J L Molinuevo

Summary

Country: Spain

Publications

  1. ncbi request reprint Screening for amnestic mild cognitive impairment and early Alzheimer's disease with M@T (Memory Alteration Test) in the primary care population
    L Rami
    Memory Alzheimer Unit, Department of Neurology, Institute of Neurosciences, Hospital Clinic i Universitari de Barcelona, Institut d Investigacio Biomedica August Pi i Sunyer, Spain
    Int J Geriatr Psychiatry 22:294-304. 2007
  2. doi request reprint Donepezil provides greater benefits in mild compared to moderate Alzheimer's disease: implications for early diagnosis and treatment
    J L Molinuevo
    Alzheimer s Disease and Other Cognitive Disorders Unit, Department of Neurology, IDIBAPS, Hospital Clinic i Universitari, Barcelona, Calle Villarroell, 170, 08036 Barcelona, Spain
    Arch Gerontol Geriatr 52:18-22. 2011
  3. doi request reprint [Role of biomarkers in the early diagnosis of Alzheimer's disease]
    José L Molinuevo Guix
    Unidad de Alzheimer y Otros Trastornos Cognitivos, Servicio de Neurologia, ICN, Hospital Clinic de Barcelona, Barcelona, Espana
    Rev Esp Geriatr Gerontol 46:39-41. 2011
  4. ncbi request reprint The AD-CSF-index discriminates Alzheimer's disease patients from healthy controls: a validation study
    Jose L Molinuevo
    Alzheimer s Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clinic, Barcelona, Spain
    J Alzheimers Dis 36:67-77. 2013
  5. doi request reprint Applying the IWG research criteria in clinical practice: feasibility and ethical issues
    Jose L Molinuevo
    Neurology Service, Alzheimer s Disease and Other Cognitive Disorders Unit, Hospital Clinic, Barcelona, Spain
    Med Clin North Am 97:477-84. 2013
  6. doi request reprint Assessment of the information provided by the medical specialist on Alzheimer's disease and that retained by the patient caregivers
    J L Molinuevo
    Servicio de Neurologia, Hospital Clinic i Universitari, Barcelona, Espana
    Neurologia 27:453-71. 2012
  7. ncbi request reprint [A new approach to the Alzheimer's disease diagnosis with biomarkers: description of the AD-CSF-Index]
    Jose L Molinuevo
    Unidad de Alzheimer y Otros Trastornos Cognitivos, Hospital Clinic, Barcelona, Espana
    Rev Neurol 54:513-22. 2012
  8. doi request reprint Identifying earlier Alzheimer's disease: insights from the preclinical and prodromal phases
    Jose Luis Molinuevo
    Alzheimer s Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clinic, Barcelona, Spain
    Neurodegener Dis 10:158-60. 2012
  9. doi request reprint Neuropsychological profile of prodromal Alzheimer's disease (Prd-AD) and their radiological correlates
    Jose L Molinuevo
    Alzheimer s Disease and Other Cognitive Disorders Unit, Department of Neurology, Institute of Neurosciences, Hospital Clinic i Universitari de Barcelona, Calle Villarroell, 170, 08036 Barcelona, Spain
    Arch Gerontol Geriatr 52:190-6. 2011
  10. ncbi request reprint [Memantine: the value of combined therapy]
    J L Molinuevo
    Hospital Clinic de Barcelona, 08036 Barcelona, Espana
    Rev Neurol 52:95-100. 2011

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Screening for amnestic mild cognitive impairment and early Alzheimer's disease with M@T (Memory Alteration Test) in the primary care population
    L Rami
    Memory Alzheimer Unit, Department of Neurology, Institute of Neurosciences, Hospital Clinic i Universitari de Barcelona, Institut d Investigacio Biomedica August Pi i Sunyer, Spain
    Int J Geriatr Psychiatry 22:294-304. 2007
    ..To design and validate a new screening test for amnestic Mild Cognitive Impairment (A-MCI) and early stage Alzheimer's disease (AD)...
