Gines Morata

Summary

Country: Spain

Publications

  1. doi request reprint Differential division rates and size control in the wing disc
    Gines Morata
    Centro de Biologia Molecular, CSIC UAM, Madrid, Spain
    Fly (Austin) 4:226-9. 2010
  2. doi request reprint Mitogenic signaling from apoptotic cells in Drosophila
    Gines Morata
    Center for Molecular Biology, Council for Scientific Research Madrid Autonomous University, Nicolas Cabrera 1, 28049, Madrid, Spain
    Dev Growth Differ 53:168-76. 2011
  3. ncbi request reprint Patterning mechanisms in the body trunk and the appendages of Drosophila
    G Morata
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Cantoblanco, Spain
    Development 126:2823-8. 1999
  4. ncbi request reprint How Drosophila appendages develop
    G Morata
    Centro de Biologia Molecular, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Madrid 28049, Spain
    Nat Rev Mol Cell Biol 2:89-97. 2001
  5. ncbi request reprint Function and regulation of homothorax in the wing imaginal disc of Drosophila
    N Azpiazu
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma de Madrid, Madrid, Spain
    Development 127:2685-93. 2000
  6. ncbi request reprint Ginés Morata
    Gines Morata
    Centro de Biologia Molecular, Madrid, Spain
    Curr Biol 16:R976-7. 2006
  7. ncbi request reprint Cell competition: the embrace of death
    Gines Morata
    Centro de Biologia Molecular, CSIC UAM, Madrid, Spain
    Dev Cell 13:1-2. 2007
  8. ncbi request reprint The role of buttonhead and Sp1 in the development of the ventral imaginal discs of Drosophila
    Carlos Estella
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Development 130:5929-41. 2003
  9. ncbi request reprint Patterning function of homothorax/extradenticle in the thorax of Drosophila
    Silvia Aldaz
    Centro de Biologia Molecular, CSIC UAM, Universidad Autonoma de Madrid, Madrid, 28049, Spain
    Development 132:439-46. 2005
  10. ncbi request reprint The Pax-homeobox gene eyegone is involved in the subdivision of the thorax of Drosophila
    Silvia Aldaz
    Centro de Biologia Molecular, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Development 130:4473-82. 2003

