J Moscat

Summary

Country: Spain

Publications

  1. pmc NF-kappaB activation by protein kinase C isoforms and B-cell function
    Jorge Moscat
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Canto Blanco, Spain
    EMBO Rep 4:31-6. 2003
  2. ncbi request reprint PKCzeta at the crossroad of NF-kappaB and Jak1/Stat6 signaling pathways
    J Moscat
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    Cell Death Differ 13:702-11. 2006
  3. ncbi request reprint Par-4 keeps the atypical PKCs at bay
    Jorge Moscat
    Centre de Biología Molecular Severe Ochoa, Consejo Superior de Investigations Cientílicos, Universidad Autonoma de Madrid, Canto Blanco, 28049 Madrid, Spain
    Cell Cycle 2:71-2. 2003
  4. pmc The atypical protein kinase Cs. Functional specificity mediated by specific protein adapters
    J Moscat
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Universidad Autonoma, Canto Blanco, Spain
    EMBO Rep 1:399-403. 2000
  5. pmc The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway
    L Sanz
    Laboratorio Glaxo Wellcome CSIC de Biología Molecular y Celular, Centro de Biología Molecular Severo Ochoa Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid, Universidad Autonoma, Canto Blanco, 28049 Madrid, Spain
    EMBO J 19:1576-86. 2000
  6. ncbi request reprint Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase
    J Lozano
    , Canto Blanco, Madrid, Spain
    J Biol Chem 269:19200-2. 1994
  7. pmc Activation of IkappaB kinase beta by protein kinase C isoforms
    M J Lallena
    Laboratorio Glaxo Wellcome CSIC de Biología Molecular y Celular, Centro de Biología Molecular Severo Ochoa Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid, Universidad Autonoma, 28049 Madrid, Spain
    Mol Cell Biol 19:2180-8. 1999
  8. pmc MEK5, a new target of the atypical protein kinase C isoforms in mitogenic signaling
    M T Diaz-Meco
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Universidad Autonoma, 28049 Madrid, Spain
    Mol Cell Biol 21:1218-27. 2001
  9. pmc The downregulation of the pro-apoptotic protein Par-4 is critical for Ras-induced survival and tumor progression
    M Barradas
    , , , Canto Blanco, Madrid, Spain
    EMBO J 18:6362-9. 1999
  10. pmc Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62
    P Sanchez
    Centro de Biología Molecular Severo Ochoa Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid, Universidad Autonoma, Canto Blanco, Spain
    Mol Cell Biol 18:3069-80. 1998

Collaborators

  • Maria T Diaz-Meco
  • H Nakano
  • I V Sandoval
  • Marie W Wooten
  • Neal Silverman
  • Jose R Bayascas
  • Takashi Ito
  • Judit Kovac
  • Chris P Ponting
  • M Serrano
  • Hideki Sumimoto
  • E Berra
  • Angeles Duran
  • Pilar Martin
  • Michael Leitges
  • Isabel Garcia-Cao
  • Sol Sotillos
  • Juana M Flores
  • Angelina Rodriguez
  • Maria Jose Lafuente
  • J Ramesh Babu
  • Jayashree Joshi
  • Juan F Linares
  • Manuel Collado
  • Juana Maria Flores
  • Eric Allemand
  • Carme Sole
  • Paul Rennert
  • Antonia Avila
  • L Sanz
  • Ramars Amanchy
  • M Lamar Seibenhener
  • M Barradas
  • James Castelli-Gair Hombría
  • Pablo J Fernandez-Marcos
  • Clara Salas
  • Anna Lena Strom
  • Anita Galvez
  • M J Lallena
  • Anita S Galvez
  • Junmin Peng
  • Kathryn Wikenheiser
  • Robert Kemppainen
  • Haining Zhu
  • Nancy Cox
  • Peterson Pathrose
  • Marta Canamero
  • Mohammed Selloum
  • Johan Auwerx
  • Marie France Champy
  • P Sanchez
  • Francisco J Diez-Guerra
  • Sandra Rodriguez-Mascarenhas
  • Sonia Guil
  • Maria J Carrascosa
  • Michael Myers
  • Ricardo Villares
  • Gabriel Marquez
  • Adrian R Krainer
  • Angel Zaballos
  • Javier F Caceres
  • Carlos Martinez-A
  • Juan Martin-Caballero
  • Irene Sizing
  • Sylvain Picard
  • Carme Gallego
  • Daniel Sanchis
  • Sonsoles Campuzano
  • Xavier Dolcet
  • Joan X Comella
  • Raffaella Gozzelino
  • Miguel F Segura
  • Humberto Gutierrez
  • Alun M Davies
  • Jacques P Brown
  • Eva Caminero
  • Luis M Criado
  • María Luisa Gaspar
  • Susana Minguet
  • A Monjas
  • C V Paya
  • G Bren
  • J Lozano
  • G de Carcer
  • M M Municio
  • I Dominguez

