Jordi Muntane

Summary

Country: Spain

Publications

  1. ncbi request reprint Targeting cell death and survival receptors in hepatocellular carcinoma
    Jordi Muntane
    Liver Research Unit, IMIBIC Instituto Maimónides para la Investigación Biomédica de Córdoba, Reina Sofia University Hospital, Cordoba, Spain
    Anticancer Agents Med Chem 11:576-84. 2011
  2. ncbi request reprint Regulation of drug metabolism and transporters
    Jordi Muntane
    Reina Sofia University Hospital, Cordoba, Spain
    Curr Drug Metab 10:932-45. 2009
  3. doi request reprint Harnessing tumor necrosis factor receptors to enhance antitumor activities of drugs
    Jordi Muntane
    Liver Research Unit, Instituto Maimónides para la Investigación Biomédica de Córdoba, Reina Sofia University Hospital, Cordoba, Spain
    Chem Res Toxicol 24:1610-6. 2011
  4. ncbi request reprint [Mechanisms of liver cell injury]
    J Muntane
    Liver Research Unit, Reina Sofia University Hospital, CIBERehd, Cordoba, Spain
    Rev Esp Enferm Dig 99:405-10. 2007
  5. doi request reprint Alteration of S-nitrosothiol homeostasis and targets for protein S-nitrosation in human hepatocytes
    Laura M Lopez-Sanchez
    Liver Research Unit, Hospital Universitario Reina Sofia, Cordoba, Spain
    Proteomics 8:4709-20. 2008
  6. ncbi request reprint The differential effect of PGE(1) on d-galactosamine-induced nitrosative stress and cell death in primary culture of human hepatocytes
    Isidora Ranchal
    Liver Unit, Reina Sofia University Hospital, Cordoba, Spain
    Prostaglandins Other Lipid Mediat 79:245-59. 2006
  7. ncbi request reprint Melatonin reduces apoptosis and necrosis induced by ischemia/reperfusion injury of the pancreas
    Francisco C Muñoz-Casares
    Department of General Surgery, Reina Sofia University Hospital, Cordoba, Spain
    J Pineal Res 40:195-203. 2006
  8. doi request reprint Melatonin exerts a more potent effect than S-adenosyl-l-methionine against iron metabolism disturbances, oxidative stress and tissue injury induced by obstructive jaundice in rats
    Juan R Munoz-Castaneda
    Liver Research Unit, Reina Sofia University Hospital, Cordoba, Spain
    Chem Biol Interact 174:79-87. 2008
  9. doi request reprint Interleukin-6 is associated with liver lipid homeostasis but not with cell death in experimental hepatic steatosis
    Miguel A Sánchez-Garrido
    Reina Sofia University Hospital, Cordoba, Spain
    Innate Immun 15:337-49. 2009
  10. ncbi request reprint Role of nitric oxide in D-galactosamine-induced cell death and its protection by PGE1 in cultured hepatocytes
    Emilio Siendones
    Unidad de Investigacion, Servicio Aparato Digestivo, Hospital Universitario Reina Sofi a, Av Menendez Pidal s n, E 14004, Cordoba, Spain
    Nitric Oxide 8:133-43. 2003

Collaborators

Detail Information

Publications52

  1. ncbi request reprint Targeting cell death and survival receptors in hepatocellular carcinoma
    Jordi Muntane
    Liver Research Unit, IMIBIC Instituto Maimónides para la Investigación Biomédica de Córdoba, Reina Sofia University Hospital, Cordoba, Spain
    Anticancer Agents Med Chem 11:576-84. 2011
    ....
  2. ncbi request reprint Regulation of drug metabolism and transporters
    Jordi Muntane
    Reina Sofia University Hospital, Cordoba, Spain
    Curr Drug Metab 10:932-45. 2009
    ..The review describes the activation process of nuclear receptors, as well as their interactions to elucidate the extended cross-talk between them in the regulation of DME...
