Marc Miravitlles

Summary

Country: Spain

Publications

  1. ncbi request reprint Detection of polymorphisms at exons 3 (Tyr113-->His) and 4 (His139-->Arg) of the microsomal epoxide hydrolase gene using fluorescence PCR method combined with melting curves analysis
    Francisco Rodriguez
    Department of Biochemistry, Hospital Universitario Vall d Hebron, Barcelona 08035, Spain
    Anal Biochem 308:120-6. 2002
  2. ncbi request reprint [Treatment failure of acute exacerbations of chronic obstructive airways disease risk factors and clinical relevance]
    Marc Miravitlles
    Servicio de Neumologia, Institut Clínic de Pneumologia i Cirugia Toràcica IDIBAPS, Barcelona, Spain
    Med Clin (Barc) 119:304-14. 2002
  3. ncbi request reprint Costs of chronic bronchitis and COPD: a 1-year follow-up study
    Marc Miravitlles
    Servei de Pneumologia, Institut Clínic de Pneumologia i Cirurgia Toràcica IDIBAPS, Hospital Clinic i Provincial, Barcelona, Spain
    Chest 123:784-91. 2003
  4. ncbi request reprint Treatment with the immunomodulator AM3 improves the health-related quality of life of patients with COPD
    Melchor Alvarez-Mon
    Departmento de Medicina, Universidad de Alcala, Carretera Madrid Barcelona, Km 33, 600, E 28871 Alcalá de Henares Madrid, Spain
    Chest 127:1212-8. 2005
  5. ncbi request reprint Characteristics of a population of COPD patients identified from a population-based study. Focus on previous diagnosis and never smokers
    Marc Miravitlles
    Servei de Pneumologia, Institut Clínic del Tòrax IDIBAPS, Red Respira FIS ISCIII RTIC 03 11, Hospital Clinic, Villarroel 170, 08036 Barcelona, Catalonia, Spain
    Respir Med 99:985-95. 2005
  6. pmc Development and results of the Spanish registry of patients with alpha-1-antitrypsin deficiency
    Beatriz Lara
    Department of Pneumology, Clinical Institute of the Thorax IDIBAPS, Hospital Clinic, Barcelona, Spain
    Int J Chron Obstruct Pulmon Dis 2:393-8. 2007
  7. doi request reprint Treatment of COPD by clinical phenotypes: putting old evidence into clinical practice
    Marc Miravitlles
    Dept of Pneumology, Hospital Universitari Vall d Hebron, Barcelona, Spain
    Eur Respir J 41:1252-6. 2013
  8. doi request reprint Costs of chronic obstructive pulmonary disease in relation to compliance with guidelines: a study in the primary care setting
    Marc Miravitlles
    Pneumology Department, Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Ther Adv Respir Dis 7:139-50. 2013
  9. doi request reprint Characterisation of the overlap COPD-asthma phenotype. Focus on physical activity and health status
    Marc Miravitlles
    Pneumology Department, Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Respir Med 107:1053-60. 2013
  10. doi request reprint A new approach to grading and treating COPD based on clinical phenotypes: summary of the Spanish COPD guidelines (GesEPOC)
    Marc Miravitlles
    Servei de Pneumologia, Hospital General Universitari Vall d Hebron, Barcelona, Spain
    Prim Care Respir J 22:117-21. 2013

Detail Information

Publications95

  1. ncbi request reprint Detection of polymorphisms at exons 3 (Tyr113-->His) and 4 (His139-->Arg) of the microsomal epoxide hydrolase gene using fluorescence PCR method combined with melting curves analysis
    Francisco Rodriguez
    Department of Biochemistry, Hospital Universitario Vall d Hebron, Barcelona 08035, Spain
    Anal Biochem 308:120-6. 2002
    ..These high-speed (about 40 min for 32 samples), highly sensitive, and specific small-volume assays with low labor requirements hold great promise as tools for rapid detection of COPD susceptibility...
  2. ncbi request reprint [Treatment failure of acute exacerbations of chronic obstructive airways disease risk factors and clinical relevance]
    Marc Miravitlles
    Servicio de Neumologia, Institut Clínic de Pneumologia i Cirugia Toràcica IDIBAPS, Barcelona, Spain
    Med Clin (Barc) 119:304-14. 2002
  3. ncbi request reprint Costs of chronic bronchitis and COPD: a 1-year follow-up study
    Marc Miravitlles
    Servei de Pneumologia, Institut Clínic de Pneumologia i Cirurgia Toràcica IDIBAPS, Hospital Clinic i Provincial, Barcelona, Spain
    Chest 123:784-91. 2003
    ..This study attempted to determine the total direct costs derived from the management of chronic bronchitis and COPD in an ambulatory setting through a prospective, 1-year, follow-up study...
  4. ncbi request reprint Treatment with the immunomodulator AM3 improves the health-related quality of life of patients with COPD
    Melchor Alvarez-Mon
    Departmento de Medicina, Universidad de Alcala, Carretera Madrid Barcelona, Km 33, 600, E 28871 Alcalá de Henares Madrid, Spain
    Chest 127:1212-8. 2005
    ..COPD has a severe impact on patient quality of life. AM3 is an orally effective immunomodulator that can normalize the defective antimicrobial functions of the immune system effector cells of COPD patients...
