Clara Menendez

Summary

Country: Spain

Publications

  1. pmc Breast milk and gut microbiota in African mothers and infants from an area of high HIV prevalence
    Raquel Gonzalez
    Barcelona Centre for International Heath Research CRESIB, Hospital Clínic Universitat de Barcelona, Barcelona, Spain Manhiça Health Research Centre CISM, Maputo, Mozambique
    PLoS ONE 8:e80299. 2013
  2. pmc Plasmodium vivax congenital malaria in an area of very low endemicity in Guatemala: implications for clinical and epidemiological surveillance in a malaria elimination context
    María Eugenia Castellanos
    Centro de Estudios en Salud, Universidad del Valle de Guatemala, 18 avenida 11 95 zona 15 Vista Hermosa 3, Guatemala, Guatemala
    Malar J 11:411. 2012
  3. pmc Intermittent preventive treatment with sulfadoxine-pyrimethamine does not modify plasma cytokines and chemokines or intracellular cytokine responses to Plasmodium falciparum in Mozambican children
    Diana Quelhas
    Centro de Investigação em Saúde da Manhiça, Manhiça, Mozambique
    BMC Immunol 13:5. 2012
  4. pmc Determinants of household demand for bed nets in a rural area of southern Mozambique
    Claire Chase
    Harvard School of Public Health, Department of Global Health and Population, Boston, MA, USA
    Malar J 8:132. 2009
  5. ncbi request reprint Reducing the burden of malaria in pregnancy by preventive strategies
    Clara Menendez
    Center for International Health, Hospital Clinic Barcelona University, Barcelona, Spain
    Lancet Infect Dis 7:126-35. 2007
  6. ncbi request reprint Malaria during pregnancy
    C Menendez
    Center for International Health, Hospital Clinic IDIBAPS, University of Barcelona, Spain
    Curr Mol Med 6:269-73. 2006
  7. pmc A randomized placebo-controlled trial of intermittent preventive treatment in pregnant women in the context of insecticide treated nets delivered through the antenatal clinic
    Clara Menendez
    Barcelona Center for International Health Research CRESIB and Department of Pathology Hospital Clinic, Institut d Investigacions Biomedicas August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 3:e1934. 2008
  8. pmc An autopsy study of maternal mortality in Mozambique: the contribution of infectious diseases
    Clara Menendez
    Barcelona Center for International Health Research CRESIB and Department of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Universitat de Barcelona, Spain
    PLoS Med 5:e44. 2008
  9. pmc Varying efficacy of intermittent preventive treatment for malaria in infants in two similar trials: public health implications
    Clara Menendez
    Barcelona Center for International Health Research CRESIB, Hospital Clinic, Institut d Investigacions Biomedicas August Pi i Sunyer IDIBAPS, Universitat de Barcelona, Spain
    Malar J 6:132. 2007
  10. ncbi request reprint The impact of placental malaria on gestational age and birth weight
    C Menendez
    Unidad de Epidemiologia y Bioestadistica, Hospital Clinic, E 08036, Barcelona, Spain
    J Infect Dis 181:1740-5. 2000

Detail Information

Publications91

  1. pmc Breast milk and gut microbiota in African mothers and infants from an area of high HIV prevalence
    Raquel Gonzalez
    Barcelona Centre for International Heath Research CRESIB, Hospital Clínic Universitat de Barcelona, Barcelona, Spain Manhiça Health Research Centre CISM, Maputo, Mozambique
    PLoS ONE 8:e80299. 2013
    ..The objective of the study was to characterize the breast milk and gut microbiota from mothers and infants from southern Mozambique, where infections and breastfeeding are prevalent...
  2. pmc Plasmodium vivax congenital malaria in an area of very low endemicity in Guatemala: implications for clinical and epidemiological surveillance in a malaria elimination context
    María Eugenia Castellanos
    Centro de Estudios en Salud, Universidad del Valle de Guatemala, 18 avenida 11 95 zona 15 Vista Hermosa 3, Guatemala, Guatemala
    Malar J 11:411. 2012
    ....
  3. pmc Intermittent preventive treatment with sulfadoxine-pyrimethamine does not modify plasma cytokines and chemokines or intracellular cytokine responses to Plasmodium falciparum in Mozambican children
    Diana Quelhas
    Centro de Investigação em Saúde da Manhiça, Manhiça, Mozambique
    BMC Immunol 13:5. 2012
    ..Multiple cytokines and chemokines were quantified in plasma by luminex, and antigen-specific cytokine production in whole blood was determined by intracellular cytokine staining and flow cytometry, at ages 5, 9, 12 and 24 months...
  4. pmc Determinants of household demand for bed nets in a rural area of southern Mozambique
    Claire Chase
    Harvard School of Public Health, Department of Global Health and Population, Boston, MA, USA
    Malar J 8:132. 2009
    ..Few studies have analysed the determinants of demand for bed nets for malaria prevention at the household level, and in particular, how demand for nets compares with demand for other mosquito prevention methods...
  5. ncbi request reprint Reducing the burden of malaria in pregnancy by preventive strategies
    Clara Menendez
    Center for International Health, Hospital Clinic Barcelona University, Barcelona, Spain
    Lancet Infect Dis 7:126-35. 2007
    ....
  6. ncbi request reprint Malaria during pregnancy
    C Menendez
    Center for International Health, Hospital Clinic IDIBAPS, University of Barcelona, Spain
    Curr Mol Med 6:269-73. 2006
    ....
