J M Mates

Summary

Country: Spain

Publications

  1. ncbi request reprint Glutaminase isoenzymes as key regulators in metabolic and oxidative stress against cancer
    J M Mates
    Department of Biología Molecular y Bioquímica, Facultad de Ciencias, Campus de Teatinos, Universidad de Malaga, Malaga, Spain
    Curr Mol Med 13:514-34. 2013
  2. doi request reprint Oxidative stress in apoptosis and cancer: an update
    José M Matés
    Department of Biología Molecular y Bioquímica, Facultad de Ciencias, Universidad de Malaga, Campus de Teatinos, Malaga, Spain
    Arch Toxicol 86:1649-65. 2012
  3. ncbi request reprint Sulphur-containing non enzymatic antioxidants: therapeutic tools against cancer
    José M Matés
    Department of Biología Molecular y Bioquímica, Facultad de Ciencias, Campus de Teatinos, Universidad de Malaga, Malaga, Spain
    Front Biosci (Schol Ed) 4:722-48. 2012
  4. doi request reprint Intracellular redox status and oxidative stress: implications for cell proliferation, apoptosis, and carcinogenesis
    José M Matés
    Department of Biología Molecular y Bioquímica, Facultad de Ciencias, Campus de Teatinos, Universidad de Malaga, Malaga, Spain
    Arch Toxicol 82:273-99. 2008
  5. ncbi request reprint Pathways from glutamine to apoptosis
    José M Matés
    Departamento de Biologia Molecular y Bioquimica, Facultad de Ciencias, Universidad de Malaga, 29071 Malaga, Spain
    Front Biosci 11:3164-80. 2006
  6. doi request reprint Roles of dioxins and heavy metals in cancer and neurological diseases using ROS-mediated mechanisms
    José M Matés
    Departmento de Biología Molecular y Bioquímica, Facultad de Ciencias, Campus de Teatinos, Universidad de Málaga, 29071 Málaga, Spain
    Free Radic Biol Med 49:1328-41. 2010
  7. ncbi request reprint Anticancer antioxidant regulatory functions of phytochemicals
    J M Mates
    Department of Biología Molecular y Bioquímica, Campus de Teatinos, Universidad de Malaga, 29071 Malaga, Spain
    Curr Med Chem 18:2315-38. 2011
  8. ncbi request reprint Natural antioxidants: therapeutic prospects for cancer and neurological diseases
    J M Mates
    Department of Biología Molecular y Bioquímica, Facultad de Ciencias, Campus de Teatinos, Universidad de Malaga, 29071 Malaga, Spain
    Mini Rev Med Chem 9:1202-14. 2009
  9. ncbi request reprint Glutamine and its relationship with intracellular redox status, oxidative stress and cell proliferation/death
    José M Matés
    Department of Molecular Biology and Biochemistry, Faculty of Sciences, University of Malaga, Campus de Teatinos, s n 29071 Malaga, Spain
    Int J Biochem Cell Biol 34:439-58. 2002
  10. ncbi request reprint Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology
    J M Mates
    Department of Molecular Biology and Biochemistry, Faculty of Sciences, University of Malaga, Campus de Teatinos, S N, 29071, Malaga, Spain
    Toxicology 153:83-104. 2000

Collaborators

  • Javier Marquez
  • M Blanca
  • J A Segura
  • Juan C Aledo
  • Zafar U Khan
  • Francisco J Alonso
  • José A Campos-Sandoval
  • Carolina Lobo
  • Lucía Olalla
  • Vanessa de la Rosa
  • Cristina Pérez-Gómez
  • Mercedes Martín-Rufián
  • Jorge Lora
  • José M Matés
  • Jose A Campos
  • J A Cornejo-Garcia
  • Antonia Gutierrez
  • Pedro M Gómez-Fabre
  • Javier Márquez
  • Carolina Cardona
  • Juan Perez
  • Juan F López-Téllez
  • Antonio J Jiménez
  • Amada R López de la Oliva
  • T D Fernandez
  • C Mayorga
  • I Bravo
  • R R-Pena
  • M J Torres
  • Beatriz Fernández-Molina
  • Maria E Gonzalez
  • Pedro Ruiz-Sánchez
  • Elisa Manzanares
  • Ignacio Núñez de Castro
  • Antonio Del Castillo-Olivares
  • B Gil-Torregrosa
  • F Sanchez-Jimenez
  • J Lozano
  • J L Urdiales

