Research Topics
| Carmen Muñoz-AlmagroSummaryCountry: Spain Publications
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Publications
Epidemiologic and clinical implications of second-generation pneumococcal conjugate vaccinesCarmen Muñoz-Almagro
Molecular Microbiology Department, University Hospital Sant Joan de Deu, Passeig Sant Joan de Deu, Esplugues, 08950, Barcelona, Spain
Curr Infect Dis Rep 15:184-90. 2013..This review is based on published literature about some of the potential advantages and challenges of the second generation of pneumococcal conjugate vaccines, with special reference to 13-valent vaccine in children and adults...
[Application of molecular amplification methods in the diagnosis and follow-up of HIV-1 infection in children infected by vertical transmission]C Munoz Almagro
Servicio de Microbiologia, Hospital Universitario Sant Joan de Deu, Esplugues, Barcelona
Med Clin (Barc) 114:769-71. 2000..To describe the vertical transmission of HIV-1 by means of molecular methods...- Influence of pneumococcal vaccine on the incidence of empyemaCarmen Muñoz-Almagro
Molecular Microbiology Department, University Hospital Sant Joan de Deu, Esplugues, Spain
Curr Opin Pulm Med 16:394-8. 2010..The aim of this review is to highlight recent reports (2009) concerning empyema and the heptavalent pneumococcal conjugate vaccine... - Quantitative real-time PCR in paediatric patients with herpes simplex infections of the central nervous systemCarmen Muñoz-Almagro
Molecular Microbiology Department, Microbiology Service, University Hospital Sant Joan de Deu, Po Sant Joan de Deu No 2, Esplugues, Barcelona, Spain
J Virol Methods 147:297-300. 2008..Further studies are needed to confirm the relationship between viral load and other clinical, pathological, and genetic variables... 
PsrP, a protective pneumococcal antigen, is highly prevalent in children with pneumonia and is strongly associated with clonal typeCarmen Muñoz-Almagro
Molecular Microbiology Department, University Hospital Sant Joan de Deu, P Sant Joan de Déu No 2, 08950 Esplugues, Barcelona, Spain
Clin Vaccine Immunol 17:1672-8. 2010..These data support the potential use of PsrP as one component in a multivalent protein-based vaccine...- Serotypes and clones causing invasive pneumococcal disease before the use of new conjugate vaccines in Catalonia, SpainCarmen Muñoz-Almagro
Molecular Microbiology Department, Hospital Sant Joan de Deu, P Sant Joan de Déu 2, 08950 Esplugues, Barcelona, Spain
J Infect 63:151-62. 2011.... - Polymerase chain reaction for diagnosis and serogrouping of meningococcal disease in childrenCarmen Muñoz-Almagro
Department of Microbiology, Hospital Sant Joan de Deu, University of Barcelona, Barcelona, Spain
Diagn Microbiol Infect Dis 63:148-54. 2009..7%; serogroup C, 7.1%; and nontypeable serogroups, 7.1%. In conclusion, real-time PCR is more rapid and sensitive than culture for diagnosis and serogrouping of IMD... - DNA bacterial load in children and adolescents with pneumococcal pneumonia and empyemaCarmen Muñoz-Almagro
Department of Molecular Microbiology, Hospital Universitari Sant Joan de Deu, University of Barcelona, Pº Sant Joan de Déu nº 2, 08950 Esplugues, Barcelona, Spain
Eur J Clin Microbiol Infect Dis 30:327-35. 2011..001). Quantification of pneumococcal DBL by real-time PCR may be helpful for the diagnosis and clinical management of pediatric patients with pneumonia and empyema... - [Diagnosis of meningococcal disease by polymerase chain reaction]Carmen Muñoz-Almagro
Servicio de Microbiología Hospital Universitario Sant Joan de Déu Esplugues de Llobregat Barcelona Spain
Med Clin (Barc) 120:721-4. 2003..The objective of the present study was to evaluate the application of a rapid and simple PCR technique to diagnose meningococcal disease... - [Prevalence of hepatitis C virus in pregnant women and vertical transmission]Carmen Muñoz-Almagro
Servicios de Microbiologia, Hospital Sant Joan de Deu, Esplugues, Barcelona, Spain