Collaborators

Detail Information

Publications42

  1. doi request reprint Differential division rates and size control in the wing disc
    Gines Morata
    Centro de Biologia Molecular, CSIC UAM, Madrid, Spain
    Fly (Austin) 4:226-9. 2010
    ..It measures the population size in each moment, determines the corresponding expression levels of developmental genes and establishes the time to arrest growth...
  2. doi request reprint Mitogenic signaling from apoptotic cells in Drosophila
    Gines Morata
    Center for Molecular Biology, Council for Scientific Research Madrid Autonomous University, Nicolas Cabrera 1, 28049, Madrid, Spain
    Dev Growth Differ 53:168-76. 2011
    ..Recent work in other organisms suggests that paracrine signaling from apoptotic cells may be of general significance in wound healing and tissue regeneration in metazoans...
  3. ncbi request reprint Patterning mechanisms in the body trunk and the appendages of Drosophila
    G Morata
    Centro de Biologia Molecular Severo Ochoa, Universidad Autonoma de Madrid, Cantoblanco, Spain
    Development 126:2823-8. 1999
    ..We speculate that, although the basic mechanisms are similar, there are significant differences in the manner the body trunk and appendages respond to them...
  4. ncbi request reprint How Drosophila appendages develop
    G Morata
    Centro de Biologia Molecular, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Madrid 28049, Spain
    Nat Rev Mol Cell Biol 2:89-97. 2001
    ..How do Drosophila appendages develop, what gives each appendage its unique identity, and what can the fruit fly teach us about appendage development in vertebrates?..
  5. ncbi request reprint Function and regulation of homothorax in the wing imaginal disc of Drosophila
    N Azpiazu
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma de Madrid, Madrid, Spain
    Development 127:2685-93. 2000
    ..We have also identified the gene teashirt (tsh) as a positive regulator of hth in the hinge. tsh plays a role specifying hinge structures, possibly in co-operation with hth...
  6. ncbi request reprint Ginés Morata
    Gines Morata
    Centro de Biologia Molecular, Madrid, Spain
    Curr Biol 16:R976-7. 2006
  7. ncbi request reprint Cell competition: the embrace of death
    Gines Morata
    Centro de Biologia Molecular, CSIC UAM, Madrid, Spain
    Dev Cell 13:1-2. 2007
    ..In a recent issue of Cell, Li and Baker (2007) show in the Drosophila wing disc that cells fated to die induce in neighboring cells the activity of engulfment genes, whose function is essential to complete the apoptotic program...
  8. ncbi request reprint The role of buttonhead and Sp1 in the development of the ventral imaginal discs of Drosophila
    Carlos Estella
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Development 130:5929-41. 2003
    ..We propose that this property is a reflection of the initial function of the btd/Sp1 genes that consists of establishing the fate of the ventral disc primordia and determining their pattern and growth...
  9. ncbi request reprint Patterning function of homothorax/extradenticle in the thorax of Drosophila
    Silvia Aldaz
    Centro de Biologia Molecular, CSIC UAM, Universidad Autonoma de Madrid, Madrid, 28049, Spain
    Development 132:439-46. 2005
    ..We also present evidence for a molecular interaction between the Hth and the Eyg proteins that may be important for the patterning of the alpha subdomain...
  10. ncbi request reprint The Pax-homeobox gene eyegone is involved in the subdivision of the thorax of Drosophila
    Silvia Aldaz
    Centro de Biologia Molecular, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Development 130:4473-82. 2003
    ..The activity of eyg gives rise to a new notum subdivision that acts upon the pre-extant one generated by the Iro genes and pnr. As a result the notum becomes subdivided into four distinct genetic domains...
  11. ncbi request reprint Generation of medial and lateral dorsal body domains by the pannier gene of Drosophila
    M Calleja
    Centro de Biologia Molecular, CSIC UAM, Spain
    Development 127:3971-80. 2000
    ..We argue that pnr acts like a classical selector gene but differs in that its expression is not propagated through cell divisions...
  12. ncbi request reprint Caudal is the Hox gene that specifies the most posterior Drosophile segment
    E Moreno
    Centro de Biologia Molecular CSIC UAM, Madrid, Spain
    Nature 400:873-7. 1999
    ..In the absence of the Hh pathway, cad induces internal analia development, probably by activating the brachyenteron and even-skipped genes...
  13. ncbi request reprint The functions of pannier during Drosophila embryogenesis
    H Herranz
    Centro de Biologia Molecular, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Development 128:4837-46. 2001
    ..These results, together with prior work on its function in adults, suggest that pnr is a major factor in the genetic subdivision of the body of Drosophila...
  14. pmc Functional and regulatory interactions between Hox and extradenticle genes
    N Azpiazu
    Centro de Biologia Molecular Centro Superior de Investigaciones Cientificas Universidad Autońoma de Madrid, Madrid, Spain
    Genes Dev 12:261-73. 1998
    ..As the Hoxd10 gene has the same properties as Drosophila BX-C genes, we suggest that the control mechanism of subcellular distribution of Exd found in Drosophila probably operates in other organisms as well...
