Roger L Milne

Summary

Country: Spain

Publications

  1. doi The average cumulative risks of breast and ovarian cancer for carriers of mutations in BRCA1 and BRCA2 attending genetic counseling units in Spain
    Roger L Milne
    Unidad de Genotipación CEGEN and Grupo de Genética Humana, Programa de Genética del Cáncer Humano, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Clin Cancer Res 14:2861-9. 2008
  2. pmc Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study
    Roger L Milne
    Genetic and Molecular Epidemiology Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre CNIO, Madrid, 28029, Spain
    Breast Cancer Res 12:R110. 2010
  3. pmc Variants in the ATM gene and breast cancer susceptibility
    Roger L Milne
    Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Center CNIO, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Genome Med 1:12. 2009
  4. pmc CYP17 genetic polymorphism, breast cancer, and breast cancer risk factors: Australian Breast Cancer Family Study
    Jiun Horng Chang
    Centre for Genetic Epidemiology, The University of Melbourne, Victoria, Australia
    Breast Cancer Res 7:R513-21. 2005
  5. doi Parity and the risk of breast and ovarian cancer in BRCA1 and BRCA2 mutation carriers
    Roger L Milne
    Grupo de Epidemiología Genética y Molecular, Programa de Genética del Cáncer Humano, Centro Nacional de Investigaciones Oncologicas CNIO, C Melchor Fernández Almagro, Madrid, Spain
    Breast Cancer Res Treat 119:221-32. 2010
  6. pmc Risk of estrogen receptor-positive and -negative breast cancer and single-nucleotide polymorphism 2q35-rs13387042
    Roger L Milne
    Genetic and Molecular Epidemiology Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre CNIO, 29029 Madrid, Spain
    J Natl Cancer Inst 101:1012-8. 2009
  7. pmc 7q21-rs6964587 and breast cancer risk: an extended case-control study by the Breast Cancer Association Consortium
    Roger L Milne
    Genetic and Molecular Epidemiology Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre, CNIO, Calle Melchor Fernandez Almagro 3, 28039 Madrid, Spain
    J Med Genet 48:698-702. 2011
  8. ncbi Confirmation of 5p12 as a susceptibility locus for progesterone-receptor-positive, lower grade breast cancer
    Roger L Milne
    Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    Cancer Epidemiol Biomarkers Prev 20:2222-31. 2011
  9. doi The importance of replication in gene-gene interaction studies: multifactor dimensionality reduction applied to a two-stage breast cancer case-control study
    Roger L Milne
    National Genotyping Centre, Spanish National Cancer Research Centre, Madrid 28029, Spain
    Carcinogenesis 29:1215-8. 2008
  10. pmc Genetic analysis of the vitamin D receptor gene in two epithelial cancers: melanoma and breast cancer case-control studies
    Eva Barroso
    Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    BMC Cancer 8:385. 2008

Detail Information

Publications45

  1. doi The average cumulative risks of breast and ovarian cancer for carriers of mutations in BRCA1 and BRCA2 attending genetic counseling units in Spain
    Roger L Milne
    Unidad de Genotipación CEGEN and Grupo de Genética Humana, Programa de Genética del Cáncer Humano, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Clin Cancer Res 14:2861-9. 2008
    ..We aimed to estimate these penetrances for women attending genetic counseling units in Spain...
  2. pmc Assessing interactions between the associations of common genetic susceptibility variants, reproductive history and body mass index with breast cancer risk in the breast cancer association consortium: a combined case-control study
    Roger L Milne
    Genetic and Molecular Epidemiology Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre CNIO, Madrid, 28029, Spain
    Breast Cancer Res 12:R110. 2010
    ....
  3. pmc Variants in the ATM gene and breast cancer susceptibility
    Roger L Milne
    Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Center CNIO, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Genome Med 1:12. 2009
    ..Other studies have evaluated associations for coding variants with intermediate frequency (1-5%), but the results are inconsistent. Larger and/or combined association studies are needed to clarify this issue...
  4. pmc CYP17 genetic polymorphism, breast cancer, and breast cancer risk factors: Australian Breast Cancer Family Study
    Jiun Horng Chang
    Centre for Genetic Epidemiology, The University of Melbourne, Victoria, Australia
    Breast Cancer Res 7:R513-21. 2005
    ..We attempted to replicate the findings of studies assessing such interactions with the -34T-->C polymorphism...