  5. ncbi request reprint Characteristics of a population of COPD patients identified from a population-based study. Focus on previous diagnosis and never smokers
    Marc Miravitlles
    Servei de Pneumologia, Institut Clínic del Tòrax IDIBAPS, Red Respira FIS ISCIII RTIC 03 11, Hospital Clinic, Villarroel 170, 08036 Barcelona, Catalonia, Spain
    Respir Med 99:985-95. 2005
    ..To identify factors associated with diagnosis and health-related quality of life (HRQL) impairment in chronic obstructive pulmonary disease (COPD) patients from a population-based epidemiological study...
  6. pmc Development and results of the Spanish registry of patients with alpha-1-antitrypsin deficiency
    Beatriz Lara
    Department of Pneumology, Clinical Institute of the Thorax IDIBAPS, Hospital Clinic, Barcelona, Spain
    Int J Chron Obstruct Pulmon Dis 2:393-8. 2007
    ..Implementation of an internet-based collection of data did not result in a lower rate of reporting to the registry. However, data from a significant number of patient included in period 1 could not be actualized in the new data base...
  7. doi request reprint Treatment of COPD by clinical phenotypes: putting old evidence into clinical practice
    Marc Miravitlles
    Dept of Pneumology, Hospital Universitari Vall d Hebron, Barcelona, Spain
    Eur Respir J 41:1252-6. 2013
    ..These well-defined clinical phenotypes could potentially be incorporated into treatment guidelines...
  8. doi request reprint Costs of chronic obstructive pulmonary disease in relation to compliance with guidelines: a study in the primary care setting
    Marc Miravitlles
    Pneumology Department, Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Ther Adv Respir Dis 7:139-50. 2013
    ..The aim of this study was to analyse the economic impact of nonadherence to the Global Initiative for Obstructive Lung Disease (GOLD) guidelines in patients with chronic obstructive pulmonary disease (COPD)...
  9. doi request reprint Characterisation of the overlap COPD-asthma phenotype. Focus on physical activity and health status
    Marc Miravitlles
    Pneumology Department, Hospital Universitari Vall d Hebron, Pg Vall d Hebron 119 129, 08035 Barcelona, Spain
    Respir Med 107:1053-60. 2013
    ..Patients with COPD may share some clinical characteristics with asthma sufferers. This phenotypic overlap between COPD and asthma is not yet well characterised...
  10. doi request reprint A new approach to grading and treating COPD based on clinical phenotypes: summary of the Spanish COPD guidelines (GesEPOC)
    Marc Miravitlles
    Servei de Pneumologia, Hospital General Universitari Vall d Hebron, Barcelona, Spain
    Prim Care Respir J 22:117-21. 2013
    ..This proposal aims to achieve a more personalised management of COPD according to the clinical characteristics and multidimensional assessment of severity...
  11. doi request reprint Previous outpatient antibiotic use in patients admitted to hospital for COPD exacerbations: room for improvement
    M Miravitlles
    Institut d Investigacio Biomedica August Pi i Sunyer IDIBAPS, Ciber de enfermedades respiratorias CIBERES, Hospital Clinic, Barcelona, Spain
    Infection 41:361-70. 2013
    ..The present study analyzed how often patients requiring hospitalization for a COPD exacerbation had received previous treatment for the exacerbation, particularly antibiotics...
  12. doi request reprint [Validation of the Spanish version of the Chronic Obstructive Pulmonary Disease-Population Screener (COPD-PS). Its usefulness and that of FEV₁/FEV₆ for the diagnosis of COPD]
    Marc Miravitlles
    Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Ciber de enfermedades respiratorias CIBERES, Hospital Clinic, Barcelona, Espana
    Med Clin (Barc) 139:522-30. 2012
    ..The chronic obstructive pulmonary disease (COPD) is a highly undiagnosed disease. The use of short screening questionnaires designed to detect chronic airflow obstruction may help to the early diagnosis of COPD...
  13. doi request reprint [Spanish COPD Guidelines (GesEPOC): Pharmacological treatment of stable COPD]
    Marc Miravitlles
    Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, Barcelona, Spain
    Aten Primaria 44:425-37. 2012
    ..GesEPOC is a new, more individualized approach to COPD treatment according to the clinical characteristics of the patients...
  14. doi request reprint Spanish COPD Guidelines (GesEPOC): pharmacological treatment of stable COPD. Spanish Society of Pulmonology and Thoracic Surgery
    Marc Miravitlles
    Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, Barcelona, Espana
    Arch Bronconeumol 48:247-57. 2012
    ..GesEPOC is a new, more individualized approach to COPD treatment according to the clinical characteristics of the patients...
  15. doi request reprint Sputum colour and bacteria in chronic bronchitis exacerbations: a pooled analysis
    Marc Miravitlles
    Institut d Investigacions Biomediques August Pi i Sunyer, CIBER de Enfermedades Respiratorias, Hospital Clinic, Barcelona, Spain
    Eur Respir J 39:1354-60. 2012
    ..However, it does not necessarily predict the need for antibiotic treatment in all patients with AECB...
  16. pmc Difficulties in differential diagnosis of COPD and asthma in primary care
    Marc Miravitlles
    Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Ciber de enfermedades respiratorias CIBERES, Hospital Clinic, Barcelona, Spain
    Br J Gen Pract 62:e68-75. 2012
    ..Chronic obstructive pulmonary disease (COPD) and asthma treatment must be based on appropriate diagnosis. However, patients receiving inhaled therapy in primary care may not be accurately diagnosed according to current guidelines...
