Victor Moreno

Summary

Country: Spain

Publications

  1. pmc Genetic and genomic analysis modeling of germline c-MYC overexpression and cancer susceptibility
    Xavier Sole
    Bioinformatics and Biostatistics Unit, and Translational Research Laboratory, Catalan Institute of Oncology, IDIBELL, L Hospitalet, Barcelona, Spain
    BMC Genomics 9:12. 2008
  2. pmc Biological convergence of cancer signatures
    Xavier Sole
    Bioinformatics and Biostatistics Unit, Catalan Institute of Oncology, IDIBELL, L Hospitalet, Barcelona, Spain
    PLoS ONE 4:e4544. 2009
  3. ncbi request reprint Effect of oral contraceptives on risk of cervical cancer in women with human papillomavirus infection: the IARC multicentric case-control study
    Victor Moreno
    Epidemiology and Cancer Registry Service, Catalan Institute of Oncology, Hospital Duran i Reynals, L Hospitalet de Llobregat, Barcelona, Spain
    Lancet 359:1085-92. 2002
  4. ncbi request reprint Male circumcision, penile human papillomavirus infection, and cervical cancer in female partners
    Xavier Castellsague
    Servei d Epidemiologia i Registre del Cancer, Institut Catala d Oncologia, Hospitalet de Llobregat, Barcelona, Spain
    N Engl J Med 346:1105-12. 2002
  5. ncbi request reprint [Time trend of breast cancer incidence in Catalonia]
    Angel Izquierdo
    Unitat d Epidemiologia i Registre de Càncer de Girona, Institut Catala d Oncologia, Girona, Spain
    Med Clin (Barc) 126:286-9. 2006
  6. pmc Integrative analysis of a cancer somatic mutome
    Pilar Hernandez
    Bioinformatics and Biostatistics Unit, and Translational Research Laboratory, Catalan Institute of Oncology, IDIBELL, L Hospitalet, Barcelona, Spain
    Mol Cancer 6:13. 2007
  7. ncbi request reprint [Population-based incidence of lymphoid neoplasms by histological subtypes in Girona (Spain), 1994-2001]
    Rafael Marcos-Gragera
    Unidad de Epidemiología y Registro de Cáncer, Institut Català d Oncologia Girona, Girona, Spain
    Med Clin (Barc) 126:5-12. 2006
  8. ncbi request reprint Cofactors associated with liver disease mortality in an HBsAg-positive Mediterranean cohort: 20 years of follow-up
    Josepa Ribes
    Epidemiology and Cancer Registration, Institut Catala d Oncologia, and Blod Bank, Hospital Universitari de Bellvitge, Hospitalet del Llobregat, Spain
    Int J Cancer 119:687-94. 2006
  9. doi request reprint The influence of alcohol consumption and hepatitis B and C infections on the risk of liver cancer in Europe
    Josepa Ribes
    Catalan Cancer Plan, IDIBELL, Catalan Institute of Oncology, Avda Gran Via s n, Km 2, 7, 08907 L Hospitalet de Llobregat, Barcelona, Spain
    J Hepatol 49:233-42. 2008
  10. ncbi request reprint [Probability of developing and dying of cancer in Catalonia during the period 1998-2001]
    Juan Ramon Gonzalez
    Servicio de Prevencion y Control del Cancer, Institut Catala d Oncologia, Barcelona, Spain
    Med Clin (Barc) 124:411-4. 2005

Collaborators

Detail Information

Publications42

  1. pmc Genetic and genomic analysis modeling of germline c-MYC overexpression and cancer susceptibility
    Xavier Sole
    Bioinformatics and Biostatistics Unit, and Translational Research Laboratory, Catalan Institute of Oncology, IDIBELL, L Hospitalet, Barcelona, Spain
    BMC Genomics 9:12. 2008
    ..Variation at 8q24 has also recently been associated with risk of breast and colorectal cancer. However, none of the risk variants map at or relatively close to known genes, with c-MYC mapping a few hundred kilobases distally...
  2. pmc Biological convergence of cancer signatures
    Xavier Sole
    Bioinformatics and Biostatistics Unit, Catalan Institute of Oncology, IDIBELL, L Hospitalet, Barcelona, Spain
    PLoS ONE 4:e4544. 2009
    ..Examination of additional, independent, cancer datasets corroborated our observations. This study proposes a comprehensive strategy for interpreting cancer signatures that reveals common design principles and systems-level properties...
