Alexander Mikhailov

Summary

Affiliation: Institute of Health Sciences/University of La Coruna
Location: La Coruna, Spain
Summary:
Alexander T. Mikhailov, MD, Ph.D., D.Sc. is a Full Professor (1992, Russian Academy of Sciences, Moscow, Russia) and Research Director (1995- ) of the Institute of Health Sciences at the University of La Coruna in Spain. He received his PhD in 1973 from the Institute of Human Morphology of the USSR/Russian Academy of Medical Sciences in Moscow after working on the biochemical differentiation of embryonic retina and brain. In 1975, he moved to the Koltzov’s Institute of Developmental Biology of the USSR/Russian Academy of Sciences, also in Moscow, where he developed an independent research program, employing cellular, biochemical and molecular biology assays to highlight the mechanisms of inductive interactions in the embryo.
As an investigator, he has crossed many scientific and geographic frontiers in his life, collaborating with leading developmental biology groups in Finland, Germany, Japan, and U. S. A. In 1993, he moved from Central Russia (Moscow) to NW Spain (La Coruña, Galicia), and his research efforts, surrounding identification of signal molecules in development and differentiation, were metamorphosed into molecular and cell biology approaches to study the role of fetal cardiac transcription factors in failing adult heart. Actions of cardiac-enriched factors (Myocardin, HOP, CARP/ANKRD1,BNP,TBX5, Pitx2) are being investigated through protein-protein interaction assays, analyses of target genes, and over- and down-expression studies in vivo, as well as in animal models of heart disease and in patients.
He was active in the Council of Developmental Biology of the USSR/Russian Academy of Sciences (as a Deputy Chairman; 1986-1993), the Finnish-Russian Group on Biology (as a scientific secretary, 1980-1992), the International Society for Developmental Biology Board (1989-1998), the Spanish Society of Developmental Biology Board (2000-2010), and the International Selection Committee: “Alexander Kowalevsky Medal” (2000- ). He served on editorial boards of the Russian Journal of Developmental Biology (1987- ) and the International Journal of Developmental Biology (1994-2000). He contributed more than 100 peer-reviewed publications and 5 books. His long-standing contributions to developmental biology were recognized by many awards, honors, and grants. He received the A. O. Kowalevsky Award (1992) from the Presidium of the Russian Academy of Sciences and Distinguished Leadership Award (1994) from the American Biographical Institute. He was elected the Corresponding member of the Russian Academy of Natural Sciences (1994), the honorary member of the International Biographical Center (Cambridge, UK; 1995) and the Saint-Petersburg Society of Naturalists (2000). His biography is listed in many directories (e.g., the Marquis “Whos Who in Science & Engineering” and “Whos Who in the World”, “The Great Russia. Names” and the Russian Biographical Encyclopedia).

Publications

  1. ncbi request reprint Male-predominant carboxylesterase expression in the reproductive system of molluscs and insects: immunochemical and biochemical similarity between Mytilus male associated polypeptide (MAP) and Drosophila sex-specific esterase S
    A T Mikhailov
    Institute of Health Sciences, University of La Coruna, Spain
    Comp Biochem Physiol B Biochem Mol Biol 118:197-208. 1997
  2. pmc In search of novel targets for heart disease: myocardin and myocardin-related transcriptional cofactors
    Alexander T Mikhailov
    Institute of Health Sciences, University of La Coruna, Campus de Oza, Building El Fortín, Las Jubias Street s n, La Coruña 15006, Spain
    Biochem Res Int 2012:973723. 2012
  3. ncbi request reprint Male-associated polypeptide (MAP) expression in different compartments of the reproductive system of the mussel Mytilus galloprovincialis: immunocytochemical and western blot study
    M Torrado
    Developmental Biology Unit, Institute of Health Sciences, University of La Coruna, Campus de Zapateira s n, E La Coruña 15071, Spain
    Cell Tissue Res 294:537-47. 1998
  4. pmc Targeted gene-silencing reveals the functional significance of myocardin signaling in the failing heart
    Mario Torrado
    Developmental Biology Group, Institute of Health Sciences, University of La Coruna, La Coruna, Spain
    PLoS ONE 6:e26392. 2011
  5. doi request reprint Exon-skipping brain natriuretic peptide variant is overexpressed in failing myocardium and attenuates brain natriuretic peptide production in vitro
    Mario Torrado
    Institute of Health Sciences, University of La Coruna, Spain
    Exp Biol Med (Maywood) 235:941-51. 2010
  6. doi request reprint Intron retention generates ANKRD1 splice variants that are co-regulated with the main transcript in normal and failing myocardium
    Mario Torrado
    Developmental Biology Group, Institute of Health Sciences, University of La Coruna, As Xubias s n, 15006 La Coruna, Spain
    Gene 440:28-41. 2009
  7. ncbi request reprint Detection of protein interactions based on GFP fragment complementation by fluorescence microscopy and spectrofluorometry
    Mario Torrado
    Institute of Health Sciences, University of La Coruna, La Coruna, Spain
    Biotechniques 44:70, 72, 74. 2008
  8. ncbi request reprint Left-right asymmetric ventricular expression of CARP in the piglet heart: regional response to experimental heart failure
    Mario Torrado
    Developmental Biology Unit, Institute of Health Sciences, University of La Coruna, Campus de Oza, Building El Fortín, Las Xubias s n, La Coruña 15006, Spain
    Eur J Heart Fail 6:161-72. 2004
  9. ncbi request reprint Myocardin mRNA is augmented in the failing myocardium: expression profiling in the porcine model and human dilated cardiomyopathy
    Mario Torrado
    Developmental Biology Unit, Institute of Health Sciences, University of La Coruna, Campus de Oza, Bldg El Fortín, As Xubias s n, 15006, La Coruna, Spain
    J Mol Med (Berl) 81:566-77. 2003
  10. ncbi request reprint Mussel MAP, a major gonad-duct esterase-like protein, is released into sea water as a dual constituent of the seminal fluid and the spermatozoon
    Mario Torrado
    Developmental Biology Unit, Institute of Health Sciences, University of La Coruna, Campus de Oza, Building El Fortín, As Xubias s n, La Coruña 15006, Spain
    J Exp Biol 206:313-26. 2003