  15. ncbi request reprint Control of Drosophila adult pattern by extradenticle
    S González-Crespo
    Centro de Biologia Molecular, Universidad Autonoma de Madrid, Spain
    Development 121:2117-25. 1995
    ..Our findings indicate that exd is critically involved in adult morphogenesis, not only in the homeotic function but also in several other developmental processes...
  16. ncbi request reprint The function of engrailed and the specification of Drosophila wing pattern
    I Guillen
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autonoma de Madrid, Spain
    Development 121:3447-56. 1995
    ....
  17. ncbi request reprint Homeotic genes of Drosophila
    G Morata
    Centro de Biologia Molecular CSIC UAM, Facultad de Ciencias, Universidad Autonoma de Madrid, Spain
    Curr Opin Genet Dev 3:606-14. 1993
    ..Comparison between Drosophila and other species suggests a common functional organization of homeotic complexes in the animal kingdom...
  18. ncbi request reprint The brinker gradient controls wing growth in Drosophila
    Francisco A Martín
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma de Madrid, Madrid 28049, Spain
    Development 131:4921-30. 2004
    ..Brk appears to downregulate the activity of genes that control cell proliferation, such as bantam...
  19. doi request reprint Cell competition, growth and size control in the Drosophila wing imaginal disc
    Francisco A Martín
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Development 136:3747-56. 2009
    ..The values predicted by the simulation are very close to those obtained experimentally...
  20. pmc A tumor-suppressing mechanism in Drosophila involving cell competition and the Hippo pathway
    Javier Menendez
    Centro de Biologia Molecular, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Madrid 28049, Spain
    Proc Natl Acad Sci U S A 107:14651-6. 2010
    ..The formation of a tumor requires in addition the formation of a microenvironment that allows mutant cells to evade cell competition...
  21. ncbi request reprint Compartments and the control of growth in the Drosophila wing imaginal disc
    Francisco A Martín
    Centro de Biologia Molecular CSIC UAM, Madrid 28049, Spain
    Development 133:4421-6. 2006
    ..We propose that this mechanism does not act by preventing cell divisions, but by lengthening the division cycle...
  22. ncbi request reprint Distinct functions of homothorax in leg development in Drosophila
    Natalia Azpiazu
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma de Madrid, Madrid, Spain
    Mech Dev 119:55-67. 2002
    ..We propose that hth/exd function contributes to the normal identity of proximal cells both by limiting the influence of the Dpp and Wg pathways and by activating proximal genes like teashirt (tsh) and aristaless (al)...
  23. ncbi request reprint How to pattern an epithelium: lessons from achaete-scute regulation on the notum of Drosophila
    Manuel Calleja
    Centro de Biologia Molecular, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Gene 292:1-12. 2002
    ..Thus there may be a common prepattern for the entire structure...
  24. pmc The homeobox gene Distal-less induces ventral appendage development in Drosophila
    N Gorfinkiel
    Centro de Biologia Molecular Severo Ochoa CSIC UAM, Universidad Autonoma de Madrid, Cantoblanco, Spain
    Genes Dev 11:2259-71. 1997
    ..However, unlike other homeotic genes, Dll expression and function is not defined by a cell lineage border. Dll also performs a secondary and late function required for the normal patterning of the wing...
  25. pmc Dpp signaling and the induction of neoplastic tumors by caspase-inhibited apoptotic cells in Drosophila
    Ainhoa Pérez-Garijo
    Centro de Biologia Molecular, Universidad Autonoma de Madrid, 28049 Madrid, Spain
    Proc Natl Acad Sci U S A 102:17664-9. 2005
    ....
  26. doi request reprint The role of Dpp and Wg in compensatory proliferation and in the formation of hyperplastic overgrowths caused by apoptotic cells in the Drosophila wing disc
    Ainhoa Pérez-Garijo
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma de Madrid, Madrid, Spain
    Development 136:1169-77. 2009
    ..In compartments containing undead cells, the adventitious Dpp/Wg signalling results in hyperplastic overgrowths...
  27. ncbi request reprint Caspase inhibition during apoptosis causes abnormal signalling and developmental aberrations in Drosophila
    Ainhoa Pérez-Garijo
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma de Madrid, Madrid 28049, Spain
    Development 131:5591-8. 2004
    ..We suggest that a similar process of uncoupling apoptosis initiation and cell death may occur during tumour formation in mammalian cells...
  28. doi request reprint Apoptosis in Drosophila: compensatory proliferation and undead cells
    Francisco A Martín
    Centro de Biologia Molecular, Universidad Autonoma de Madrid, Madrid, Spain
    Int J Dev Biol 53:1341-7. 2009
    ..We describe their effects in epithelial architecture and growth in some detail, and discuss the possible relationship between undead cells and compensatory proliferation...
  29. ncbi request reprint Organization of the Drosophila head as revealed by the ectopic expression of the Ultrabithorax product
    A González-Reyes
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma, Madrid, Spain
    Development 113:1459-71. 1991
    ..Our results also indicate that most or all the larval head structures derive from precursor cells of ventral origin...