  17. doi request reprint Clinical phenotypes of COPD: identification, definition and implications for guidelines
    Marc Miravitlles
    Institut d Investigacions Biomediques August Pi i Sunyer, CIBER de Enfermedades Respiratorias, Hospital Clinic, Barcelona, Spain
    Arch Bronconeumol 48:86-98. 2012
    ....
  18. pmc Pulsed moxifloxacin for the prevention of exacerbations of chronic obstructive pulmonary disease: a randomized controlled trial
    Sanjay Sethi
    Division of Pulmonary, Critical Care and Sleep Medicine, University of Buffalo, State University of New York, Buffalo, NY, USA
    Respir Res 11:10. 2010
    ..This proof-of-concept study evaluates whether intermittent pulsed moxifloxacin treatment could reduce the frequency of these exacerbations...
  19. pmc Systemic inflammation in chronic obstructive pulmonary disease: a population-based study
    Francisco Garcia-Rio
    Pneumology Service, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain
    Respir Res 11:63. 2010
    ..The aims of this study were to compare the levels of several systemic biomarkers between stable COPD patients and healthy subjects from a population-based sample, and to assess their distribution according to clinical variables...
  20. pmc Effectiveness of anti-inflammatory treatment versus antibiotic therapy and placebo for patients with non-complicated acute bronchitis with purulent sputum. The BAAP Study protocol
    Carl Llor
    University Rovira i Virgili, Primary Healthcare Centre Jaume I, Tarragona, Spain
    BMC Pulm Med 11:38. 2011
    ..Thus, the aim of this study is to evaluate the clinical effectiveness of a schedule of an oral anti-inflammatory compared with an antibiotic regimen and another group assigned to receive a placebo...
  21. doi request reprint New horizons in early stage COPD--improving knowledge, detection and treatment
    Marc Decramer
    Respiratory Division, University of Leuven, Herestraat 49, Leuven, Belgium
    Respir Med 105:1576-87. 2011
    ....
  22. ncbi request reprint [Antimicrobial treatment of exacerbation in chronic obstructive pulmonary disease: 2007 consensus statement]
    Marc Miravitlles
    Sociedad Española de Neumología y Cirugía Torácica SEPAR
    Arch Bronconeumol 44:100-8. 2008
  23. doi request reprint Socioeconomic status and health-related quality of life of patients with chronic obstructive pulmonary disease
    Marc Miravitlles
    Fundació Clínic, Institut d Investigacions Biomediques August Pi i Sunyer, CIBER de Enfermedades Respiratorias, Hospital Clinic, Barcelona, Spain
    Respiration 82:402-8. 2011
    ..Socioeconomic status (SES) is an important determinant of health and premature death. However, the impact of poor SES on the health status of patients with chronic obstructive pulmonary disease (COPD) has not been well determined...
  24. doi request reprint Prevalence of COPD in Spain: impact of undiagnosed COPD on quality of life and daily life activities
    M Miravitlles
    Fundació Clínic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Barcelona, Spain
    Thorax 64:863-8. 2009
    ....
  25. doi request reprint [Individually-tailored treatment of chronic obstructive pulmonary disease: a proposed change]
    Marc Miravitlles
    Fundació Clínic, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Espana
    Arch Bronconeumol 45:27-34. 2009
    ....
  26. pmc Antibiotic treatment of exacerbations of COPD in general practice: long-term impact on health-related quality of life
    Marc Miravitlles
    Fundació Clínic, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, CIBER de Enfermedades Respiratorias, Barcelona, Spain
    Int J Chron Obstruct Pulmon Dis 5:11-9. 2010
    ....
  27. pmc Colour of sputum is a marker for bacterial colonisation in chronic obstructive pulmonary disease
    Marc Miravitlles
    Fundació Clínic, Institut d Investigacions Biomediques August Pi i Sunyer, CIBER de Enfermedades Respiratorias, Barcelona, Spain
    Respir Res 11:58. 2010
    ..Bacterial colonisation in chronic obstructive pulmonary disease (COPD) contributes to airway inflammation and modulates exacerbations. We assessed risk factors for bacterial colonisation in COPD...
  28. doi request reprint Prevention of exacerbations of COPD with pharmacotherapy
    M Miravitlles
    Servei de Pneumologia, Hospital Clinic, Villarroel 170, Barcelona, Spain
    Eur Respir Rev 19:119-26. 2010
    ....
  29. doi request reprint COPD severity score as a predictor of failure in exacerbations of COPD. The ESFERA study
    Marc Miravitlles
    Fundació Clínic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Ciber de enfermedades respiratorias CIBERES, Hospital Clinic, Barcelona, Spain
    Respir Med 105:740-7. 2011
    ..This study evaluates the COPD severity score (COPDSS) as a predictor of clinical failure, together with other severity, activity and quality of life measurements, in patients with exacerbated COPD...
  30. doi request reprint Cough and sputum production as risk factors for poor outcomes in patients with COPD
    Marc Miravitlles
    CIBER de Enfermedades Respiratorias, Hospital Clinic, Barcelona, Spain
    Respir Med 105:1118-28. 2011
    ....
  31. ncbi request reprint Pharmacoeconomic evaluation of acute exacerbations of chronic bronchitis and COPD
    Marc Miravitlles
    Center Servei de Pneumologia, Hospital General Universitari Vall d Hebron, Barcelona
    Chest 121:1449-55. 2002
    ..Although exacerbations are the main cause of medical visits and hospitalizations of patients with chronic bronchitis and COPD, little information is available on the costs of their management...