Detail Information

Publications35

  1. pmc NF-kappaB activation by protein kinase C isoforms and B-cell function
    Jorge Moscat
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Canto Blanco, Spain
    EMBO Rep 4:31-6. 2003
    ..These studies have also given rise to a number of important questions that must be answered with further experimentation to establish accurately the signalling pathways that regulate B-cell function through NF-kappaB...
  2. ncbi request reprint PKCzeta at the crossroad of NF-kappaB and Jak1/Stat6 signaling pathways
    J Moscat
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    Cell Death Differ 13:702-11. 2006
    ....
  3. ncbi request reprint Par-4 keeps the atypical PKCs at bay
    Jorge Moscat
    Centre de Biología Molecular Severe Ochoa, Consejo Superior de Investigations Cientílicos, Universidad Autonoma de Madrid, Canto Blanco, 28049 Madrid, Spain
    Cell Cycle 2:71-2. 2003
  4. pmc The atypical protein kinase Cs. Functional specificity mediated by specific protein adapters
    J Moscat
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Universidad Autonoma, Canto Blanco, Spain
    EMBO Rep 1:399-403. 2000
    ....
  5. pmc The atypical PKC-interacting protein p62 channels NF-kappaB activation by the IL-1-TRAF6 pathway
    L Sanz
    Laboratorio Glaxo Wellcome CSIC de Biología Molecular y Celular, Centro de Biología Molecular Severo Ochoa Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid, Universidad Autonoma, Canto Blanco, 28049 Madrid, Spain
    EMBO J 19:1576-86. 2000
    ..Together, these results indicate that p62 is an important intermediary not only in TNFalpha but also in IL-1 signaling to NF-kappaB through the specific adapters RIP and TRAF6...
  6. ncbi request reprint Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase
    J Lozano
    , Canto Blanco, Madrid, Spain
    J Biol Chem 269:19200-2. 1994
    ..In keeping with this notion, we also demonstrate here that zeta PKC is activated in vitro by ceramide and in vivo by treatment of NIH-3T3 fibroblasts with SMase...
  7. pmc Activation of IkappaB kinase beta by protein kinase C isoforms
    M J Lallena
    Laboratorio Glaxo Wellcome CSIC de Biología Molecular y Celular, Centro de Biología Molecular Severo Ochoa Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid, Universidad Autonoma, 28049 Madrid, Spain
    Mol Cell Biol 19:2180-8. 1999
    ..Collectively, these results demonstrate a critical role for the PKC isoforms in the NF-kappaB pathway at the level of IKKbeta activation and IkappaB degradation...
  8. pmc MEK5, a new target of the atypical protein kinase C isoforms in mitogenic signaling
    M T Diaz-Meco
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Universidad Autonoma, 28049 Madrid, Spain
    Mol Cell Biol 21:1218-27. 2001
    ..From all these results, we conclude that MEK5 is a critical target of the aPKCs during mitogenic signaling...
  9. pmc The downregulation of the pro-apoptotic protein Par-4 is critical for Ras-induced survival and tumor progression
    M Barradas
    , , , Canto Blanco, Madrid, Spain
    EMBO J 18:6362-9. 1999
    ..This indicates that the downregulation of Par-4 by oncogenic Ras is a critical event in tumor progression...
  10. pmc Localization of atypical protein kinase C isoforms into lysosome-targeted endosomes through interaction with p62
    P Sanchez
    Centro de Biología Molecular Severo Ochoa Consejo Superior de Investigaciones Científicas Universidad Autónoma de Madrid, Universidad Autonoma, Canto Blanco, Spain
    Mol Cell Biol 18:3069-80. 1998
    ..This is particularly relevant in light of the role played by the aPKCs in mitogenic cell signaling events...
  11. pmc Lambda-interacting protein, a novel protein that specifically interacts with the zinc finger domain of the atypical protein kinase C isotype lambda/iota and stimulates its kinase activity in vitro and in vivo
    M T Diaz-Meco
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Universidad Autonoma, Spain
    Mol Cell Biol 16:105-14. 1996
    ....
  12. pmc DaPKC-dependent phosphorylation of Crumbs is required for epithelial cell polarity in Drosophila
    Sol Sotillos
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas and Univerisidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    J Cell Biol 166:549-57. 2004
    ..These results provide a mechanistic framework for the functional interaction between the Par-3-Par-6-aPKC and Crumbs-Sdt-Patj complexes based in the posttranslational modification of Crb by DaPKC...
