Alfredo Mayor

Summary

Country: Spain

Publications

  1. pmc Rosetting in Plasmodium vivax: a cytoadhesion phenotype associated with anaemia
    Alejandro Marín-Menéndez
    Barcelona Centre for International Health Research CRESIB, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    PLoS Negl Trop Dis 7:e2155. 2013
  2. pmc VAR2CSA signatures of high Plasmodium falciparum parasitemia in the placenta
    Eduard Rovira-Vallbona
    Barcelona Centre for International Health Research, CRESIB, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 8:e69753. 2013
  3. pmc Plasmodium vivax congenital malaria in an area of very low endemicity in Guatemala: implications for clinical and epidemiological surveillance in a malaria elimination context
    María Eugenia Castellanos
    Centro de Estudios en Salud, Universidad del Valle de Guatemala, 18 avenida 11 95 zona 15 Vista Hermosa 3, Guatemala, Guatemala
    Malar J 11:411. 2012
  4. pmc A direct comparison of real time PCR on plasma and blood to detect Plasmodium falciparum infection in children
    Abigail A Lamikanra
    Nuffield Department of Clinical Laboratory Sciences, University of Oxford, and National Health Service Blood and Transplant, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, UK
    Malar J 11:201. 2012
  5. doi request reprint Improved pregnancy outcomes in women exposed to malaria with high antibody levels against Plasmodium falciparum
    Alfredo Mayor
    Barcelona Center for International Health Research, Hospital Clínic Universitat de Barcelona, Spain
    J Infect Dis 207:1664-74. 2013
  6. doi request reprint Placental infection with Plasmodium vivax: a histopathological and molecular study
    Alfredo Mayor
    Barcelona Centre for International Health Research CRESIB, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    J Infect Dis 206:1904-10. 2012
  7. pmc Immunoglobulins against the surface of Plasmodium falciparum-infected erythrocytes increase one month after delivery
    Alfredo Mayor
    Barcelona Centre for International Health Research, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    Malar J 11:130. 2012
  8. doi request reprint How hidden can malaria be in pregnant women? Diagnosis by microscopy, placental histology, polymerase chain reaction and detection of histidine-rich protein 2 in plasma
    Alfredo Mayor
    Barcelona Center for International Health Research, Hospital Clínic Universitat de Barcelona, Spain
    Clin Infect Dis 54:1561-8. 2012
  9. pmc Sub-microscopic infections and long-term recrudescence of Plasmodium falciparum in Mozambican pregnant women
    Alfredo Mayor
    Centre de Recerca en Salut Internacional de Barcelona, Hospital Clinic Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Rosselló 132, E 08036 Barcelona, Spain
    Malar J 8:9. 2009
  10. doi request reprint Molecular markers of resistance to sulfadoxine-pyrimethamine during intermittent preventive treatment for malaria in Mozambican infants
    Alfredo Mayor
    Centre de Recerca en Salut Internacional de Barcelona, Hospital Clínic Institut d Investigacions Biomèdicas August Pí i Sunyer, Universitat de Barcelona, Barcelona, Spain
    J Infect Dis 197:1737-42. 2008

Collaborators

Detail Information

Publications43

  1. pmc Rosetting in Plasmodium vivax: a cytoadhesion phenotype associated with anaemia
    Alejandro Marín-Menéndez
    Barcelona Centre for International Health Research CRESIB, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    PLoS Negl Trop Dis 7:e2155. 2013
    ..vivax sequestration and organ injury although its physiological impact is still unknown. Here, we aimed to describe clinically-relevant cytoadhesive phenotypes of P. vivax isolates...
  2. pmc VAR2CSA signatures of high Plasmodium falciparum parasitemia in the placenta
    Eduard Rovira-Vallbona
    Barcelona Centre for International Health Research, CRESIB, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 8:e69753. 2013
    ..Sequences contributing to high parasitemia may be critical for the functional characterization of VAR2CSA and the development of tools against placental malaria. ..
  3. pmc Plasmodium vivax congenital malaria in an area of very low endemicity in Guatemala: implications for clinical and epidemiological surveillance in a malaria elimination context
    María Eugenia Castellanos
    Centro de Estudios en Salud, Universidad del Valle de Guatemala, 18 avenida 11 95 zona 15 Vista Hermosa 3, Guatemala, Guatemala
    Malar J 11:411. 2012
    ....