  7. pmc A randomized placebo-controlled trial of intermittent preventive treatment in pregnant women in the context of insecticide treated nets delivered through the antenatal clinic
    Clara Menendez
    Barcelona Center for International Health Research CRESIB and Department of Pathology Hospital Clinic, Institut d Investigacions Biomedicas August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 3:e1934. 2008
    ..Current recommendations to prevent malaria in African pregnant women rely on insecticide treated nets (ITNs) and intermittent preventive treatment (IPTp). However, there is no information on the safety and efficacy of their combined use...
  8. pmc An autopsy study of maternal mortality in Mozambique: the contribution of infectious diseases
    Clara Menendez
    Barcelona Center for International Health Research CRESIB and Department of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Universitat de Barcelona, Spain
    PLoS Med 5:e44. 2008
    ..The aim of this study was to accurately describe the causes of maternal death in order to contribute to its reduction, in one of the regions of the world with the highest maternal mortality ratios...
  9. pmc Varying efficacy of intermittent preventive treatment for malaria in infants in two similar trials: public health implications
    Clara Menendez
    Barcelona Center for International Health Research CRESIB, Hospital Clinic, Institut d Investigacions Biomedicas August Pi i Sunyer IDIBAPS, Universitat de Barcelona, Spain
    Malar J 6:132. 2007
    ..Understanding the reasons for the discrepant results will help to elucidate the action mechanism of this intervention, which is essential for rational policy formulation...
  10. ncbi request reprint The impact of placental malaria on gestational age and birth weight
    C Menendez
    Unidad de Epidemiologia y Bioestadistica, Hospital Clinic, E 08036, Barcelona, Spain
    J Infect Dis 181:1740-5. 2000
    ..This study also shows that placental malaria causes prematurity even in high-transmission areas. The impact of maternal malaria on infant mortality may be greater than was thought previously...
  11. ncbi request reprint Congenital malaria: the least known consequence of malaria in pregnancy
    Clara Menendez
    Barcelona Center for International Health Research CRESIB, Hospital Clinic, Institut d Investigacions Biomedicas August Pi i Sunyer, University of Barcelona, Spain
    Semin Fetal Neonatal Med 12:207-13. 2007
    ..There is also a lack of consensus on the clinical guidelines for its management. More research is needed in order to establish adequate preventive and management recommendations to avoid this consequence of malaria in pregnancy...
  12. ncbi request reprint Malaria-related anaemia
    C Menendez
    Unidad de Epidemiologia y Bioestadisica, Hospital Clinic, Barcelona, Spain
    Parasitol Today 16:469-76. 2000
    ..In this review, Clara Menendez, Alan Fleming and Pedro Alonso focus on recent advances in our knowledge of the pathophysiology, epidemiology, ..
  13. pmc Malaria prevention with IPTp during pregnancy reduces neonatal mortality
    Clara Menendez
    Barcelona Centre for International Health Research CRESIB, Hospital Clinic, Institut d Investigacions Biomedicas August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 5:e9438. 2010
    ..Malaria in pregnancy may affect neonatal survival, though no strong evidence exists to support this association...
  14. pmc Sub-microscopic infections and long-term recrudescence of Plasmodium falciparum in Mozambican pregnant women
    Alfredo Mayor
    Centre de Recerca en Salut Internacional de Barcelona, Hospital Clinic Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Rosselló 132, E 08036 Barcelona, Spain
    Malar J 8:9. 2009
    ..Control of malaria in pregnancy remains a public health challenge. Improvements in its correct diagnosis and the adequacy of protocols to evaluate anti-malarial drug efficacy in pregnancy, are essential to achieve this goal...
  15. doi request reprint The effect of intermittent preventive treatment during pregnancy on malarial antibodies depends on HIV status and is not associated with poor delivery outcomes
    Elisa Serra-Casas
    Barcelona Centre for International Health Research, Hospital Clinic Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
    J Infect Dis 201:123-31. 2010
    ..However, studies reporting the effect of IPTp on malaria-specific immunity are scarce and are based on findings in human immunodeficiency virus (HIV)-negative primigravidae...
  16. pmc Impact of malaria at the end of pregnancy on infant mortality and morbidity
    Azucena Bardaji
    Barcelona Centre for International Health Research and Department of Pathology, Hospital Clinic, Institut d Investigacions Biomedicas August Pi i Sunyer, Universitat de Barcelona, Spain
    J Infect Dis 203:691-9. 2011
    ..There is some consensus that malaria in pregnancy may negatively affect infant's mortality and malaria morbidity, but there is less evidence concerning the factors involved...
  17. ncbi request reprint Severe pneumonia in Mozambican young children: clinical and radiological characteristics and risk factors
    Betuel Sigauque
    Centro de Investigação em Saúde da Manhiça, Maputo, Mozambique
    J Trop Pediatr 55:379-87. 2009
    ..Pneumonia is a leading cause of hospitalization and death among children in Africa. We describe the clinical presentation of severe pneumonia among hospitalized children in a malaria endemic area with a high prevalence of HIV infection...
  18. doi request reprint HIV and placental infection modulate the appearance of drug-resistant Plasmodium falciparum in pregnant women who receive intermittent preventive treatment
    Clara Menendez
    Barcelona Centre for International Health Research, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    Clin Infect Dis 52:41-8. 2011
    ..We aimed to determine the impact of IPTp and human immunodeficiency virus (HIV) infection on molecular markers of SP resistance and the clinical relevance of resistant infections...