  13. pmc Crosstalk between PKCzeta and the IL4/Stat6 pathway during T-cell-mediated hepatitis
    Angeles Duran
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Madrid, Spain
    EMBO J 23:4595-605. 2004
    ..In contrast, Par-4-/- mice have increased sensitivity to ConA-induced liver damage and IL-4 signaling. This unveils a novel and critical involvement of PKCzeta in the IL-4/Stat6 signaling pathway in vitro and in vivo...
  14. pmc Control of T helper 2 cell function and allergic airway inflammation by PKCzeta
    Pilar Martin
    Centro de Biología Molecular Severo Ochoa and Departamento de Inmunologia y Oncologia Centro Nacional de Biotecnología, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    Proc Natl Acad Sci U S A 102:9866-71. 2005
    ..Moreover, PKCzeta-/- mice display dramatic inhibition of ovalbumin-induced allergic airway disease, strongly suggesting that PKCzeta can be a therapeutic target in asthma...
  15. pmc The signaling adapter p62 is an important mediator of T helper 2 cell function and allergic airway inflammation
    Pilar Martin
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Cantoblanco, Madrid, Spain
    EMBO J 25:3524-33. 2006
    ....
  16. pmc Par-4 inhibits Akt and suppresses Ras-induced lung tumorigenesis
    Jayashree Joshi
    Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, OH 45267, USA
    EMBO J 27:2181-93. 2008
    ....
  17. ncbi request reprint The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis
    Angeles Duran
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma, Canto Blanco, 28049 Madrid, Spain
    Dev Cell 6:303-9. 2004
    ..These observations demonstrate that p62 is an important mediator during osteoclastogenesis and induced bone remodeling...
  18. ncbi request reprint Akt regulation and lung cancer: a novel role and mechanism of action for the tumor suppressor Par-4
    Maria T Diaz-Meco
    Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, Cincinnati, Ohio 45267, USA
    Cell Cycle 7:2817-20. 2008
    ....
  19. pmc Essential role of RelA Ser311 phosphorylation by zetaPKC in NF-kappaB transcriptional activation
    Angeles Duran
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Canto Blanco, 28049 Madrid, Spain
    EMBO J 22:3910-8. 2003
    ..These results demonstrate the mechanism whereby zetaPKC regulates NF-kappaB activation in vivo...
  20. pmc Genetic inactivation of Par4 results in hyperactivation of NF-kappaB and impairment of JNK and p38
    Isabel Garcia-Cao
    Department of Immunology and Oncology, Centro Nacional de Biotecnologia, Universidad Autonoma de Madrid, Canto Blanco, 28049 Madrid, Spain
    EMBO Rep 4:307-12. 2003
    ..Higher levels of an anti-apoptotic JNK-inhibitor protein, X-chromosome-linked inhibitor of apoptosis, in Par4(-/-) EFs might explain the inhibition of JNK activation in these cells...
  21. pmc Role of zeta PKC in B-cell signaling and function
    Pilar Martin
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas Universidad Autonoma de Madrid, Canto Blanco, E 28049 Madrid, Spain
    EMBO J 21:4049-57. 2002
    ..Furthermore, zeta PKC-/- mice are unable to mount an optimal T-cell-dependent immune response. Collectively, these results genetically establish a critical role for zeta PKC in B-cell function in vitro and in vivo...
  22. pmc The Drosophila atypical protein kinase C-ref(2)p complex constitutes a conserved module for signaling in the toll pathway
    Antonia Avila
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma, Canto Blanco, 28049 Madrid, Spain
    Mol Cell Biol 22:8787-95. 2002
    ..Collectively, these results demonstrate the conservation of the p62-aPKC complex for the control of innate immunity signal transduction in Drosophila melanogaster...
  23. doi request reprint Essential role of sequestosome 1/p62 in regulating accumulation of Lys63-ubiquitinated proteins
    Marie W Wooten
    Department of Biological Sciences, Program in Cell and Molecular Biosciences, Auburn University, Auburn, Alabama 36849, USA
    J Biol Chem 283:6783-9. 2008
    ..Thus, p62 has a bifunctional role in regulation of an E3 ubiquitin-protein ligase, TRAF6, and a DUB, CYLD, to balance the turnover of Lys63-polyubiquitinated proteins such as TrkA...
  24. doi request reprint Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration
