Alberto Munoz

Summary

Country: Spain

Publications

  1. ncbi request reprint Cation-chloride cotransporters and GABA-ergic innervation in the human epileptic hippocampus
    Alberto Munoz
    Instituto Cajal, CSIC, Madrid, Spain
    Epilepsia 48:663-73. 2007
  2. ncbi request reprint JNK activation is critical for Aplidin-induced apoptosis
    Ana Cuadrado
    Pharma Mar SA, E 28770 Colmenar Viejo, Madrid, Spain
    Oncogene 23:4673-80. 2004
  3. ncbi request reprint The expression levels of the transcriptional regulators p300 and CtBP modulate the correlations between SNAIL, ZEB1, E-cadherin and vitamin D receptor in human colon carcinomas
    Cristina Peña
    Department of Medical Oncology, Hospital Universitario Puerta de Hierro, Madrid, Spain
    Int J Cancer 119:2098-104. 2006
  4. pmc Vitamin D receptor deficiency enhances Wnt/β-catenin signaling and tumor burden in colon cancer
    Maria Jesus Larriba
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid, Spain
    PLoS ONE 6:e23524. 2011
  5. ncbi request reprint 1alpha,25-Dihydroxyvitamin D3 regulates the expression of Id1 and Id2 genes and the angiogenic phenotype of human colon carcinoma cells
    Nuria Isabel Fernandez-Garcia
    Instituto de Investigaciones Biomedicas CSIC UAM, Madrid, Spain
    Oncogene 24:6533-44. 2005
  6. doi request reprint Vitamin D has wide regulatory effects on histone demethylase genes
    Fabio Pereira
    Department of Cancer Biology, Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid, Spain
    Cell Cycle 11:1081-9. 2012
  7. pmc Novel snail1 target proteins in human colon cancer identified by proteomic analysis
    Maria Jesus Larriba
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid, Spain
    PLoS ONE 5:e10221. 2010
  8. pmc RhoA-ROCK and p38MAPK-MSK1 mediate vitamin D effects on gene expression, phenotype, and Wnt pathway in colon cancer cells
    Paloma Ordonez-Moran
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid, Spain
    J Cell Biol 183:697-710. 2008
  9. ncbi request reprint Aplidin induces the mitochondrial apoptotic pathway via oxidative stress-mediated JNK and p38 activation and protein kinase C delta
    Luis F Garcia-Fernandez
    Drug Discovery Department, PharmaMar, S A, E 28760 Tres Cantos, Madrid, Spain
    Oncogene 21:7533-44. 2002
  10. doi request reprint Effects of amyloid-β plaque proximity on the axon initial segment of pyramidal cells
    Gonzalo León-Espinosa
    Laboratorio Cajal de Circuitos Corticales CTB, Universidad Politecnica de Madrid, Campus Montegancedo S N, Pozuelo de Alarcon, Madrid, Spain
    J Alzheimers Dis 29:841-52. 2012

Collaborators

Detail Information

Publications42

  1. ncbi request reprint Cation-chloride cotransporters and GABA-ergic innervation in the human epileptic hippocampus
    Alberto Munoz
    Instituto Cajal, CSIC, Madrid, Spain
    Epilepsia 48:663-73. 2007
    ....
  2. ncbi request reprint JNK activation is critical for Aplidin-induced apoptosis
    Ana Cuadrado
    Pharma Mar SA, E 28770 Colmenar Viejo, Madrid, Spain
    Oncogene 23:4673-80. 2004
    ..We conclude that phosphorylation by JNK of c-Jun and additional substrate(s) is crucial for Aplidin activity...
  3. ncbi request reprint The expression levels of the transcriptional regulators p300 and CtBP modulate the correlations between SNAIL, ZEB1, E-cadherin and vitamin D receptor in human colon carcinomas
    Cristina Peña
    Department of Medical Oncology, Hospital Universitario Puerta de Hierro, Madrid, Spain
    Int J Cancer 119:2098-104. 2006
    ..These results indicate that the levels of expression of CtBP and p300 are critical for the action of SNAIL and ZEB1, which have a pivotal role in EMT, and show the importance of CtBP and p300 for tumor progression...