  5. doi Parity and the risk of breast and ovarian cancer in BRCA1 and BRCA2 mutation carriers
    Roger L Milne
    Grupo de Epidemiología Genética y Molecular, Programa de Genética del Cáncer Humano, Centro Nacional de Investigaciones Oncologicas CNIO, C Melchor Fernández Almagro, Madrid, Spain
    Breast Cancer Res Treat 119:221-32. 2010
    ..Whether later age at first birth is also protective for ovarian cancer in mutation carriers requires further confirmation...
  6. pmc Risk of estrogen receptor-positive and -negative breast cancer and single-nucleotide polymorphism 2q35-rs13387042
    Roger L Milne
    Genetic and Molecular Epidemiology Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre CNIO, 29029 Madrid, Spain
    J Natl Cancer Inst 101:1012-8. 2009
    ..We attempted to confirm this association using the Breast Cancer Association Consortium...
  7. pmc 7q21-rs6964587 and breast cancer risk: an extended case-control study by the Breast Cancer Association Consortium
    Roger L Milne
    Genetic and Molecular Epidemiology Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre, CNIO, Calle Melchor Fernandez Almagro 3, 28039 Madrid, Spain
    J Med Genet 48:698-702. 2011
    ..The authors have now assessed this association more comprehensively using 16 independent case-control studies...
  8. ncbi Confirmation of 5p12 as a susceptibility locus for progesterone-receptor-positive, lower grade breast cancer
    Roger L Milne
    Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    Cancer Epidemiol Biomarkers Prev 20:2222-31. 2011
    ..We aimed to further explore this association overall, and by tumor histopathology, in the Breast Cancer Association Consortium...
  9. doi The importance of replication in gene-gene interaction studies: multifactor dimensionality reduction applied to a two-stage breast cancer case-control study
    Roger L Milne
    National Genotyping Centre, Spanish National Cancer Research Centre, Madrid 28029, Spain
    Carcinogenesis 29:1215-8. 2008
    ..Just as for genetic main effects, the replication of positive findings in additional independent series is essential...
  10. pmc Genetic analysis of the vitamin D receptor gene in two epithelial cancers: melanoma and breast cancer case-control studies
    Eva Barroso
    Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    BMC Cancer 8:385. 2008
    ..In this study, the VDR gene has been evaluated in two epithelial cancers BC and MM...
  11. doi A 7 Mb region within 11q13 may contain a high penetrance gene for breast cancer
    Juan Manuel Rosa-Rosa
    Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre CNIO, Melchor Fernandez Almagro 3, Madrid, 28029, Spain
    Breast Cancer Res Treat 118:151-9. 2009
    ..Although we have not found any deleterious mutations in the coding region of these genes, data from STR markers confirm 11q13 as a candidate region to contain a breast cancer susceptibility gene...
  12. pmc Risk of pancreatic cancer in breast cancer families from the breast cancer family registry
    Evelina Mocci
    Genetic and Molecular Epidemiology Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    Cancer Epidemiol Biomarkers Prev 22:803-11. 2013
    ..The aim of this study was to estimate pancreatic cancer risk in high-risk breast cancer families according to the BRCA mutation status...
  13. ncbi Haplotype patterns in cancer-related genes with long-range linkage disequilibrium: no evidence of association with breast cancer or positive selection
    Gloria Ribas
    Human Genetics Group, Human Cancer Genetics Programme, Spanish National Cancer Centre CNIO, Madrid, Spain
    Eur J Hum Genet 16:252-60. 2008
    ..4); however, these genes did not show evidence of positive selection. Finally, we found no evidence that the haplotypes formed by SNPs in the 20 genes are associated with breast cancer...
  14. ncbi Immunohistochemical classification of non-BRCA1/2 tumors identifies different groups that demonstrate the heterogeneity of BRCAX families
    Emiliano Honrado
    Department of Human Genetics, Spanish National Cancer Centre, Melchor Fernandez Almagro 3, Madrid, Spain
    Mod Pathol 20:1298-306. 2007
    ..In addition we have defined a subset of them that have somatic inactivation of the BRCA1 gene...
  15. doi Pigmentation-related genes and their implication in malignant melanoma susceptibility
    Lara P Fernandez
    Human Genetics Group, Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid E 28029, Spain
    Exp Dermatol 18:634-42. 2009
    ..We also found that several variants in the pigmentation genes considered were associated with intermediate phenotypic characteristics. Our findings highlight the potential importance of pigmentation genes in sporadic MM susceptibility...