Med Clin (Barc) 118:452-4. 2002..The objectives of this study were to know the seroprevalence of HCV in pregnant women and to determine its vertical transmission rate as well as the viremia evolution in infected children... - Clinical presentation of invasive pneumococcal disease in Spain in the era of heptavalent conjugate vaccineMaria F de Sevilla
Hospital Universitari Sant Joan de Deu, Barcelona, Spain
Pediatr Infect Dis J 31:124-8. 2012..The aim of this study was to analyze the rate of incidence, clinical presentation, serotype, and clonal distribution of invasive pneumococcal disease (IPD) in the era of heptavalent pneumococcal conjugate vaccine (PCV7) in Barcelona, Spain... - Pneumococcal carriage in children attending a hospital outpatient clinic in the era of pneumococcal conjugate vaccines in BarcelonaSusanna Hernandez-Bou
Pediatric Emergency Department, Hospital Sant Joan de Deu, Universitat de Barcelona, Barcelona, Spain
Diagn Microbiol Infect Dis 74:258-62. 2012..In our pediatric population, NVT were predominant among pneumococcal carriers whereas antibiotic resistance was significantly associated with VT. PCV13 can substantially increase the serotype coverage of S.pneumoniae in healthy carriers... - [Rapid diagnosis of herpetic meningoencephalitis by PCR]Carmen Muñoz-Almagro
Servicios de Microbiologia, Hospital Sant Joan de Deu, Esplugues de Llobregat, Barcelona, Espana
Enferm Infecc Microbiol Clin 20:110-2. 2002..To evaluate the usefulness of a rapid and simple PCR method in the diagnosis of herpetic meningoencephalitis in a pediatric population... - Viral coinfection in children less than five years old with invasive pneumococcal diseaseCristian Launes
Infectious Diseases Unit, Department of Pediatrics, Hospital Sant Joan de Deu, Barcelona, Spain
Pediatr Infect Dis J 31:650-3. 2012..Viral detection occurred significantly more often in those episodes caused by nonhighly invasive serotypes (29/40; 72%), suggesting that a viral synergism could help those serotypes to make invasiveness more likely... - Emergence of invasive pneumococcal disease caused by nonvaccine serotypes in the era of 7-valent conjugate vaccineCarmen Muñoz-Almagro
Department of Microbiology, Hospital Universitari Sant Joan de Deu, Esplugues, Spain
Clin Infect Dis 46:174-82. 2008..Little is known about the epidemiology of invasive pneumococcal disease (IPD) after the introduction of 7-valent pneumococcal conjugate vaccine (PCV7) in Spain and other European countries... - Risk factors for invasive pneumococcal disease in a community with a high proportion of non vaccine serotypesPilar Ciruela
Agència de Salut Pública de Catalunya, Generalitat of Catalonia, Barcelona, Spain
Vaccine 31:960-6. 2013..Attending day care or school was a strong risk factor for IPD, while vaccination was protective in children aged <24 months. Age and antibiotic use in the previous month were associated with penicillin-nonsusceptible IPD... - Prevalence and clonal distribution of pcpA, psrP and Pilus-1 among pediatric isolates of Streptococcus pneumoniaeLaura Selva
Molecular Microbiology Department, University Hospital Sant Joan de Deu, Barcelona, Spain
PLoS ONE 7:e41587. 2012..These results indicate that PcpA, and subsequently Psrp and Pilus-1 together might be good candidates to be used in a next-generation of multivalent pneumococcal protein vaccine... - Direct detection of Streptococcus pneumoniae in positive blood cultures by real-time polymerase chain reactionLaura Selva
Molecular Microbiology Department, University Hospital Sant Joan de Deu, Esplugues Barcelona, Spain
Diagn Microbiol Infect Dis 66:204-6. 2010..For the 128 blood culture bottles tested, the assay had 94% and 98.4% sensitivity and specificity, respectively. This assay provides rapid and accurate identification of this pathogen... - The prevalence of GB virus C/hepatitis G virus RNA among healthy and HCV-infected Catalan childrenGemma Claret
Pediatrics Department, Agrupació Sanitària Hospital Clínic, Hospital Sant Joan de Deu, Universitat de Barcelona, Passeig Sant Joan de Deu, 2, 08950, Barcelona, Spain
Eur J Pediatr 167:991-4. 2008..In conclusion, while GBV-C viremia is more frequent among HCV-infected pediatric patients, it is neither associated with liver disease nor has any influence on HCV-related chronic hepatitis... - Impact of human immunodeficiency virus coinfection on the progression of mother-to-child transmitted hepatitis C virus infectionGemma Claret-Teruel