  30. ncbi request reprint Genetic evidence for the subdivision of the arthropod limb into coxopodite and telopodite
    S González-Crespo
    Centro de Biologia Molecular, Consejo Superior de Investigaciones Cientificas, Universidad Autonoma de Madrid, Spain
    Development 122:3921-8. 1996
    ..Finally, we show that in the crustacean Artemia, exd and Dll are expressed in comparable patterns as in Drosophila, suggesting a conserved genetic mechanism subdividing the arthropod limb...
  31. ncbi request reprint Autocatalysis and phenotypic expression of Drosophila homeotic gene Deformed: its dependence on polarity and homeotic gene function
    A González-Reyes
    Centro de Biologia Molecular, Universidad Autonoma de Madrid, Spain
    Development 116:1059-68. 1992
    ..Our results also suggest that the differentiation of cirri is induced by Dfd-expressing cells in non-expressing neighboring cells, and that this interaction occurs across the parasegmental border...
  32. pmc Tissue homeostasis in the wing disc of Drosophila melanogaster: immediate response to massive damage during development
    Salvador C Herrera
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma de Madrid, Madrid, Spain
    PLoS Genet 9:e1003446. 2013
    ....
  33. ncbi request reprint The developmental effect of overexpressing a Ubx product in Drosophila embryos is dependent on its interactions with other homeotic products
    A González-Reyes
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma, Canto Blanco, Madrid, Spain
    Cell 61:515-22. 1990
    ..In segment A9 the highly expressed Ubx product is phenotypically suppressed by the r product of Abdominal-B. The presence of high levels of Ubx protein is also irrelevant in the telson...
  34. ncbi request reprint Ectopic expression of homeotic genes caused by the elimination of the Polycomb gene in Drosophila imaginal epidermis
    A Busturia
    Centro de Biologia Molecular, Universidad Autonoma de Madrid, Spain
    Development 104:713-20. 1988
    ..We have established a hierarchical order among these genes: Antp less than Scr less than Ubx less than abd-A less than Abd-B. In addition, we show that the engrailed gene is ectopically active in Pc- imaginal cells...
  35. ncbi request reprint Are cross-regulatory interactions between homoeotic genes functionally significant?
    A González-Reyes
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma, Madrid, Spain
    Nature 344:78-80. 1990
    ..Hence our results challenge the view that these, and possibly other cross-regulatory interactions have a role in determining segmental identity...
  36. pmc Different forms of Ultrabithorax proteins generated by alternative splicing are functionally equivalent
    A Busturia
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma, Madrid, Spain
    EMBO J 9:3551-5. 1990
    ..We argue that the different Ubx proteins are developmentally equivalent and that the slight mutant phenotype observed in UbxMX17 flies is not due to the abnormal set of Ubx proteins but to a breakpoint in a cis-regulatory region...
  37. ncbi request reprint Expression and regulation of the abd-A gene of Drosophila
    A Macias
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma, Madrid, Spain
    Development 110:1197-207. 1990
    ..Finally, we show that the abd-A gene is down-regulated in part of the Abdominal-B (Abd-B) domain, precisely in those regions where the Abd-B gene is expressed at high levels...
  38. ncbi request reprint Normal and ectopic domains of the homeotic gene Sex combs reduced of Drosophila
    S Pelaz
    Centro de Biologia Molecular, Universidad Autonoma de Madrid, Spain
    Development 117:917-23. 1993
    ..It is repressed by the BX-C genes in the meso-, metathoracic and the abdominal segments...
  39. ncbi request reprint Conserved regulation of proximodistal limb axis development by Meis1/Hth
    N Mercader
    Departamento de Inmunologia y Oncologia, Centro Nacional de Biotecnologia, CSIC UAM, Madrid, Spain
    Nature 402:425-9. 1999
    ..We suggest that restriction of Meis1/Hth to proximal regions of the vertebrate and insect limb is essential to specify cell fates and differentiation patterns along the P-D axis of the limb...
  40. ncbi request reprint Visualization of gene expression in living adult Drosophila
    M Calleja
    Centro de Biologia Molecular, Universidad Autonoma de Madrid, Consejo Superior de Investigaciones Cientificas, Madrid 28049, Spain
    Science 274:252-5. 1996
    ..The boundary between two of these domains coincides with localized expression of the signaling molecule wingless...
  41. ncbi request reprint Genetic structure of the abd-A gene of Drosophila
    A Busturia
    Centro de Biologia Molecular, Universidad Autonoma de Madrid, Spain
    Development 107:575-83. 1989
    ..Regulatory region 1, 3' to the transcription unit, contains positive and negative regulatory elements. Regulatory region 2, 5' to the transcription unit, establishes the correct level of abd-A activity in the abdominal metameres...
  42. pmc Trans regulation in the Ultrabithorax gene of Drosophila: alterations in the promoter enhance transvection
    A Martinez-Laborda
    Centro de Biologia Molecular CSIC UAM, Universidad Autonoma de Madrid, Spain
    EMBO J 11:3645-52. 1992
    ..We speculate that the region altered in the mutations may have a wildtype function to ensure cis-autonomy of the regulation of Ubx transcription...