  16. ncbi Association study of 69 genes in the ret pathway identifies low-penetrance loci in sporadic medullary thyroid carcinoma
    Sergio Ruiz-Llorente
    Hereditary Endocrine Cancer Group, Human Genetics Group, Biomedical Research Institute, CSIC, UAM, Madrid, Spain
    Cancer Res 67:9561-7. 2007
    ..These results highlight the utility of association studies using homogeneous series of cases for better understanding complex diseases...
  17. ncbi Evaluating HapMap SNP data transferability in a large-scale genotyping project involving 175 cancer-associated genes
    Gloria Ribas
    Grupo de Genética Humana Programa de Patología Molecular, Centro Nacional de Investigaciones Oncologicas CNIO, C Melchor Fdz Almagro 3, E 28029 Madrid, Spain
    Hum Genet 118:669-79. 2006
    ..Our results show generally high concordance with HapMap data in allele frequencies and haplotype distributions and confirm the applicability of HapMap SNP data to the study of complex diseases among the Spanish population...
  18. ncbi DNA glycosylases involved in base excision repair may be associated with cancer risk in BRCA1 and BRCA2 mutation carriers
    Ana Osorio
    Human Genetics Group, Spanish National Cancer Centre CNIO, Madrid, Spain Biomedical Network on Rare Diseases CIBERER, Madrid, Spain
    PLoS Genet 10:e1004256. 2014
    ..12 95%CI: 1.03-1.21, p = 4.8 × 10(-3)). DNA glycosylases involved in the first steps of the BER pathway may be associated with cancer risk in BRCA1/2 mutation carriers and should be more comprehensively studied...
  19. ncbi Succinate dehydrogenase D variants do not constitute a risk factor for developing C cell hyperplasia or sporadic medullary thyroid carcinoma
    Alberto Cascon
    Hereditary Endocrine Cancer Group, Department of Human Genetics, Centro Nacional de Investigaciones Oncologicas, Melchor Fernandez Almagro 3, E 28029 Madrid, Spain
    J Clin Endocrinol Metab 90:2127-30. 2005
    ..Finally, we looked for evidence of CCH or any other thyroid disease in a panel of germ-line SDH (B or D) mutation carriers and found none. We conclude that SDHD variants do not constitute a risk factor for developing CCH or sporadic MTC...
  20. ncbi Genetic Variation in the TP53 Pathway and Bladder Cancer Risk. A Comprehensive Analysis
    Silvia Pineda
    Spanish National Cancer Research Center CNIO, Madrid, Spain
    PLoS ONE 9:e89952. 2014
    ..We carried out an in depth assessment of associations between common germline variants in the TP53 pathway and bladder cancer risk...
  21. pmc Pancreatic cancer risk and levels of trace elements
    André F S Amaral
    Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Centre CNIO, C Melchor Fernandez Almagro 3, Madrid, Spain
    Gut 61:1583-8. 2012
    ..Among other carcinogens, tobacco contains cadmium, a metal previously associated with an increased risk of EPC. This study evaluated the association between concentrations of trace elements in toenails and EPC risk...
  22. pmc The potential value of sibling controls compared with population controls for association studies of lifestyle-related risk factors: an example from the Breast Cancer Family Registry
    Roger L Milne
    Genetic and Molecular Epidemiology Group, Human Cancer Genetics Programme, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    Int J Epidemiol 40:1342-54. 2011
    ..We hypothesized that unaffected sisters may provide a more appropriate comparison group than unrelated population controls...
  23. pmc Common breast cancer-predisposition alleles are associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers
    Antonis C Antoniou
    Cancer Research UK, Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, UK
    Am J Hum Genet 82:937-48. 2008
    ....
  24. doi The high producer variant of the Fc-receptor like-3 (FCRL3) gene is involved in protection against multiple sclerosis
    Fuencisla Matesanz
    Instituto de Parasitologia y Biomedicina Lopez Neyra, Consejo Superior de Investigaciones Cientificas, Granada, Spain
    J Neuroimmunol 195:146-50. 2008
    ..94; P-value = 0.007) as was the G variant of N28D, but no association was found for rs11264799/FCRL3_4. Haplotype analysis confirmed these associations with highly consistent effect sizes for haplotypes carrying the C allele of FCRL3_3...
