David Monk

Summary

Country: Spain

Publications

  1. ncbi Conference report for the 2nd MC-GARD series on "Interplay among genetics, epigenetics and non-coding RNAs"
    David Monk
    Imprinting and Cancer Group, Cancer Epigenetics and Biology Program, Catalan Institute of Oncology, L Hospitalet de Llobregat, Barcelona, Spain
    Epigenetics 3:230-3. 2008
  2. ncbi Reciprocal imprinting of human GRB10 in placental trophoblast and brain: evolutionary conservation of reversed allelic expression
    David Monk
    Clinical and Molecular Genetics Unit, Institute of Child Health, University College London, London WC1N 1EH, UK
    Hum Mol Genet 18:3066-74. 2009
  3. ncbi Deciphering the cancer imprintome
    David Monk
    Imprinting and Cancer Group, Epigenetics and Cancer Biology Program, Bellvitge Institute for Biomedical Research IDIBELL, L Hospitalet de Llobregat, 08907, Barcelona, Spain
    Brief Funct Genomics 9:329-39. 2010
  4. pmc Human imprinted retrogenes exhibit non-canonical imprint chromatin signatures and reside in non-imprinted host genes
    David Monk
    Imprinting and Cancer Group, Cancer Epigenetics and Biology Program, Bellvitge Institute for Biomedical Research IDIBELL, L Hospitalet de Llobregat, 08907, Barcelona, Spain
    Nucleic Acids Res 39:4577-86. 2011
  5. pmc Characterization of novel paternal ncRNAs at the Plagl1 locus, including Hymai, predicted to interact with regulators of active chromatin
    Isabel Iglesias-Platas
    Servicio de Neonatologia, Hospital Sant Joan de Deu, Fundació Sant Joan de Déu, Barcelona, Spain
    PLoS ONE 7:e38907. 2012
  6. pmc Comparative analysis of human chromosome 7q21 and mouse proximal chromosome 6 reveals a placental-specific imprinted gene, TFPI2/Tfpi2, which requires EHMT2 and EED for allelic-silencing
    David Monk
    Institute of Child Health, London, UK
    Genome Res 18:1270-81. 2008
  7. ncbi Stability of genomic imprinting and gestational-age dynamic methylation in complicated pregnancies conceived following assisted reproductive technologies
    Cristina Camprubí
    Imprinting and Cancer Group, Cancer Epigenetics and Biology Program, Bellvitge Institute for Biomedical Research, L Hospitalet de Llobregat, Barcelona, Spain
    Biol Reprod 89:50. 2013
  8. doi Genome-wide allelic methylation analysis reveals disease-specific susceptibility to multiple methylation defects in imprinting syndromes
    Franck Court
    Imprinting and Cancer Group, Cancer Epigenetics and Biology Program PEBC, Bellvitge Institute for Biomedical Research IDIBELL, L Hospitalet de Llobregat, Barcelona, Spain
    Hum Mutat 34:595-602. 2013
  9. pmc Genome-wide parent-of-origin DNA methylation analysis reveals the intricacies of human imprinting and suggests a germline methylation-independent mechanism of establishment
    Franck Court
    Imprinting and Cancer Group, Cancer Epigenetic and Biology Program, Institut d Investigacio Biomedica de Bellvitge, Hospital Duran i Reynals, 08908 Barcelona, Spain
    Genome Res 24:554-69. 2014
  10. ncbi Does genomic imprinting play a role in autoimmunity?
    Cristina Camprubí
    Imprinting and Cancer Group, Cancer Epigenetics and Biology Program PEBC, Bellvitge Institute ofBiomedical Investigation, Barcelona, Spain
    Adv Exp Med Biol 711:103-16. 2011