  19. pmc Malaria in rural Mozambique. Part II: children admitted to hospital
    Quique Bassat
    Barcelona Center for International Health Research CRESIB, Hospital Clinic Institut d Investigacions Biomediques August Pi i Sunyer, University of Barcelona, Rosselló 132, E 08036 Barcelona, Spain
    Malar J 7:37. 2008
    ..Minimum community based-incidence rates (MCBIRs) complement hospital data, describing the malaria burden in the community...
  20. ncbi request reprint Impact of maternal human immunodeficiency virus infection on birth outcomes and infant survival in rural Mozambique
    Denise Naniche
    Barcelona Center for International Health Research, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
    Am J Trop Med Hyg 80:870-6. 2009
    ..6-22.4). Assessment of the impact of HIV infection on birth outcomes in rural Africa is essential for tailoring public health measures to reduce mother-to-child transmission of HIV and excess infant mortality...
  21. ncbi request reprint Molecular markers of resistance to sulfadoxine-pyrimethamine during intermittent preventive treatment for malaria in Mozambican infants
    Alfredo Mayor
    Centre de Recerca en Salut Internacional de Barcelona, Hospital Clínic Institut d Investigacions Biomèdicas August Pí i Sunyer, Universitat de Barcelona, Barcelona, Spain
    J Infect Dis 197:1737-42. 2008
    ..There is concern about the impact that increasing in vivo resistance to SP has on the efficacy of IPTi, as well as about the potential contribution of IPTi to increases in resistance...
  22. pmc The epidemiology of malaria in adults in a rural area of southern Mozambique
    Alfredo Mayor
    Center for International Health, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain
    Malar J 6:3. 2007
    ..The present study was undertaken to investigate the clinical, parasitological and haematological status of adults exposed to malaria, and to characterize parasites in these individuals who progressively acquire protective immunity...
  23. pmc Assessment of exposure to DDT and metabolites after indoor residual spraying through the analysis of thatch material from rural African dwellings
    Maria N Manaca
    Centro de Investigação em Saúde da Manhiça CISM, Maputo, Mozambique
    Environ Sci Pollut Res Int 19:756-62. 2012
    ..This approach was used to assess the exposure to DDT in the residents of the dwellings after indoor residual spraying (IRS) following recommended sanitation practices against malaria vectors...
  24. doi request reprint Severe malnutrition among children under the age of 5 years admitted to a rural district hospital in southern Mozambique
    Tacilta Nhampossa
    Centro de Investigação em Saúde da Manhiça CISM, Vila da Manhiça, Rua 12, PO Box 1929, Maputo, Mozambique
    Public Health Nutr 16:1565-74. 2013
    ..To describe the burden, clinical characteristics and prognostic factors of severe malnutrition in children under the age of 5 years...
  25. ncbi request reprint Relationship between haemoglobin and haematocrit in the definition of anaemia
    Llorenç Quintó
    Centre de Salut Internacional, CSI, Hospital Clinic IDIBAPS, Universitat de Barcelona, Barcelona, Spain
    Trop Med Int Health 11:1295-302. 2006
    ..Haematocrit (Hct) (%) is usually defined as three times the value of haemoglobin (Hgb) (g/dl), while the clinical definition of anaemia is related to either an abnormal Hct or Hgb value...
  26. pmc Clinical malaria in African pregnant women
    Azucena Bardaji
    Barcelona Centre for International Health Research, Hospital Clinic, Institut d Investigacions Biomedicas August Pi i Sunyer IDIBAPS, Universitat de Barcelona, Barcelona, Spain
    Malar J 7:27. 2008
    ..This study aim to characterize the clinical presentation of malaria in African pregnant women and to evaluate the adequacy of case management based on clinical complaints...
  27. ncbi request reprint Reduction of antimalarial antibodies by HIV infection is associated with increased risk of Plasmodium falciparum cord blood infection
    Denise Naniche
    Barcelona Centre for International Health Research CRESIB, Hospital Clínic Universitat de Barcelona, Spain
    J Infect Dis 205:568-77. 2012
    ..Human immunodeficiency virus (HIV) might increase cord blood P. falciparum infection by decreasing maternal antimalarial-specific antibodies...
  28. pmc Persistence of Plasmodium falciparum parasites in infected pregnant Mozambican women after delivery
    Elisa Serra-Casas
    Barcelona Centre for International Health Research, Hospital Clinic, Universitat de Barcelona, Rosselló 132, 08036 Barcelona, Spain
    Infect Immun 79:298-304. 2011
    ..Interventions that reduce malaria during pregnancy may translate into a lower risk of postpartum infection...
  29. pmc Clinico-pathological discrepancies in the diagnosis of causes of maternal death in sub-Saharan Africa: retrospective analysis
    Jaume Ordi
    Department of Pathology Hospital Clinic, Universitat de Barcelona, Institut d Investigacions Biomediques August Pi i Sunyer, Barcelona, Spain
    PLoS Med 6:e1000036. 2009
    ..Clinical diagnostic errors may play a significant role in this problem and might also have major implications for the evaluation of current estimations of causes of maternal death...
  30. ncbi request reprint Seasonal variations in maternal mortality in Maputo, Mozambique: the role of malaria
    Cleofe Romagosa
    Department of Pathology, Hospital Clinic, University of Barcelona Institut d Investigacions Biomèdiques August Pi i Sunyer, Barcelona, Spain
    Trop Med Int Health 12:62-7. 2007
    ..To evaluate the impact of malaria on maternal death through the analysis of the seasonal variations of crude and malaria-specific maternal mortality rates...