  2. doi request reprint Donepezil provides greater benefits in mild compared to moderate Alzheimer's disease: implications for early diagnosis and treatment
    J L Molinuevo
    Alzheimer s Disease and Other Cognitive Disorders Unit, Department of Neurology, IDIBAPS, Hospital Clinic i Universitari, Barcelona, Calle Villarroell, 170, 08036 Barcelona, Spain
    Arch Gerontol Geriatr 52:18-22. 2011
    ..We concluded that in AD patients on donepezil, cognition remains stable at 6 months. The beneficial effect of donepezil treatment, in terms of cognition and functionality, is greater for mild than for moderate AD...
  3. doi request reprint [Role of biomarkers in the early diagnosis of Alzheimer's disease]
    José L Molinuevo Guix
    Unidad de Alzheimer y Otros Trastornos Cognitivos, Servicio de Neurologia, ICN, Hospital Clinic de Barcelona, Barcelona, Espana
    Rev Esp Geriatr Gerontol 46:39-41. 2011
    ..Patients with Alzheimer's disease show reduced Aβ₄₂-amyloid levels and increased total and phosphorylated tau levels in cerebrospinal fluid...
  4. ncbi request reprint The AD-CSF-index discriminates Alzheimer's disease patients from healthy controls: a validation study
    Jose L Molinuevo
    Alzheimer s Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clinic, Barcelona, Spain
    J Alzheimers Dis 36:67-77. 2013
    ..Objective: To study and validate the diagnostic accuracy of an easy-to-use normalized CSF biomarker index, the AD-CSF-index, in different European populations...
  5. doi request reprint Applying the IWG research criteria in clinical practice: feasibility and ethical issues
    Jose L Molinuevo
    Neurology Service, Alzheimer s Disease and Other Cognitive Disorders Unit, Hospital Clinic, Barcelona, Spain
    Med Clin North Am 97:477-84. 2013
    ..Furthermore, the potential benefit of an early diagnosis may be mediated through an autonomous decision...
  6. doi request reprint Assessment of the information provided by the medical specialist on Alzheimer's disease and that retained by the patient caregivers
    J L Molinuevo
    Servicio de Neurologia, Hospital Clinic i Universitari, Barcelona, Espana
    Neurologia 27:453-71. 2012
    ..The aim of this study is to compare the clinical information on AD provided by the physicians and that perceived by caregivers and to assess factors associated with differences in perception...
  7. ncbi request reprint [A new approach to the Alzheimer's disease diagnosis with biomarkers: description of the AD-CSF-Index]
    Jose L Molinuevo
    Unidad de Alzheimer y Otros Trastornos Cognitivos, Hospital Clinic, Barcelona, Espana
    Rev Neurol 54:513-22. 2012
    ....
  8. doi request reprint Identifying earlier Alzheimer's disease: insights from the preclinical and prodromal phases
    Jose Luis Molinuevo
    Alzheimer s Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clinic, Barcelona, Spain
    Neurodegener Dis 10:158-60. 2012
    ..Overall, these findings suggest that the preclinical stage is biologically active and that there may be structural changes when amyloid is starting its deposition...
  9. doi request reprint Neuropsychological profile of prodromal Alzheimer's disease (Prd-AD) and their radiological correlates
    Jose L Molinuevo
    Alzheimer s Disease and Other Cognitive Disorders Unit, Department of Neurology, Institute of Neurosciences, Hospital Clinic i Universitari de Barcelona, Calle Villarroell, 170, 08036 Barcelona, Spain
    Arch Gerontol Geriatr 52:190-6. 2011
    ....
  10. ncbi request reprint [Memantine: the value of combined therapy]
    J L Molinuevo
    Hospital Clinic de Barcelona, 08036 Barcelona, Espana
    Rev Neurol 52:95-100. 2011
    ....
  11. ncbi request reprint [Efficacy of memantine in the treatment of Alzheimer's disease]
    J L Molinuevo Guix
    Unitat de Memoria Alzheimer, ICMSN, Hospital Clinic, Barcelona
    Neurologia 20:686-91. 2005
    ..From a socio-economic perspective, these effects mean lower global cost of disease, therefore being a cost-effective drug...