  3. doi request reprint Harnessing tumor necrosis factor receptors to enhance antitumor activities of drugs
    Jordi Muntane
    Liver Research Unit, Instituto Maimónides para la Investigación Biomédica de Córdoba, Reina Sofia University Hospital, Cordoba, Spain
    Chem Res Toxicol 24:1610-6. 2011
    ..The present review is focused on the different therapeutic strategies such as targeted antibodies or small molecules addressed to selective stimulated DR-mediated apoptosis or reduce cell proliferation in cancer cells...
  4. ncbi request reprint [Mechanisms of liver cell injury]
    J Muntane
    Liver Research Unit, Reina Sofia University Hospital, CIBERehd, Cordoba, Spain
    Rev Esp Enferm Dig 99:405-10. 2007
  5. doi request reprint Alteration of S-nitrosothiol homeostasis and targets for protein S-nitrosation in human hepatocytes
    Laura M Lopez-Sanchez
    Liver Research Unit, Hospital Universitario Reina Sofia, Cordoba, Spain
    Proteomics 8:4709-20. 2008
    ....
  6. ncbi request reprint The differential effect of PGE(1) on d-galactosamine-induced nitrosative stress and cell death in primary culture of human hepatocytes
    Isidora Ranchal
    Liver Unit, Reina Sofia University Hospital, Cordoba, Spain
    Prostaglandins Other Lipid Mediat 79:245-59. 2006
    ..In conclusion, the administration of PGE(1) during advanced d-GalN cytotoxicity induced nitrosative stress and lost its cytoprotective properties in cultured human hepatocytes...
  7. ncbi request reprint Melatonin reduces apoptosis and necrosis induced by ischemia/reperfusion injury of the pancreas
    Francisco C Muñoz-Casares
    Department of General Surgery, Reina Sofia University Hospital, Cordoba, Spain
    J Pineal Res 40:195-203. 2006
    ..Preventive or therapeutic administration of melatonin protected against the induction of oxidative stress and tissue injury, and restored cell function in experimental pancreatic IR in rats...
  8. doi request reprint Melatonin exerts a more potent effect than S-adenosyl-l-methionine against iron metabolism disturbances, oxidative stress and tissue injury induced by obstructive jaundice in rats
    Juan R Munoz-Castaneda
    Liver Research Unit, Reina Sofia University Hospital, Cordoba, Spain
    Chem Biol Interact 174:79-87. 2008
    ..In conclusion, the effect of melatonin and SAMe on Fe metabolism may be included in the beneficial properties of these agents on lipid peroxidation and tissue injury induced by OJ...
  9. doi request reprint Interleukin-6 is associated with liver lipid homeostasis but not with cell death in experimental hepatic steatosis
    Miguel A Sánchez-Garrido
    Reina Sofia University Hospital, Cordoba, Spain
    Innate Immun 15:337-49. 2009
    ..Furthermore, PC is identified as a new survival agent that reverses several TNFalpha-inducible responses that are likely to promote steatosis and necrosis...
  10. ncbi request reprint Role of nitric oxide in D-galactosamine-induced cell death and its protection by PGE1 in cultured hepatocytes
    Emilio Siendones
    Unidad de Investigacion, Servicio Aparato Digestivo, Hospital Universitario Reina Sofi a, Av Menendez Pidal s n, E 14004, Cordoba, Spain
    Nitric Oxide 8:133-43. 2003
    ..The present study suggests that low NO production induced by PGE(1) preadministration reduces D-GalN-induced cell death through its capacity to reduce iNOS expression and NO production caused by the hepatotoxin...
  11. ncbi request reprint Melatonin prevents brain oxidative stress induced by obstructive jaundice in rats
    Adolfo Cruz
    Department of General Surgery, Reina Sofia University Hospital, Avenida Menendez Pidal s n, Cordoba, Spain
    J Neurosci Res 85:3652-6. 2007
    ..In conclusion, the treatment with melatonin decreased lipid peroxidation and recovered the antioxidant status in the brain from cholestatic animals...
