Research Topics
| Victor MorenoSummaryCountry: Spain Publications
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Detail Information
Publications
Genetic and genomic analysis modeling of germline c-MYC overexpression and cancer susceptibilityXavier Sole
Bioinformatics and Biostatistics Unit, and Translational Research Laboratory, Catalan Institute of Oncology, IDIBELL, L Hospitalet, Barcelona, Spain
BMC Genomics 9:12. 2008..Variation at 8q24 has also recently been associated with risk of breast and colorectal cancer. However, none of the risk variants map at or relatively close to known genes, with c-MYC mapping a few hundred kilobases distally...- Biological convergence of cancer signaturesXavier Sole
Bioinformatics and Biostatistics Unit, Catalan Institute of Oncology, IDIBELL, L Hospitalet, Barcelona, Spain
PLoS ONE 4:e4544. 2009..Examination of additional, independent, cancer datasets corroborated our observations. This study proposes a comprehensive strategy for interpreting cancer signatures that reveals common design principles and systems-level properties... 
Effect of oral contraceptives on risk of cervical cancer in women with human papillomavirus infection: the IARC multicentric case-control studyVictor Moreno
Epidemiology and Cancer Registry Service, Catalan Institute of Oncology, Hospital Duran i Reynals, L Hospitalet de Llobregat, Barcelona, Spain
Lancet 359:1085-92. 2002..We aimed to assess how use of oral contraceptives affected risk of cervical cancer in women who tested positive for HPV DNA...- Male circumcision, penile human papillomavirus infection, and cervical cancer in female partnersXavier Castellsague
Servei d Epidemiologia i Registre del Cancer, Institut Catala d Oncologia, Hospitalet de Llobregat, Barcelona, Spain
N Engl J Med 346:1105-12. 2002..It is uncertain whether male circumcision reduces the risks of penile human papillomavirus (HPV) infection in the man and of cervical cancer in his female partner... - [Time trend of breast cancer incidence in Catalonia]Angel Izquierdo
Unitat d Epidemiologia i Registre de Càncer de Girona, Institut Catala d Oncologia, Girona, Spain
Med Clin (Barc) 126:286-9. 2006..To investigate the age, period and birth cohort effect in the time trends of breast cancer incidence, Decarli and La Vecchia and Holdford's methods were used... - Integrative analysis of a cancer somatic mutomePilar Hernandez
Bioinformatics and Biostatistics Unit, and Translational Research Laboratory, Catalan Institute of Oncology, IDIBELL, L Hospitalet, Barcelona, Spain
Mol Cancer 6:13. 2007..The recent identification of the collection of somatically mutated genes in breast tumors (breast cancer somatic "mutome") allows the comprehensive study of its function and organization in complex networks... - [Population-based incidence of lymphoid neoplasms by histological subtypes in Girona (Spain), 1994-2001]Rafael Marcos-Gragera
Unidad de Epidemiología y Registro de Cáncer, Institut Català d Oncologia Girona, Girona, Spain
Med Clin (Barc) 126:5-12. 2006..We aimed to assess the distribution of the lymphoid neoplasms and their histological subtypes in accordance with the World Health Organization (WHO) classification by calculating their incidences rates in our area... - Cofactors associated with liver disease mortality in an HBsAg-positive Mediterranean cohort: 20 years of follow-upJosepa Ribes
Epidemiology and Cancer Registration, Institut Catala d Oncologia, and Blod Bank, Hospital Universitari de Bellvitge, Hospitalet del Llobregat, Spain
Int J Cancer 119:687-94. 2006..These results support screening and adequate follow-up among HBsAg-positive subjects at high risk to develop liver disease, particularly when these risk cofactors are present... 
