Vicente Molina

Summary

Country: Spain

Publications

  1. ncbi request reprint Anatomical and functional cerebral variables associated with basal symptoms but not risperidone response in minimally treated schizophrenia
    Vicente Molina
    Department of Psychiatry, Hospital Doce de Octubre, Avda de Cordoba Km 5 4, 28041 Madrid, Spain
    Psychiatry Res 124:163-75. 2003
  2. ncbi request reprint Cerebral metabolic changes induced by clozapine in schizophrenia and related to clinical improvement
    Vicente Molina
    Department of Psychiatry, Hospital Doce de Octubre, Madrid, Spain
    Psychopharmacology (Berl) 178:17-26. 2005
  3. ncbi request reprint N-acetyl-aspartate levels in the dorsolateral prefrontal cortex in the early years of schizophrenia are inversely related to disease duration
    Vicente Molina
    Department of Psychiatry, Hospital Clinico, Paseo de S Vicente 58 182, Salamanca 37007, Spain
    Schizophr Res 73:209-19. 2005
  4. ncbi request reprint Olanzapine-induced cerebral metabolic changes related to symptom improvement in schizophrenia
    Vicente Molina
    Department of Psychiatry, Hospital Clinico Universitario, Salamanca, Spain
    Int Clin Psychopharmacol 20:13-8. 2005
  5. ncbi request reprint Direct association between orbitofrontal atrophy and the response of psychotic symptoms to olanzapine in schizophrenia
    Vicente Molina
    Department of Psychiatry, Hospital Clinico, Salamanca, Spain
    Int Clin Psychopharmacol 19:221-8. 2004
  6. ncbi request reprint Lower prefrontal gray matter volume in schizophrenia in chronic but not in first episode schizophrenia patients
    Vicente Molina
    Department of Psychiatry, Hospital Doce de Octubre, Edificio de Medicina Comunitaria, Avda De Córdoba, Km 5 4, 28041 Madrid, Spain
    Psychiatry Res 131:45-56. 2004
  7. ncbi request reprint Long-term olanzapine treatment and p300 parameters in schizophrenia
    Vicente Molina
    Hospital Clinico Universitario de Salamanca, Salamanca, Spain
    Neuropsychobiology 50:182-8. 2004
  8. ncbi request reprint Prefrontal atrophy in first episodes of schizophrenia associated with limbic metabolic hyperactivity
    Vicente Molina
    Department of Psychiatry, Hospital Clinico Universitario, Paseo de San Vicente, 58 182, E 37007 Salamanca, Spain
    J Psychiatr Res 39:117-27. 2005
  9. ncbi request reprint Increase in gray matter and decrease in white matter volumes in the cortex during treatment with atypical neuroleptics in schizophrenia
    Vicente Molina
    Department of Psychiatry, Hospital Clinico Universitario, P S Vicente, 58 182 Salamanca 37007, Spain
    Schizophr Res 80:61-71. 2005
  10. ncbi request reprint Anatomical and functional brain variables associated with clozapine response in treatment-resistant schizophrenia
    Vicente Molina
    Department of Psychiatry, Hospital Doce de Octubre, Edificio de Medicina Comunitaria, Avda De Córdoba, Km 5 4, 28041 Madrid, Spain
    Psychiatry Res 124:153-61. 2003

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Anatomical and functional cerebral variables associated with basal symptoms but not risperidone response in minimally treated schizophrenia
    Vicente Molina
    Department of Psychiatry, Hospital Doce de Octubre, Avda de Cordoba Km 5 4, 28041 Madrid, Spain
    Psychiatry Res 124:163-75. 2003
    ..We conclude that there is evidence of a significant association between basal symptoms and DLPFC atrophy and limbic hyperactivity at rest in recent-onset schizophrenic patients...
  2. ncbi request reprint Cerebral metabolic changes induced by clozapine in schizophrenia and related to clinical improvement
    Vicente Molina
    Department of Psychiatry, Hospital Doce de Octubre, Madrid, Spain
    Psychopharmacology (Berl) 178:17-26. 2005
    ..Clozapine is of special interest, since it is one of the most effective antipsychotic drugs and demonstrates a distinctive mechanism of action in pre-clinical studies with respect to typical neuroleptics...