    J Ramesh Babu
    Department of Biological Sciences, Program in Cellular and Molecular Biosciences, Auburn University, Auburn, Alabama 36849, USA
    J Neurochem 106:107-20. 2008
    ..Thus, these findings provide new insight into manifestation of sporadic Alzheimer disease and the impact of obesity...
  25. doi request reprint The signaling adaptor p62 is an important NF-kappaB mediator in tumorigenesis
    Angeles Duran
    Department of Molecular Oncogenesis, Genome Research Institute, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA
    Cancer Cell 13:343-54. 2008
    ....
  26. doi request reprint Polarized subcellular localization of Jak/STAT components is required for efficient signaling
    Sol Sotillos
    CABD CSIC, Universidad Pablo de Olavide, 41013 Sevilla, Spain
    Curr Biol 18:624-9. 2008
    ..Our results also suggest that receptor polarization in the ectoderm cell membrane restricts the cell's response to ligands provided by neighboring cells...
  27. ncbi request reprint OPR, PC and AID: all in the PB1 family
    Chris P Ponting
    Trends Biochem Sci 27:10. 2002
  28. ncbi request reprint Signal integration and diversification through the p62 scaffold protein
    Jorge Moscat
    Department of Genome Science, Genome Research Institute, University of Cincinnati, 2180 E Galbraith Road, Cincinnati, OH 45237, USA
    Trends Biochem Sci 32:95-100. 2007
    ..The availability of mice in which p62 has been genetically inactivated is providing new insight into the mechanism and function of p62 at a whole-organism level...
  29. ncbi request reprint The atypical PKC scaffold protein P62 is a novel target for anti-inflammatory and anti-cancer therapies
    Jorge Moscat
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma, Canto Blanco, 28049 Madrid, Spain
    Adv Enzyme Regul 42:173-9. 2002
  30. ncbi request reprint Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62
    Angelina Rodriguez
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Cantoblanco, 28049 Madrid, Spain
    Cell Metab 3:211-22. 2006
    ..We propose that p62 normally antagonizes basal ERK activity and adipocyte differentiation and that its loss leads to the hyperactivation of ERK that favors adipogenesis and obesity...
  31. ncbi request reprint The p62 scaffold regulates nerve growth factor-induced NF-kappaB activation by influencing TRAF6 polyubiquitination
    Marie W Wooten
    Department of Biological Sciences, Program in Cell and Molecular Biosciences, Auburn University, Alabama 36849, USA
    J Biol Chem 280:35625-9. 2005
    ..These results provide evidence for a mechanism whereby p62 serves to regulate the NF-kappaB pathway...
  32. pmc Tumour-suppression activity of the proapoptotic regulator Par4
    Isabel Garcia-Cao
    Spanish National Cancer Center CNIO, 3 Melchor Fernandez Almagro Street, Madrid 28029, Spain
    EMBO Rep 6:577-83. 2005
    ..These data show that Par4 has an important role in tumour suppression, with a particular relevance in the endometrium and prostate...
  33. pmc Regulation of heterogenous nuclear ribonucleoprotein A1 transport by phosphorylation in cells stressed by osmotic shock
    Eric Allemand
    Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA
    Proc Natl Acad Sci U S A 102:3605-10. 2005
    ..Furthermore, F-peptide phosphorylation modulates the interaction of hnRNP A1 with transportin Trn1. Our findings suggest that the phosphorylation of F-peptide by cell-signaling pathways regulates the rate of hnRNP A1 nuclear import...
  34. pmc The death receptor antagonist FAIM promotes neurite outgrowth by a mechanism that depends on ERK and NF-kapp B signaling
    Carme Sole
    Group Cell Signalling and Apoptosis, Department of Basic Medical Sciences, Universitat de Lleida, 25008 Lleida, Spain
    J Cell Biol 167:479-92. 2004
    ..These results reveal a new function of FAIM in promoting neurite outgrowth by a mechanism involving activation of the Ras-ERK pathway and NF-kappa B...
  35. pmc Regulation of mature T lymphocyte proliferation and differentiation by Par-4
    Maria Jose Lafuente
    Centro de Biologia Molecular Severo Ochoa, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Canto Blanco, 28049 Madrid, Spain
    EMBO J 22:4689-98. 2003
    ..This is compelling evidence that Par-4 is a novel modulator of the immune response through its ability to impact aPKC activity, which translates into lower JNK signaling...