  31. pmc Malaria in rural Mozambique. Part I: children attending the outpatient clinic
    Caterina Guinovart
    Barcelona Center for International Health Research CRESIB, Hospital Clinic Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Rosselló 132, E 08036 Barcelona, Spain
    Malar J 7:36. 2008
    ..Malaria represents a huge burden for the health care services across Africa. Describing malaria attending health services contributes to quantify the burden and describe the epidemiology and clinical presentation...
  32. ncbi request reprint Duration of protection with RTS,S/AS02A malaria vaccine in prevention of Plasmodium falciparum disease in Mozambican children: single-blind extended follow-up of a randomised controlled trial
    Pedro L Alonso
    Centre de Salut Internacional, Hospital Clinic Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Villarroel 170, 08036 Barcelona, Spain
    Lancet 366:2012-8. 2005
    ..An important remaining issue is the durability of protection against clinical disease in these children...
  33. pmc Immunoglobulins against the surface of Plasmodium falciparum-infected erythrocytes increase one month after delivery
    Alfredo Mayor
    Barcelona Centre for International Health Research, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    Malar J 11:130. 2012
    ..Immunological and physiological alterations associated with pregnancy that persist after delivery may contribute to the susceptibility to P. falciparum during early postpartum period...
  34. pmc Age-dependent IgG subclass responses to Plasmodium falciparum EBA-175 are differentially associated with incidence of malaria in Mozambican children
    Carlota Dobano
    Barcelona Centre for International Health Research, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    Clin Vaccine Immunol 19:157-66. 2012
    ..Deeper understanding of the acquisition of antibodies against vaccine target antigens in early infancy is crucial for the rational development and deployment of malaria control tools in this vulnerable population...
  35. pmc Age interactions in the development of naturally acquired immunity to Plasmodium falciparum and its clinical presentation
    John J Aponte
    Barcelona Centre for International Health Research, Hospital Clinic IDIBAPS, Universitat de Barcelona, Barcelona, Spain
    PLoS Med 4:e242. 2007
    ..We investigated the role of age in disease incidence and the effects of chemoprophylaxis on clinical immunity development to Plasmodium falciparum during a randomised controlled trial...
  36. ncbi request reprint Severity of anaemia is associated with bone marrow haemozoin in children exposed to Plasmodium falciparum
    Ruth Aguilar
    Barcelona Centre for International Health Research CRESIB, Hospital Clinic University of Barcelona, Barcelona, Spain CIBER Epidemiology and Public Health CIBERESP, Barcelona, Spain Manhiça Health Research Centre CISM, Maputo, Mozambique
    Br J Haematol 164:877-87. 2014
    ..This finding may have clinical implications for the development of drugs targeted to prevent and treat malarial-anaemia...
  37. pmc Erythropoietin levels are not independently associated with malaria-attributable severe disease in Mozambican children
    Núria Díez-Padrisa
    Centre de Recerca en Salut Internacional de Barcelona, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 6:e24090. 2011
    ..Severe malaria is difficult to differentiate from other forms of malaria or other infections with similar symptoms. Any parameter associated to malaria-attributable severe disease could help to improve severe malaria diagnosis...
  38. pmc Antimicrobial drug resistance trends of bacteremia isolates in a rural hospital in southern Mozambique
    Inacio Mandomando
    Centro de Investigação em Saúde da Manhiça, Vila da Manhiça, Rua 12, PO Box 1929, Maputo, Mozambique
    Am J Trop Med Hyg 83:152-7. 2010
    ..Quinolones and third-generation cephalosporines may be needed in the short term to manage community-acquired infections...
  39. doi request reprint Population characteristics of young African women influencing prenatal exposure to DDT (Manhiça, Mozambique)
    Maria N Manaca
    Centro de Investigação em Saúde da Manhiça, Maputo, Mozambique
    Environ Sci Pollut Res Int 20:3472-9. 2013
    ..Children from multiparae women showed much lower concentrations than primiparae women. Children from mothers with secondary school level exhibited lower concentrations of these pesticides than mothers with lower degree of education...
  40. doi request reprint How hidden can malaria be in pregnant women? Diagnosis by microscopy, placental histology, polymerase chain reaction and detection of histidine-rich protein 2 in plasma
    Alfredo Mayor
    Barcelona Center for International Health Research, Hospital Clínic Universitat de Barcelona, Spain
    Clin Infect Dis 54:1561-8. 2012
    ..The performance of different methods to detect P. falciparum in pregnancy and the clinical relevance of undetected infections were evaluated...
  41. doi request reprint Drug exposure and pregnancy outcome in Mozambique
    Esperança Sevene
    Universidade Eduardo Mondlane, Faculdade de Medicina, CIMed, Maputo, Mozambique
    Paediatr Drugs 14:43-9. 2012
    ..The intake of medicines during pregnancy can have negative or toxic effects on the fetus, possibly leading to adverse pregnancy outcomes...
  42. ncbi request reprint A randomized comparison of two anemia treatment regimens in Tanzanian children
    David Schellenberg
    Centre for International Health, Institut d Investigacions Biomedicas August Pi i Sunyer, Hospital Clinic, Villarroel 170, Barcelona 08036, Spain
    Am J Trop Med Hyg 71:428-33. 2004
    ..06). Compliance was satisfactory in only 39% (82 of 209) of the children in the first week of treatment. Extending the duration of therapy and improving compliance may have health benefits for anemic children in malaria-endemic settings...