  4. pmc A direct comparison of real time PCR on plasma and blood to detect Plasmodium falciparum infection in children
    Abigail A Lamikanra
    Nuffield Department of Clinical Laboratory Sciences, University of Oxford, and National Health Service Blood and Transplant, John Radcliffe Hospital, Headington, Oxford, OX3 9DU, UK
    Malar J 11:201. 2012
    ..However the efficiencies of each method have not been compared using samples obtained from infants less than one year old...
  5. doi request reprint Improved pregnancy outcomes in women exposed to malaria with high antibody levels against Plasmodium falciparum
    Alfredo Mayor
    Barcelona Center for International Health Research, Hospital Clínic Universitat de Barcelona, Spain
    J Infect Dis 207:1664-74. 2013
    ..Here, we aimed to identify clinically relevant antibody responses, taking into consideration variations in parasite exposure and human immunodeficiency virus type 1 (HIV) infection status...
  6. doi request reprint Placental infection with Plasmodium vivax: a histopathological and molecular study
    Alfredo Mayor
    Barcelona Centre for International Health Research CRESIB, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    J Infect Dis 206:1904-10. 2012
    ..Evidence of the presence of Plasmodium vivax in the placenta is scarce and inconclusive. This information is relevant to understanding whether P. vivax affects placental function and how it may contribute to poor pregnancy outcomes...
  7. pmc Immunoglobulins against the surface of Plasmodium falciparum-infected erythrocytes increase one month after delivery
    Alfredo Mayor
    Barcelona Centre for International Health Research, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    Malar J 11:130. 2012
    ..Immunological and physiological alterations associated with pregnancy that persist after delivery may contribute to the susceptibility to P. falciparum during early postpartum period...
  8. doi request reprint How hidden can malaria be in pregnant women? Diagnosis by microscopy, placental histology, polymerase chain reaction and detection of histidine-rich protein 2 in plasma
    Alfredo Mayor
    Barcelona Center for International Health Research, Hospital Clínic Universitat de Barcelona, Spain
    Clin Infect Dis 54:1561-8. 2012
    ..The performance of different methods to detect P. falciparum in pregnancy and the clinical relevance of undetected infections were evaluated...
  9. pmc Sub-microscopic infections and long-term recrudescence of Plasmodium falciparum in Mozambican pregnant women
    Alfredo Mayor
    Centre de Recerca en Salut Internacional de Barcelona, Hospital Clinic Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Rosselló 132, E 08036 Barcelona, Spain
    Malar J 8:9. 2009
    ..Control of malaria in pregnancy remains a public health challenge. Improvements in its correct diagnosis and the adequacy of protocols to evaluate anti-malarial drug efficacy in pregnancy, are essential to achieve this goal...
  10. doi request reprint Molecular markers of resistance to sulfadoxine-pyrimethamine during intermittent preventive treatment for malaria in Mozambican infants
    Alfredo Mayor
    Centre de Recerca en Salut Internacional de Barcelona, Hospital Clínic Institut d Investigacions Biomèdicas August Pí i Sunyer, Universitat de Barcelona, Barcelona, Spain
    J Infect Dis 197:1737-42. 2008
    ..There is concern about the impact that increasing in vivo resistance to SP has on the efficacy of IPTi, as well as about the potential contribution of IPTi to increases in resistance...
  11. pmc Parity and placental infection affect antibody responses against Plasmodium falciparum during pregnancy
    Alfredo Mayor
    Barcelona Centre for International Health Research CRESIB, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    Infect Immun 79:1654-9. 2011
    ..Results of this study show that parity and placental infection can modulate immune responses during pregnancy against malaria parasites...
  12. pmc The epidemiology of malaria in adults in a rural area of southern Mozambique
    Alfredo Mayor
    Center for International Health, Hospital Clinic, IDIBAPS, University of Barcelona, Barcelona, Spain
    Malar J 6:3. 2007
    ..The present study was undertaken to investigate the clinical, parasitological and haematological status of adults exposed to malaria, and to characterize parasites in these individuals who progressively acquire protective immunity...
  13. pmc Functional and immunological characterization of a Duffy binding-like alpha domain from Plasmodium falciparum erythrocyte membrane protein 1 that mediates rosetting
    Alfredo Mayor
    Barcelona Centre for International Health Research, Hospital Clinic Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
    Infect Immun 77:3857-63. 2009
    ..Further studies are required to elucidate the role of these antibodies in protection from malaria...
  14. doi request reprint The effect of intermittent preventive treatment during pregnancy on malarial antibodies depends on HIV status and is not associated with poor delivery outcomes
    Elisa Serra-Casas
    Barcelona Centre for International Health Research, Hospital Clinic Institut d Investigacions Biomediques August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
    J Infect Dis 201:123-31. 2010
    ..However, studies reporting the effect of IPTp on malaria-specific immunity are scarce and are based on findings in human immunodeficiency virus (HIV)-negative primigravidae...