  3. ncbi request reprint N-acetyl-aspartate levels in the dorsolateral prefrontal cortex in the early years of schizophrenia are inversely related to disease duration
    Vicente Molina
    Department of Psychiatry, Hospital Clinico, Paseo de S Vicente 58 182, Salamanca 37007, Spain
    Schizophr Res 73:209-19. 2005
    ..Therefore, reduced prefrontal levels of NAA may be limited to chronic schizophrenia patients...
  4. ncbi request reprint Olanzapine-induced cerebral metabolic changes related to symptom improvement in schizophrenia
    Vicente Molina
    Department of Psychiatry, Hospital Clinico Universitario, Salamanca, Spain
    Int Clin Psychopharmacol 20:13-8. 2005
    ..These correlation patterns suggest that the functional mechanism of action of olanzapine may share traits from both typical and atypical neuroleptics...
  5. ncbi request reprint Direct association between orbitofrontal atrophy and the response of psychotic symptoms to olanzapine in schizophrenia
    Vicente Molina
    Department of Psychiatry, Hospital Clinico, Salamanca, Spain
    Int Clin Psychopharmacol 19:221-8. 2004
    ....
  6. ncbi request reprint Lower prefrontal gray matter volume in schizophrenia in chronic but not in first episode schizophrenia patients
    Vicente Molina
    Department of Psychiatry, Hospital Doce de Octubre, Edificio de Medicina Comunitaria, Avda De Córdoba, Km 5 4, 28041 Madrid, Spain
    Psychiatry Res 131:45-56. 2004
    ..No significant differences were found between those receiving atypical and typical antipsychotic drugs during the previous year...
  7. ncbi request reprint Long-term olanzapine treatment and p300 parameters in schizophrenia
    Vicente Molina
    Hospital Clinico Universitario de Salamanca, Salamanca, Spain
    Neuropsychobiology 50:182-8. 2004
    ..Our data also suggest that, in addition to this, some further changes in P300 amplitude might depend on the clinical state of the patients...
  8. ncbi request reprint Prefrontal atrophy in first episodes of schizophrenia associated with limbic metabolic hyperactivity
    Vicente Molina
    Department of Psychiatry, Hospital Clinico Universitario, Paseo de San Vicente, 58 182, E 37007 Salamanca, Spain
    J Psychiatr Res 39:117-27. 2005
    ..These findings support a loss in PF inhibitory capacity as a possible link between anatomical and functional alterations in schizophrenia...
  9. ncbi request reprint Increase in gray matter and decrease in white matter volumes in the cortex during treatment with atypical neuroleptics in schizophrenia
    Vicente Molina
    Department of Psychiatry, Hospital Clinico Universitario, P S Vicente, 58 182 Salamanca 37007, Spain
    Schizophr Res 80:61-71. 2005
    ..These GM and WM changes were not related to changes in weight. Thus, treatment with risperidone and clozapine in schizophrenia may have an effect on gray and white matter volume and needs further exploration...
  10. ncbi request reprint Anatomical and functional brain variables associated with clozapine response in treatment-resistant schizophrenia
    Vicente Molina
    Department of Psychiatry, Hospital Doce de Octubre, Edificio de Medicina Comunitaria, Avda De Córdoba, Km 5 4, 28041 Madrid, Spain
    Psychiatry Res 124:153-61. 2003
    ..We conclude that clinical improvement with clozapine may be related with the anatomy and metabolic activity of specific brain areas, with the structural integrity of the DLPF and temporal regions showing the maximum predictive capacity...
  11. ncbi request reprint Dorsolateral prefrontal and superior temporal volume deficits in first-episode psychoses that evolve into schizophrenia
    Vicente Molina
    Dept of Psychiatry, Hospital Clinico de Salamanca, Paseo de San Vicente, 58 182, 37007, Salamanca, Spain
    Eur Arch Psychiatry Clin Neurosci 256:106-11. 2006
    ..Our findings indicate that subtle structural defects are already found by the time of the first psychotic break in schizophrenia, although clinical implications for these differences seem unclear...
  12. ncbi request reprint Dorsolateral prefrontal cortex contribution to abnormalities of the P300 component of the event-related potential in schizophrenia
    Vicente Molina
    Department of Psychiatry, Hospital Clinico Universitario, Paseo de San Vicente, 58 182, 37007 Salamanca, Spain
    Psychiatry Res 140:17-26. 2005
    ..It is therefore suggested that the prefrontal cortex could be implicated in the P300 amplitude reduction in schizophrenia...