Detail Information

Publications66

  1. ncbi request reprint Male-predominant carboxylesterase expression in the reproductive system of molluscs and insects: immunochemical and biochemical similarity between Mytilus male associated polypeptide (MAP) and Drosophila sex-specific esterase S
    A T Mikhailov
    Institute of Health Sciences, University of La Coruna, Spain
    Comp Biochem Physiol B Biochem Mol Biol 118:197-208. 1997
    ..Taken together, the results indicate that MAP of M. galloprovincialis is structurally and functionally related to esterase S of D. virilis ejaculatory bulbs...
  2. pmc In search of novel targets for heart disease: myocardin and myocardin-related transcriptional cofactors
    Alexander T Mikhailov
    Institute of Health Sciences, University of La Coruna, Campus de Oza, Building El Fortín, Las Jubias Street s n, La Coruña 15006, Spain
    Biochem Res Int 2012:973723. 2012
    ....
  3. ncbi request reprint Male-associated polypeptide (MAP) expression in different compartments of the reproductive system of the mussel Mytilus galloprovincialis: immunocytochemical and western blot study
    M Torrado
    Developmental Biology Unit, Institute of Health Sciences, University of La Coruna, Campus de Zapateira s n, E La Coruña 15071, Spain
    Cell Tissue Res 294:537-47. 1998
    ..e., mantle and visceral mass) only, although the polypeptide is also detected in other somatic organs in both males and females...
  4. pmc Targeted gene-silencing reveals the functional significance of myocardin signaling in the failing heart
    Mario Torrado
    Developmental Biology Group, Institute of Health Sciences, University of La Coruna, La Coruna, Spain
    PLoS ONE 6:e26392. 2011
    ..However, the molecular and functional consequences of myocd upregulation in HF are still unclear...
  5. doi request reprint Exon-skipping brain natriuretic peptide variant is overexpressed in failing myocardium and attenuates brain natriuretic peptide production in vitro
    Mario Torrado
    Institute of Health Sciences, University of La Coruna, Spain
    Exp Biol Med (Maywood) 235:941-51. 2010
    ..Our work uncovers an important role of alternative exon skipping in the regulation of NPPB gene expression, thereby pinpointing a putative new mechanism for post-transcriptional regulation of NPPB production and secretion...
  6. doi request reprint Intron retention generates ANKRD1 splice variants that are co-regulated with the main transcript in normal and failing myocardium
    Mario Torrado
    Developmental Biology Group, Institute of Health Sciences, University of La Coruna, As Xubias s n, 15006 La Coruna, Spain
    Gene 440:28-41. 2009
    ..Overall, our findings demonstrate that in cardiomyocytes ANKRD1 can exist in multiple isoforms which may contribute to the functional diversity of this factor in heart development and disease...
  7. ncbi request reprint Detection of protein interactions based on GFP fragment complementation by fluorescence microscopy and spectrofluorometry
    Mario Torrado
    Institute of Health Sciences, University of La Coruna, La Coruna, Spain
    Biotechniques 44:70, 72, 74. 2008
    ..Collectively, the results demonstrate that the combination of microscopic and spectrofluorometric detection provides a time-saving and sensitive alternative to existing methods of fluorescence complementation analysis...
  8. ncbi request reprint Left-right asymmetric ventricular expression of CARP in the piglet heart: regional response to experimental heart failure
    Mario Torrado
    Developmental Biology Unit, Institute of Health Sciences, University of La Coruna, Campus de Oza, Building El Fortín, Las Xubias s n, La Coruña 15006, Spain
    Eur J Heart Fail 6:161-72. 2004
    ..We tested whether CARP expression correlates with postnatal ventricular hypertrophy and to what extent CARP can be sensitive to Dox treatment in vivo...
  9. ncbi request reprint Myocardin mRNA is augmented in the failing myocardium: expression profiling in the porcine model and human dilated cardiomyopathy