  32. ncbi request reprint Exacerbations of chronic obstructive pulmonary disease: when are bacteria important?
    M Miravitlles
    Servei de Pneumologia, Institut Clinic de Pneumologia i Cirurgia Toracica, IDBAPS, Hospital Clinic i Provincial, Barcelona, Spain
    Eur Respir J Suppl 36:9s-19s. 2002
    ..These include the role of viral infection, the importance of residual bacterial colonisation and the impact of new antibiotics on the treatment of exacerbations...
  33. ncbi request reprint [Pneumologists: Where are we going and where have we come from?]
    M Miravitlles
    Comisión Nacional de Neumología, Servicio de Neumologia, Hospital Universitario Vall d Hebron, Barcelona, Spain
    Arch Bronconeumol 38:334-5. 2002
  34. ncbi request reprint [Development and results of a screening program for COPD in primary care. The PADOC Project(Program for the Increase in the Diagnosis of COPD in Primary Care]
    M Miravitlles
    Servicio de Neumologia, Hospital General Vall d Hebron, Barcelona
    Arch Bronconeumol 36:500-5. 2000
    ..6%) were not seen by the referral pneumologist. Agreement between spirometric measurements taken by primary care physicians and pneumologists was low for FVC but good for FEV1...
  35. ncbi request reprint Treatment and quality of life in patients with chronic obstructive pulmonary disease
    M Miravitlles
    Servei de Pneumologia, Hospital General Vall d Hebron, Barcelona, Spain
    Qual Life Res 11:329-38. 2002
    ..These findings suggest that the use of multiple drugs in the treatment of patients with COPD is associated with worse total SGRQ scores. The effect of drugs, their dosages and associations with other drugs on HRQL merit further research...
  36. ncbi request reprint Influence of deficient alpha1-anti-trypsin phenotypes on clinical characteristics and severity of asthma in adults
    M Miravitlles
    Department of Pneumology, Hospital Universitari Vall d Hebron, Barcelona, Spain
    Respir Med 96:186-92. 2002
    ..Heterozygote phenotypes for the deficiency do not appear to confer greater severity or different clinical expression of asthma in adults...
  37. ncbi request reprint Factors associated with increased risk of exacerbation and hospital admission in a cohort of ambulatory COPD patients: a multiple logistic regression analysis. The EOLO Study Group
    M Miravitlles
    Servei de Pneumologia, Hospital General Universitari Vall d Hebron, Barcelona, Spain
    Respiration 67:495-501. 2000
    ....
  38. ncbi request reprint Relationship between bacterial flora in sputum and functional impairment in patients with acute exacerbations of COPD. Study Group of Bacterial Infection in COPD
    M Miravitlles
    Pneumology Department, Hospital Vall d Hebron, Barcelona, Spain
    Chest 116:40-6. 1999
    ..To investigate the possible relationship between functional respiratory impairment measured by FEV1 and isolation of diverse pathogens in the sputum of patients with exacerbations of COPD...
  39. ncbi request reprint [Epidemiological study of chronic obstructive pulmonary disease in Spain (IBERPOC): recruitment and field work]
    M Miravitlles
    Servicio de Neumologia, Hospital General Vall d Hebron, Barcelona
    Arch Bronconeumol 35:152-8. 1999
    ..Similar epidemiological studies should consider problems derived from the lack of adequate census data, as well as to avoid defining areas of extreme population dispersion in order to facilitate field work...
  40. ncbi request reprint [Use of the Internet in a multicenter study of chronic obstructive pulmonary disease in primary care. Pilot phase of the EFEMAP study]
    M Miravitlles
    Servicio de Neumologia, Institut Clínic de Pneumologia i Cirurgia Toràcica IDIBAPS, Hospital Clinic i Provincial, Barcelona, Spain
    Arch Bronconeumol 38:427-30. 2002
    ..To determine the reliability of clinical data collection and transmission by Internet in a multicenter primary care study...
  41. ncbi request reprint Emphysema due to alpha-antitrypsin deficiency: familial study of the YBARCELONA variant
    Marc Miravitlles
    Department of Pneumology, Clinical Institute of Pneumology and Thoracic Surgery, Hospital Clinic IDIBAPS, Barcelona, Spain
    Chest 124:404-6. 2003
    ..The risk associated with this variant in its heterozygous form may be similar to that described for PiMZ...
  42. pmc Geographic differences in clinical characteristics and management of COPD: the EPOCA study
    Marc Miravitlles
    Servei de Pneumologia, Institut Clinic del Torax, Hospital Clinic, Barcelona, Spain
    Int J Chron Obstruct Pulmon Dis 3:803-14. 2008
    ..We aimed to characterize the profile of patients with COPD in a number of countries and their treatment in order to evaluate adherence to recommendations of international guidelines...
  43. ncbi request reprint Chronic respiratory symptoms, spirometry and knowledge of COPD among general population
    Marc Miravitlles
    Servei de Pneumologia, Institut Clínic del Tòrax IDIBAPS, Hospital Clinic, Barcelona, Catalonia, Spain
    Respir Med 100:1973-80. 2006
    ..This study analyses the frequency of respiratory symptoms and the knowledge about COPD in the general population, together with the use of spirometry in individuals at risk of COPD...
  44. ncbi request reprint Frequency of multi-dimensional COPD indices and relation with disease activity markers
    Francisco Garcia-Rio
    Servicio de Neumologia, Hospital Universitario La Paz, IdiPAZ, Madrid, Spain
    COPD 10:436-43. 2013
    ..The systemic biomarkers showed a less consistent relation with several indices. In a population-based sample of COPD patients, the SAFE index reaches the highest relation with physical activity, co-morbidity and health status...