  4. pmc Vitamin D receptor deficiency enhances Wnt/β-catenin signaling and tumor burden in colon cancer
    Maria Jesus Larriba
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid, Spain
    PLoS ONE 6:e23524. 2011
    ..In conclusion, VDR controls the level of nuclear β-catenin in colon cancer cells and can therefore attenuate the impact of oncogenic mutations that activate the Wnt/β-catenin pathway...
  5. ncbi request reprint 1alpha,25-Dihydroxyvitamin D3 regulates the expression of Id1 and Id2 genes and the angiogenic phenotype of human colon carcinoma cells
    Nuria Isabel Fernandez-Garcia
    Instituto de Investigaciones Biomedicas CSIC UAM, Madrid, Spain
    Oncogene 24:6533-44. 2005
    ....
  6. doi request reprint Vitamin D has wide regulatory effects on histone demethylase genes
    Fabio Pereira
    Department of Cancer Biology, Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid, Spain
    Cell Cycle 11:1081-9. 2012
    ..Thus, 1,25(OH) 2D 3 exerts an ample regulatory effect on the expression of histone-modifying enzymes involved in epigenetic regulation that may mediate its actions on gene transcription and cell phenotype...
  7. pmc Novel snail1 target proteins in human colon cancer identified by proteomic analysis
    Maria Jesus Larriba
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid, Spain
    PLoS ONE 5:e10221. 2010
    ..However, only a few studies have used proteomics as a tool for the characterization of proteins mediating EMT...
  8. pmc RhoA-ROCK and p38MAPK-MSK1 mediate vitamin D effects on gene expression, phenotype, and Wnt pathway in colon cancer cells
    Paloma Ordonez-Moran
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid, Spain
    J Cell Biol 183:697-710. 2008
    ..Thus, the action of 1,25(OH)(2)D(3) on colon carcinoma cells depends on the dual action of VDR as a transcription factor and a nongenomic activator of RhoA-ROCK and p38MAPK-MSK1...
  9. ncbi request reprint Aplidin induces the mitochondrial apoptotic pathway via oxidative stress-mediated JNK and p38 activation and protein kinase C delta
    Luis F Garcia-Fernandez
    Drug Discovery Department, PharmaMar, S A, E 28760 Tres Cantos, Madrid, Spain
    Oncogene 21:7533-44. 2002
    ..PKC-delta thus appears as an important component necessary for full caspase cascade activation and execution of apoptosis, which most probably initiates a positive feedback loop further amplifying the apoptotic process...
  10. doi request reprint Effects of amyloid-β plaque proximity on the axon initial segment of pyramidal cells
    Gonzalo León-Espinosa
    Laboratorio Cajal de Circuitos Corticales CTB, Universidad Politecnica de Madrid, Campus Montegancedo S N, Pozuelo de Alarcon, Madrid, Spain
    J Alzheimers Dis 29:841-52. 2012
    ..Thus, despite a lack of gross structural alterations in the AIS, this decrease in GABAergic innervation may deregulate AIS activity and contribute to the hyperactivity of neurons in contact with Aβ plaques...
  11. doi request reprint In vitro maturation of the cisternal organelle in the hippocampal neuron's axon initial segment
    Diana Sanchez-Ponce
    Instituto Cajal, CSIC, 28002 Madrid, Spain
    Mol Cell Neurosci 48:104-16. 2011
    ....
  12. ncbi request reprint The first locked side-chain analogues of calcitriol (1alpha,25-dihydroxyvitamin D3) induce vitamin D receptor transcriptional activity
    Xenxo Pérez-García
    Departamento de Química Orgánica y Unidad Asociada al CSIC, Universidad de Santiago de Compostela, 15706 Santiago de Compostela, Madrid, Spain
    Org Lett 5:4033-6. 2003
    ..Analogues 3a and 3b show potency similar to that of 1alpha,25-(OH)2-D3, whereas 3c was less active. The novel analogues efficiently bind VDR in vivo to induce transcription from a consensus vitamin D responsive element (VDRE)...
