Research Topics
Species | Pedro J ModregoSummaryCountry: Spain Publications
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Publications
Longitudinal magnetic resonance spectroscopy as marker of cognitive deterioration in mild cognitive impairmentPedro J Modrego
Department of Neurology, Hospital Miguel Servet, Zaragoza, Spain
Am J Alzheimers Dis Other Demen 26:631-6. 2011..We hypothesize that magnetic resonance spectroscopy (MRS) could be a useful surrogate marker to monitor progression of cognitive impairment in patients with amnestic MCI...
Plasmatic B-type natriuretic peptide and C-reactive protein in hyperacute stroke as markers of CT-evidence of brain edemaPedro J Modrego
Dept of Neurology Miguel Servet University Hospital Zaragoza Spain
Int J Med Sci 5:18-23. 2008..The purpose of this work is to investigate whether elevation of these proteins at baseline predicts CT-evidence of brain edema...
Depression in patients with mild cognitive impairment increases the risk of developing dementia of Alzheimer type: a prospective cohort studyPedro J Modrego
Neurology Unit, Hospital de Alcañiz, Alcaniz, Spain
Arch Neurol 61:1290-3. 2004..Mild cognitive impairment has been regarded as a precursor to dementia of Alzheimer type, but not all patients with mild cognitive impairment develop dementia...- Changes in metabolite ratios after treatment with rivastigmine in Alzheimer's disease: a nonrandomised controlled trial with magnetic resonance spectroscopyPedro J Modrego
Neurology Unit, Hospital de Alcañiz, Alcaniz, Spain
CNS Drugs 20:867-77. 2006..Magnetic resonance spectroscopy (MRS) provides a method of determining changes in such parameters... - Predictors of conversion to dementia of probable Alzheimer type in patients with mild cognitive impairmentPedro J Modrego
Neurology Department, Miguel Servet University Hospital, Zaragoza, Spain
Curr Alzheimer Res 3:161-70. 2006..Approximately half the patients convert to dementia within 3 years. Since no all patients convert to dementia it is essential to find reliable predictors so as to start the appropriate treatment as soon as possible... - Conversion from mild cognitive impairment to probable Alzheimer's disease predicted by brain magnetic resonance spectroscopyPedro J Modrego
Neurology Unit, Hospital de Alcañiz, Spain
Am J Psychiatry 162:667-75. 2005.... - Carotid intima-media thickness as a predictor of response to cholinesterase inhibitors in Alzheimer's disease: an open-label trialPedro J Modrego
Department of Neurology, Hospital Universitario Miguel Servet, Zaragoza, Spain
CNS Drugs 23:253-60. 2009..However, there may be important inter-individual variations ranging from no improvement at all to significant improvement and long periods of stabilization. Carotid atherosclerosis is associated with cognitive decline in elderly people... - Contrast/Noise ratio on conventional MRI and choline/creatine ratio on proton MRI spectroscopy accurately discriminate low-grade from high-grade cerebral gliomasNicolas Fayed
Magnetic Resonance Unit, Clinica Quiron, Miguel Servet University Hospital, Zaragoza, Spain
Acad Radiol 13:728-37. 2006..The aim of this study is to determine whether histological grade of tumors may be predicted by means of conventional gadolinium-enhanced MRI and proton magnetic resonance spectroscopy (MRS)... - Brain glutamate levels are decreased in Alzheimer's disease: a magnetic resonance spectroscopy studyNicolas Fayed
Department of Radiology, Clinica Quiron, Zaragoza, Spain
Am J Alzheimers Dis Other Demen 26:450-6. 2011..In AD, the levels of Glu and NAA are decreased in comparison with MCI and normality, which reflects loss of neurons... - The contribution of magnetic resonance spectroscopy and echoplanar perfusion-weighted MRI in the initial assessment of brain tumoursNicolas Fayed
Magnetic Resonance Unit, Clinica Quiron, Zaragoza, Spain
J Neurooncol 72:261-5. 2005..We conclude that, individually considered, MRS is superior to Perfusion-weighted MRI in the initial assessment of brain tumours. Perfusion MRI has not demonstrated predictive power to distinguish malignant from benign tumours... - Correlation of findings in advanced MRI techniques with global severity scales in patients with Parkinson diseasePedro J Modrego
Neurology Department, Hospital Miguel Servet, Zaragoza, Spain
Acad Radiol 18:235-41. 2011..This work is aimed at determining whether magnetic resonance spectroscopy (MRS) and diffusion tensor imaging (DTI) may correlate with disease severity in a series of Parkinson disease (PD) patients... - The cerebrovascular pathology in Alzheimer's disease and its influence on clinical variablesPedro J Modrego
Department of Neurology, Hospital Universitario Miguel Servet, Zaragoza, Spain