  3. ncbi request reprint Effect of oral contraceptives on risk of cervical cancer in women with human papillomavirus infection: the IARC multicentric case-control study
    Victor Moreno
    Epidemiology and Cancer Registry Service, Catalan Institute of Oncology, Hospital Duran i Reynals, L Hospitalet de Llobregat, Barcelona, Spain
    Lancet 359:1085-92. 2002
    ..We aimed to assess how use of oral contraceptives affected risk of cervical cancer in women who tested positive for HPV DNA...
  4. ncbi request reprint Male circumcision, penile human papillomavirus infection, and cervical cancer in female partners
    Xavier Castellsague
    Servei d Epidemiologia i Registre del Cancer, Institut Catala d Oncologia, Hospitalet de Llobregat, Barcelona, Spain
    N Engl J Med 346:1105-12. 2002
    ..It is uncertain whether male circumcision reduces the risks of penile human papillomavirus (HPV) infection in the man and of cervical cancer in his female partner...
  5. ncbi request reprint [Time trend of breast cancer incidence in Catalonia]
    Angel Izquierdo
    Unitat d Epidemiologia i Registre de Càncer de Girona, Institut Catala d Oncologia, Girona, Spain
    Med Clin (Barc) 126:286-9. 2006
    ..To investigate the age, period and birth cohort effect in the time trends of breast cancer incidence, Decarli and La Vecchia and Holdford's methods were used...
  6. pmc Integrative analysis of a cancer somatic mutome
    Pilar Hernandez
    Bioinformatics and Biostatistics Unit, and Translational Research Laboratory, Catalan Institute of Oncology, IDIBELL, L Hospitalet, Barcelona, Spain
    Mol Cancer 6:13. 2007
    ..The recent identification of the collection of somatically mutated genes in breast tumors (breast cancer somatic "mutome") allows the comprehensive study of its function and organization in complex networks...
  7. ncbi request reprint [Population-based incidence of lymphoid neoplasms by histological subtypes in Girona (Spain), 1994-2001]
    Rafael Marcos-Gragera
    Unidad de Epidemiología y Registro de Cáncer, Institut Català d Oncologia Girona, Girona, Spain
    Med Clin (Barc) 126:5-12. 2006
    ..We aimed to assess the distribution of the lymphoid neoplasms and their histological subtypes in accordance with the World Health Organization (WHO) classification by calculating their incidences rates in our area...
  8. ncbi request reprint Cofactors associated with liver disease mortality in an HBsAg-positive Mediterranean cohort: 20 years of follow-up
    Josepa Ribes
    Epidemiology and Cancer Registration, Institut Catala d Oncologia, and Blod Bank, Hospital Universitari de Bellvitge, Hospitalet del Llobregat, Spain
    Int J Cancer 119:687-94. 2006
    ..These results support screening and adequate follow-up among HBsAg-positive subjects at high risk to develop liver disease, particularly when these risk cofactors are present...
  9. doi request reprint The influence of alcohol consumption and hepatitis B and C infections on the risk of liver cancer in Europe
    Josepa Ribes
    Catalan Cancer Plan, IDIBELL, Catalan Institute of Oncology, Avda Gran Via s n, Km 2, 7, 08907 L Hospitalet de Llobregat, Barcelona, Spain
    J Hepatol 49:233-42. 2008
    ..To assess the variability of liver cancer (LC) risk associated with hepatitis B (HBV) and hepatitis C (HCV) viruses and alcohol intake in 2002 throughout Europe...
  10. ncbi request reprint [Probability of developing and dying of cancer in Catalonia during the period 1998-2001]
    Juan Ramon Gonzalez
    Servicio de Prevencion y Control del Cancer, Institut Catala d Oncologia, Barcelona, Spain
    Med Clin (Barc) 124:411-4. 2005
    ..We intended to estimate the probability of developing and dying from cancer in Catalonia during the period 1998-2001...
  11. ncbi request reprint WAERS: an application for Web-assisted estimation of relative survival
    Ramon Clèries
    Servei d Epidemiologia i Registre del Cancer, Institut Catala d Oncologia, L Hospitalet de Llobregat Spain, Barcelona, Spain
    Med Inform Internet Med 32:169-75. 2007
    ..This application can be also useful for cohort mortality studies and for registries of several diseases...
  12. ncbi request reprint Underexpression of transcriptional regulators is common in metastatic breast cancer cells overexpressing Bcl-xL
    Olga Mendez
    Centre d Oncologia Molecular, Institut de Recerca Oncologica, IDIBELL, Hospital Duran i Reynals, Gran Via s n, Km 2, 7, E 08907 L Hospitalet Ll, Barcelona, Spain
    Carcinogenesis 27:1169-79. 2006
    ....