  13. pmc Developmental expression of Kv potassium channels at the axon initial segment of cultured hippocampal neurons
    Diana Sanchez-Ponce
    Department of Functional and Systems Neurobiology, Instituto Cajal, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    PLoS ONE 7:e48557. 2012
    ..This distribution of potassium channels in the AIS further emphasizes the heterogeneity of this structure in different neuronal populations, as proposed previously, and suggests corresponding differences in action potential regulation...
  14. doi request reprint Colocalization of α-actinin and synaptopodin in the pyramidal cell axon initial segment
    Diana Sanchez-Ponce
    Department of Functional and Systems Neurobiology, Instituto Cajal, CSIC, 28002 Madrid, Spain
    Cereb Cortex 22:1648-61. 2012
    ..Together, these results indicate that α-actinin and the actin cytoskeleton are important components of the cisternal organelle that are probably required to stabilize the AIS...
  15. ncbi request reprint Vitamin D: Proteases, protease inhibitors and cancer
    Silvia Alvarez-Díaz
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid, Spain
    Cell Cycle 9:32-7. 2010
    ..Thus, proteases and protease inhibitors are candidates to mediate to a certain extent the complex action of 1,25(OH)(2)D(3) in cancer cells...
  16. ncbi request reprint Neuronal HuD gene encoding a mRNA stability regulator is transcriptionally repressed by thyroid hormone
    Ana Cuadrado
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid, Spain
    J Neurochem 86:763-73. 2003
    ..This is the first report of a gene encoding an mRNA stability regulator that is under T3 control. The results suggest that HuD may mediate some T3 effects by altering the half-life of mRNAs for acetylcholinesterase and other genes...
  17. pmc Cystatin D is a candidate tumor suppressor gene induced by vitamin D in human colon cancer cells
    Silvia Alvarez-Díaz
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid, Spain
    J Clin Invest 119:2343-58. 2009
    ..Based on these data, we propose that CST5 has tumor suppressor activity that may contribute to the antitumoral action of 1alpha,25(OH)2D3 in colon cancer...
  18. ncbi request reprint Double bouquet cell in the human cerebral cortex and a comparison with other mammals
    Inmaculada Ballesteros Yáñez
    Cajal Institute, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    J Comp Neurol 486:344-60. 2005
    ..We conclude that, although these interneurons may be an important element in the organization of cortical microcolumns in primates, this is not the case in other mammalian species...
  19. ncbi request reprint Kahalalide F, a new marine-derived compound, induces oncosis in human prostate and breast cancer cells
    Yajaira Suarez
    Pharma Mar S A, Madrid, Spain
    Mol Cancer Ther 2:863-72. 2003
    ..Together, these data indicate that KF induces cell death via oncosis preferentially in tumor cells...
  20. doi request reprint Proteomic analysis of 1α,25-dihydroxyvitamin D3 action on human colon cancer cells reveals a link to splicing regulation
    Iván Cristobo
    Functional Proteomics Laboratory, Centro de Investigaciones Biologicas, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    J Proteomics 75:384-97. 2011
    ....
  21. pmc c-Jun N-terminal kinase phosphorylation is a biomarker of plitidepsin activity
    Maria J Munoz-Alonso
    PharmaMar, Avda de los Reyes, 1, Pol Ind La Mina Norte, Colmenar Viejo E 28770, Madrid, Spain
    Mar Drugs 11:1677-92. 2013
    ..These findings suggest that changes in JNK activity provide a reliable biomarker for plitidepsin activity and this could be useful for designing clinical trials and maximizing the efficacy of plitidepsin...
  22. doi request reprint Aromatase expression in the normal and epileptic human hippocampus
    Josue G Yague
    Instituto Cajal, CSIC, Avenida Doctor Arce 37, E 28002 Madrid, Spain
    Brain Res 1315:41-52. 2010
    ..The widespread expression of aromatase in a large population of neurons in the normal and damaged hippocampus suggests that local estrogen formation may play an important role in human hippocampal function...
  23. doi request reprint Casein kinase 2 and microtubules control axon initial segment formation
    Diana Sanchez-Ponce
    Department of Cellular, Molecular and Developmental Neurobiology, Instituto Cajal, CSIC, 28002 Madrid, Spain
    Mol Cell Neurosci 46:222-34. 2011
    ..In conclusion, our results demonstrate a mutual dependence of CK2, ankyrinG and pIκBα for their concentration at the axon initial segment, which is related to the specific characteristics of microtubules at the AIS...