  15. doi request reprint HIV and placental infection modulate the appearance of drug-resistant Plasmodium falciparum in pregnant women who receive intermittent preventive treatment
    Clara Menendez
    Barcelona Centre for International Health Research, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    Clin Infect Dis 52:41-8. 2011
    ..We aimed to determine the impact of IPTp and human immunodeficiency virus (HIV) infection on molecular markers of SP resistance and the clinical relevance of resistant infections...
  16. ncbi request reprint A variant in the gene FUT9 is associated with susceptibility to placental malaria infection
    Martin Sikora
    Institute of Evolutionary Biology UPF CSIC, CEXS UPF PRBB, Barcelona, Catalonia, Spain
    Hum Mol Genet 18:3136-44. 2009
    ..These results therefore suggest an involvement of this antigen in the pathogenesis of placental malaria infection...
  17. pmc Age-dependent IgG subclass responses to Plasmodium falciparum EBA-175 are differentially associated with incidence of malaria in Mozambican children
    Carlota Dobano
    Barcelona Centre for International Health Research, Hospital Clinic, Universitat de Barcelona, Barcelona, Spain
    Clin Vaccine Immunol 19:157-66. 2012
    ..Deeper understanding of the acquisition of antibodies against vaccine target antigens in early infancy is crucial for the rational development and deployment of malaria control tools in this vulnerable population...
  18. ncbi request reprint Reduction of antimalarial antibodies by HIV infection is associated with increased risk of Plasmodium falciparum cord blood infection
    Denise Naniche
    Barcelona Centre for International Health Research CRESIB, Hospital Clínic Universitat de Barcelona, Spain
    J Infect Dis 205:568-77. 2012
    ..Human immunodeficiency virus (HIV) might increase cord blood P. falciparum infection by decreasing maternal antimalarial-specific antibodies...
  19. pmc Persistence of Plasmodium falciparum parasites in infected pregnant Mozambican women after delivery
    Elisa Serra-Casas
    Barcelona Centre for International Health Research, Hospital Clinic, Universitat de Barcelona, Rosselló 132, 08036 Barcelona, Spain
    Infect Immun 79:298-304. 2011
    ..Interventions that reduce malaria during pregnancy may translate into a lower risk of postpartum infection...
  20. pmc Cytokine and antibody responses to Plasmodium falciparum in naïve individuals during a first malaria episode: effect of age and malaria exposure
    Gemma Moncunill
    Barcelona Centre for International Health Research CRESIB, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 8:e55756. 2013
    ..Although IL-12 was elevated in children, overall the data do not support a role of age in immune responses to a first malaria episode. A T(H)1/pro-inflammatory response was the hallmark of non-immune subjects...
  21. pmc Transcription of var genes other than var2csa in Plasmodium falciparum parasites infecting Mozambican pregnant women
    Eduard Rovira-Vallbona
    Barcelona Centre for International Health Research, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    J Infect Dis 204:27-35. 2011
    ..This phenomenon is mediated by a var gene coding for VAR2CSA, which adheres to chondroitin sulphate A. However, the contribution of parasites transcribing other var genes to maternal infections has not been well characterized...
  22. pmc A randomized placebo-controlled trial of intermittent preventive treatment in pregnant women in the context of insecticide treated nets delivered through the antenatal clinic
    Clara Menendez
    Barcelona Center for International Health Research CRESIB and Department of Pathology Hospital Clinic, Institut d Investigacions Biomedicas August Pi i Sunyer, Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 3:e1934. 2008
    ..Current recommendations to prevent malaria in African pregnant women rely on insecticide treated nets (ITNs) and intermittent preventive treatment (IPTp). However, there is no information on the safety and efficacy of their combined use...
  23. ncbi request reprint Severity of anaemia is associated with bone marrow haemozoin in children exposed to Plasmodium falciparum
    Ruth Aguilar
    Barcelona Centre for International Health Research CRESIB, Hospital Clinic University of Barcelona, Barcelona, Spain CIBER Epidemiology and Public Health CIBERESP, Barcelona, Spain Manhiça Health Research Centre CISM, Maputo, Mozambique
    Br J Haematol 164:877-87. 2014
    ..This finding may have clinical implications for the development of drugs targeted to prevent and treat malarial-anaemia...