  43. pmc Transcription of var genes other than var2csa in Plasmodium falciparum parasites infecting Mozambican pregnant women
    Eduard Rovira-Vallbona
    Barcelona Centre for International Health Research, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    J Infect Dis 204:27-35. 2011
    ..This phenomenon is mediated by a var gene coding for VAR2CSA, which adheres to chondroitin sulphate A. However, the contribution of parasites transcribing other var genes to maternal infections has not been well characterized...
  44. pmc Parity and placental infection affect antibody responses against Plasmodium falciparum during pregnancy
    Alfredo Mayor
    Barcelona Centre for International Health Research CRESIB, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    Infect Immun 79:1654-9. 2011
    ..Results of this study show that parity and placental infection can modulate immune responses during pregnancy against malaria parasites...
  45. ncbi request reprint Efficacy and safety of intermittent preventive treatment with sulfadoxine-pyrimethamine for malaria in African infants: a pooled analysis of six randomised, placebo-controlled trials
    John J Aponte
    Barcelona Centre for International Health Research, Hospital Clinic, University of Barcelona, Barcelona, Spain
    Lancet 374:1533-42. 2009
    ..Intermittent preventive treatment (IPT) is a promising strategy for malaria control in infants. We undertook a pooled analysis of the safety and efficacy of IPT in infants (IPTi) with sulfadoxine-pyrimethamine in Africa...
  46. ncbi request reprint Haematological and biochemical indices in young African children: in search of reference intervals
    Llorenç Quintó
    Centre de Salut Internacional, Hospital Clinic IDIBAPS, Universitat de Barcelona, Barcelona, Spain
    Trop Med Int Health 11:1741-8. 2006
    ..Few studies have been performed in Africa questioning the validity of these values when applied to local African populations...
  47. doi request reprint Rapid suppression of HIV-RNA is associated with improved control of immune activation in Mozambican adults initiating antiretroviral therapy with low CD4 counts
    Jose M Almeida
    Centro de Investigação em Saúde de Manhiça, Maputo, Mozambique
    AIDS Res Hum Retroviruses 27:705-11. 2011
    ..001). This study suggests that rapid suppression of HIV-RNA may lead to a lower rate of reappearance of HIV-RNA, which could impact CD8 T cell activation levels in patients initiating cART at low CD4 counts...
  48. doi request reprint Community-acquired bacteremia among children admitted to a rural hospital in Mozambique
    Betuel Sigauque
    Centro de Investigação em Saúde da Manhiça, Maputo, Mozambique
    Pediatr Infect Dis J 28:108-13. 2009
    ..Although community-acquired bacteremia is an important cause of childhood mortality in Africa, recognition of disease burden and potential impact of bacterial vaccines is limited...
  49. ncbi request reprint The changing epidemiology of malaria in Ifakara Town, southern Tanzania
    David Schellenberg
    Centre for International Health, Institut de Investigaciones Biomedicas August Pi I Sunyer, Barcelona, Spain
    Trop Med Int Health 9:68-76. 2004
    ..Even in low/moderate malaria transmission settings, where older children suffer most malaria episodes, targeting effective malaria control at infants may produce important reductions in infant mortality caused by malaria...
  50. pmc VAR2CSA signatures of high Plasmodium falciparum parasitemia in the placenta
    Eduard Rovira-Vallbona
    Barcelona Centre for International Health Research, CRESIB, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 8:e69753. 2013
    ..Sequences contributing to high parasitemia may be critical for the functional characterization of VAR2CSA and the development of tools against placental malaria. ..
  51. ncbi request reprint The safety and efficacy of sulfadoxine-pyrimethamine, amodiaquine, and their combination in the treatment of uncomplicated Plasmodium falciparum malaria
    David Schellenberg
    Unidad de Epidemiologia, Hospital Clinic, Barcelona, Spain
    Am J Trop Med Hyg 67:17-23. 2002
    ..6% vs. SP 29.9%; P = 0.001). The level of R1 resistance to SP may herald a rapid decline in its efficacy as SP drug pressure increases. Coadministration of AQ+SP may delay this...
  52. pmc Low antibodies against Plasmodium falciparum and imbalanced pro-inflammatory cytokines are associated with severe malaria in Mozambican children: a case-control study
    Eduard Rovira-Vallbona
    Barcelona Centre for International Health Research, CRESIB, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    Malar J 11:181. 2012
    ..Altered antibody and cellular immunity against P. falciparum might contribute to increase the risk of developing SM...
  53. pmc Costs associated with low birth weight in a rural area of Southern Mozambique
    Elisa Sicuri
    Barcelona Centre for International Health Research CRESIB, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 6:e28744. 2011
    ..This study aims to estimate the costs to the health system and to the household and the Disability Adjusted Life Years (DALYs) arising from infant deaths associated with LBW in Southern Mozambique...
  54. ncbi request reprint Severe malaria and concomitant bacteraemia in children admitted to a rural Mozambican hospital
    Quique Bassat
    Barcelona Center for International Health Research, University of Barcelona, Barcelona, Spain
    Trop Med Int Health 14:1011-9. 2009
    ..To describe the prevalence, aetiology and prognostic implications of coexisting invasive bacterial disease in children admitted with severe malaria in a rural Mozambican Hospital...
