATR...
  10. pmc Global chromatin compaction limits the strength of the DNA damage response
    Matilde Murga
    Genomic Instability Group, Molecular Oncology Programme, Spanish National Cancer Center, Madrid 28029, Spain
    J Cell Biol 178:1101-8. 2007
    ..We propose that slight differences in the epigenetic configuration might account for the cell-to-cell variation in the strength of the DDR observed when groups of cells are challenged with DNA breaks...
  11. pmc INK4a/ARF limits the expansion of cells suffering from replication stress
    Angela Monasor
    Genomic Instability Group, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    Cell Cycle 12:1948-54. 2013
    ..Our data reveal an unknown role for INK4a/ARF in limiting the expansion of cells suffering from persistent replication stress, linking this well-known tumor suppressor to the maintenance of genomic integrity. ..
  12. ncbi request reprint Why cells respond differently to DNA damage: a chromatin perspective
    Oscar Fernandez-Capetillo
    Genomic Instability Group, Molecular Oncology Programme, Spanish National Cancer Research Centre, Madrid, Spain
    Cell Cycle 7:980-3. 2008
    ..We here provide an overview of the available data, including our own, that would be supportive of such a model and discuss how this perspective might be used to explain previous observations...
  13. pmc A proteomic characterization of factors enriched at nascent DNA molecules
    Andrés J López-Contreras
    Genomic Instability Group, Spanish National Cancer Research Centre, Madrid 28029, Spain
    Cell Rep 3:1105-16. 2013
    ..This resource provides a panoramic view of the proteins that concentrate in the surroundings of the replisome, which should facilitate future investigations on DNA replication and genome maintenance...