Juan Mendez

Summary

Country: Spain

Publications

  1. doi request reprint Temporal regulation of DNA replication in mammalian cells
    Juan Mendez
    DNA replication Group, Molecular Oncology Programme, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    Crit Rev Biochem Mol Biol 44:343-51. 2009
  2. pmc Cohesin organizes chromatin loops at DNA replication factories
    Emmanuelle Guillou
    DNA replication Group, Spanish National Cancer Research Centre CNIO, E 28029 Madrid, Spain
    Genes Dev 24:2812-22. 2010
  3. doi request reprint Visualization of the MCM DNA helicase at replication factories before the onset of DNA synthesis
    Tomas Aparicio
    DNA replication Group, Molecular Oncology Programme, Spanish National Cancer Research Centre CNIO, Melchor Fernandez Almagro, 3, 28029, Madrid, Spain
    Chromosoma 121:499-507. 2012
  4. pmc The human GINS complex associates with Cdc45 and MCM and is essential for DNA replication
    Tomas Aparicio
    DNA replication Group, Molecular Oncology Programme, Spanish National Cancer Research Center CNIO, Madrid, Spain
    Nucleic Acids Res 37:2087-95. 2009
  5. pmc Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication
    Arkaitz Ibarra
    DNA replication Group, Molecular Oncology Programme, Spanish National Cancer Research Centre CNIO, Melchor Fernandez Almagro, 3 E 28029 Madrid, Spain
    Proc Natl Acad Sci U S A 105:8956-61. 2008
  6. doi request reprint Genomic stability and tumour suppression by the APC/C cofactor Cdh1
    Irene Garcia-Higuera
    Cell Division and Cancer Group, Centro Nacional de Investigaciones Oncologicas CNIO, Madrid, Spain
    Nat Cell Biol 10:802-11. 2008
  7. ncbi request reprint CDC6: from DNA replication to cell cycle checkpoints and oncogenesis
    Luis R Borlado
    DNA replication Group, Molecular Oncology Programme, Spanish National Cancer Research Centre, Melchor Fernandez Almagro 3, E 28029 Madrid, Spain
    Carcinogenesis 29:237-43. 2008
  8. pmc Molecular architecture of the human GINS complex
    Jasminka Boskovic
    Structural Biology and Biocomputing Programme, Macromolecular Crystallography Group, Spanish National Cancer Research Center CNIO, Madrid, Spain
    EMBO Rep 8:678-84. 2007

Collaborators

  • Marcos Malumbres
  • Ana Losada
  • Tomas Aparicio
  • Emmanuelle Guillou
  • Arkaitz Ibarra
  • Etienne Schwob
  • Irene Garcia-Higuera
  • Luis R Borlado
  • Guillermo Montoya
  • Javier Coloma
  • Jasminka Boskovic
  • Diego Megias
  • Vincent Coulon
  • Ignacio Casal
  • Daniel Rico
  • Juan Casado-Vela
  • Sergio Moreno
  • Marta Canamero
  • Eusebio Manchado
  • Pierre Dubus
  • Min Zhou
  • Carol V Robinson

Detail Information

Publications8

  1. doi request reprint Temporal regulation of DNA replication in mammalian cells
    Juan Mendez
    DNA replication Group, Molecular Oncology Programme, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    Crit Rev Biochem Mol Biol 44:343-51. 2009
    ..This review covers our current understanding of the mechanisms that determine RT in mammalian cells, its possible biological significance and how unscheduled alterations of the RT program may predispose to human disease...
  2. pmc Cohesin organizes chromatin loops at DNA replication factories
    Emmanuelle Guillou
    DNA replication Group, Spanish National Cancer Research Centre CNIO, E 28029 Madrid, Spain
    Genes Dev 24:2812-22. 2010
    ..These results give a new dimension to the role of cohesin in the architectural organization of interphase chromatin, by showing its participation in DNA replication...
  3. doi request reprint Visualization of the MCM DNA helicase at replication factories before the onset of DNA synthesis
    Tomas Aparicio
    DNA replication Group, Molecular Oncology Programme, Spanish National Cancer Research Centre CNIO, Melchor Fernandez Almagro, 3, 28029, Madrid, Spain
    Chromosoma 121:499-507. 2012
    ..Most MCM complexes are released from chromatin, except for a small but detectable fraction that remains at the forks during the S phase, as expected for a replicative helicase...
  4. pmc The human GINS complex associates with Cdc45 and MCM and is essential for DNA replication
    Tomas Aparicio
    DNA replication Group, Molecular Oncology Programme, Spanish National Cancer Research Center CNIO, Madrid, Spain
    Nucleic Acids Res 37:2087-95. 2009
    ..Down-regulation of hGINS destabilizes CMG, causes a G1-S arrest and slows down ongoing DNA replication, effectively blocking cell proliferation. Our data support the notion that hGINS is an essential component of the human replisome...
  5. pmc Excess MCM proteins protect human cells from replicative stress by licensing backup origins of replication
    Arkaitz Ibarra
    DNA replication Group, Molecular Oncology Programme, Spanish National Cancer Research Centre CNIO, Melchor Fernandez Almagro, 3 E 28029 Madrid, Spain
    Proc Natl Acad Sci U S A 105:8956-61. 2008
    ..Our data show that the chromatin-bound "excess" Mcm2-7 complexes play an important role in maintaining genomic integrity under conditions of replicative stress...
  6. doi request reprint Genomic stability and tumour suppression by the APC/C cofactor Cdh1
    Irene Garcia-Higuera
    Cell Division and Cancer Group, Centro Nacional de Investigaciones Oncologicas CNIO, Madrid, Spain
    Nat Cell Biol 10:802-11. 2008
    ..These results indicate that Cdh1 is required for preventing unscheduled proliferation of specific progenitor cells and protecting mammalian cells from genomic instability...
  7. ncbi request reprint CDC6: from DNA replication to cell cycle checkpoints and oncogenesis
    Luis R Borlado
    DNA replication Group, Molecular Oncology Programme, Spanish National Cancer Research Centre, Melchor Fernandez Almagro 3, E 28029 Madrid, Spain
    Carcinogenesis 29:237-43. 2008
    ..These findings indicate that deregulation of CDC6 expression in human cells poses a serious risk of carcinogenesis...
  8. pmc Molecular architecture of the human GINS complex
    Jasminka Boskovic
    Structural Biology and Biocomputing Programme, Macromolecular Crystallography Group, Spanish National Cancer Research Center CNIO, Madrid, Spain
    EMBO Rep 8:678-84. 2007
    ..The structure and DNA-binding data suggest how GINS could interact with DNA and also its possible role in the CMG helicase complex...