  55. ncbi request reprint The effects of short-term iron supplementation on iron status in infants in malaria-endemic areas
    Clara Menendez
    Center for International Health y Departamento de Bioquimica Clínica Institut d Investigacions Biome diques August Pi i Sunyer Hospital Clinic, Villarroeal 170, E 08036, Barcelona, Spain
    Am J Trop Med Hyg 71:434-40. 2004
    ..7% versus 37.3% at 12 months of age). We concluded that iron supplementation between the ages of 2-6 months improves iron status at least up to 12 months of age. Malaria infection does not contribute to iron deficiency...
  56. ncbi request reprint Intermittent preventive antimalarial treatment for Tanzanian infants: follow-up to age 2 years of a randomised, placebo-controlled trial
    David Schellenberg
    Centre for International Health, Institut d Investigacions Biomedicas August Pi i Sunyer IDIBAPS, Hospital Clinic, Barcelona, Spain
    Lancet 365:1481-3. 2005
    ....
  57. ncbi request reprint Impact of HIV Exposure on Health Outcomes in HIV-Negative Infants Born to HIV-Positive Mothers in Sub-Saharan Africa
    Cinta Moraleda
    Manhiça Health Research Centre CISM, Maputo, Mozambique Barcelona Centre for International Health Research CRESIB, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain National Institute of Health, Maputo, Mozambique and National Directorate of Health, Ministry of Health, Maputo, Mozambique
    J Acquir Immune Defic Syndr 65:182-9. 2014
    ..Up to 30% of infants may be HIV-exposed noninfected (ENI) in countries with high HIV prevalence, but the impact of maternal HIV on the child's health remains unclear...
  58. pmc Similar efficacy and safety of artemether-lumefantrine (Coartem®) in African infants and children with uncomplicated falciparum malaria across different body weight ranges
    Quique Bassat
    Barcelona Centre for International Health Research CRESIB, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
    Malar J 10:369. 2011
    ..The objectives of the current analysis were to compare the efficacy and safety of AL across different body weight ranges in African children, and to examine the age and body weight relationship in this population...
  59. pmc A targeted association study of immunity genes and networks suggests novel associations with placental malaria infection
    Martin Sikora
    Institute of Evolutionary Biology UPF CSIC, CEXS UPF PRBB, Barcelona, Catalonia, Spain
    PLoS ONE 6:e24996. 2011
    ..To our knowledge, this is the first large-scale genetic study on placental malaria infection to date, opening the door for follow-up studies trying to elucidate the genetic basis of this neglected form of malaria...
  60. pmc Association of severe malaria outcomes with platelet-mediated clumping and adhesion to a novel host receptor
    Alfredo Mayor
    Barcelona Centre for International Health Research CRESIB, Hospital Clínic Institut d Investigacions Biomèdiques August Pi i Sunyer IDIBAPS, Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 6:e19422. 2011
    ..Identification of P. falciparum cytoadherence phenotypes that are associated with severe malaria may lead to the development of novel strategies against life-threatening malaria...
  61. ncbi request reprint A variant in the gene FUT9 is associated with susceptibility to placental malaria infection
    Martin Sikora
    Institute of Evolutionary Biology UPF CSIC, CEXS UPF PRBB, Barcelona, Catalonia, Spain
    Hum Mol Genet 18:3136-44. 2009
    ..These results therefore suggest an involvement of this antigen in the pathogenesis of placental malaria infection...
  62. doi request reprint Concentration of DDT compounds in breast milk from African women (Manhiça, Mozambique) at the early stages of domestic indoor spraying with this insecticide
    Maria N Manaca
    Centro de Investigação em Saúde da Manhiça CISM, Maputo, Mozambique
    Chemosphere 85:307-14. 2011
    ..These differences overcome the age effect in DDT accumulation between the two groups and evidence that women transfer a significant proportion of their body burden of DDT and its metabolites to their infants...
  63. doi request reprint Improved pregnancy outcomes in women exposed to malaria with high antibody levels against Plasmodium falciparum
    Alfredo Mayor
    Barcelona Center for International Health Research, Hospital Clínic Universitat de Barcelona, Spain
    J Infect Dis 207:1664-74. 2013
    ..Here, we aimed to identify clinically relevant antibody responses, taking into consideration variations in parasite exposure and human immunodeficiency virus type 1 (HIV) infection status...
  64. pmc Incidence and predictors of immune reconstitution inflammatory syndrome in a rural area of Mozambique
    Emilio Letang
    Centro de Investigação em Saúde de Manhiça, Manhiça, Maputo, Mozambique
    PLoS ONE 6:e16946. 2011
    ..A prospective observational cohort study was conducted to assess the incidence, clinical characteristics, outcome and predictors of IRIS in rural Mozambique...
  65. doi request reprint Comparison of placental blood microscopy and the ICT HRP2 rapid diagnostic test to detect placental malaria
    Ruth Aguilar
    Barcelona Centre for International Health Research CRESIB, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    Trans R Soc Trop Med Hyg 106:573-5. 2012
    ..Discordances were found at low parasitemias (<500 parasites/μL) or negative microscopy. The results suggest that the HRP2-RDTs from ICT diagnostics is a good alternative to microscopy for diagnosing placental malaria at delivery...