  25. pmc Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics
    Montserrat Garcia-Closas
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Marylan, United States of America
    PLoS Genet 4:e1000054. 2008
    ..Understanding the etiologic heterogeneity of breast cancer may ultimately result in improvements in prevention, early detection, and treatment...
  26. ncbi The HER2 I655V polymorphism and risk of breast cancer in women < age 40 years
    Karen G Montgomery
    Cancer Genetics Laboratory, Victorian Breast Cancer Research Consortium, Peter MacCallum Cancer Institute, St Andrews Place, East Melbourne, Victoria 3002, Australia
    Cancer Epidemiol Biomarkers Prev 12:1109-11. 2003
    ..3-6.2; P = 0.005), gave the best fit under parsimony. Although the biological role of the I655V polymorphism is not known, large independent studies of early onset breast cancer are warranted to attempt to replicate this finding...
  27. ncbi Oral contraceptive use and risk of early-onset breast cancer in carriers and noncarriers of BRCA1 and BRCA2 mutations
    Roger L Milne
    Centre for Genetic Epidemiology, The University of Melbourne, Level 2, 723 Swanston Street, Carlton, Victoria 3053, Australia
    Cancer Epidemiol Biomarkers Prev 14:350-6. 2005
    ..Recent oral contraceptive use has been associated with a small increase in breast cancer risk and a substantial decrease in ovarian cancer risk. The effects on risks for women with germ line mutations in BRCA1 or BRCA2 are unclear...
  28. ncbi A protein-truncating mutation in CYP17A1 in three sisters with early-onset breast cancer
    John L Hopper
    Centre for Genetic Epidemiology, The University of Melbourne, Carlton, Victoria, Australia
    Hum Mutat 26:298-302. 2005
    ....
  29. ncbi No increased risk of breast cancer associated with alcohol consumption among carriers of BRCA1 and BRCA2 mutations ages <50 years
    Valerie McGuire
    Department of Health Research and Policy, Stanford University School of Medicine, Health Research and Stanford, CA 94305 5405, USA
    Cancer Epidemiol Biomarkers Prev 15:1565-7. 2006
  30. ncbi BRCA1 and BRCA2 mutation carriers, oral contraceptive use, and breast cancer before age 50
    Robert W Haile
    Department of Preventive Medicine, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, MS 9175, Los Angeles, CA 90089 9175, USA
    Cancer Epidemiol Biomarkers Prev 15:1863-70. 2006
    ..Understanding the effect of oral contraceptives on risk of breast cancer in BRCA1 or BRCA2 mutation carriers is important because oral contraceptive use is a common, modifiable practice...
  31. ncbi A common coding variant in CASP8 is associated with breast cancer risk
    Angela Cox
    Sheffield University Medical School, Sheffield S10 2RX, UK
    Nat Genet 39:352-8. 2007
    ..02-1.13) and 1.16 (95% c.i.: 1.08-1.25), respectively; P(trend) = 2.8 x 10(-5)). These results demonstrate that common breast cancer susceptibility alleles with small effects on risk can be identified, given sufficiently powerful studies...
  32. ncbi Immunohistochemical expression of DNA repair proteins in familial breast cancer differentiate BRCA2-associated tumors
    Emiliano Honrado
    Human Genetics Department Centro Nacional Investigaciones Oncológicas Melchor Fernández Almagro, 3 28029 Madrid, Spain
    J Clin Oncol 23:7503-11. 2005
    ..Because BRCA1 and BRCA2 genes participate in the DNA repair pathway, we have performed an immunohistochemical study with markers related to this pathway to establish the profile of the three groups...
  33. pmc Genome-wide association study identifies novel breast cancer susceptibility loci
    Douglas F Easton
    CR UK Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK
    Nature 447:1087-93. 2007
    ..05 level compared with an estimated 1,343 that would be expected by chance, indicating that many additional common susceptibility alleles may be identifiable by this approach...
  34. ncbi IL2RA/CD25 polymorphisms contribute to multiple sclerosis susceptibility
    Fuencisla Matesanz
    J Neurol 254:682-4. 2007
  35. pmc An international initiative to identify genetic modifiers of cancer risk in BRCA1 and BRCA2 mutation carriers: the Consortium of Investigators of Modifiers of BRCA1 and BRCA2 (CIMBA)
    Georgia Chenevix-Trench
    Queensland Institute for Medical Research, Brisbane, Australia
    Breast Cancer Res 9:104. 2007
    ....