Infectious Diseases Unit, Department of Pediatrics, Hospital Sant Joan de Deu, Universitat de Barcelona, Barcelona, Spain
Pediatr Infect Dis J 30:801-4. 2011.... - Viral load at diagnosis and influenza A H1N1 (2009) disease severity in childrenCristian Launes
Infectious Diseases Unit, Department of Pediatrics, Hospital Sant Joan de Deu, University of Barcelona, Barcelona, Spain
Influenza Other Respi Viruses 6:e89-92. 2012..73; P=0.03). Having <4.5 log10 copies/ml with ≥ 5 days of symptoms was associated with a lower risk of requiring MV... - Effectiveness of 7-valent pneumococcal conjugate vaccine in the prevention of invasive pneumococcal disease in children aged 7-59 months. A matched case-control studyAngela Dominguez
Departament de Salut Publica, Universitat de Barcelona, Barcelona, Spain
Vaccine 29:9020-5. 2011..The results of this study carried out in a population with intermediate vaccination coverage confirm those of other observational studies showing high levels of effectiveness of routine 7-valent pneumococcal conjugate vaccination... - Severe enterovirus disease in febrile neonatesIolanda Jordan
University Hospital Sant Joan de Deu, Esplugues de Llobregat, Barcelona, Spain
Enferm Infecc Microbiol Clin 27:399-402. 2009..Our aim was to describe the characteristics and outcome of group of febrile neonates with severe enterovirus infection compared to a group of neonates with severe bacterial infection... - Emergence of invasive pneumococcal disease caused by multidrug-resistant serotype 19A among children in BarcelonaCarmen Muñoz-Almagro
Department of Microbiology, Hospital Sant Joan de Deu, University of Barcelona, Passeig Sant Joan de Deu, 08950 Esplugues, Barcelona, Spain
J Infect 59:75-82. 2009..To describe the epidemiology of invasive pneumococcal disease (IPD) caused by Streptococcus pneumoniae serotype 19A... - Identification of vaccine human papillomavirus genotypes in squamous intraepithelial lesions (CIN2-3)Eduardo Gonzalez-Bosquet
Department of Obstetrics and Gynecology, Hospital Sant Joan de Deu, University of Barcelona, Esplugues, Barcelona, Spain
Gynecol Oncol 111:9-12. 2008..To identify the prevalence of human papillomavirus vaccine genotypes and non-vaccine genotypes implicated in the appearance of cervical intraepithelial neoplasia (CIN2-3)... - 2009 Influenza A H1N1 infections: delays in starting treatment with oseltamivir were associated with a more severe diseaseCristian Launes
Infectious Diseases Unit, Department of Pediatrics, Hospital Universitari Sant Joan de Deu, Universitat de Barcelona, Barcelona, Spain
Pediatr Infect Dis J 30:622-5. 2011..Of the 127 patients, 24 required pediatric intensive care unit admission. Four patients died. Patients admitted with chronic conditions and those in whom oseltamivir was delayed more than 72 hours had a more severe disease... - Rapid and easy identification of capsular serotypes of Streptococcus pneumoniae by use of fragment analysis by automated fluorescence-based capillary electrophoresisLaura Selva
Molecular Microbiology Department, University Hospital Sant Joan de Deu, Barcelona, Spain
J Clin Microbiol 50:3451-7. 2012..These results indicate that FAF-mPCR is a good method to determine the capsular serotype of Streptococcus pneumoniae... - Impact of CD4 T cell count on the outcome of planned treatment interruptions in early-treated human immunodeficiency virus-infected childrenClaudia Fortuny
Infectious Diseases Unit, Department of Pediatrics, Hospital Sant Joan de Deu, Universitat de Barcelona, Barcelona, Spain
Pediatr Infect Dis J 30:435-8. 2011..Our results suggest that early treatment in HIV-infected infants increases their potential to safely control viral replication after PTI for long periods... - Detection of human papillomavirus infection in women attending a colposcopy clinicLaura Selva
Department of Molecular Microbiology, University Hospital Sant Joan de Deu, 08950 Esplugues, Barcelona, Spain