  24. pmc High antibody responses against Plasmodium falciparum in immigrants after extended periods of interrupted exposure to malaria
    Gemma Moncunill
    Barcelona Centre for International Health Research CRESIB, Hospital Clínic Universitat de Barcelona Barcelona, Catalonia, Spain
    PLoS ONE 8:e73624. 2013
    ..Malaria immunity is commonly believed to wane in the absence of Plasmodium falciparum exposure, based on limited epidemiological data and short-lived antibody responses in some longitudinal studies in endemic areas...
  25. pmc Cytokine profiling in immigrants with clinical malaria after extended periods of interrupted exposure to Plasmodium falciparum
    Gemma Moncunill
    Barcelona Centre for International Health Research CRESIB, Hospital Clínic Universitat de Barcelona Barcelona, Catalonia, Spain
    PLoS ONE 8:e73360. 2013
    ..falciparum appeared to be reduced. Understanding the mechanisms to maintain non-pathogenic effector responses is important to develop new malaria control strategies. ..
  26. pmc Low antibodies against Plasmodium falciparum and imbalanced pro-inflammatory cytokines are associated with severe malaria in Mozambican children: a case-control study
    Eduard Rovira-Vallbona
    Barcelona Centre for International Health Research, CRESIB, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    Malar J 11:181. 2012
    ..Altered antibody and cellular immunity against P. falciparum might contribute to increase the risk of developing SM...
  27. pmc A targeted association study of immunity genes and networks suggests novel associations with placental malaria infection
    Martin Sikora
    Institute of Evolutionary Biology UPF CSIC, CEXS UPF PRBB, Barcelona, Catalonia, Spain
    PLoS ONE 6:e24996. 2011
    ..To our knowledge, this is the first large-scale genetic study on placental malaria infection to date, opening the door for follow-up studies trying to elucidate the genetic basis of this neglected form of malaria...
  28. pmc Association of severe malaria outcomes with platelet-mediated clumping and adhesion to a novel host receptor
    Alfredo Mayor
    Barcelona Centre for International Health Research CRESIB, Hospital Clínic Institut d Investigacions Biomèdiques August Pi i Sunyer IDIBAPS, Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 6:e19422. 2011
    ..Identification of P. falciparum cytoadherence phenotypes that are associated with severe malaria may lead to the development of novel strategies against life-threatening malaria...
  29. pmc Molecular evidence for the localization of Plasmodium falciparum immature gametocytes in bone marrow
    Ruth Aguilar
    Barcelona Centre for International Health Research CRESIB, Hospital Clinic de Barcelona, University of Barcelona, Barcelona, Spain
    Blood 123:959-66. 2014
    ..Our results highlight the high prevalence and abundance of early sexual stages in bone marrow, as well as the relationship between hematological disturbances and gametocyte development in this tissue. ..
  30. doi request reprint Comparison of placental blood microscopy and the ICT HRP2 rapid diagnostic test to detect placental malaria
    Ruth Aguilar
    Barcelona Centre for International Health Research CRESIB, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    Trans R Soc Trop Med Hyg 106:573-5. 2012
    ..Discordances were found at low parasitemias (<500 parasites/μL) or negative microscopy. The results suggest that the HRP2-RDTs from ICT diagnostics is a good alternative to microscopy for diagnosing placental malaria at delivery...
  31. doi request reprint Evolutionary analysis of genes of two pathways involved in placental malaria infection
    Martin Sikora
    Evolutionary Biology Unit, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona Biomedical Research Park, Carrer Dr Aiguader 88, 08003, Barcelona, Catalonia, Spain
    Hum Genet 123:343-57. 2008
    ..We propose to use the present methods in a systematic way to help identify candidate regions under positive selection as a consequence of malaria...
  32. pmc Inadequate efficacy of a new formulation of fosmidomycin-clindamycin combination in Mozambican children less than three years old with uncomplicated Plasmodium falciparum malaria
    Miguel Lanaspa
    Barcelona Centre for International Health Research, CRESIB, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    Antimicrob Agents Chemother 56:2923-8. 2012
    ..Additional studies should be conducted to respond to the many uncertainties arising from this trial, which should not discourage further evaluation of this promising combination...
  33. doi request reprint HIV and malaria interactions: where do we stand?
    Raquel Gonzalez
    Barcelona Centre for International Heath Research CRESIB, Hospital Clinic IDIBAPS, Universitat de Barcelona, Spain
    Expert Rev Anti Infect Ther 10:153-65. 2012
    ..We focus on the latest available data, pointing out key future research areas and challenges of the field...