  66. ncbi request reprint Polarisation microscopy increases the sensitivity of hemozoin and Plasmodium detection in the histological assessment of placental malaria
    Cleofe Romagosa
    Department of Anatomical Pathology, Facultat de Medicina, Institut d Investigacions Biomèdiques August Pi i Sunyer Hospital Clínic, Universitat de Barcelona, Villarroel 170, 08036 Barcelona, Spain
    Acta Trop 90:277-84. 2004
    ..This method can be useful to investigators working in the malaria field...
  67. pmc Rosetting in Plasmodium vivax: a cytoadhesion phenotype associated with anaemia
    Alejandro Marín-Menéndez
    Barcelona Centre for International Health Research CRESIB, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    PLoS Negl Trop Dis 7:e2155. 2013
    ..vivax sequestration and organ injury although its physiological impact is still unknown. Here, we aimed to describe clinically-relevant cytoadhesive phenotypes of P. vivax isolates...
  68. ncbi request reprint Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study
    Silvia de Sanjose
    IDIBELL, Institut Català d Oncologia Catalan Institute of Oncology, L Hospitalet de Llobregat, Barcelona, Spain
    Lancet Oncol 11:1048-56. 2010
    ..We aimed to provide novel and comprehensive data about the worldwide genotype distribution in patients with invasive cervical cancer...
  69. ncbi request reprint Efficacy of the RTS,S/AS02A vaccine against Plasmodium falciparum infection and disease in young African children: randomised controlled trial
    Pedro L Alonso
    Centre de Salut Internacional, Hospital Clinic IDIBAPS, Universitat de Barcelona, Barcelona, Spain
    Lancet 364:1411-20. 2004
    ..RTS,S/AS02A is a pre-erythrocytic vaccine candidate based on Plasmodium falciparum circumsporozoite surface antigen. We aimed to assess vaccine efficacy, immunogenicity, and safety in young African children...
  70. pmc Challenges in the diagnosis of iron deficiency in children exposed to high prevalence of infections
    Ruth Aguilar
    Barcelona Centre for International Heath Research, Hospital Clinic, University of Barcelona, Barcelona, Spain
    PLoS ONE 7:e50584. 2012
    ..With the objective of improving iron deficiency diagnosis and thus, its management, we evaluated the performance of iron markers in children exposed to high infection pressure...
  71. doi request reprint Intermittent preventive treatment of malaria in pregnant women and infants: making best use of the available evidence
    Azucena Bardaji
    University of Barcelona, Hospital Clinic, Barcelona Centre for International Health Research, Roselló, 132, 08036, Barcelona, Spain
    Expert Opin Pharmacother 13:1719-36. 2012
    ..Yet, the effectiveness of the IPT strategy may be impaired by the increasing resistance to sulfadoxine-pyrimethamine (SP), and the scarcity of alternative antimalarial drugs...
  72. pmc Cost-effectiveness of intermittent preventive treatment of malaria in pregnancy in southern Mozambique
    Elisa Sicuri
    Barcelona Centre for International Health Research RESIB, Hospital Clinic IDIBAPS, Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 5:e13407. 2010
    ..Malaria in pregnancy is a public health problem for endemic countries. Economic evaluations of malaria preventive strategies in pregnancy are needed to guide health policies...
  73. doi request reprint Rapid spread and genetic diversification of HIV type 1 subtype C in a rural area of southern Mozambique
    Maria Lahuerta
    Barcelona Center for International Health Research CRESIB, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Universtitat de Barcelona, Barcelona, Spain
    AIDS Res Hum Retroviruses 24:327-35. 2008
    ..These results indicate the rapid spread and diversification of subtype C virus in Mozambique where HIV-1 prevalence in the Manhiça antenatal clinic reached 23% in 2004...
  74. pmc Dihydroartemisinin-piperaquine and artemether-lumefantrine for treating uncomplicated malaria in African children: a randomised, non-inferiority trial
    Quique Bassat
    Barcelona Centre for International Health Research CRESIB, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 4:e7871. 2009
    ..Dihydroartemisinin-piperaquine (DHA-PQP) is a promising fixed-dose ACT with limited information on its safety and efficacy in African children...
  75. doi request reprint Development of vaccines to prevent malaria in pregnant women: WHO MALVAC meeting report
    Clara Menendez
    Barcelona Center for International Health Research CRESIB, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    Expert Rev Vaccines 10:1271-80. 2011
    ..We conclude with the formulation of a conceptual framework for research and development for vaccines to prevent malaria in pregnant women...
  76. ncbi request reprint Community response to intermittent preventive treatment delivered to infants (IPTi) through the EPI system in Manhiça, Mozambique
    Robert Pool
    London School of Hygiene and Tropical Medicine, London, UK, and Center for International Health, Hospital Clinic, IDIBAPS, Barcelona, Spain
    Trop Med Int Health 11:1670-8. 2006
    ..In particular, whether the introduction of IPTi negatively affects community attitudes to, or use of, EPI; or, conversely, whether and if so how, the concurrent delivery of IPTi and immunization influences perceptions of IPTi...
  77. pmc Inadequate efficacy of a new formulation of fosmidomycin-clindamycin combination in Mozambican children less than three years old with uncomplicated Plasmodium falciparum malaria
    Miguel Lanaspa
    Barcelona Centre for International Health Research, CRESIB, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    Antimicrob Agents Chemother 56:2923-8. 2012
    ..Additional studies should be conducted to respond to the many uncertainties arising from this trial, which should not discourage further evaluation of this promising combination...
  78. doi request reprint HIV and malaria interactions: where do we stand?