Diagn Microbiol Infect Dis 64:416-21. 2009..The main aim of this study is to know the distribution of different types of HPV in women attending a colposcopy clinic for cervical dysplasia... - Cost of hospitalizing children with invasive pneumococcal pneumoniaPedro Brotons
Department of Microbiology, Hospital Sant Joan de Déu University of Barcelona, Esplugues, Barcelona, Spain
Vaccine 31:1117-22. 2013..Although invasive pneumococcal pneumonia remains responsible for a significant number of child hospitalizations, specific data on hospital resource utilization and related costs are limited... - Evolution of mitochondrial DNA content after planned interruption of HAART in HIV-infected pediatric patientsAntoni Noguera
Unitat d Infectologia, Servei de Pediatria, Hospital Sant Joan de Deu, University of Barcelona, Barcelona, Spain
AIDS Res Hum Retroviruses 26:1015-8. 2010..In this series, PTI led to a partial restoration of mtDNA levels and a significant decrease in lactate values... - Prevalence of human metapneumovirus among hospitalized children younger than 1 year in Catalonia, SpainMarta Camps
Department of Microbiology, Hospital Clinic i Provincial de Barcelona, Barcelona, Spain
J Med Virol 80:1452-60. 2008.... - [Low prevalence of Mycoplasma pneumoniae infection in children with acute pharyngitis]María Fernández de Sevilla
Agrupació Sanitària Hospital Sant Joan de Déu Clínic, Universitat de Barcelona, Esplugues de Llobregat, Espana
Enferm Infecc Microbiol Clin 27:403-5. 2009..The aim of this study is to determine the role of Mycoplasma pneumoniae in pediatric patients with acute pharyngitis and in a healthy control group... - Low serum carnitine in HIV-infected children on antiretroviral treatmentM A Vilaseca
Department of Biochemistry, Hospital Sant Joan de Deu, University of Barcelona, Barcelona, Spain
Eur J Clin Nutr 57:1317-22. 2003..We analysed the relation among serum carnitine, its amino-acid precursors (methionine and lysine), clinical evaluation and antiretroviral therapy... - Neonatal pulmonary tuberculosis evolving to a destroyed lungL Alsina
Department of Paediatrics, Agrupació Sanitària Hospital Clínic, Hospital Sant Joan de Deu, Universitat de Barcelona, Spain
Int J Tuberc Lung Dis 12:573-5. 2008..A high index of clinical suspicion is required when evaluating pregnant women at risk for TB and their ill children, as early identification and treatment can prevent the devastating consequences of TB... - Hyperhomocysteinaemia and folate deficiency in human immunodeficiency virus-infected childrenM A Vilaseca
Servei de Bioquimica, Hospital Sant Joan de Deu, Passeig Sant Joan de Deu, 2, Universitat de Barcelona, Barcelona, Spain
Eur J Clin Invest 31:992-8. 2001..We studied the relationship of these vitamins and methionine with tHcy values... - Comparison of conization and limited excision of the transformation zone (LETZ) in the treatment of squamous intraepithelial lesions (SIL) of the uterine cervixE Gonzalez Bosquet
Department of Obstetrics and Gynecology, Hospital Sant Joan de Deu, University of Barcelona, Spain
Eur J Gynaecol Oncol 29:123-5. 2008..To compare the treatment of squamous intraepithelial lesions of the uterine cervix using conization with limited excision of the transformation zone (LETZ)... - Value of anaerobic blood cultures in pediatricsA Gene
Pediatric Infectious Diseases Unit, Hospital Sant Joan de Deu, Passeig Sant Joan de Déu 2, 08950 Esplugues de Llobregat, Barcelona, Spain
Eur J Clin Microbiol Infect Dis 24:47-50. 2005..Considering that the quantity of blood available from pediatric patients for blood cultures is usually small, it may be reasonable to limit the use of anaerobic blood cultures to patients with the highest risk... - Characterisation of invasive pneumococcal isolates in Catalan children up to 5 years of age, 1989-2000C Latorre
Microbiology Service, Hospital Sant Joan de Deu, Passeig Sant Joan de Déu 2, 08950 Esplugues, Barcelona, Spain
Clin Microbiol Infect 10:177-81. 2004..Resistance to penicillin, tetracycline, chloramphenicol and erythromycin was the most common pattern (18.8% of strains). Most isolates (80.2%) belonged to serogroups/types included in the heptavalent conjugate vaccine... - Predictive factors for the detection of CIN II-III in the follow-up of women with CIN IE Gonzalez-Bosquet