  24. ncbi request reprint Nuclear receptors: genomic and non-genomic effects converge
    Paloma Ordonez-Moran
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid, Spain
    Cell Cycle 8:1675-80. 2009
    ..Here, we will discuss these novel findings and also those indicating transcriptional regulation through ligand-dependent and -independent crosstalk of nuclear receptors with beta-catenin or VDR-interacting repressor (VDIR)...
  25. pmc A genomic approach highlights common and diverse effects and determinants of susceptibility on the yeast Saccharomyces cerevisiae exposed to distinct antimicrobial peptides
    Belen Lopez-Garcia
    Departamento de Ciencia de los Alimentos, Instituto de Agroquímica y Tecnología de Alimentos IATA, CSIC, Burjassot, Valencia, Spain
    BMC Microbiol 10:289. 2010
    ..In this study, a genomic approach was undertaken on the model yeast Saccharomyces cerevisiae to characterize the antifungal effect of two unrelated AMP...
  26. doi request reprint Genetic consequences of habitat fragmentation in long-lived tree species: the case of the mediterranean Holm Oak (Quercus ilex, L.)
    Joaquín Ortego
    Departamento de Ecologia Evolutiva, Museo Nacional de Ciencias Naturales
    J Hered 101:717-26. 2010
    ..Overall, our findings point to long-term genetic shifts in population structure of holm oaks in fragmented landscapes; however, further research is required on pollen dispersal and gene flow in this species...
  27. doi request reprint Identification and rational design of novel antimicrobial peptides for plant protection
    Jose F Marcos
    Departamento de Ciencia de los Alimentos, Instituto de Agroquimica y Tecnologia de Alimentos CSIC, 46100 Burjassot, Spain
    Annu Rev Phytopathol 46:273-301. 2008
    ..The elucidation of the mode of action and interaction with microbes will assist the improvement of peptide design with a view to targeting specific problems in agriculture and providing new tools for plant protection...
  28. pmc Studies on the mode of action of the antifungal hexapeptide PAF26
    Alberto Munoz
    Instituto de Agroquímica y Tecnología de Alimentos IATA, Apartado de Correos 73, Burjassot, E 46100 Valencia, Spain
    Antimicrob Agents Chemother 50:3847-55. 2006
    ..We propose that PAF26 is a short, de novo-designed penetratin-type peptide that has multiple detrimental effects on target fungi, which ultimately result in permeation and killing...
  29. ncbi request reprint Double-bouquet cells in the monkey and human cerebral cortex with special reference to areas 17 and 18
    Javier DeFelipe
    Cajal Institute CSIC, Avenida Dr Arce 37, 28002 Madrid, Spain
    Prog Brain Res 154:15-32. 2006
    ..This suggests important differences in the microcolumnar organization between these areas, the functional significance of which awaits detailed correlative physiological and microanatomical studies...
  30. pmc Plasma 25-hydroxyvitamin D(3) and bladder cancer risk according to tumor stage and FGFR3 status: a mechanism-based epidemiological study
    André F S Amaral
    Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre, Madrid, Spain
    J Natl Cancer Inst 104:1897-904. 2012
    ..However, little is known regarding urothelial bladder cancer (UBC). We analyzed the association between plasma 25(OH)D(3) and overall risk of UBC, as well as according to stage and FGFR3 molecular subphenotypes...
  31. doi request reprint New role of IKK alpha/beta phosphorylated I kappa B alpha in axon outgrowth and axon initial segment development
    Diana Sanchez-Ponce
    Department of Cellular, Molecular and Developmental Neurobiology, Instituto Cajal, CSIC, Av Doctor Arce 37, Madrid 28002, Spain
    Mol Cell Neurosci 37:832-44. 2008
    ..These results demonstrate a new role for proteins of the NFkappaB pathway in the acquisition of neuronal polarity and its involvement in the development of the axon initial segment...
  32. ncbi request reprint E-cadherin and vitamin D receptor regulation by SNAIL and ZEB1 in colon cancer: clinicopathological correlations
    Cristina Peña
    Department of Medical Oncology, Hospital Universitario Puerta de Hierro, Madrid, Spain
    Hum Mol Genet 14:3361-70. 2005
    ....