  36. ncbi Polymorphisms in TRAIL receptor genes and risk of breast cancer in Spanish women
    José I Martínez-Ferrandis
    Laboratorio de Genetica Molecular, Centro de Investigacion Principe Felipe, Valencia, Spain
    Cancer Biomark 3:89-93. 2007
    ..A decreased efficiency of DcR2 to work as decoy receptor for TRAIL, would facilitate the apoptotic pathway in cells at risk...
  37. ncbi Prognosis of premenopausal breast cancer and childbirth prior to diagnosis
    Kelly Anne Phillips
    Peter MacCallum Cancer Centre, University of Melbourne, Carlton, Victoria 3053, Australia
    J Clin Oncol 22:699-705. 2004
    ..The time interval between last childbirth and subsequent breast cancer diagnosis is emerging as an important prognostic factor for premenopausal women...
  38. ncbi Obesity and outcomes in premenopausal and postmenopausal breast cancer
    Sherene Loi
    Peter MacCallum Cancer Centre, 723 Swanston Street, Carlton, Victoria 3053, Australia
    Cancer Epidemiol Biomarkers Prev 14:1686-91. 2005
    ..Obesity is associated with adverse outcomes in postmenopausal women with breast cancer. In premenopausal women, the association is less clear...
  39. ncbi Agreement between self-reported breast cancer treatment and medical records in a population-based Breast Cancer Family Registry
    Kelly Anne Phillips
    Peter MacCallum Cancer Centre
    J Clin Oncol 23:4679-86. 2005
    ..Although self-report data on treatment for breast cancer are collected in some large epidemiologic studies, their accuracy is unknown...
  40. ncbi An inverse association between ovarian cysts and breast cancer in the breast cancer family registry
    Julia A Knight
    Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Canada
    Int J Cancer 118:197-202. 2006
    ..Further study of ovarian cysts may increase our understanding of hormonal and other mechanisms of breast cancer etiology...
  41. ncbi Medical radiation exposure and breast cancer risk: findings from the Breast Cancer Family Registry
    Esther M John
    Northern California Cancer Center, Fremont, CA 94538, USA
    Int J Cancer 121:386-94. 2007
    ..Given the widespread and increasing use of medical diagnostic radiation, continued surveillance of breast cancer risk is warranted, particularly in women at specific genetic risk, such as those carrying mutations in BRCA1 or BRCA2...
  42. ncbi A twin study of genetic influences on epilepsy outcome
    Michael R Johnson
    Epilepsy Research Institute and Department of Medicine Neurology, University of Melbourne, Austin and Repatriation Medical Centre, West Heidelberg, Australia
    Twin Res 6:140-6. 2003
    ..The observed high correlations for outcome suggest that, for epilepsy, susceptibility genes also have a major influence on outcome...
  43. ncbi Analyzing the etiology of benign rolandic epilepsy: a multicenter twin collaboration
    Lata Vadlamudi
    Epilepsy Research Centre, Department of Medicine Neurology, University of Melbourne, Austin Health, Heidelberg, Victoria, Australia
    Epilepsia 47:550-5. 2006
    ..We analyzed a large sample of twins from four international twin registers to probe the genetics of BRE. We also aim to synthesize the apparently conflicting family and twin data into a model of BRE etiology...
  44. ncbi Mammographic densities during the menopausal transition: a longitudinal study of Australian-born women
    Janet R Guthrie
    Office for Gender and Health, Department of Psychiatry, The University of Melbourne, and St Vincent s BreastScreen, St Vincent s Hospital, Victoria, Australia
    Menopause 14:208-15. 2007
    ..The objective of this study was to investigate hormonal and other factors associated with mammographic density during the menopausal transition and in postmenopause...
  45. pmc Psychosocial factors and survival of young women with breast cancer: a population-based prospective cohort study
    Kelly Anne Phillips
    Division of Haematology and Medical Oncology, Peter MacCallum Cancer Centre, University of Melbourne, Carlton, Victoria 3053, Australia
    J Clin Oncol 26:4666-71. 2008
    ..Most women with early-stage breast cancer believe that psychosocial factors are an important influence over whether their cancer will recur. Studies of the issue have produced conflicting results...