Department of Obstetrics and Gynecology, Hospital Sant Joan de Deu, University of Barcelona, Esplugues Barcelona
Eur J Gynaecol Oncol 31:369-71. 2010..To determine which factors may increase the risk that women diagnosed with CIN I may later develop CIN II-III... - [Compliance with a culture-based strategy to prevent perinatal Group B streptococcal infection in a third-level hospital]Laia Alsina-Manrique
Servicios de Pediatría, Hospital Sant Joan de Deu, Universidad de Barcelona, Espana
Enferm Infecc Microbiol Clin 24:505-8. 2006..1%) and only partially amenable to improvements. Effectively, there are inherent limitations to the protocol that can be resolved with the use of other strategies, such as tests for quick identification of genital carrier status... - Pneumococcal serotypes causing acute otitis media among children in Barcelona (1992-2011): emergence of the multiresistant clone ST320 of serotype 19AAmadeu Gene
Department of Molecular Microbiology, Hospital Universitari Sant Joan de Deu, Esplugues, Spain
Pediatr Infect Dis J 32:e128-33. 2013..There is scarce information about changes in serotypes and clonal types of Streptococcus pneumoniae causing acute otitis media (AOM) in recent years, particularly in European countries... - Clinical risk factors are more relevant than respiratory viruses in predicting bronchiolitis severitySílvia Ricart
Department of Pediatrics, Hospital Universitari Sant Joan de Deu, Barcelona, Spain
Pediatr Pulmonol 48:456-63. 2013..Whether specific viruses or the classical clinical risk factors are more important in determining severe bronchiolitis is not well established... - Human Metapneumovirus in the Cerebrospinal Fluid of a Patient With Acute EncephalitisIván Sánchez Fernández
Department of Child Neurology, Hospital Sant Joan de Deu, Barcelona, Spain
Arch Neurol 69:649-52. 2012..To report, to our knowledge, the first case of detection of human metapneumovirus in the cerebrospinal fluid of a patient during acute encephalitis... - Easy diagnosis of invasive pneumococcal diseaseLaura Selva
University Hospital Sant Joan de Deu, Barcelona, Spain
Emerg Infect Dis 17:1125-7. 2011..DBS screening is a reliable method that requires only a small amount of blood; it is used for the diagnosis of several human diseases (3,4)... - Pandemic influenza A (2009 H1N1) in children with acute lymphoblastic leukaemiaCristian Launes
Departments of Paediatric Haematology, Hospital Sant Joan de Deu de Barcelona, Esplugues de Llobregat, Barcelona, Spain
Br J Haematol 149:874-8. 2010..ALL patients under maintenance treatment had mild disease. In conclusion, in our series only patients under intensive treatment developed a moderate to severe disease... - Prognostic factors for the development of vaginal intraepithelial neoplasiaE Gonzalez Bosquet
Department of Obstetrics and Gynecology, Hospital Sant Joan de Deu, University of Barcelona, Barcelona, Spain
Eur J Gynaecol Oncol 29:43-5. 2008..To identify risk factors for the appearance of vaginal intraepithelial neoplasia (VAIN)... - Novel influenza A (H1N1) encephalitis in a 3-month-old infantL Sánchez-Torrent
Pediatric Infectious Diseases Unit, Pediatric Department, Corporació Sanitària Hospital Sant Joan de Déu Clínic, Universitat de Barcelona, Passeig Sant Joan de Deu, 2, Esplugues de Llobregat, 08950, Barcelona, Spain
Infection 38:227-9. 2010..The infection was confirmed in nasopharyngeal aspirate and cerebrospinal fluid. Treatment with oseltamivir was started. He was discharged without any neurologic sequelae... - Secondary alteration of the transferrin isoelectric focusing pattern in a case of bacterial meningitisE Quintana
Institut de Bioquimica Clinica, Hospital Clinic, Barcelona, Spain
J Inherit Metab Dis 30:267. 2007..Furthermore, our findings highlight the possibility that the type 2 IEF pattern of serum sialotransferrin detected in some patients with neonatal death due to organ failure and septic events might be secondary to the infectious process...