  12. doi request reprint Calcium-dependent nitric oxide production is involved in the cytoprotective properties of n-acetylcysteine in glycochenodeoxycholic acid-induced cell death in hepatocytes
    Sandra González-Rubio
    Liver Research Unit, Reina Sofia University Hospital, Cordoba, Spain
    Toxicol Appl Pharmacol 242:165-72. 2010
    ..The increase of NO production by Ca2+-dependent NOS-3 expression during NAC administration reduces cell death in GCDCA-treated hepatocytes...
  13. ncbi request reprint Radical surgery-peritonectomy and intraoperative intraperitoneal chemotherapy for the treatment of peritoneal carcinomatosis in recurrent or primary ovarian cancer
    Sebastián Rufián
    Department of General Surgery, Reina Sofia University Hospital, Cordoba, Spain
    J Surg Oncol 94:316-24. 2006
    ....
  14. ncbi request reprint Melatonin prevents experimental liver cirrhosis induced by thioacetamide in rats
    Adolfo Cruz
    Department of General Surgery, Reina Sofia University Hospital, Cordoba, Spain
    J Pineal Res 39:143-50. 2005
    ..Melatonin prevented the oxidative stress-related changes associated with TAA toxicity. In conclusion, the study showed that melatonin prevents the tissue damage and fibrosis associated with TAA-induced liver cirrhosis in rats...
  15. ncbi request reprint Role of NF-kappaB activation and nitric oxide expression during PGE protection against d-galactosamine-induced cell death in cultured rat hepatocytes
    Dalia Fouad
    Unidad Clínica Aparato Digestivo, Hospital Universitario Reina Sofia, Cordoba, Spain
    Liver Int 24:227-36. 2004
    ..The present study shows that the cytoprotection by PGE1 against D-GalN-induced apoptosis was related to NF-kappaB-dependent iNOS expression...
  16. doi request reprint Improvement of capecitabine antitumoral activity by melatonin in pancreatic cancer
    Juan Ruiz-Rabelo
    Department of Surgery, Reina Sofia University Hospital, Cordoba, Spain
    Pancreas 40:410-4. 2011
    ..The purpose of our study was to evaluate the effects of the addition of melatonin and capecitabine on experimental pancreatic cancer...
  17. doi request reprint Nitric oxide mimics transcriptional and post-translational regulation during α-tocopherol cytoprotection against glycochenodeoxycholate-induced cell death in hepatocytes
    Raul Gonzalez
    Instituto Maimónides para la Investigación Biomédica de Córdoba, Reina Sofia University Hospital, Cordoba, Spain
    J Hepatol 55:133-44. 2011
    ..Whether α-Tocopherol regulates oxidative and nitrosative stress, bile acid transporter expression and their NO-dependent post-translational modifications, and cell death were assessed in vitro and in vivo...
  18. ncbi request reprint Parachlorophenylalanine exacerbates oxidative stress induced by gentamicin in rats
    Juan R Munoz-Castaneda
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Cordoba, Cordoba, Spain
    Basic Clin Pharmacol Toxicol 97:174-8. 2005
    ..These results support the prooxidant action of PCPA in brain tissue and its capacity to exacerbate the oxidative stress and renal dysfunction induced by gentamicin, as well as the possible antioxidant property of serotonin...
  19. doi request reprint Cytoprotective properties of rifampicin are related to the regulation of detoxification system and bile acid transporter expression during hepatocellular injury induced by hydrophobic bile acids
    Raul Gonzalez
    Liver Research Unit, Hospital Universitario Reina Sofia, IMIBIC Instituto Maimónides para la Investigación Biomédica de Córdoba, Av Menendez Pidal s n, 14004 Cordoba, Spain
    J Hepatobiliary Pancreat Sci 18:740-50. 2011
    ..This study evaluated the effect of rifampicin on the expression of different detoxification systems and bile acid transporters during in-vivo and in-vitro experimental models of cholestasis...