  13. pmc RiskDiff: a web tool for the analysis of the difference due to risk and demographic factors for incidence or mortality data
    Joan Valls
    Catalan Cancer Registry, Catalan Institute of Oncology, Barcelona, Catalonia
    BMC Public Health 9:473. 2009
    ..The method proposed by Bashir and Estève, which splits the observed variation into three components: risk, population structure and population size is a common choice at practice...
  14. ncbi request reprint [Automatic calculation of relative survival through the web. The WAERS project of the Catalan Institute of Oncology]
    Ramon Clèries
    Servei d Epidemiologia i Registre del Cancer, Institut Catala d Oncologia, Barcelona, Spain
    Gac Sanit 19:71-5. 2005
    ..This application could also be useful for cohort mortality studies...
  15. ncbi request reprint Polymorphisms in genes of nucleotide and base excision repair: risk and prognosis of colorectal cancer
    Victor Moreno
    Institut d Investigacio Biomedica de Bellvitge, Institut Catala d Oncologia, Hospitalet, Barcelona, Spain
    Clin Cancer Res 12:2101-8. 2006
    ..We have undertaken a comprehensive study of common polymorphisms in genes of DNA repair, exploring both the risk of developing colorectal cancer and the prognosis of patients...
  16. pmc Variability in prescription drug expenditures explained by adjusted clinical groups (ACG) case-mix: a cross-sectional study of patient electronic records in primary care
    Alba Aguado
    Catalan Institute of Oncology, IDIBELL, L Hospitalet, Barcelona, Spain
    BMC Health Serv Res 8:53. 2008
    ..We have estimated the variability in pharmacy costs explained by ACG in centers using patient electronic records, profiled centers and physicians and analyzed the correlation between cost and quality of prescription...
  17. ncbi request reprint Caspase-3 activity, response to chemotherapy and clinical outcome in patients with colon cancer
    Javier De Oca
    Departament of Surgery, Hospital Universitario de Bellvitge, Feixa Llarga s n, 08907 LHospitalet de Llobregat, Barcelona, Spain
    Int J Colorectal Dis 23:21-7. 2008
    ..This study evaluates the putative clinical usefulness of measuring caspase-3 activity as a prognostic factor in colonic cancer patients receiving 5-fluoracil adjuvant chemotherapy...
  18. doi request reprint Functional characterization of the novel APC N1026S variant associated with attenuated familial adenomatous polyposis
    Mireia Menendez
    Laboratori de Recerca Translacional, Departament de Prevenció i Control del Càncer, Servei d Epidemiologia i Registre del Cancer, Institut d Investigació Biomèdica de Bellvitge Institut Català d Oncologia, L Hospitalet de Llobregat, Barcelona, Spain
    Gastroenterology 134:56-64. 2008
    ..The variant was located in the first of the 4 highly conserved 15-amino acid (AA) repeats within the beta-catenin union domain. Our aim was to determine its functional relevance to establish its pathogenicity...
  19. ncbi request reprint Genomic and transcriptomic prognostic factors in R0 Dukes B and C colorectal cancer patients
    Elisenda Vendrell
    Institut d Investigacio Biomedica de Bellvitge, L Hospitalet, Barcelona, Catalonia, Spain
    Int J Oncol 30:1099-107. 2007
    ..We conclude that genomic and transcriptomic profiling of colorectal carcinomas may contribute as novel prognostic markers, but it does not improve outcome prediction when global profiles or signatures are considered...
  20. ncbi request reprint Health impacts of long-term exposure to disinfection by-products in drinking water in Europe: HIWATE
    Mark J Nieuwenhuijsen
    Centre for research in Environmental, Epidemiology CREAL, Parc de Recerca Biomédical de Barcelona PRBB, Barcelona, Spain
    J Water Health 7:185-207. 2009
    ..The outcome will be improved risk assessment and better information for risk management. The work is divided into different topics (exposure assessment, epidemiology, risk assessment and management) and studies...
  21. ncbi request reprint Mutations in TP53 are a prognostic factor in colorectal hepatic metastases undergoing surgical resection
    David G Mollevi
    Laboratory of Translational Research, Institut Català d Oncologia IDIBELL, L Hospitalet de Llobregat, Barcelona, Spain
    Carcinogenesis 28:1241-6. 2007
    ..009). P53 and P21 protein immunostaining did not show correlation with survival. TP53 mutational status seems to be an important prognostic factor in patients undergoing surgical resection of colorectal cancer HMs...