  34. pmc Impact of the RTS,S malaria vaccine candidate on naturally acquired antibody responses to multiple asexual blood stage antigens
    Joseph J Campo
    Centre de Recerca en Salut Internacional de Barcelona, Hospital Clínic Universitat de Barcelona, Barcelona, Spain
    PLoS ONE 6:e25779. 2011
    ....
  35. pmc An autopsy study of maternal mortality in Mozambique: the contribution of infectious diseases
    Clara Menendez
    Barcelona Center for International Health Research CRESIB and Department of Pathology, Hospital Clinic, Institut d Investigacions Biomediques August Pi i Sunyer IDIBAPS, Universitat de Barcelona, Spain
    PLoS Med 5:e44. 2008
    ..The aim of this study was to accurately describe the causes of maternal death in order to contribute to its reduction, in one of the regions of the world with the highest maternal mortality ratios...
  36. ncbi request reprint [Molecular epidemiological surveillance of markers for antimalarial drugs in Plasmodium falciparum isolates imported to Barcelona, Spain]
    Joaquim Gascon
    Centro de Salud Internacional, IDIBAPS, Hospital Clinic de Barcelona, Barcelona, Spain
    Med Clin (Barc) 125:286-9. 2005
    ..falciparum isolates imported by travellers...
  37. ncbi request reprint Congenital malaria: the least known consequence of malaria in pregnancy
    Clara Menendez
    Barcelona Center for International Health Research CRESIB, Hospital Clinic, Institut d Investigacions Biomedicas August Pi i Sunyer, University of Barcelona, Spain
    Semin Fetal Neonatal Med 12:207-13. 2007
    ..There is also a lack of consensus on the clinical guidelines for its management. More research is needed in order to establish adequate preventive and management recommendations to avoid this consequence of malaria in pregnancy...
  38. ncbi request reprint Pregnancy and malaria exposure are associated with changes in the B cell pool and in plasma eotaxin levels
    Pilar Requena
    Barcelona Centre for International Health Research, Hospital Clinic University of Barcelona, 08036 Barcelona, Spain
    J Immunol 193:2971-83. 2014
    ..These findings are important to understand immunity to infections like malaria that result in negative outcomes for both the mother and the newborn and may have important implications on vaccine development...
  39. ncbi request reprint Plasmodium falciparum multiple infections in Mozambique, its relation to other malariological indices and to prospective risk of malaria morbidity
    Alfredo Mayor
    Centro de Investigaçao em Saúde da Manhiça CISM Ministerio de Saúde, Maputo, Mozambique
    Trop Med Int Health 8:3-11. 2003
    ..This change in the association between multiplicity and risk of clinical malaria may indicate a shift in the host response to P. falciparum...
  40. ncbi request reprint Malaria in pregnancy in rural Mozambique: the role of parity, submicroscopic and multiple Plasmodium falciparum infections
    Francisco Saute
    Centro de Investigação em Saúde da Manhiça, Instituto Nacional de Saude, Maputo, Mozambique
    Trop Med Int Health 7:19-28. 2002
    ..It also tried to assess the frequency and effect on anaemia of submicroscopic and multiple falciparum infections...
  41. pmc Impact of intermittent preventive treatment with sulfadoxine-pyrimethamine on antibody responses to erythrocytic-stage Plasmodium falciparum antigens in infants in Mozambique
    Diana Quelhas
    Centro de Investigação em Saúde da Manhiça CISM, Manhiça, Mozambique
    Clin Vaccine Immunol 15:1282-91. 2008
    ..IPTi with SP given through the EPI reduces the frequency of malarial illness while allowing the development of naturally acquired antibody responses to P. falciparum antigens...
  42. ncbi request reprint Receptor-binding residues lie in central regions of Duffy-binding-like domains involved in red cell invasion and cytoadherence by malaria parasites
    Alfredo Mayor
    Malaria Group, International Centre for Genetic Engineering and Biotechnology ICGEB, PO Box 10504, Aruna Asaf Ali Marg, New Delhi 110067, India
    Blood 105:2557-63. 2005
    ..Determination of functional regions within DBL domains is the first step toward understanding the structure-function bases for their interaction with diverse host receptors...
  43. ncbi request reprint [Clinical presentation and complications of Plasmodium falciparum malaria in two populations: travelers and immigrants]
    Elisa Salvadó
    Seccion de Medicina Tropical, Centro de Salud Internacional, Hospital Clinic de Barcelona, Barcelona, Espana
    Enferm Infecc Microbiol Clin 26:282-4. 2008
    ..Only natives of malaria-endemic areas can acquire a certain degree of immunity to the disease. It is not known whether immunity is lost when contact with the parasite is discontinued...