Britt Mellstrom

Summary

Country: Spain

Publications

  1. ncbi Gas1 is induced during and participates in excitotoxic neuronal death
    Britt Mellstrom
    Departamento de Biologia Molecular y Celular, Centro Nacional de Biotecnologia, 28049 Madrid, Spain
    Mol Cell Neurosci 19:417-29. 2002
  2. doi Sumoylation regulates nuclear localization of repressor DREAM
    Malgorzata Palczewska
    Centro Nacional de Biotecnologia, CSIC, Madrid, Spain
    Biochim Biophys Acta 1813:1050-8. 2011
  3. doi The DREAM protein is associated with thyroid enlargement and nodular development
    Marcos Rivas
    Departamento Biologia Molecular y Celular, Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Mol Endocrinol 23:862-70. 2009
  4. doi Increased B cell proliferation and reduced Ig production in DREAM transgenic mice
    Magali Savignac
    Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    J Immunol 185:7527-36. 2010
  5. ncbi Calcium-dependent transcription of cytokine genes in T lymphocytes
    Magali Savignac
    Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Pflugers Arch 454:523-33. 2007
  6. ncbi Gas1 is related to the glial cell-derived neurotrophic factor family receptors alpha and regulates Ret signaling
    J Ruben Cabrera
    Department of Molecular and Cellular Biology, Centro Nacional de Biotecnologia, Consejo Superior Investigaciones Cientificas, 28049 Madrid, Spain
    J Biol Chem 281:14330-9. 2006
  7. pmc Ca2+-dependent transcriptional control of Ca2+ homeostasis
    Jose R Naranjo
    National Center of Biotechnology, Consejo Superior de Investigaciones Científicas CSIC and the Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, 28049 Madrid, Spain
    J Biol Chem 287:31674-80. 2012
  8. doi Redox signaling regulates transcriptional activity of the Ca2+-dependent repressor DREAM
    Marcos Rivas
    Dpto Biología Molecular y Celular, Centro Nacional de Biotecnologia, C S I C, Madrid, Spain
    Antioxid Redox Signal 14:1237-43. 2011
  9. doi Ca2+-operated transcriptional networks: molecular mechanisms and in vivo models
    Britt Mellstrom
    Centro Nacional de Biotecnologia, Consejo Superior Investigaciones Cientificas, Madrid, Spain
    Physiol Rev 88:421-49. 2008
  10. ncbi G protein-coupled receptor kinase 2-mediated phosphorylation of downstream regulatory element antagonist modulator regulates membrane trafficking of Kv4.2 potassium channel
    Ana Ruiz-Gomez
    Departamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa Universidad Autonoma de Madrid Consejo Superior de Investigaciones Científicas, Campus de Cantoblanco, 28049 Madrid, Spain
    J Biol Chem 282:1205-15. 2007

Collaborators

  • Jose R Naranjo
  • Ana M Rojas
  • Luis Sanchez-Pulido
  • Pilar Santisteban
  • Monica Lamas
  • Alfonso Gutierrez-Adan
  • S Manes
  • Magali Savignac
  • Marcos Rivas
  • Malgorzata Palczewska
  • Koldo Aurrekoetxea
  • Fran Ledo
  • Alfonso Valencia
  • Rosa Gomez-Villafuertes
  • Ana Ruiz-Gomez
  • Begona Torres
  • J Ruben Cabrera
  • Wolfgang A Link
  • Iñigo Casafont
  • Miguel Lafarga
  • Kedar Ghimire
  • Juan C Oliveros
  • Eric Pinaud
  • Laurent Delpy
  • Anne Gaelle Bebin
  • Gabriella Morreale de Escobar
  • Gaetano Cali
  • Daniela Terracciano
  • Alfonso M Ferrara
  • Mariastella Zannini
  • Daniel Tornero
  • Carmen González-García
  • Federico Mayor
  • Helena Holguin
  • Valentín Ceña
  • Esperanza Morato
  • Paz González
  • Belen Pintado
  • Juan P Albar
  • Torsten M Madsen
  • Leonor Kremer