  22. doi request reprint Maximizing association statistics over genetic models
    Juan R Gonzalez
    Center for research in environmental epidemiology CREAL, Barcelona, Spain
    Genet Epidemiol 32:246-54. 2008
    ..A simulation study shows that the use of the max-statistic is a powerful approach that provides safeguard against model uncertainty...
  23. ncbi request reprint Genetic pathways and genome-wide determinants of clinical outcome in colorectal cancer
    Rosa Ana Risques
    Institut de Recerca Oncologica, Hospital Duran i Reynals, Granvia km 2 7, 08907 L Hospitalet, 08907 Barcelona, Spain
    Cancer Res 63:7206-14. 2003
    ..We postulate that these groups represent alternative pathways of tumor progression, each with determinants of aggressiveness. This indicates a need for different prognostic assessments depending on which group the tumor belongs to...
  24. ncbi request reprint CLEAR-test: combining inference for differential expression and variability in microarray data analysis
    Joan Valls
    Bioinformatics and Biostatistics Unit, and Translational Research Laboratory, Catalan Institute of Oncology, IDIBELL, L Hospitalet, 08907 Barcelona, Spain
    J Biomed Inform 41:33-45. 2008
    ..In addition, the CLEAR-test improves the z-test by capturing reproducible genes with high variability...
  25. ncbi request reprint Hypermethylation of the prostacyclin synthase (PTGIS) promoter is a frequent event in colorectal cancer and associated with aneuploidy
    Jordi Frigola
    Molecular Oncology, IDIBELL Institut de Recerca Oncologica, Gran Via Km 2 7, Hospital Duran i Reynals, L Hospitalet, Barcelona 08907, Spain
    Oncogene 24:7320-6. 2005
    ..In the adjusted model, PTGIS methylation, but not p53 mutation, maintained the association with aneuploidy. We conclude that epigenetic inactivation of the PTGIS gene is a recurrent alteration in colorectal carcinogenesis...
  26. ncbi request reprint Anti-apoptotic proteins induce non-random genetic alterations that result in selecting breast cancer metastatic cells
    Olga Mendez
    Centre d Oncologia Molecular, Institut de Recerca Oncològica IDIBELL, Barcelona, Spain
    Clin Exp Metastasis 22:297-307. 2005
    ..We therefore propose that genetic instability is a molecular mechanism favored by anti-apoptotic proteins involved in the selection of highly metastatic cells during tumorigenesis, a pathogenic event favoring the expansion of metastasis...
  27. ncbi request reprint [Use of DNA chips (microarrays) in medicine: technical foundations and basic procedures for statistical analysis of results]
    Victor Moreno
    Unidad de Bioestadística y Bioinformática, Servicio de Epidemiología y Registro del Cáncer, Instituto Catalán de Oncología, Hospital Duran i Reynals, L Hospitalet de Llobregat, Barcelona, Spain
    Med Clin (Barc) 122:73-9. 2004
    ..Finally we will comment on multivariate methods to detect patterns in gene expression...
  28. ncbi request reprint Differential DNA hypermethylation and hypomethylation signatures in colorectal cancer
    Jordi Frigola
    IDIBELL Institut de Recerca Oncologica, L Hospitalet, Barcelona, Spain
    Hum Mol Genet 14:319-26. 2005
    ..Subgroups of colorectal tumors show specific genetic and epigenetic signatures and display distinctive correlates with overall survival...
  29. ncbi request reprint Validation of RNA arbitrarily primed PCR probes hybridized to glass cDNA microarrays: application to the analysis of limited samples
    Mònica Grau
    Institut d Investigació Biomèdica de Bellvitge Institut Català d Oncologia, Translational Research Laboratory, Unit of Biostatistics and Bioinformatics, Cancer Epidemiology Department, Barcelona, Spain
    Clin Chem 51:93-101. 2005
    ..The aim of this study was to evaluate the feasibility of using hybridization of RAP-PCR products as transcriptome representations to analyze differential gene expression in a microarray platform...
  30. ncbi request reprint Role of parity and human papillomavirus in cervical cancer: the IARC multicentric case-control study
    Nubia Munoz
    Unit of Field and Intervention Studies, International Agency for Research on Cancer, 150 cours Albert Thomas, F 69372, Cedex 08, Lyon, France
    Lancet 359:1093-101. 2002
    ..To assess the role of reproductive factors in the progression from HPV infection to cancer, we did a pooled analysis including only HPV-positive women...