  45. doi request reprint Underdiagnosis of chronic obstructive pulmonary disease in women: quantification of the problem, determinants and proposed actions
    Julio Ancochea
    Servicio de Neumologia, Hospital de la Princesa, Instituto de Investigación Sanitaria Princesa IP, Madrid, Spain
    Arch Bronconeumol 49:223-9. 2013
    ..The EPI-SCAN study is an epidemiologic, observational study conducted at 11 Spanish centers on the general population aged 40 to 80...
  46. pmc Insights into interventions in managing COPD patients: lessons from the TORCH and UPLIFT studies
    Marc Miravitlles
    Fundació Clínic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Hospital Clinic, Barcelona, Spain
    Int J Chron Obstruct Pulmon Dis 4:185-201. 2009
    ..With the more optimistic view of benefits from drug treatment of COPD that these trials provide, a review of prescribing practices is warranted...
  47. doi request reprint Chronic obstructive pulmonary disease
    Marc Decramer
    Respiratory Division, University Hospital, University of Leuven, Leuven, Belgium
    Lancet 379:1341-51. 2012
    ..Besides improving symptoms, these treatments are also thought to lead to some degree of disease modification. Future research should be directed towards the development of agents that notably affect the course of disease...
  48. doi request reprint Characterisation of exacerbations of chronic bronchitis and COPD in Europe: the GIANT study
    Marc Miravitlles
    Servei de Pneumologia Institut Clínic del Tòrax Hospital Clínic, Barcelona, Spain
    Ther Adv Respir Dis 3:267-77. 2009
    ..The GIANT study collected information on patients with acute exacerbations of chronic bronchitis (AECB) and chronic obstructive pulmonary disease (COPD) and the effect of treatment with moxifloxacin...
  49. ncbi request reprint Variables associated with recovery from acute exacerbations of chronic bronchitis and chronic obstructive pulmonary disease
    Marc Miravitlles
    Pneumology Department, Institut Clínic del Tòrax IDIBAPS, Red Respira FIS ISCIII RTIC 03 11, Hospital Clinic, Villarroel 170, 08036 Barcelona, Catalonia, Spain
    Respir Med 99:955-65. 2005
    ..To identify risk factors for late recovery and failure after ambulatory treatment of exacerbations of chronic bronchitis (CB) and chronic obstructive pulmonary disease (COPD)...
  50. ncbi request reprint [Effect of AM3 on health-related quality of life in patients with chronic obstructive pulmonary disease belonging to risk groups]
    Marc Miravitlles
    Servicio de Neumologia, Institut Clínic del Tòrax IDIBAPS, Hospital Clinic, Barcelona, Espana
    Med Clin (Barc) 130:688-92. 2008
    ..This study examined the effect of AM3 on the quality of life of patients in different risk groups and identified the factors associated with change in this variable...
  51. ncbi request reprint [Clinical efficacy of moxifloxacin in the treatment of exacerbations of chronic bronchitis: a systematic review and meta-analysis]
    Marc Miravitlles
    Servei de Pneumologia, Institut Clínic del Tòrax IDIBAPS, Hospital Clinic, Barcelona, Espana
    Arch Bronconeumol 43:22-8. 2007
    ..Our objective was to compare the clinical efficacy of moxifloxacin to that of the antibiotic regimens routinely used to treat such exacerbations by a systematic review of the literature and a meta-analysis...
  52. ncbi request reprint Glutathione S-transferase P1 and lung function in patients with alpha1-antitrypsin deficiency and COPD
    Francisco Rodriguez
    Department of Biochemistry, Hospital Vall d Hebron, Barcelona, Spain
    Chest 127:1537-43. 2005
    ..The glutathione S-transferase P1 (GSTP1) gene is involved in detoxification of electrophilic substances of tobacco smoke. A polymorphism at nucleotide 315 of this gene alters its enzymatic activity...
  53. ncbi request reprint Clinical outcomes and cost analysis of exacerbations in chronic obstructive pulmonary disease
    Marc Miravitlles
    Pneumology Department, Hospital Universitari Vall d Hebron, P Vall d Hebron 119 129, 08035, Barcelona, Spain
    Lung 191:523-30. 2013
    ..This study investigated the clinical outcomes of outpatients with moderate to severe exacerbated COPD and their related costs...
  54. doi request reprint Overdiagnosing subjects with COPD using the 0.7 fixed ratio: correlation with a poor health-related quality of life
    Francisco Garcia-Rio
    Servicio de Neumologia, Hospital Universitario La Paz, IdiPAZ, Paseo de la Castellana, 261, 28046 Madrid, Spain
    Chest 139:1072-80. 2011
    ..7 but > LLN (ratio-only group) vs subjects without COPD and those with mild or moderate to severe COPD...
  55. doi request reprint Factors determining the quality of life of patients with COPD in primary care
    Marc Miravitlles
    Servicio de Neumologia, Institut Clínic del Tòrax IDIBAPS, Hospital Clinic, Villarroel 170 UVIR, esc 2, planta 3 08036 Barceona, Spain
    Ther Adv Respir Dis 1:85-92. 2007
    ..To describe the health-related quality of life (HRQL) in a cohort of COPD patients recruited in primary care and identify the variables of the patients and the treatment associated with impaired HRQL...