The influence of alcohol consumption and hepatitis B and C infections on the risk of liver cancer in EuropeJosepa Ribes
Catalan Cancer Plan, IDIBELL, Catalan Institute of Oncology, Avda Gran Via s n, Km 2, 7, 08907 L Hospitalet de Llobregat, Barcelona, Spain
J Hepatol 49:233-42. 2008..To assess the variability of liver cancer (LC) risk associated with hepatitis B (HBV) and hepatitis C (HCV) viruses and alcohol intake in 2002 throughout Europe...- [Probability of developing and dying of cancer in Catalonia during the period 1998-2001]Juan Ramon Gonzalez
Servicio de Prevencion y Control del Cancer, Institut Catala d Oncologia, Barcelona, Spain
Med Clin (Barc) 124:411-4. 2005..We intended to estimate the probability of developing and dying from cancer in Catalonia during the period 1998-2001... - WAERS: an application for Web-assisted estimation of relative survivalRamon Clèries
Servei d Epidemiologia i Registre del Cancer, Institut Catala d Oncologia, L Hospitalet de Llobregat Spain, Barcelona, Spain
Med Inform Internet Med 32:169-75. 2007..This application can be also useful for cohort mortality studies and for registries of several diseases... - Underexpression of transcriptional regulators is common in metastatic breast cancer cells overexpressing Bcl-xLOlga Mendez
Centre d Oncologia Molecular, Institut de Recerca Oncologica, IDIBELL, Hospital Duran i Reynals, Gran Via s n, Km 2, 7, E 08907 L Hospitalet Ll, Barcelona, Spain
Carcinogenesis 27:1169-79. 2006.... - RiskDiff: a web tool for the analysis of the difference due to risk and demographic factors for incidence or mortality dataJoan Valls
Catalan Cancer Registry, Catalan Institute of Oncology, Barcelona, Catalonia
BMC Public Health 9:473. 2009..The method proposed by Bashir and Estève, which splits the observed variation into three components: risk, population structure and population size is a common choice at practice... - [Automatic calculation of relative survival through the web. The WAERS project of the Catalan Institute of Oncology]Ramon Clèries
Servei d Epidemiologia i Registre del Cancer, Institut Catala d Oncologia, Barcelona, Spain
Gac Sanit 19:71-5. 2005..This application could also be useful for cohort mortality studies... - Polymorphisms in genes of nucleotide and base excision repair: risk and prognosis of colorectal cancerVictor Moreno
Institut d Investigacio Biomedica de Bellvitge, Institut Catala d Oncologia, Hospitalet, Barcelona, Spain
Clin Cancer Res 12:2101-8. 2006..We have undertaken a comprehensive study of common polymorphisms in genes of DNA repair, exploring both the risk of developing colorectal cancer and the prognosis of patients... - Variability in prescription drug expenditures explained by adjusted clinical groups (ACG) case-mix: a cross-sectional study of patient electronic records in primary careAlba Aguado
Catalan Institute of Oncology, IDIBELL, L Hospitalet, Barcelona, Spain
BMC Health Serv Res 8:53. 2008..We have estimated the variability in pharmacy costs explained by ACG in centers using patient electronic records, profiled centers and physicians and analyzed the correlation between cost and quality of prescription... - Caspase-3 activity, response to chemotherapy and clinical outcome in patients with colon cancerJavier De Oca
Departament of Surgery, Hospital Universitario de Bellvitge, Feixa Llarga s n, 08907 LHospitalet de Llobregat, Barcelona, Spain
Int J Colorectal Dis 23:21-7. 2008..This study evaluates the putative clinical usefulness of measuring caspase-3 activity as a prognostic factor in colonic cancer patients receiving 5-fluoracil adjuvant chemotherapy... - Functional characterization of the novel APC N1026S variant associated with attenuated familial adenomatous polyposisMireia Menendez
Laboratori de Recerca Translacional, Departament de Prevenció i Control del Càncer, Servei d Epidemiologia i Registre del Cancer, Institut d Investigació Biomèdica de Bellvitge Institut Català d Oncologia, L Hospitalet de Llobregat, Barcelona, Spain
Gastroenterology 134:56-64. 2008..The variant was located in the first of the 4 highly conserved 15-amino acid (AA) repeats within the beta-catenin union domain. Our aim was to determine its functional relevance to establish its pathogenicity... - Genomic and transcriptomic prognostic factors in R0 Dukes B and C colorectal cancer patientsElisenda Vendrell
Institut d Investigacio Biomedica de Bellvitge, L Hospitalet, Barcelona, Catalonia, Spain
Int J Oncol 30:1099-107. 2007..We conclude that genomic and transcriptomic profiling of colorectal carcinomas may contribute as novel prognostic markers, but it does not improve outcome prediction when global profiles or signatures are considered... - Health impacts of long-term exposure to disinfection by-products in drinking water in Europe: HIWATEMark J Nieuwenhuijsen