  31. ncbi request reprint Cervical coinfection with human papillomavirus (HPV) types and possible implications for the prevention of cervical cancer by HPV vaccines
    Fabian Mendez
    Escuela de Salud Publica, Universidad del Valle, Cali, Colombia
    J Infect Dis 192:1158-65. 2005
    ..Subjects with incident HPV-16 or -18 infection had 5-7 times higher odds of acquiring a subsequent HPV-58 infection than subjects not infected with HPV-16 or -18. This might affect the protection conferred by effective HPV vaccines...
  32. ncbi request reprint A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of colorectal cancer
    Stefano Landi
    Genetica, Dip Scienze Uomo e Ambiente, University of Pisa, Italy
    Pharmacogenet Genomics 15:535-46. 2005
    ....
  33. ncbi request reprint Time trends incidence of both major histologic types of esophageal carcinomas in selected countries, 1973-1995
    A Paloma Vizcaino
    Unit of Descriptive Epidemiology, International Agency for Research on Cancer, Lyon, France
    Int J Cancer 99:860-8. 2002
    ..Modeling was unable to distinguish which trends were the results of changes in risk between generations (as cohort effects), or changes in all age groups simultaneously (as a period effect)...
  34. ncbi request reprint Association of common polymorphisms in inflammatory genes interleukin (IL)6, IL8, tumor necrosis factor alpha, NFKB1, and peroxisome proliferator-activated receptor gamma with colorectal cancer
    Stefano Landi
    International Agency for Research on Cancer, 69372 Lyon, France S L, L G P, F C
    Cancer Res 63:3560-6. 2003
    ..This is the first report that IL6, IL8, and PPARG genes are important in relation to inflammation-related risk of sporadic CRC...
  35. ncbi request reprint A TP53 polymorphism is associated with increased risk of colorectal cancer and with reduced levels of TP53 mRNA
    Federica Gemignani
    International Agency for Research on Cancer, Lyon 69372, France
    Oncogene 23:1954-6. 2004
    ..However, we found reduced levels of TP53 mRNA associated with the A2 allele. In conclusion, the epidemiological study suggests a role for p53PIN3 in tumorigenesis, supported by the in vitro characterization of this variant...
  36. ncbi request reprint Interleukin-4 and interleukin-4 receptor polymorphisms and colorectal cancer risk
    Stefano Landi
    Genetics Department of Biology, University of Pisa, Via S Giuseppe 22, 56126, Pisa, Italy
    Eur J Cancer 43:762-8. 2007
    ..96; 95% CI=1.11-3.47; P-interaction=0.006). However, when sub-groups are analysed, the findings should be taken with caution for the weakening of the statistical power...
  37. ncbi request reprint Colorectal cancer risk and the APC D1822V variant
    Mireia Menendez
    Int J Cancer 112:161-3. 2004
  38. ncbi request reprint Polymorphisms in sulfotransferases SULT1A1 and SULT1A2 are not related to colorectal cancer
    Victor Moreno
    Int J Cancer 113:683-6. 2005
  39. pmc Organochlorine exposure and colorectal cancer risk
    Mike Howsam
    Laboratoire Universitaire de Médécine du Travail, Lille, France
    Environ Health Perspect 112:1460-6. 2004
    ..The trend and magnitude of the association, as well as the observation of a molecular fingerprint in tumors, raise the possibility that this finding may be causal...
  40. pmc Diffuse large B-cell lymphoma subgroups have distinct genetic profiles that influence tumor biology and improve gene-expression-based survival prediction
    Silvia Bea
    Department of Pathology and Hematology Hospital Clinic, University of Barcelona, Spain
    Blood 106:3183-90. 2005
    ..In addition, gains involving the chromosomal region 3p11-p12 provided prognostic information that was statistically independent of the previously defined gene-expression-based survival model, thereby improving its predictive power...
  41. ncbi request reprint Polymorphisms of the dopamine receptor gene DRD2 and colorectal cancer risk
    Federica Gemignani
    International Agency for Research on Cancer, Lyon, France
    Cancer Epidemiol Biomarkers Prev 14:1633-8. 2005
    ..Future studies on dopamine receptor-mediated signal transduction may provide new insight into the mechanisms of colorectal cancer and suggest new therapeutic strategies...
  42. ncbi request reprint Accounting for error due to misclassification of exposures in case-control studies of gene-environment interaction
    Li Zhang
    Department of Quantitative Health Sciences, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    Stat Med 27:2756-83. 2008
    ..A real data set on a case-control study of colorectal cancer where a validation subsample is available for assessing genotyping error is used to illustrate our methods...