  56. ncbi request reprint Determining factors in the prescription of moxifloxacin in exacerbations of chronic bronchitis in the primary-care setting
    Marc Miravitlles
    Pneumology Department, Clinical Institute of Thorax IDIBAPS, Clinic Hospital, Barcelona, Spain
    Clin Drug Investig 27:95-104. 2007
    ..To describe the characteristics of patients and exacerbations that may determine the choice of an antibacterial in exacerbations of chronic bronchitis (ECB)...
  57. doi request reprint An economic analysis of pharmacological treatment of COPD in Spain
    Marc Miravitlles
    Servei de Pneumologia, Institut Clínic del Tòrax IDIBAPS, Ciber de enfermedades respiratorias CIBERES, Hospital Clinic, Barcelona, Spain
    Respir Med 103:714-21. 2009
    ..COPD is a prevalent disease that generates high use of resources. The objective of this study was to quantify the economic consequences of non-adherence to GOLD guidelines for the management of COPD patients...
  58. doi request reprint Variability of respiratory symptoms in severe COPD
    María José Espinosa de los Monteros
    Servicio de Neumologia, Hospital Virgen de la Salud, Toledo, Spain
    Arch Bronconeumol 48:3-7. 2012
    ..Nevertheless, COPD patients report having "bad days". The objective of this present study was to evaluate the variability of the respiratory symptoms and their impact on the daily activities of a cohort of Spanish COPD patients...
  59. ncbi request reprint Use of spirometry and patterns of prescribing in COPD in primary care
    Marc Miravitlles
    Department of Pneumology, Institut Clínic del Tòrax IDIBAPS, Servicio de Neumologia, Hospital Clinic, Villarroel 170 08036, Barcelona, Spain
    Respir Med 101:1753-60. 2007
    ..To investigate the use and interpretation of spirometry in primary care (PC) in the diagnosis of chronic obstructive pulmonary disease (COPD) and to identify the treatment schedules administered...
  60. ncbi request reprint [Impact of chronic obstructive pulmonary disease on activities of daily living: results of the EIME multicenter study]
    Francisco Javier Alvarez-Gutiérrez
    Servicio de Neumologia, Red Respira RTIC 03 11 ISCIII, Hospital Virgen del Rocio, Sevilla, Espana
    Arch Bronconeumol 43:64-72. 2007
    ..To do this, we examined the relationship between questionnaire results and clinical variables, lung function measurements, socioeconomic status, and validated quality of life questionnaires...
  61. ncbi request reprint [New treatments for chronic obstructive pulmonary disease]
    Marc Miravitlles
    Servicio de Neumologia, Institut d Investigacions Biomediques August Pi i Sunyer, Red Respira RTIC 03 11 ISCIII, Hospital Clinic, Barcelona, Spain
    Med Clin (Barc) 125:65-74. 2005
    ..In the future, new specific antiinflammatories such as phosphodiesterase 4 inhibitors or agents with a potential action in tissue regeneration could lead to new perspectives, as well as to new questions, in COPD treatment...
  62. doi request reprint Changes in management of chronic obstructive pulmonary disease (COPD) in primary care: EMMEPOC study
    Néstor Soler
    Servei de Pneumologia, Institut del Tòrax, Hospital Clinic, IDIBAPS, Universitat de Barcelona, Villarroel 170, 08036 Barcelona, Spain
    Respir Med 104:67-75. 2010
    ..The use of a portable device to perform spirometry tests was evaluated to adequately categorize COPD and reduce other diagnostic interventions...
  63. ncbi request reprint Moxifloxacin: a respiratory fluoroquinolone
    Marc Miravitlles
    Servei de Pneumologia, Institut Clínic del Tòrax IDIBAPS, Ciber de enfermedades respiratorias CIBERES, Hospital Clinic, Barcelona, Spain
    Expert Opin Pharmacother 9:1755-72. 2008
    ..Moxifloxacin is a fourth-generation fluoroquinolone that has been shown to be effective against Gram-positive, Gram-negative, and atypical strains, as well as multi-drug resistant Streptococcus pneumoniae...
  64. ncbi request reprint [Alpha1-antitrypsin deficiency: situation in Spain and development of a screening program]
    Cristian de la Roza
    Servicio de Neumologia, Institut Clinic del Torax, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Red Respira RTIC 03 11 ISCIII, Hospital Clinic, Barcelona, Espana
    Arch Bronconeumol 42:290-8. 2006
    ..This strategy is crucial in Spain, where the disease is under diagnosed, mainly due to a low index of suspicion among doctors...
  65. doi request reprint Chronic bronchial infection in COPD. Is there an infective phenotype?
    Zinka Matkovic
    Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Ciber de enfermedades respiratorias CIBERES, Hospital Clinic, Barcelona, Spain
    Respir Med 107:10-22. 2013
    ..Therefore, the isolation of pathogenic bacteria in stable COPD should be considered as a form of chronic infection rather than colonisation. This new approach may have important implications for the management of patients with COPD...
  66. doi request reprint Predictors of adverse outcome in patients hospitalised for exacerbation of chronic obstructive pulmonary disease
    Zinka Matkovic
    Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, CIBER de Enfermedades Respiratorias, Barcelona, Spain
    Respiration 84:17-26. 2012
    ..It is crucial to identify risk factors for poor evolution of patients admitted to hospital with chronic obstructive pulmonary disease (COPD) in order to provide adequate intensive therapy and closer follow-up...