  20. doi request reprint The reduction of cell death and proliferation by p27(Kip1) minimizes DNA damage in an experimental model of genotoxicity
    Isidora Ranchal
    Liver Research Unit, Reina Sofia University Hospital, Cordoba, Spain
    Int J Cancer 125:2270-80. 2009
    ..The study showed that the p27 reduced cell proliferation and death, as well as the accumulation of DNA damage in hepatocarcinogenesis...
  21. doi request reprint Mitochondrial-driven ubiquinone enhances extracellular calcium-dependent nitric oxide production and reduces glycochenodeoxycholic acid-induced cell death in hepatocytes
    Sandra González-Rubio
    Liver Research Unit, Reina Sofia University Hospital, Cordoba, Spain
    Chem Res Toxicol 22:1984-91. 2009
    ..The conclusion is that the recovery of Ca(2+)-dependent NOS-3 expression by Mito Q may be considered an additional cytoprotective property of an antioxidant...
  22. ncbi request reprint N-acetylcysteine, coenzyme Q10 and superoxide dismutase mimetic prevent mitochondrial cell dysfunction and cell death induced by d-galactosamine in primary culture of human hepatocytes
    Raul Gonzalez
    Liver Research Unit, Reina Sofia University Hospital, Cordoba, Spain
    Chem Biol Interact 181:95-106. 2009
    ....
  23. doi request reprint Detection and proteomic identification of S-nitrosated proteins in human hepatocytes
    Laura M Lopez-Sanchez
    Liver Research Unit, Hospital Universitario Reina Sofia, Cordoba, Spain
    Methods Enzymol 440:273-81. 2008
    ..This methodology is based on the biotin switch method, which labels S-nitrosated proteins with an affinity tag, allowing their selective detection and proteomic identification...
  24. ncbi request reprint S-Nitrosation of proteins during D-galactosamine-induced cell death in human hepatocytes
    Laura M Lopez-Sanchez
    Liver Research Unit, Hospital Universitario Reina Sofia, Cordoba, Spain
    Free Radic Res 41:50-61. 2007
    ..Among them, seven were also identified in d-GalN-treated hepatocytes. The results here reported underline the importance of the alteration of SNO homeostasis during d-GalN-induced cell death in human hepatocytes...
  25. doi request reprint Cardiotrophin-1 reduces ischemia/reperfusion injury during liver transplant
    Patricia Aguilar-Melero
    Liver Research Unit, Instituto Maimónides para la Investigación Biomédica de Córdoba, Reina Sofia University Hospital, Cordoba, Spain
    J Surg Res 181:e83-91. 2013
    ..The present study is the first report to show that the administration of CT-1 to donors would benefit the outcome of OLT...
  26. doi request reprint Impact of age on liver regeneration response to injury after partial hepatectomy in a rat model
    Juan Manuel Sánchez-Hidalgo
    Unit of Hepatobiliary Surgery and Liver Transplantation, University Hospital Reina Sofia, Cordoba, Spain
    J Surg Res 175:e1-9. 2012
    ..Liver resection is a feasible treatment for multiple liver diseases. There is no evidence about the impact of age on liver regeneration...
  27. ncbi request reprint Cytoprotective properties of alpha-tocopherol are related to gene regulation in cultured D-galactosamine-treated human hepatocytes
    Raul Gonzalez
    Liver Research Unit, Reina Sofia University Hospital, CIBERehd, E 14004 Cordoba, Spain
    Free Radic Biol Med 43:1439-52. 2007
    ..In conclusion, the cytoprotective properties of alpha-tocopherol are mostly related to gene regulation rather than to antioxidant activity in toxin-induced cell death in hepatocytes...