  12. ncbi request reprint [Memantine]
    J L Molinuevo
    Unidad de Memoria Alzheimer Servicio de Neurología ICMSN Hospital Clinic i Universitari, Barcelona, Spain
    Neurologia 18:255-61. 2003
    ..We will review both aspects as well as the basic mechanisms mediating glutamatergic neurodegeneration and the implication of glutamate in cognition...
  13. doi request reprint Naming is associated with left temporal pole metabolite levels in neurodegenerative diseases
    L Rami
    Alzheimer s Disease and Other Cognitive Disorders Unit, Department of Neurology, Institute of Neurosciences, Hospital Clinic i Universitari de Barcelona, Barcelona, Spain
    Dement Geriatr Cogn Disord 25:212-7. 2008
    ..To investigate the relationship between performance in language tests and levels of brain metabolites in two selected left temporal lobe regions...
  14. doi request reprint Neuroimaging and biochemical markers in the three variants of primary progressive aphasia
    S Gil-Navarro
    Alzheimer s Disease and Other Cognitive Disorders Unit, Department of Neurology, Hospital Clinic, Barcelona, Spain
    Dement Geriatr Cogn Disord 35:106-17. 2013
    ..To investigate in variants of primary progressive aphasia (PPA) the association between current clinical and neuroimaging criteria and biochemical/genetic markers at the individual level...
  15. ncbi request reprint A novel PSEN1 mutation (K239N) associated with Alzheimer's disease with wide range age of onset and slow progression
    A Lladó
    Alzheimer s Disease and Other Cognitive Disorders Unit, Institut d Investigacio Biomedica August Pi i Sunyer IDIBAPS, Hospital Clinic, Barcelona, Spain
    Eur J Neurol 17:994-6. 2010
    ..To describe a novel mutation (K239N) in the PSEN1 associated with familial Alzheimer's disease (AD)...
  16. ncbi request reprint Cortical brain metabolism as measured by proton spectroscopy is related to memory performance in patients with amnestic mild cognitive impairment and Alzheimer's disease
    L Rami
    Department of Neurology, Institute of Neurosciences, Hospital Clinic i Universitari de Barcelona, Barcelona, Spain
    Dement Geriatr Cogn Disord 24:274-9. 2007
    ..To characterize metabolite abnormalities across the continuum of degenerative disease from mild impairment to dementia...
  17. doi request reprint Clinical features and APOE genotype of pathologically proven early-onset Alzheimer disease
    M Balasa
    Alzheimer s Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clinic, Institut d Investigacio Biomedica August Pi i Sunyer, Barcelona, Spain
    Neurology 76:1720-5. 2011
    ..Our aim was to describe the clinical features, APOE genotype, and its pathologic correlations of neuropathologic confirmed EOAD...
  18. doi request reprint Decreased striatal dopamine transporter uptake in the non-fluent/agrammatic variant of primary progressive aphasia
    S Gil-Navarro
    Alzheimer s Disease and Other Cognitive Disorders Unit, Neurology Department, Hospital Clinic, Barcelona, Spain
    Eur J Neurol 20:1459-e126. 2013
    ..The objective of the present study was to study whether non-fluent/agrammatic patients without parkinsonism at baseline present decreased striatal 123I-FP-CIT uptake...
  19. ncbi request reprint A novel mutation in the PSEN1 gene (L286P) associated with familial early-onset dementia of Alzheimer type and lobar haematomas
    R Sanchez-Valle
    Alzheimer s Disease and Other Cognitive Disorders Unit, Hospital Clinic, Barcelona, Spain
    Eur J Neurol 14:1409-12. 2007
    ..L286P is a novel mutation in PSEN1 that causes familial early-onset AD and brain haematomas related to amyloid angiopathy...
  20. ncbi request reprint [Posterior cortical atrophy. Its neuropsychological profile and differences from typical Alzheimer's disease]
    C Caprile
    Unidad de Alzheimer y Otros Trastornos Cognitivos, Servicio de Neurologia, ICN, Hospital Clinic i Universitari de Barcelona, Barcelona, Espana
    Rev Neurol 48:178-82. 2009
    ....
  21. ncbi request reprint [Psychological impact of the diagnosis of Alzheimer's disease]
    A Lladó
    Unidad de Alzheimer y Otros Trastornos Cognitivos, Servicio de Neurologia, Hospital Clinic i Universitari, Barcelona, Spain
    Neurologia 23:294-8. 2008
    ..This present work aimed to investigate if the disclosure of the diagnosis generates any emotional or psychological impact on the patient or his/her caregiver...