  67. pmc Moxifloxacin in the management of exacerbations of chronic bronchitis and COPD
    Marc Miravitlles
    Servei de Pneumologia, Institut Clínic del Tòrax IDIBAPS, Hospital Clinic, Barcelona, Spain
    Int J Chron Obstruct Pulmon Dis 2:191-204. 2007
    ..The current article reviews the use of moxifloxacin in bacterial exacerbations of CB and COPD...
  68. ncbi request reprint Exacerbations, hospital admissions and impaired health status in chronic obstructive pulmonary disease
    Marc Miravitlles
    Servei de Pneumologia, Institut Clínic del Tòrax IDIBAPS, Red Respira RTIC 03 11 ISCIII, Hospital Clinic, Barcelona, Spain
    Qual Life Res 15:471-80. 2006
    ..These results, together with previous studies, confirm that impairment in health status in COPD is both a marker of risk for, and a consequence of, frequent exacerbations and admissions...
  69. doi request reprint Factors associated with the evolution of lung function in patients with alpha-1 antitrypsin deficiency in the Spanish registry
    Gema Tirado-Conde
    Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Ciber de enfermedades respiratorias CIBERES, Hospital Clinic, Barcelona, Espana
    Arch Bronconeumol 47:495-503. 2011
    ....
  70. doi request reprint Rare alpha-1-antitrypsin variants: are they really so rare?
    Francisco Rodriguez-Frias
    Servicio de Bioquimica, Hospital Universitario Vall d Hebron, Paseo Valle Hebron s n, Barcelona 08035, Spain
    Ther Adv Respir Dis 6:79-85. 2012
    ..Augmentation therapy is recommended in patients with emphysema and PI*ZZ genotype, but there is little evidence regarding the implications of rare variants on therapy...
  71. doi request reprint Alpha-1-antitrypsin and other proteinase inhibitors
    Marc Miravitlles
    Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic, CIBER de Enfermedades Respiratorias, Barcelona, Spain
    Curr Opin Pharmacol 12:309-14. 2012
    ..However, no drugs are yet available to increase antiprotease protection of the lower airways of smokers...
  72. doi request reprint Compliance with guidelines in the treatment of asthma exacerbations in primary care
    Xavier Flor-Escriche
    Universitat Autonoma de Barcelona, Equip d Atenció Primària Chafarinas, SAP Muntanya, Barcelona, Spain
    Ther Adv Respir Dis 5:369-75. 2011
    ..To describe the approach to asthma exacerbations in a primary care centre in comparison with current guidelines and to ascertain the resolution of the episodes...
  73. ncbi request reprint Patient's perception of exacerbations of COPD--the PERCEIVE study
    Marc Miravitlles
    Servei de Pneumologia, Institut Clínic del Tòrax IDIBAPS, Hospital Clinic Barcelona, Spain
    Respir Med 101:453-60. 2007
    ..New data are provided on the impact of COPD and its exacerbations on the daily life of patients. These data will help to develop PROs designed to evaluate the effectiveness of different therapies for exacerbated COPD...
  74. doi request reprint [Respiratory disease registries in Spain: fundamentals and organization]
    Beatriz Lara
    Servicio de Neumologia, Hospital Universitario Arnau de Vilanova, Institut de Recerca Biomedica de Lleida, Centro de Investigación Biomédica en Red de Enfermedades Respiratorias CIBERES, Instituto de Salud Carlos III, Espana
    Arch Bronconeumol 47:389-96. 2011
    ..Therefore, the activities of the professionals involved in the registries have spread the knowledge about the diseases studied, promoting the exchange of information among workgroups...
  75. ncbi request reprint Rapid screening for alpha1-antitrypsin deficiency in patients with chronic obstructive pulmonary disease using dried blood specimens
    Francisco Rodriguez
    Department of Biochemistry, Hospital Universitario Vall d Hebron, Barcelona, Spain
    Am J Respir Crit Care Med 166:814-7. 2002
    ..This single-step, cost-effective technology is optimal for working with small amounts of DNA, as are present in DBS. The method is suitable for large-scale screening, in cases where PI type is important...
  76. ncbi request reprint [Chronic obstructive pulmonary disease. Impact and exacerbations]
    Marc Miravitlles
    Servicio de Neumologia, Institut Clínic de Pneumologia i Cirurgia Toràcica IDIBAPS, Hospital Clinic, Barcelona
    Rev Enferm 27:29-34. 2004
    ..The majority of these acute crises are produced by bronchial infections and they have an important effect on a patient's quality of life and on the evolution of a patient's illness...
  77. doi request reprint Variability in the performing of spirometry and its consequences in the treatment of COPD in primary care
    Mònica Monteagudo
    Área científica IDIAP Jordi Gol, Barcelona, Espana
    Arch Bronconeumol 47:226-33. 2011
    ..Several studies have approached the use of spirometry in the treatment of chronic obstructive pulmonary disease (COPD) in Primary Care (PC), but few have analysed its impact on the treatment of the patient with COPD...
  78. doi request reprint Augmentation therapy for emphysema due to alpha-1-antitrypsin deficiency
    Gema Tirado-Conde
    Servei de Pneumologia Hospital Clinic, Villarroel 170, 08036 Barcelona, Spain
    Ther Adv Respir Dis 2:13-21. 2008
    ..Furthermore, the identification of a large number of patients will allow the development of new clinical trials aimed at finding better treatments for this infrequent condition...