  28. doi request reprint Effects of capecitabine and celecoxib in experimental pancreatic cancer
    Alvaro Arjona-Sanchez
    Department of General Surgery, Reina Sofia University Hospital, Cordoba, Spain
    Pancreatology 10:641-7. 2010
    ..The aim of the study was the identification of beneficial properties of combined celecoxib and capecitabine treatment during an experimental pancreatic cancer model...
  29. doi request reprint Neoadjuvant intraperitoneal chemotherapy with paclitaxel for the radical surgical treatment of peritoneal carcinomatosis in ovarian cancer: a prospective pilot study
    Francisco C Muñoz-Casares
    Department of General Surgery Surgical Oncology Unit, Reina Sofia University Hospital, Avda Menendez Pidal s n, 14004 Cordoba, Spain
    Cancer Chemother Pharmacol 68:267-74. 2011
    ....
  30. doi request reprint Targeting hepatoma using nitric oxide donor strategies
    Raul Gonzalez
    Department of Biochemistry and Molecular Biology, University of Cordoba, Cordoba, Spain
    Antioxid Redox Signal 18:491-506. 2013
    ..The antitumoral activity of NO was also evaluated in the subcutaneous implantation of NOS-3-overexpressing hepatoma cells, as well NO donor injection into wild-type hepatoma-derived tumors implanted in xenograft mouse models...
  31. doi request reprint Unraveling the S-nitrosoproteome: tools and strategies
    Laura M Lopez-Sanchez
    Unidad de Investigacion, Hospital Universitario Reina Sofia, Cordoba, Spain
    Proteomics 9:808-18. 2009
    ..The development of new analytical methods and strategies over the past several years now allows us to investigate the nitrosoproteome on a global scale...
  32. doi request reprint Impact of donor graft steatosis on overall outcome and viral recurrence after liver transplantation for hepatitis C virus cirrhosis
    Javier Briceno
    Unit of Hepatobiliary Surgery and Liver Transplantation, Reina Sofia University Hospital, Centro de Investigación Biomédica en Red en Enfermedades Hepáticas y Digestivas CIBEREHD, Cordoba, Spain
    Liver Transpl 15:37-48. 2009
    ..Fibrosis evolution is higher when graft steatosis is >30%. OLT with >30% steatotic donor livers should be precluded in HCV recipients...
  33. ncbi request reprint Beneficial properties of melatonin in an experimental model of pancreatic cancer
    Juan F Ruiz-Rabelo
    Department of General Surgery, Reina Sofia University Hospital, Cordoba, Spain
    J Pineal Res 43:270-5. 2007
    ..In conclusion, treatment with melatonin reduced oxidative damage and cancer nodules induced by BOP in the pancreas...
  34. ncbi request reprint Dual effect of ethanol on cell death in primary culture of human and rat hepatocytes
    Rafael Castilla
    Unidad Clínica Aparato Digestivo, Hospital Universitario Reina Sofia, Cordoba, Spain
    Alcohol Alcohol 39:290-6. 2004
    ..The aim of the present study was to evaluate the effect of a broad range of ethanol concentrations on apoptosis and necrosis in primary culture of human and rat hepatocytes...
  35. pmc Proteomic analysis for developing new biomarkers of hepatocellular carcinoma
    Maria Pleguezuelo
    Maria Pleguezuelo, Ruben Ciria, Liver Research Unit and Academic Department of Surgery, Reina Sofia University Hospital, Avda Menendez Pidal s n, Cordoba 14004, Spain
    World J Hepatol 2:127-35. 2010
    ..To identify new markers of hepatocellular carcinoma (HCC) using a proteomic analysis...
  36. ncbi request reprint Mitochondrial drug targets in cell death and cancer
    Gustavo Ferrín
    Liver Research Unit, Instituto Maimónides para la Investigación Biomédica de Córdoba, Reina Sofia University Hospital, Cordoba, Spain
    Curr Pharm Des 17:2002-16. 2011
    ....