Collaborators

Detail Information

Publications15

  1. ncbi Conference report for the 2nd MC-GARD series on "Interplay among genetics, epigenetics and non-coding RNAs"
    David Monk
    Imprinting and Cancer Group, Cancer Epigenetics and Biology Program, Catalan Institute of Oncology, L Hospitalet de Llobregat, Barcelona, Spain
    Epigenetics 3:230-3. 2008
    ..The organizers brought together approximately 120 participants from all over the world to discuss epigenetic mechanisms in relation to normal and disease states, with emphasis on diagnosis, prognosis and therapeutic interventions...
  2. ncbi Reciprocal imprinting of human GRB10 in placental trophoblast and brain: evolutionary conservation of reversed allelic expression
    David Monk
    Clinical and Molecular Genetics Unit, Institute of Child Health, University College London, London WC1N 1EH, UK
    Hum Mol Genet 18:3066-74. 2009
    ..The strong conservation of the opposite allelic expression in placenta versus brain supports the hypothesis that GRB10 imprinting evolved to mediate diverse roles in mammalian growth and behaviour...
  3. ncbi Deciphering the cancer imprintome
    David Monk
    Imprinting and Cancer Group, Epigenetics and Cancer Biology Program, Bellvitge Institute for Biomedical Research IDIBELL, L Hospitalet de Llobregat, 08907, Barcelona, Spain
    Brief Funct Genomics 9:329-39. 2010
    ..The recent advances in technology that might facilitate the identification and characterization of the epigenetic profiles of cancer will also be described...
  4. pmc Human imprinted retrogenes exhibit non-canonical imprint chromatin signatures and reside in non-imprinted host genes
    David Monk
    Imprinting and Cancer Group, Cancer Epigenetics and Biology Program, Bellvitge Institute for Biomedical Research IDIBELL, L Hospitalet de Llobregat, 08907, Barcelona, Spain
    Nucleic Acids Res 39:4577-86. 2011
    ..Finally, we show that the genes immediately flanking the host genes in mouse and human are biallelically expressed in a range of tissues, suggesting that these loci are distinct from large imprinted clusters...
  5. pmc Characterization of novel paternal ncRNAs at the Plagl1 locus, including Hymai, predicted to interact with regulators of active chromatin
    Isabel Iglesias-Platas
    Servicio de Neonatologia, Hospital Sant Joan de Deu, Fundació Sant Joan de Déu, Barcelona, Spain
    PLoS ONE 7:e38907. 2012
    ..The two ncRNAs could therefore help to protect the paternal allele from DNA methylation by attracting Trithorax proteins that mediate H3 lysine-4 methylation...
  6. pmc Comparative analysis of human chromosome 7q21 and mouse proximal chromosome 6 reveals a placental-specific imprinted gene, TFPI2/Tfpi2, which requires EHMT2 and EED for allelic-silencing
    David Monk
    Institute of Child Health, London, UK
    Genome Res 18:1270-81. 2008
    ..This unexpected general lack of repressive histone modifications suggests that this domain may utilize a different silencing mechanism as compared to other imprinted domains...
  7. ncbi Stability of genomic imprinting and gestational-age dynamic methylation in complicated pregnancies conceived following assisted reproductive technologies
    Cristina Camprubí
    Imprinting and Cancer Group, Cancer Epigenetics and Biology Program, Bellvitge Institute for Biomedical Research, L Hospitalet de Llobregat, Barcelona, Spain
    Biol Reprod 89:50. 2013
    ..This study confirms that children conceived by ART do not show variability in imprinted regulation and that loss-of-imprinting is not commonly associated with nonsyndromic IUGR or prematurity. ..
  8. doi Genome-wide allelic methylation analysis reveals disease-specific susceptibility to multiple methylation defects in imprinting syndromes
    Franck Court
    Imprinting and Cancer Group, Cancer Epigenetics and Biology Program PEBC, Bellvitge Institute for Biomedical Research IDIBELL, L Hospitalet de Llobregat, Barcelona, Spain
    Hum Mutat 34:595-602. 2013
    ..This work illustrates that further extensive molecular characterization of these rare patients is required to fully understand the mechanism underlying the etiology of imprint establishment and maintenance...
  9. pmc Genome-wide parent-of-origin DNA methylation analysis reveals the intricacies of human imprinting and suggests a germline methylation-independent mechanism of establishment
    Franck Court
    Imprinting and Cancer Group, Cancer Epigenetic and Biology Program, Institut d Investigacio Biomedica de Bellvitge, Hospital Duran i Reynals, 08908 Barcelona, Spain
    Genome Res 24:554-69. 2014
    ..Therefore, placental-specific imprinting provides evidence for an inheritable epigenetic state that is independent of DNA methylation and the existence of a novel imprinting mechanism at these loci. ..
  10. ncbi Does genomic imprinting play a role in autoimmunity?
    Cristina Camprubí
    Imprinting and Cancer Group, Cancer Epigenetics and Biology Program PEBC, Bellvitge Institute ofBiomedical Investigation, Barcelona, Spain
    Adv Exp Med Biol 711:103-16. 2011
    ..In this chapter, we discuss how parent-of-origin effects and genomic imprinting may play a role in autoimmunity and speculate how imprinted miRNAs may influence the expression of many target autoimmune associated genes...
  11. pmc Maternal inheritance of a promoter variant in the imprinted PHLDA2 gene significantly increases birth weight
    Miho Ishida
    Clinical and Molecular Genetics Unit, Institute of Child Health, University College London, London, UK
    Am J Hum Genet 90:715-9. 2012
    ..Moreover, when the mother was homozygous for RS1, the influence on birth weight was 155 g (p = 0.04; 95% CI = 9-300), which is a similar magnitude to the reduction in birth weight caused by maternal smoking...
  12. ncbi Screening individuals with intellectual disability, autism and Tourette's syndrome for KCNK9 mutations and aberrant DNA methylation within the 8q24 imprinted cluster
    Marta Sánchez Delgado
    Imprinting and Cancer Group, Cancer Epigenetics and Biology Program PEBC, Bellvitge Institute for Biomedical Research IDIBELL, L Hospitalet de Llobregat, 08907, Barcelona, Spain
    Am J Med Genet B Neuropsychiatr Genet 165:472-8. 2014
    ..2014 Wiley Periodicals, Inc. ..
  13. doi Genotype of an individual single nucleotide polymorphism regulates DNA methylation at the TRPC3 alternative promoter
    Alex Martin-Trujillo
    Cancer Epigenetic and Biology Program, Institut d Investigacio Biomedica de Bellvitge, Hospital Duran i Reynals, Barcelona, Spain
    Epigenetics 6:1236-41. 2011
    ..807), when compared to a control population. Our results suggest that the TRPC3 alternative promoter is a methylation quantitative-trait locus that may be involved in modulating the ataxia phenotype...
  14. ncbi STOX1 is not imprinted and is not likely to be involved in preeclampsia
    Isabel Iglesias-Platas
    Nat Genet 39:279-80; author reply 280-1. 2007
  15. pmc Epigenetic allele silencing unveils recessive RYR1 mutations in core myopathies
    Haiyan Zhou
    Dubowitz Neuromuscular Centre, Department of Paediatrics, Imperial College, Hammersmith Hospital London, United Kingdom
    Am J Hum Genet 79:859-68. 2006
    ..Furthermore, our data suggest that imprinting is a likely mechanism for this phenomenon and that similar mechanisms could play a role in human phenotypic heterogeneity...