Detail Information

Publications16

  1. ncbi Gas1 is induced during and participates in excitotoxic neuronal death
    Britt Mellstrom
    Departamento de Biologia Molecular y Celular, Centro Nacional de Biotecnologia, 28049 Madrid, Spain
    Mol Cell Neurosci 19:417-29. 2002
    ..These results indicate that Gas1 is induced by activation of glutamate receptors and is part of the gene expression program directing neuronal death after mild excitotoxic insults...
  2. doi Sumoylation regulates nuclear localization of repressor DREAM
    Malgorzata Palczewska
    Centro Nacional de Biotecnologia, CSIC, Madrid, Spain
    Biochim Biophys Acta 1813:1050-8. 2011
    ..Our results show that sumoylation regulates the nuclear localization of DREAM in differentiated neurons. This article is part of a Special Issue entitled: 11th European Symposium on Calcium...
  3. doi The DREAM protein is associated with thyroid enlargement and nodular development
    Marcos Rivas
    Departamento Biologia Molecular y Celular, Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Mol Endocrinol 23:862-70. 2009
    ..Taken together, these findings identify a mechanism for the control of TSHR activity and provide a new approach for the study and treatment of thyroid pathologies associated with impaired TSHR function...
  4. doi Increased B cell proliferation and reduced Ig production in DREAM transgenic mice
    Magali Savignac
    Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    J Immunol 185:7527-36. 2010
    ..Our results disclose, to our knowledge, a novel function of DREAM in proliferation and Ig synthesis in B lymphocytes...
  5. ncbi Calcium-dependent transcription of cytokine genes in T lymphocytes
    Magali Savignac
    Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Pflugers Arch 454:523-33. 2007
    ..e., NFAT, MEF2, and DREAM, involved in cytokine gene expression...
  6. ncbi Gas1 is related to the glial cell-derived neurotrophic factor family receptors alpha and regulates Ret signaling
    J Ruben Cabrera
    Department of Molecular and Cellular Biology, Centro Nacional de Biotecnologia, Consejo Superior Investigaciones Cientificas, 28049 Madrid, Spain
    J Biol Chem 281:14330-9. 2006
    ..Consequently, when Gas1 is induced, Ret-mediated GDNF-dependent survival effects are compromised...
  7. pmc Ca2+-dependent transcriptional control of Ca2+ homeostasis
    Jose R Naranjo
    National Center of Biotechnology, Consejo Superior de Investigaciones Científicas CSIC and the Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas CIBERNED, 28049 Madrid, Spain
    J Biol Chem 287:31674-80. 2012
    ..Here, we review recent work on Ca(2+)-dependent mechanisms and effectors that regulate the transcription of genes encoding proteins involved in the maintenance of the homeostasis of Ca(2+) in the cell...
  8. doi Redox signaling regulates transcriptional activity of the Ca2+-dependent repressor DREAM
    Marcos Rivas
    Dpto Biología Molecular y Celular, Centro Nacional de Biotecnologia, C S I C, Madrid, Spain
    Antioxid Redox Signal 14:1237-43. 2011
    ..Finally, we show that transient DREAM knockdown sensitizes PC12 cells to H(2)O(2)-induced oxidative stress, suggesting a protective role for DREAM against oxidative damage...
  9. doi Ca2+-operated transcriptional networks: molecular mechanisms and in vivo models
    Britt Mellstrom
    Centro Nacional de Biotecnologia, Consejo Superior Investigaciones Cientificas, Madrid, Spain
    Physiol Rev 88:421-49. 2008
    ..When possible, the review also presents in vivo models in which the genes encoding these calcium sensors-transducers have been modified, to emphasize the critical role of these Ca(2+)-operated mechanisms in many physiological functions...
  10. ncbi G protein-coupled receptor kinase 2-mediated phosphorylation of downstream regulatory element antagonist modulator regulates membrane trafficking of Kv4.2 potassium channel
    Ana Ruiz-Gomez
    Departamento de Biología Molecular and Centro de Biología Molecular Severo Ochoa Universidad Autonoma de Madrid Consejo Superior de Investigaciones Científicas, Campus de Cantoblanco, 28049 Madrid, Spain
    J Biol Chem 282:1205-15. 2007
    ..2 channel trafficking and calcineurin de-phosphorylated GRK2-phosphorylated DREAM in vitro. Our results indicate that these two Ca2+-dependent posttranslational events regulate the activity of DREAM on Kv4.2 channel function...
  11. ncbi Split personality of transcription factors inside and outside the nuclear border
    Jose R Naranjo
    Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    Sci STKE 2007:pe5. 2007
    ..Here we describe three transcription factors that, when outside the nucleus, regulate calcium homeostasis by three independent but convergent mechanisms...
  12. pmc Transcriptional repressor DREAM regulates T-lymphocyte proliferation and cytokine gene expression
    Magali Savignac
    Departamento de Biologia Molecular y Celular, Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas, Madrid, Spain
    EMBO J 24:3555-64. 2005
    ..Importantly, specific transient knockdown of DREAM or KChIP-2 induced basal expression of IL-2 and IFNgamma in wild-type splenocytes. These data propose DREAM and KChIP-2 as Ca2+-dependent repressors of the immune response...
  13. ncbi Searching for a role of NCX/NCKX exchangers in neurodegeneration
    Rosa Gomez-Villafuertes
    Centro Nacional de Biotecnologia, CSIC, Madrid, Spain
    Mol Neurobiol 35:195-202. 2007
    ..In this review, we summarize the current knowledge about the Na+/Ca2+ exchanger families and their implications in neurodegenerative disorders...
  14. ncbi Transcriptional repressor DREAM interacts with thyroid transcription factor-1 and regulates thyroglobulin gene expression
    Marcos Rivas
    Dpto Biología Molecular y Celular, Centro Nacional de Biotecnologia, CSIC 28049 Madrid, Spain
    J Biol Chem 279:33114-22. 2004
    ..Furthermore, chromatin immunoprecipitation experiments in FRTL-5 cells confirmed that Tg is a bona fide target gene for DREAM transrepression in thyroid follicular cells...
  15. ncbi Day-night changes in downstream regulatory element antagonist modulator/potassium channel interacting protein activity contribute to circadian gene expression in pineal gland
    Wolfgang A Link
    Departamento Biologia Molecular y Celular, Centro Nacional de Biotecnologia, Consejo Superior de Investigaciones Cientificas, 28049 Madrid, Spain
    J Neurosci 24:5346-55. 2004
    ..Our data suggest involvement of the family of DREAM repressors in the regulation of rhythmically expressed genes engaged in circadian rhythms...
  16. pmc Ca2+-dependent block of CREB-CBP transcription by repressor DREAM
    Fran Ledo
    Centro Nacional de Biotecnologia, C S I C, Madrid, Spain
    EMBO J 21:4583-92. 2002
    ..Thus, Ca2+-dependent interactions between DREAM and CREB represent a novel point of cross-talk between cAMP and Ca2+ signalling pathways in the nucleus...