  22. doi request reprint [Profile of the informal carer associated with the clinical management of the Alzheimer's disease patient refractory to symptomatic treatment of the disease]
    J L Molinuevo
    Servicio de Neurologia, Hospital Clinic i Universitari, Barcelona, Espana
    Neurologia 26:518-27. 2011
    ..The aim of this work is to determine the profile of informal caregivers of non-responder AD patients and to evaluate the different factors that affect their quality of life, burden and overall satisfaction with treatment...
  23. doi request reprint PICOGEN: five years experience with a genetic counselling program for dementia
    J Fortea
    Unidad de Alzheimer y Otros Trastornos Cognitivos, Hospital Clinic de Barcelona, Barcelona, Spain
    Neurologia 26:143-9. 2011
    ..We describe the 5 year experience of a genetic counselling program for familial dementias (the PICOGEN program)...
  24. ncbi request reprint [Discriminatory validity and association of the mini-mental test (MMSE) and the memory alteration test (M@T) with a neuropsychological battery in patients with amnestic mild cognitive impairment and Alzheimer's disease]
    L Rami
    Unidad de Alzheimer y Otros Trastornos Cognitivos, Servicio de Neurologia, Instituto de Neurociencias, Hospital Clinic i Universitari de Barcelona, Barcelona, Spain
    Rev Neurol 49:169-74. 2009
    ....
  25. ncbi request reprint [New mutation in the PSEN1 (E120G) gene associated with early onset Alzheimer's disease]
    A Lladó
    Unitat d Alzheimer i altres trastorns cognitius, Servei de Neurologia, ICN, Hospital Clinic de Barcelona, Institut d Investigacio Biomedica August Pi i Sunyer IDIBAPS, Barcelona, Espana
    Neurologia 25:13-6. 2010
    ..To describe a novel mutation in exon 5 of the presenilin 1 gene (E120G)associated with early-onset autosomal dominant Alzheimer's disease (AD)...
  26. ncbi request reprint [Standard values of frontal cognitive functioning tests for those over 60 years of age]
    L Rami
    Hospital Clinic de Barcelona, 08036 Barcelona, Espana
    Rev Neurol 45:268-71. 2007
    ..There are some neuropsychological test with a good sensibility for cognitive disorders affecting frontal lobe damage. AIM. To provide normative data for test that assess frontal cognitive function in population over 60 years old...
  27. doi request reprint The memory alteration test (M@T) discriminates between subjective memory complaints, mild cognitive impairment and Alzheimer's disease
    L Rami
    Alzheimer s Disease and Other Cognitive Disorders Unit, Department of Neurology, Institute of Neurosciences, Hospital Clinic i Universitari de Barcelona, Institut d Investigacio Biomedica August Pi i Sunyer, C Villarroell, 170, 08036 Barcelona, Spain
    Arch Gerontol Geriatr 50:171-4. 2010
    ..99). We conclude that the M@T provides efficient and valid discrimination between SMC subjects and A-MCI, and between SMC subjects and mild AD...
  28. ncbi request reprint MAPT gene duplications are not a cause of frontotemporal lobar degeneration
    A Lladó
    Alzheimer s Disease and Other Cognitive Disorders Unit, Neurology Service, Hospital Clínic and the August Pi i Sunyer Institute of Biomedical Research IDIBAPS, Barcelona, Spain
    Neurosci Lett 424:61-5. 2007
    ..Although our study was limited by the relatively small number of patients, it does not support the theory that chromosomal rearrangements in this region are a cause of FTLD...
  29. doi request reprint Problem-solving abilities and frontal lobe cortical thickness in healthy aging and mild cognitive impairment
    G Sánchez-Benavides
    Group of Behavioral Neurology, Neuropsychopharmacology Program, Institut Municipal d Investigacio Medica, Barcelona, Spain
    J Int Neuropsychol Soc 16:836-45. 2010
    ....