  33. ncbi request reprint Vitamin D and cancer: an update of in vitro and in vivo data
    Paloma Ordonez-Moran
    Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Madrid, Spain
    Front Biosci 10:2723-49. 2005
    ..Some vitamin D compounds have reached clinical trials, but results are still scarce...
  34. ncbi request reprint GABABR1 receptor protein expression in human mesial temporal cortex: changes in temporal lobe epilepsy
    Alberto Munoz
    Instituto Cajal, CSIC, Ave Dr Arce 37, 28002 Madrid, Spain
    J Comp Neurol 449:166-79. 2002
    ..This reduction in GABA(B)R1a-b expression could contribute to the pathophysiology of temporal lobe epilepsy...
  35. doi request reprint Epigenetics and environment: a complex relationship
    Oscar Aguilera
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid, Spain
    J Appl Physiol (1985) 109:243-51. 2010
    ..We discuss the possible impact of epigenetic changes on physiological and pathophysiological processes, depending in part on whether these changes occur during embryonic development or adulthood...
  36. ncbi request reprint Brainstem abscess due to plant foreign body in a dog
    Isidro Mateo
    Resonancia Magnética Veterinaria, Madrid, Spain
    J Vet Intern Med 21:535-8. 2007
  37. ncbi request reprint Alien/CSN2 gene expression is regulated by thyroid hormone in rat brain
    Stephan P Tenbaum
    Instituto de Investigaciones Biomedicas CSIC UAM, c Arturo Duperier 4, 28029, Madrid, Spain
    Dev Biol 254:149-60. 2003
    ..This suggests a negative feedback mechanism between TR and its own corepressor. Thus, the reduction of corepressor levels may represent a control mechanism of TR-mediated gene silencing...
  38. ncbi request reprint PSA-NCAM immunoreactivity in chandelier cell axon terminals of the human temporal cortex
    Jon I Arellano
    Instituto Cajal, CSIC, E 28002 Madrid, Spain
    Cereb Cortex 12:617-24. 2002
    ..The results suggest that chandelier terminals in layers II and III of the human entorhinal cortex and temporal neocortex might be particularly susceptible to plastic changes...
  39. ncbi request reprint Estimation of high-density regions using One-Class Neighbor Machines
    Alberto Munoz
    Department of Statistics, University Carlos III, Getafe, Madrid, Spain
    IEEE Trans Pattern Anal Mach Intell 28:476-80. 2006
    ..In particular, the OCNM solution asymptotically converges to the exact minimum volume set prespecified. Finally, numerical results illustrating the advantage of the new method are shown...
  40. ncbi request reprint Epigenetic alterations of the Wnt/beta-catenin pathway in human disease
    Oscar Aguilera
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid, Spain
    Endocr Metab Immune Disord Drug Targets 7:13-21. 2007
    ..Here we review the alterations of the Wnt/beta-catenin signalling cascade and discuss the biological significance and relationship between mutation and/or epigenetic silencing within the same pathway...
  41. ncbi request reprint Inhibition of proliferation and expression of T1 and cyclin D1 genes by thyroid hormone in mammary epithelial cells
    Jose Manuel Gonzalez-Sancho
    Instituto de Investigaciones Biomedicas Alberto Sols, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Madrid, Spain
    Mol Carcinog 34:25-34. 2002
    ..Our results showed that T(3) reduced the proliferation of mammary epithelial cells and inhibited the expression of cyclin D1 and T1 genes...
  42. ncbi request reprint Comparative study of antimicrobial peptides to control citrus postharvest decay caused by Penicillium digitatum
    Alberto Munoz
    Departamento de Ciencia de los Alimentos, Instituto de Agroquímica y Tecnología de Alimentos IATA, CSIC, Apartado de Correos 73, Burjassot, 46100 Valencia, Spain
    J Agric Food Chem 55:8170-6. 2007
    ..digitatum. The short tryptophan-rich cationic peptides PAF26, PAF38, PAF40, and BM0 were lethal to conidia of P. digitatum, and this property is correlated with better protection in the decay control test...