Am J Alzheimers Dis Other Demen 23:91-6. 2008..The presence or absence of both microinfarctions and hypertension had no influence in the scores of the clinical scales. We conclude that the vascular component is common in AD but only as coincident pathology... - Comparative study of cerebral white matter in autism and attention-deficit/hyperactivity disorder by means of magnetic resonance spectroscopyNicolas Fayed
Magnetic Resonance Unit, , Avda Juan Carlos I, 21, 50009, Zaragoza, Spain
Acad Radiol 12:566-9. 2005..We hypothesize that the higher concentration of NAA in the white matter of ADHD points to mitochondrial hypermetabolism. This may constitute a new substrate in the pathophysiology and merits further research... - Magnetic resonance imaging based clinical research in Alzheimer's diseaseNicolas Fayed
Department of Neuroradiology, Hospital Quiron, Zaragoza, Spain
J Alzheimers Dis 31:S5-18. 2012..Magnetic resonance spectroscopy has proven useful to monitor progression and response to treatment in AD, as well as a biomarker of early AD in mild cognitive impairment... - The effect of drugs for Alzheimer disease assessed by means of neuroradiological techniquesPedro J Modrego
Department of Neurology, Miguel Servet University Hospital, Zaragoza, Spain
Curr Med Chem 13:3417-24. 2006..Memantine has emerged as an alternative for advanced stages of the disease. Apart from clinical scales, neuroradiologic techniques have proven useful to assess the effect of these drugs on the brain of AD patients... - The clinical significance of plasmatic amyloid A{beta}-40 peptide levels in Alzheimer's disease patients treated with galantaminePedro J Modrego
Neurology Department, Miguel Servet University Hospital, Zaragoza, Spain
Am J Alzheimers Dis Other Demen 23:286-90. 2008..The authors conclude that determining plasmatic Abeta-40 peptide levels could be useful in predicting and monitoring response to treatment in AD... - Depression in Alzheimer's disease. Pathophysiology, diagnosis, and treatmentPedro J Modrego
Department of Neurology, Hospital Universitario Miguel Servet, Zaragoza, Spain
J Alzheimers Dis 21:1077-87. 2010..Further large randomized controlled clinical trials are warranted in order to know the best drug to begin with and the actual degree of efficacy... 
Magnetic resonance spectroscopy in the prediction of early conversion from amnestic mild cognitive impairment to dementia: a prospective cohort studyPedro J Modrego
Department of Neurology, Hospital Universitario Miguel Servet, Zaragoza, Spain
BMJ Open 1:e000007. 2011..8; 95% CI 0.69 to 0.89). Neither the APOE4 genotype nor leuco-araiosis was predictive of conversion to dementia. Conclusion MRS is a valuable biomarker to predict early conversion to dementia in patients with amnestic MCI...- Comparative test-retest reliability of metabolite values assessed with magnetic resonance spectroscopy of the brain. The LCModel versus the manufacturer softwareNicolas Fayed
Magnetic Resonance Unit, Hospital Quiron, Zaragoza, Spain
Neurol Res 31:472-7. 2009.... - Recurrence and survival after first-ever stroke in the area of Bajo Aragon, Spain. A prospective cohort studyPedro J Modrego
Neurology Unit, Hospital de Alcañiz, 44600, Spain
J Neurol Sci 224:49-55. 2004..The purpose of this work is to estimate the risk of stroke recurrence and mortality in the community of Bajo Aragón, Spain and to compare it with previous studies conducted in other countries... - Dystonia induced by gabapentinMiguel A Pina
Neurology Unit, Hospital Obispo Polanco de Teruel, Teruel, Spain
Ann Pharmacother 39:380-2. 2005..Gabapentin has been used to treat dystonias with variable results. CONCLUSIONS: Although gabapentin is widely used and well tolerated, it can cause dystonic reactions, which are reversible after drug withdrawal... - White matter proton MR spectroscopy in children with isolated developmental delay: does it mean delayed myelination?Nicolas Fayed
Magnetic Resonance Unit, Clinica Quiron, Avda de la Ilustración 12, C39, 50012 Zaragoza, Spain
Acad Radiol 13:229-35. 2006..The goal of our study is to determine whether magnetic resonance spectroscopy (MRS) is able to detect alterations in the white matter supporting the hypothesis of delayed myelination in children with IDD and normal MRI... - Evidence of brain damage after high-altitude climbing by means of magnetic resonance imagingNicolas Fayed
Magnetic Resonance Unit, Clinica Quirón de Zaragoza, Spain
Am J Med 119:168.e1-6. 2006..The purpose of our work is to study the risk of brain lesions in mountain climbers by means of conventional MRI and magnetic resonance spectroscopy (MRS)... - Evidence of brain dysfunction in attention deficit-hyperactivity disorder: a controlled study with proton magnetic resonance spectroscopyNicolas Fayed
Magnetic Resonance Unit, Clinica Quiron, 50009 Zaragoza, Spain
Acad Radiol 14:1029-35. 2007..Our study is aimed at finding evidence of dysfunction with more refined MRI techniques such as diffusion-weighted MRI and spectroscopy...