  37. ncbi request reprint Can systemic cytokines predict relapse of inflammatory bowel disease?
    Valle García-Sánchez
    Gastroenterology Unit, Reina University Sofia Hospital, Cordoba, Spain
    Hepatogastroenterology 57:524-30. 2010
    ..To determine the value of systemic cytokines as predictors of relapse in inflammatory bowel disease (IBD)...
  38. ncbi request reprint PGE1 abolishes the mitochondrial-independent cell death pathway induced by D-galactosamine in primary culture of rat hepatocytes
    Emilio Siendones
    Clinical Unit of Digestive Apparatus, University Hospital Reina Sofia, Cordoba, Spain
    J Gastroenterol Hepatol 20:108-16. 2005
    ..In addition, we evaluated if PGE1 was able to modulate different parameters related to D-GalN-induced apoptosis in cultured rat hepatocytes...
  39. doi request reprint Role of serum cytokine profile in ulcerative colitis assessment
    Manuel Luís Rodríguez-Perálvarez
    Department of Gastroenterology, Reina Sofia University Hospital, Cordoba, Spain
    Inflamm Bowel Dis 18:1864-71. 2012
    ..Several cytokines are overexpressed in the colonic mucosa of patients with ulcerative colitis (UC). The measurement of these parameters in plasma could be useful in diagnosis and disease assessment...
  40. ncbi request reprint The role of hyperthermic intraoperative intraperitoneal chemotherapy (HIPEC) in the treatment of peritoneal carcinomatosis in recurrent ovarian cancer
    Francisco C Muñoz-Casares
    Department of General Surgery, Surgical Oncology Unit, Reina Sofia University Hospital, Cordoba, Spain
    Clin Transl Oncol 11:753-9. 2009
    ..The purpose of this research is to evaluate the role of the administration of HIPEC...
  41. ncbi request reprint Altered protein expression and protein nitration pattern during d-galactosamine-induced cell death in human hepatocytes: a proteomic analysis
    Antonio Rodriguez-Ariza
    Liver Research Unit, Hospital Universitario Reina Sofia, Cordoba, Spain
    Liver Int 25:1259-69. 2005
    ..This study aimed to identify protein expression changes during the induction of apoptosis and necrosis by d-GalN in cultured human hepatocytes...
  42. ncbi request reprint Ovariectomy exacerbates oxidative stress and cardiopathy induced by adriamycin
    Juan Rafael Munoz-Castaneda
    Department of Biochemistry and Molecular Biology, School of Medicine, Reina Sofia University Hospital, Cordoba, Spain
    Gynecol Endocrinol 22:74-9. 2006
    ..In conclusion, the absence of hormones caused by OVX or menopause may induce or accelerate pre-existing cardiovascular dysfunctions...
  43. ncbi request reprint Role of serotonin in cerebral oxidative stress in rats
    Juan R Munoz-Castaneda
    Department of Biochemistry and Molecular Biology, School of Medicine, Avda Menendez Pidal s n 14004 Cordoba, Spain
    Acta Neurobiol Exp (Wars) 66:1-6. 2006
    ..In conclusion, our study supports the view that the antioxidant properties of serotonin protect against basal oxidative stress in brain...
  44. ncbi request reprint Estradiol and catecholestrogens protect against adriamycin-induced oxidative stress in erythrocytes of ovariectomized rats
    Juan R Munoz-Castaneda
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Cordoba, Avda Menendez Pidal s n C P 14004 Cordoba, Spain
    Toxicol Lett 160:196-203. 2006
    ..In conclusion, the administration of estrogens and cathecolestrogens counteract the oxidative stress in erythrocytes and plasma induced by OVX in presence or not toxic injury...