  13. ncbi request reprint Association between excessive frontal cerebrospinal fluid and illness duration in males but not in females with schizophrenia
    Vicente Molina
    Department of Psychiatry, Hospital Clinico Universitario, Paseo de San Vicente, 58 182, 37007 Salamanca, Spain
    Eur Psychiatry 20:332-8. 2005
    ..We hypothesized that the poorer global outcome and treatment response in males with schizophrenia are related to a greater cortical volume loss as compared to females...
  14. ncbi request reprint No association between dorsolateral prefrontal gray matter deficit and N-acetyl aspartate ratios in schizophrenia
    Vicente Molina
    Department of Psychiatry, Hospital Universitario, Salamanca, Spain
    Neuropsychobiology 54:171-8. 2006
    ..This was also true for the chronic and first episode groups analyzed separately. These results do not support a neuronal tissue deficit as contributing to the cortical volume deficit in schizophrenia, at least in the DLPF region...
  15. doi request reprint Association between cerebral metabolic and structural abnormalities and cognitive performance in schizophrenia
    Vicente Molina
    Dept of Psychiatry, Hospital Universitario, Salamanca, Spain
    Psychiatry Res 173:88-93. 2009
    ..We may conclude that hypofrontality during cognitive activation, and the degree of DLPF structural deficit may be associated to a particular profile of cognitive deficit, including lower processing speed and working memory capacity...
  16. ncbi request reprint Association between relative temporal and prefrontal sulcal cerebrospinal fluid and illness duration in schizophrenia
    Vicente Molina
    Department of Psychiatry, Hospital Doce de Octubre, Edificio de Medicina Comunitaria, Avda De Córdoba, Km 5 4, 28041, Madrid, Spain
    Schizophr Res 58:305-12. 2002
    ..No significant association between CSF volumes and AOS was found in any region. Our findings support the existence of a degenerative process in schizophrenia located in prefrontal and temporal areas...
  17. ncbi request reprint Randomized trial of clozapine vs. risperidone in treatment-naïve first-episode schizophrenia: results after one year
    Javier Sanz-Fuentenebro
    Department of Psychiatry, Hospital 12 de Octubre, Madrid, Spain
    Schizophr Res 149:156-61. 2013
    ....
  18. doi request reprint Different gray matter patterns in chronic schizophrenia and chronic bipolar disorder patients identified using voxel-based morphometry
    Vicente Molina
    Department of Psychiatry, Hospital Universitario de Salamanca, Paseo de San Vicente, Spain
    Eur Arch Psychiatry Clin Neurosci 261:313-22. 2011
    ..In this comparison, the BD patients showed a limited cortical and subcortical GM deficit. These results support a partly different pattern of GM deficits associated to chronic Sz and chronic BD, with some degree of overlapping...
  19. doi request reprint Biochemical changes in the cingulum in patients with schizophrenia and chronic bipolar disorder
    Fernando Sarramea Crespo
    Department of Psychiatry, Complejo Hospitalario, Carretera Bailén Motril sn, Jaen, CP 23009, Spain
    Eur Arch Psychiatry Clin Neurosci 258:394-401. 2008
    ..Such an increase seems to be more intense than in psychosis-free bipolar disorder patients...
  20. doi request reprint Subcortical and cortical gray matter differences between Kraepelinian and non-Kraepelinian schizophrenia patients identified using voxel-based morphometry
    Vicente Molina
    Servicio de Psiquiatria, Hospital Universitario de Salamanca, Salamanca, Spain
    Psychiatry Res 184:16-22. 2010
    ..Thus, Kraepelinian patients may be characterized by a distinct pattern of brain abnormalities, in particular, in subcortical regions...
  21. doi request reprint Limbic hyperactivity associated to verbal memory deficit in schizophrenia
    Vanessa Suazo
    Institute of Biomedical Research IBSAL, Salamanca, Spain
    J Psychiatr Res 47:843-50. 2013
    ..P3b but not P3a amplitude was significantly lower in patients. The limbic overactivation in the patients may contribute to their cognitive deficits in verbal memory...