Centre for research in Environmental, Epidemiology CREAL, Parc de Recerca Biomédical de Barcelona PRBB, Barcelona, Spain
J Water Health 7:185-207. 2009..The outcome will be improved risk assessment and better information for risk management. The work is divided into different topics (exposure assessment, epidemiology, risk assessment and management) and studies... - Mutations in TP53 are a prognostic factor in colorectal hepatic metastases undergoing surgical resectionDavid G Mollevi
Laboratory of Translational Research, Institut Català d Oncologia IDIBELL, L Hospitalet de Llobregat, Barcelona, Spain
Carcinogenesis 28:1241-6. 2007..009). P53 and P21 protein immunostaining did not show correlation with survival. TP53 mutational status seems to be an important prognostic factor in patients undergoing surgical resection of colorectal cancer HMs... - Maximizing association statistics over genetic modelsJuan R Gonzalez
Center for research in environmental epidemiology CREAL, Barcelona, Spain
Genet Epidemiol 32:246-54. 2008..A simulation study shows that the use of the max-statistic is a powerful approach that provides safeguard against model uncertainty... - Genetic pathways and genome-wide determinants of clinical outcome in colorectal cancerRosa-Ana Risques
, Hospital Duran i Reynals, Granvia km 2.7, 08907 L'Hospitalet, 08907 Barcelona, Spain
Cancer Res 63:7206-14. 2003..We postulate that these groups represent alternative pathways of tumor progression, each with determinants of aggressiveness. This indicates a need for different prognostic assessments depending on which group the tumor belongs to... - CLEAR-test: combining inference for differential expression and variability in microarray data analysisJoan Valls
Bioinformatics and Biostatistics Unit, and Translational Research Laboratory, Catalan Institute of Oncology, IDIBELL, L Hospitalet, 08907 Barcelona, Spain
J Biomed Inform 41:33-45. 2008..In addition, the CLEAR-test improves the z-test by capturing reproducible genes with high variability... - Hypermethylation of the prostacyclin synthase (PTGIS) promoter is a frequent event in colorectal cancer and associated with aneuploidyJordi Frigola
Molecular Oncology, IDIBELL Institut de Recerca Oncologica, Gran Via Km 2 7, Hospital Duran i Reynals, L Hospitalet, Barcelona 08907, Spain
Oncogene 24:7320-6. 2005..In the adjusted model, PTGIS methylation, but not p53 mutation, maintained the association with aneuploidy. We conclude that epigenetic inactivation of the PTGIS gene is a recurrent alteration in colorectal carcinogenesis... - Anti-apoptotic proteins induce non-random genetic alterations that result in selecting breast cancer metastatic cellsOlga Mendez
Centre d Oncologia Molecular, Institut de Recerca Oncològica IDIBELL, Barcelona, Spain
Clin Exp Metastasis 22:297-307. 2005..We therefore propose that genetic instability is a molecular mechanism favored by anti-apoptotic proteins involved in the selection of highly metastatic cells during tumorigenesis, a pathogenic event favoring the expansion of metastasis... - [Use of DNA chips (microarrays) in medicine: technical foundations and basic procedures for statistical analysis of results]Victor Moreno
Unidad de Bioestadística y Bioinformática, Servicio de Epidemiología y Registro del Cáncer, Instituto Catalán de Oncología, Hospital Duran i Reynals, L Hospitalet de Llobregat, Barcelona, Spain
Med Clin (Barc) 122:73-9. 2004..Finally we will comment on multivariate methods to detect patterns in gene expression... - Differential DNA hypermethylation and hypomethylation signatures in colorectal cancerJordi Frigola
, L'Hospitalet, Barcelona, Spain
Hum Mol Genet 14:319-26. 2005..Subgroups of colorectal tumors show specific genetic and epigenetic signatures and display distinctive correlates with overall survival... - Validation of RNA arbitrarily primed PCR probes hybridized to glass cDNA microarrays: application to the analysis of limited samplesMònica Grau
Institut d Investigació Biomèdica de Bellvitge Institut Català d Oncologia, Translational Research Laboratory, Unit of Biostatistics and Bioinformatics, Cancer Epidemiology Department, Barcelona, Spain
Clin Chem 51:93-101. 2005..The aim of this study was to evaluate the feasibility of using hybridization of RAP-PCR products as transcriptome representations to analyze differential gene expression in a microarray platform... - Role of parity and human papillomavirus in cervical cancer: the IARC multicentric case-control studyNubia Munoz
Unit of Field and Intervention Studies, International Agency for Research on Cancer, 150 cours Albert Thomas, F 69372, Cedex 08, Lyon, France