  45. ncbi request reprint Effect of 17-beta-estradiol administration during adriamycin-induced cardiomyopathy in ovariectomized rat
    Juan R Munoz-Castaneda
    Department of Biochemistry and Molecular Biology, School of Medicine, University of Cordoba, Spain
    Eur J Pharmacol 523:86-92. 2005
    ..Our study showed that 17-beta-estradiol reduced all of the parameters related to oxidative stress and cardiac injury in ovariectomized rats treated with adriamycin...
  46. ncbi request reprint Obstruction in patients with colorectal cancer increases morbidity and mortality in association with altered nutritional status
    José María Gallardo-Valverde
    Surgery Department, Reina Sofia University Hospital, Cordoba, Spain
    Nutr Cancer 53:169-76. 2005
    ..The increased morbidity and mortality of CRC patients was also associated with acute phase response, inflammation, and low serum cholesterol and triglyceride concentration...
  47. ncbi request reprint PGE1-induced NO reduces apoptosis by D-galactosamine through attenuation of NF-kappaB and NOS-2 expression in rat hepatocytes
    Emilio Siendones
    Unidad de Investigacion, Unidad Clínica Aparato Digestivo, Hospital Universitario Reina Sofia, Cordoba, Spain
    Hepatology 40:1295-303. 2004
    ..Therefore, a dual role for NO in PGE1-treated D-GalN-induced toxicity in hepatocytes is characterized by a rapid NO release that attenuates the late and proapoptotic NOS-2 expression...
  48. doi request reprint Does fecal calprotectin predict relapse in patients with Crohn's disease and ulcerative colitis?
    Valle García-Sánchez
    Gastroenterology Unit, Hospital Universitario Reina Sofia, Cordoba, Spain
    J Crohns Colitis 4:144-52. 2010
    ..The possible differences in its predictive capacity in Crohn's disease (CD) versus ulcerative colitis (UC), and the different phenotypes, are also examined...
  49. ncbi request reprint The protective role of coenzyme Q10 in renal injury associated with extracorporeal shockwave lithotripsy: a randomised, placebo-controlled clinical trial
    Julia Carrasco
    Department of Urology, Reina Sofia University Hospital, Cordoba, Spain
    BJU Int 113:942-50. 2014
    ..To determine the efficacy of coenzyme Q10 (CoQ10) in preventing renal injury in patients with lithiasis undergoing extracorporeal shockwave lithotripsy (ESWL)...
  50. ncbi request reprint IL-6 and IGF-1 are independent prognostic factors of liver steatosis and non-alcoholic steatohepatitis in morbidly obese patients
    David García-Galiano
    Liver Research Unit, Reina Sofia University Hospital, CIBER HEPAD, Cordoba, Spain
    Obes Surg 17:493-503. 2007
    ..The identification of non-invasive prognostic factors of liver steatosis and NASH are relevant for the unravelling of the mechanisms of this disease, as well as for the clinical diagnoses of these patients...
  51. ncbi request reprint Melatonin prevents oxidative stress and hepatocyte cell death induced by experimental cholestasis
    Francisco J Padillo
    Unit of Hepatobiliary Surgery, Department of General Surgery, Reina Sofia University Hospital, Avda Menendez Pidal s n 14 004, Cordoba, Spain
    Free Radic Res 38:697-704. 2004
    ..004) with a significant improvement in all oxidative stress markers. In conclusion, our results showed that MEL recovered the antioxidant status and reduced apoptosis and necrosis induced by experimental cholestasis...
  52. ncbi request reprint Effect of internal biliary drainage on plasma levels of endotoxin, cytokines, and C-reactive protein in patients with obstructive jaundice
    Francisco J Padillo
    Department of Surgery 5a B, Hospital Reina Sofia, Avda Menendez Pidal s n, 14 004, Cordoba, Spain
    World J Surg 26:1328-32. 2002
    ..After biliary drainage a transitory improvement of these alterations was observed, although values remained high 1 week postdrainage. These findings were associated with positive bile cultures...