  79. ncbi request reprint Moxifloxacin in respiratory tract infections
    Marc Miravitlles
    Servei de Pneumologia i Allergia Respiratoria IDIBAPS, Red Respira RTIC 03 11, ISCIII, Hospital Clinic, Barcelona, Spain
    Expert Opin Pharmacother 6:283-93. 2005
    ..Treatment guidelines should take into account the results of clinical trials with moxifloxacin in order to establish the role of this antimicrobial in the therapeutic arsenal against respiratory tract infections...
  80. doi request reprint [Residency training of European respiratory medicine specialists: The HERMES project]
    Gema Tirado-Conde
    Servei de Pneumologia, Institut Clínic del Tòrax IDIBAPS, Hospital Clinic, Barcelona, Espana
    Arch Bronconeumol 45:92-9. 2009
    ....
  81. doi request reprint Do we need new antibiotics for treating exacerbations of COPD?
    Marc Miravitlles
    Servei de Pneumologia Hospital Clinic, UVIR, Villarroel 170, Barcelona, Spain
    Ther Adv Respir Dis 1:61-76. 2007
    ....
  82. ncbi request reprint [Guidelines for the diagnosis and management of alpha-1 antitrypsin deficiency]
    Rafael Vidal
    Servicio de Neumologia, Hospital Universitari Vall d Hebron, Barcelona, Espana
    Arch Bronconeumol 42:645-59. 2006
  83. ncbi request reprint Antibody production deficiency with normal IgG levels in bronchiectasis of unknown etiology
    Montserrat Vendrell
    Department of Pneumology, Hospital Josep Trueta, Girona, Spain
    Chest 127:197-204. 2005
    ..No defined cause of bronchiectasis is currently found in approximately 50% of cases. Bronchiectasis is a common long-term complication in patients with primary hypogammaglobulinemia...
  84. ncbi request reprint It's time for an aetiology-based definition of chronic obstructive pulmonary disease
    Marc Miravitlles
    Respirology 12:317-9. 2007
  85. pmc Modelling the 5-year cost effectiveness of tiotropium, salmeterol and ipratropium for the treatment of chronic obstructive pulmonary disease in Spain
    Maureen P M H Rutten-van Mölken
    Institute for Medical Technology Assessment, Erasmus MC, P O Box 1738, 3000 DR, Rotterdam, The Netherlands
    Eur J Health Econ 8:123-35. 2007
    ..In Spain, tiotropium demonstrated the highest expected net benefit for ratios of the willingness to pay per QALY, well within accepted limits...
  86. ncbi request reprint Health-related QOL in acute exacerbations of chronic bronchitis and chronic obstructive pulmonary disease: a review of the literature
    Helen Doll
    Oxford Outcomes, Old Barn, Jericho Farm, Cassington, Oxford, UK
    Pharmacoeconomics 23:345-63. 2005
    ..However, the recall period of the SGRQ symptoms component should be shortened to make it more appropriate for use during acute exacerbation...
  87. ncbi request reprint [Variability of antibiotic prescribing for respiratory tract infections in two European countries]
    Carles Llor
    Sociedad Catalana de Medicina de Familia, Spain
    Enferm Infecc Microbiol Clin 23:598-604. 2005
    ..The aim of this study was to compare the antibiotics prescribed by general practitioners (GPs) for RTIs between Spain and Denmark...
  88. doi request reprint A 4-year trial of tiotropium in chronic obstructive pulmonary disease
    Donald P Tashkin
    David Geffen School of Medicine at the University of California, Los Angeles 90095 1690, USA
    N Engl J Med 359:1543-54. 2008
    ..Previous studies showing that tiotropium improves multiple end points in patients with chronic obstructive pulmonary disease (COPD) led us to examine the long-term effects of tiotropium therapy...
  89. ncbi request reprint [Emphysema due to alpha-1-antitrypsin deficiency: is it really an uncommon disease?]
    Marc Miravitlles
    Med Clin (Barc) 123:778-9. 2004
  90. ncbi request reprint No more equivalence trials for antibiotics in exacerbations of COPD, please
    Marc Miravitlles
    Chest 125:811-3. 2004
  91. ncbi request reprint Can cumulative tobacco consumption, FTND score, and carbon monoxide concentration in expired air be predictors of chronic obstructive pulmonary disease?
    Carlos Jiménez-Ruiz
    Unidad de Tabaquismo, Instituto de Salud Pública, Comunidad de Madrid, Spain
    Nicotine Tob Res 6:649-53. 2004
    ..Cumulative consumption of tobacco was associated with the diagnosis of COPD. For each point increase in the FTND score, the probability of a smoker developing COPD increased by 11%...
  92. ncbi request reprint Chronic obstructive pulmonary disease: the disease and its burden to society
    David M G Halpin
    Department of Respiratory Medicine, Royal Devon and Exeter Hospital, Exeter, United Kingdom
    Proc Am Thorac Soc 3:619-23. 2006
    ....
  93. ncbi request reprint [Delayed prescription of antibiotics. Also for COPD?]
    Marc Miravitlles
    Med Clin (Barc) 126:677. 2006
  94. ncbi request reprint [Use of spirometry in the diagnosis and treatment of chronic obstructive pulmonary disease in primary care]
    Karlos Naberan
    Grupo de Neumología de la Sociedad Catalana de Medicina de Familia, Espana
    Arch Bronconeumol 42:638-44. 2006
    ....
  95. ncbi request reprint [Chronic obstructive pulmonary disease: disease or Zugzwang's syndrome?]
    Josep Morera
    Med Clin (Barc) 130:655-6. 2008