  22. doi request reprint Convergent evidence of the contribution of TP53 genetic variation (Pro72Arg) to metabolic activity and white matter volume in the frontal lobe in schizophrenia patients
    Vicente Molina
    Department of Psychiatry, Hospital Clinico de Salamanca, Salamanca, Spain
    Neuroimage 56:45-51. 2011
    ..Our results suggest that TP53 might influence aspects of myelin and white matter integrity which may account for some of the frontal dysfunction features commonly described in these patients...
  23. ncbi request reprint Gamma power and cognition in patients with schizophrenia and their first-degree relatives
    Alvaro Díez
    Basic Psychology, Psychobiology and Methodology Department, School of Psychology, University of Salamanca, Salamanca, Spain
    Neuropsychobiology 69:120-8. 2014
    ..Gamma oscillations are essential for functional neural assembly formation underlying higher cerebral functions. Previous studies concerning gamma band power in schizophrenia have yielded diverse results...
  24. ncbi request reprint Structural correlates of cognitive deficit and elevated gamma noise power in schizophrenia
    Vanessa Suazo
    Neuroscience Institute of Castilla y León, School of Psychology, University of Salamanca, Salamanca, Spain Biomedical Research Institute of Salamanca, Salamanca, Spain
    Psychiatry Clin Neurosci 68:206-15. 2014
    ..The aim of this study was to assess the relation between cognition, gray matter (GM) volumes and gamma noise power (amount of background oscillatory activity in the gamma band) in schizophrenia...
  25. doi request reprint Elevated noise power in gamma band related to negative symptoms and memory deficit in schizophrenia
    Vanessa Suazo
    Institute for Biomedical Research of Salamanca IBSAL, Spain
    Prog Neuropsychopharmacol Biol Psychiatry 38:270-5. 2012
    ..Noise power (scalp-recorded electroencephalographic activity unlocked to stimuli) may offer a non-invasive window to assess this possibility...
  26. doi request reprint No association between prepulse inhibition of the startle reflex and neuropsychological deficit in chronic schizophrenia
    Vicente Molina
    Department of Psychiatry, Hospital Clinico Universitario, Salamanca, Spain
    Eur Arch Psychiatry Clin Neurosci 260:609-15. 2010
    ..Our results suggest that PPI deficits in schizophrenia patients may not contribute to the cognitive deficits typical of that illness, at least in patients with a non-significant PPI decrease...
  27. ncbi request reprint Cerebral metabolic patterns in chronic and recent-onset schizophrenia
    Manuel Desco
    Department of Experimental Medicine, Hospital General Universitario Gregorio Maranon, Dr Esquerdo 46, E 28007 Madrid, Spain
    Psychiatry Res 122:125-35. 2003
    ..The main effect of the long-term administration of haloperidol seems to be an increase of cerebellar, basal ganglia and motor area metabolism...
  28. ncbi request reprint Effect of interleukin-1beta gene functional polymorphism on dorsolateral prefrontal cortex activity in schizophrenic patients
    Sergi Papiol
    Departament de Biologia Animal, Unitat d Antropologia, Facultat de Biologia, Universitat de Barcelona, Barcelona, Spain
    Am J Med Genet B Neuropsychiatr Genet 144:1090-3. 2007
    ..Genetic variants with influence on brain functionality may account for the neurocognitive heterogeneity observed in schizophrenic patients...
  29. ncbi request reprint An electrophysiological (ERP) component, the recognition potential, in the assessment of brain semantic networks in patients with schizophrenia
    Manuel Martín-Loeches
    Cognitive Neuroscience Unit, Centre for Human Evolution and Behavior, UCM ISCIII, c Sinesio Delgado 4, Pabellón 14, 28029 Madrid, Spain
    Schizophr Res 71:393-404. 2004
    ..RP reduction suggests that a fewer number of networks' elements are activated when an incoming word is processed, thus supporting hypoactivation of the semantic networks as the basis for ThD...
  30. ncbi request reprint Ventricular enlargement in schizophrenia is associated with a genetic polymorphism at the interleukin-1 receptor antagonist gene
    Sergi Papiol
    Unitat d Antropologia, Departament de Biologia Animal, Facultat de Biologia, Universitat de Barcelona, Av Diagonal 645, 08028 Barcelona, Spain
    Neuroimage 27:1002-6. 2005
    ..01) ventricles. Sex and illness duration were controlled for in the analyses. Our results, though preliminary, suggest that IL-1RN gene might contribute to the ventricular volumetric changes observed in schizophrenic patients...