Lancet 359:1093-101. 2002..To assess the role of reproductive factors in the progression from HPV infection to cancer, we did a pooled analysis including only HPV-positive women... - Cervical coinfection with human papillomavirus (HPV) types and possible implications for the prevention of cervical cancer by HPV vaccinesFabian Mendez
Escuela de Salud Publica, Universidad del Valle, Cali, Colombia
J Infect Dis 192:1158-65. 2005..Subjects with incident HPV-16 or -18 infection had 5-7 times higher odds of acquiring a subsequent HPV-58 infection than subjects not infected with HPV-16 or -18. This might affect the protection conferred by effective HPV vaccines... - A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of colorectal cancerStefano Landi
Genetica, Dip. Scienze Uomo e Ambiente, University of Pisa, Italy
Pharmacogenet Genomics 15:535-46. 2005..50-0.94 for carriers, respectively). CONCLUSIONS: The present data suggest a role for CYP1B1 and CYP1A1 as new candidate genes in the etiology of CRC and confirm the carcinogenic role of aromatic amines metabolism for colorectum... - Time trends incidence of both major histologic types of esophageal carcinomas in selected countries, 1973-1995A Paloma Vizcaino
Unit of Descriptive Epidemiology, International Agency for Research on Cancer, Lyon, France
Int J Cancer 99:860-8. 2002..Modeling was unable to distinguish which trends were the results of changes in risk between generations (as cohort effects), or changes in all age groups simultaneously (as a period effect)... - Association of common polymorphisms in inflammatory genes interleukin (IL)6, IL8, tumor necrosis factor alpha, NFKB1, and peroxisome proliferator-activated receptor gamma with colorectal cancerStefano Landi
International Agency for Research on Cancer, 69372 Lyon, France S L, L G P, F C
Cancer Res 63:3560-6. 2003..This is the first report that IL6, IL8, and PPARG genes are important in relation to inflammation-related risk of sporadic CRC... - A TP53 polymorphism is associated with increased risk of colorectal cancer and with reduced levels of TP53 mRNAFederica Gemignani
International Agency for Research on Cancer, Lyon 69372, France
Oncogene 23:1954-6. 2004..However, we found reduced levels of TP53 mRNA associated with the A2 allele. In conclusion, the epidemiological study suggests a role for p53PIN3 in tumorigenesis, supported by the in vitro characterization of this variant... - Interleukin-4 and interleukin-4 receptor polymorphisms and colorectal cancer riskStefano Landi
Genetics Department of Biology, University of Pisa, Via S Giuseppe 22, 56126, Pisa, Italy
Eur J Cancer 43:762-8. 2007..96; 95% CI=1.11-3.47; P-interaction=0.006). However, when sub-groups are analysed, the findings should be taken with caution for the weakening of the statistical power... - Colorectal cancer risk and the APC D1822V variantMireia Menendez
Int J Cancer 112:161-3. 2004 - Polymorphisms in sulfotransferases SULT1A1 and SULT1A2 are not related to colorectal cancerVictor Moreno
Int J Cancer 113:683-6. 2005 - Organochlorine exposure and colorectal cancer riskMike Howsam
, Lille, France
Environ Health Perspect 112:1460-6. 2004..The trend and magnitude of the association, as well as the observation of a molecular fingerprint in tumors, raise the possibility that this finding may be causal... - Diffuse large B-cell lymphoma subgroups have distinct genetic profiles that influence tumor biology and improve gene-expression-based survival predictionSilvia Bea
Department of Pathology and Hematology Hospital Clinic, University of Barcelona, Spain
Blood 106:3183-90. 2005..In addition, gains involving the chromosomal region 3p11-p12 provided prognostic information that was statistically independent of the previously defined gene-expression-based survival model, thereby improving its predictive power... - Polymorphisms of the dopamine receptor gene DRD2 and colorectal cancer riskFederica Gemignani
International Agency for Research on Cancer, Lyon, France
Cancer Epidemiol Biomarkers Prev 14:1633-8. 2005..Future studies on dopamine receptor-mediated signal transduction may provide new insight into the mechanisms of colorectal cancer and suggest new therapeutic strategies... - Accounting for error due to misclassification of exposures in case-control studies of gene-environment interactionLi Zhang
Department of Quantitative Health Sciences, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
Stat Med 27:2756-83. 2008..A real data set on a case-control study of colorectal cancer where a validation subsample is available for assessing genotyping error is used to illustrate our methods...