    Mario Torrado
    Developmental Biology Unit, Institute of Health Sciences, University of La Coruna, Campus de Oza, Bldg El Fortín, As Xubias s n, 15006, La Coruna, Spain
    J Mol Med (Berl) 81:566-77. 2003
    ....
  10. ncbi request reprint Mussel MAP, a major gonad-duct esterase-like protein, is released into sea water as a dual constituent of the seminal fluid and the spermatozoon
    Mario Torrado
    Developmental Biology Unit, Institute of Health Sciences, University of La Coruna, Campus de Oza, Building El Fortín, As Xubias s n, La Coruña 15006, Spain
    J Exp Biol 206:313-26. 2003
    ....
  11. ncbi request reprint Carboxylesterases moonlight in the male reproductive tract: a functional shift pivotal for male fertility
    A T Mikhailov
    Developmental Biology Unit, Institute of Health Sciences, University of La Coruna, La Coruna, Spain
    Front Biosci 5:E53-62. 2000
    ....
  12. ncbi request reprint The cardiac ankyrin repeat domain 1 protein: do you know enough about its dimerization properties?
    Alexander T Mikhailov
    Institute of Health Sciences, University of La Coruna, La Coruña 15006, Spain
    J Muscle Res Cell Motil 27:203-4; author reply 251-2. 2006
  13. doi request reprint In vivo forced expression of myocardin in ventricular myocardium transiently impairs systolic performance in early neonatal pig heart
    Mario Torrado
    Developmental Biology Group, Institute of Health Sciences, University of La Coruna, Spain
    Int J Dev Biol 53:1457-67. 2009
    ..Extended analysis on day 7 post-delivery revealed a drop decrease in myocd-A transgene expression in target LVFW regions which was correlated with normalization of the LV systolic parameters in experimented piglets...
  14. ncbi request reprint Carboxylesterase overexpression in the male reproductive tract: a universal safeguarding mechanism?
    A T Mikhailov
    Developmental Biology Unit, Institute of Health Sciences, University of La Coruna, Spain
    Reprod Fertil Dev 11:133-45. 1999
    ....
  15. doi request reprint Russian comparative embryology takes form: a conceptual metamorphosis toward "evo-devo"
    Alexander T Mikhailov
    Developmental Biology Group, Institute of Health Sciences, University of La Coruna, Campus de Oza, Las Jubias Str s n, La Coruna, Spain
    Evol Dev 14:9-19. 2012
    ..The focus on comparative evolutionary embryology, which was established by Kowalevsky and Mechnikoff, still continues to be popular in present-day "evo-devo" research in Russia...
  16. ncbi request reprint From development to evolution: the re-establishment of the "Alexander Kowalevsky Medal"
    Alexander T Mikhailov
    Developmental Biology Unit, Institute of Health Sciences, University of La Coruna, Spain
    Int J Dev Biol 46:693-8. 2002
    ..In re-establishing this international award, the Society is pleased to recognize both the present awardees and the memory of Kowalevsky, whose work pointed to that we now call evolutionary developmental biology...
  17. doi request reprint The enigmatic role of the ankyrin repeat domain 1 gene in heart development and disease
    Alexander T Mikhailov
    Developmental Biology Group, Institute of Health Sciences, University of La Coruna, La Coruna, Spain
    Int J Dev Biol 52:811-21. 2008
    ....
  18. ncbi request reprint Consequences of the Spemann-Mangold organizer concept for embryological research in Russia: personal impressions
    A T Mikhailov
    Institute of Health Sciences, University of La Coruna, Spain
    Int J Dev Biol 45:83-96. 2001
    ....
  19. ncbi request reprint Developmental patterns of crystallin expression during lens fiber differentiation in amphibians
    A T Mikhailov
    Kol tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow
    Int J Dev Biol 41:883-91. 1997
    ..On this basis, it is suggested that ontogenetic and tissue- or cell-specific changes in Pax gene expression may result in altered programs for activation of crystallin genes in embryonic, adult, and regenerating lens...