  30. ncbi request reprint Significant changes in the tau A0 and A3 alleles in progressive supranuclear palsy and improved genotyping by silver detection
    R Oliva
    Genetics Service, Institut de Investigacions Biomediques August Pi i Sonyer, Barcelona, Spain
    Arch Neurol 55:1122-4. 1998
    ..Progressive supranuclear palsy (PSP) is characterized by intraneuronal inclusions of neurofibrillary tangles formed by aggregated tau protein. A significant association between the tau gene A0/A0 genotype and PSP recently has been reported...
  31. ncbi request reprint [Perception Digital Test (PDT) for the assessment of incipient visual disorder in initial Alzheimer's disease]
    L Rami
    Unidad Memoria Alzheimer, Servicio de Neurologia, Institut Clínic de Neurociències IDIBAPS, Hospital Clinic i Universitari, Barcelona
    Neurologia 22:342-7. 2007
    ..The second objective is to validate the test in a group of patients with mild AD, stage 4 in the Global Deterioration Scale (GDS) (AD-4)...
  32. ncbi request reprint Whole genome analysis in a consanguineous family with early onset Alzheimer's disease
    J Clarimon
    Memory Unit, Alzheimer s Laboratory, and Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, Neurology Department, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain
    Neurobiol Aging 30:1986-91. 2009
    ..We provide here the first catalog of autozygosity in EOAD and suggest that the regions identified are excellent candidate loci for a recessive genetic lesion causing this disease...
  33. ncbi request reprint Late-onset frontotemporal dementia associated with a novel PGRN mutation
    A Lladó
    Alzheimer s Disease and Cognitive Disorders Unit, Neurology Service, Hospital Clinic and Institut d Investigació Biomèdica August Pi i Sunyer IDIBAPS, Barcelona, Spain
    J Neural Transm 114:1051-4. 2007
    ..The A303AfsX57 mutation is consistent with a nucleotide deletion in exon 8 (c908delC). This deletion causes a frameshift at codon 303 that introduces a premature termination codon (A303AfsX57)...
  34. ncbi request reprint Diagnostic validity of the Alzheimer's disease functional assessment and change scale in mild cognitive impairment and mild to moderate Alzheimer's disease
    R M Manero
    Service of Neurology and Section of Behavioral Neurology and Dementias, Hospital del Mar, Barcelona, Spain
    Dement Geriatr Cogn Disord 37:366-75. 2014
    ..Conclusion: The ADFACS is a reliable, valid, and sensitive instrument to assess functional abilities; it is useful in dementia assessment for elderly populations. © 2013 S. Karger AG, Basel. ..
  35. ncbi request reprint Brain tau expression and correlation with the H1/H1 tau genotype in frontotemporal lobar degeneration patients
    A Lladó
    Alzheimer s Disease and Other Cognitive Disorders Unit, Service of Neurology, Hospital Clinic and Institut d Investigació Biomèdica August Pi i Sunyer IDIBAPS, Barcelona, Spain
    J Neural Transm 114:1585-8. 2007
    ..The 4R/3R mRNA ratio in frontal cortex was similar in FTLD patients and controls. The H1/H1 genotype carriers showed a significant increase in 4R/3R mRNA ratio, suggesting that this genotype could modulate the tau mRNA splicing...
  36. ncbi request reprint [Relearning vocabulary. A comparative analysis between a case of dementia and Alzheimer's disease with predominant compromise of language]
    Núria Montagut
    Hospital de Día de Enfermedades Neurodegenerativas, Barcelona, Espana
    Rev Neurol 50:152-6. 2010
    ..In Alzheimer's disease (AD) with predominant compromise of language, anomia is also the main symptom. The study examined the capacity to relearn vocabulary of two patients, each exhibiting one of these two forms of degenerative anomia...
  37. doi request reprint The Atorvastatin/Donepezil in Alzheimer's Disease Study (LEADe): design and baseline characteristics
    Roy W Jones
    RICE The Research Institute for the Care of Older People, Royal United Hospital, Bath, United Kingdom
    Alzheimers Dement 4:145-53. 2008
    ....
  38. ncbi request reprint A novel MAPT mutation (P301T) associated with familial frontotemporal dementia
    A Lladó
    Eur J Neurol 14:e9-10. 2007