    Raquel Gonzalez
    Barcelona Centre for International Heath Research CRESIB, Hospital Clinic IDIBAPS, Universitat de Barcelona, Spain
    Expert Rev Anti Infect Ther 10:153-65. 2012
    ..We focus on the latest available data, pointing out key future research areas and challenges of the field...
  79. pmc Cost-effectiveness of intermittent preventive treatment of malaria in infants (IPTi) for averting anaemia in Gabon: a comparison between intention to treat and according to protocol analyses
    Elisa Sicuri
    Barcelona Centre for International Health Research, Hospital Clinic, Universitat de Barcelona, Rosselló 132, Barcelona 08036, Spain
    Malar J 10:305. 2011
    ..Specifically, ATP was statistically significant, while ITT analysis was borderline. The main reason for the difference between ITT and ATP populations was migration...
  80. ncbi request reprint Treatment and prevention of malaria in pregnancy and newborn
    Oriol Coll
    Department of Maternal Fetal Medicine, Institut Clinic de Ginecologia, Obstetricia i Neonatologia, Institut d Investigacions Biomediques August Pi i Sunyer, Hospital Clinic de Barcelona, Barcelona, Spain
    J Perinat Med 36:15-29. 2008
    ..In this paper, we review the pathology, diagnosis, and current recommendations for treatment and prevention of malaria in the pregnant woman and her infant...
  81. ncbi request reprint Malaria infection does not appear to modify the risk of bronchiolitis early in life
    Clara Menendez
    Unidad de Epidemiologia y Bioestadistica, Institut d Investigaciones Mediques August Pi i Sunyer, Hospital Clinic, Barcelona, Spain
    Pediatr Infect Dis J 21:249-54. 2002
    ..Information on the role of parasites in this context is limited. Bronchiolitis in infancy has been linked with asthmatic symptoms later in childhood, although the underlying cause of this association is unknown...
  82. doi request reprint Pyrethroid use-malaria control and individual applications by households for other pests and home garden use
    Maria Luisa Feo
    Institute of Environmental Assessment and Water Research IDÆA CSIC, Jordi Girona, Barcelona, Catalonia, Spain
    Environ Int 38:67-72. 2012
    ....
  83. ncbi request reprint Guidelines and considerations for testing malaria vaccines in pregnant women
    Clara Menendez
    Barcelona Center for International Health Research CRESIB, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Universitat de Barcelona, Spain
    Hum Vaccin 6:21-6. 2010
    ....
  84. ncbi request reprint Vaccine-related HPV genotypes in women with and without cervical cancer in Mozambique: burden and potential for prevention
    Xavier Castellsague
    IDIBELL, Institut Català d Oncologia ICO, L Hospitalet de Llobregat, Barcelona, Spain
    Int J Cancer 122:1901-4. 2008
    ..The introduction of an efficacious HPV 16/18 vaccine could potentially prevent the occurrence of 72% of cervical cancer cases and up to 81% of the cases if full cross-protection against HPVs 31 and 45 is assumed...
  85. ncbi request reprint Treatment and prevention of malaria in pregnancy: opportunities and challenges
    Stephen J Rogerson
    University of Melbourne, Department of Medicine, Royal Melbourne Hospital, Australia
    Expert Rev Anti Infect Ther 4:687-702. 2006
    ..Prevention of pregnancy malaria by vaccination may also become possible, but targets must be closely defined, and strategies developed to test candidates against meaningful end points...
  86. ncbi request reprint Antimalarial drugs in pregnancy: a review
    Francois Nosten
    Shoklo Malaria Research Unit, 63110 Mae Sot, Thailand
    Curr Drug Saf 1:1-15. 2006
    ..For these reasons there is an urgent need to assess the safety and efficacy of antimalarial treatments in pregnancy, including artemisinin based combination therapies...
  87. ncbi request reprint Intermittent preventive treatment for malaria control administered at the time of routine vaccinations in Mozambican infants: a randomized, placebo-controlled trial
    Eusebio Macete
    Manhiça Health Research Center, Manhiça, Mozambique
    J Infect Dis 194:276-85. 2006
    ..There is an urgent need to deploy and develop new control tools that will reduce the intolerable burden of malaria. Intermittent preventive treatment in infants (IPTi) has the potential to become an effective tool for malaria control...
  88. ncbi request reprint Risk factors for presentation to hospital with severe anaemia in Tanzanian children: a case-control study
    Elizeus Kahigwa
    Ifakara Health Research and Development Centre, Ifakara, Tanzania
    Trop Med Int Health 7:823-30. 2002
    ..The concentration of anaemia in infants and problems of access to health services and adequate case management underline the need for targeted preventive strategies for anaemia control...
  89. ncbi request reprint Malaria in pregnancy in rural Mozambique: the role of parity, submicroscopic and multiple Plasmodium falciparum infections
    Francisco Saute
    Centro de Investigação em Saúde da Manhiça, Instituto Nacional de Saude, Maputo, Mozambique
    Trop Med Int Health 7:19-28. 2002
    ..It also tried to assess the frequency and effect on anaemia of submicroscopic and multiple falciparum infections...
  90. ncbi request reprint The IPTi Consortium: research for policy and action
    David Schellenberg
    Department of Infectious Diseases, London School of Hygiene and Tropical Medicine, University of London, Keppel Street, London WC1E 7HT, UK
    Trends Parasitol 22:296-300. 2006
    ..This review summarizes the available information on IPTi and presents the consortium's approach to determining whether IPTi might be a valuable additional strategy in programs to control malaria...