Detail Information

Publications32

  1. ncbi request reprint Glutaminase isoenzymes as key regulators in metabolic and oxidative stress against cancer
    J M Mates
    Department of Biología Molecular y Bioquímica, Facultad de Ciencias, Campus de Teatinos, Universidad de Malaga, Malaga, Spain
    Curr Mol Med 13:514-34. 2013
    ..Thus, modulation of GA function may be a new therapeutic target for cancer treatment...
  2. doi request reprint Oxidative stress in apoptosis and cancer: an update
    José M Matés
    Department of Biología Molecular y Bioquímica, Facultad de Ciencias, Universidad de Malaga, Campus de Teatinos, Malaga, Spain
    Arch Toxicol 86:1649-65. 2012
    ..Finally, in this review, we discuss new knowledge about recent tools that provide powerful antioxidant strategies, and designing methods to deliver to target cells, in the prevention and treatment of cancer...
  3. ncbi request reprint Sulphur-containing non enzymatic antioxidants: therapeutic tools against cancer
    José M Matés
    Department of Biología Molecular y Bioquímica, Facultad de Ciencias, Campus de Teatinos, Universidad de Malaga, Malaga, Spain
    Front Biosci (Schol Ed) 4:722-48. 2012
    ..In fact, glutathione depletion is an early hallmark observed in apoptosis and it has been demonstrated as a common feature of cancer...
  4. doi request reprint Intracellular redox status and oxidative stress: implications for cell proliferation, apoptosis, and carcinogenesis
    José M Matés
    Department of Biología Molecular y Bioquímica, Facultad de Ciencias, Campus de Teatinos, Universidad de Malaga, Malaga, Spain
    Arch Toxicol 82:273-99. 2008
    ....
  5. ncbi request reprint Pathways from glutamine to apoptosis
    José M Matés
    Departamento de Biologia Molecular y Bioquimica, Facultad de Ciencias, Universidad de Malaga, 29071 Malaga, Spain
    Front Biosci 11:3164-80. 2006
    ..Following, we will describe as glutamine and the related species glutamate, glutathione and glucosamine can play important roles in the pathways leading to apoptosis...
  6. doi request reprint Roles of dioxins and heavy metals in cancer and neurological diseases using ROS-mediated mechanisms
    José M Matés
    Departmento de Biología Molecular y Bioquímica, Facultad de Ciencias, Campus de Teatinos, Universidad de Málaga, 29071 Málaga, Spain
    Free Radic Biol Med 49:1328-41. 2010
    ..Copper also has been shown to have an important role in neurodegenerative diseases such as Alzheimer disease, Parkinson disease, and amyotrophic lateral sclerosis...
  7. ncbi request reprint Anticancer antioxidant regulatory functions of phytochemicals
    J M Mates
    Department of Biología Molecular y Bioquímica, Campus de Teatinos, Universidad de Malaga, 29071 Malaga, Spain
    Curr Med Chem 18:2315-38. 2011
    ..Finally, we will outline the use of bioactive phytochemicals on synergistic actions involved in the prevention and treatment of cancer as well as its future prospects...
  8. ncbi request reprint Natural antioxidants: therapeutic prospects for cancer and neurological diseases
    J M Mates
    Department of Biología Molecular y Bioquímica, Facultad de Ciencias, Campus de Teatinos, Universidad de Malaga, 29071 Malaga, Spain
    Mini Rev Med Chem 9:1202-14. 2009
    ..This mini-review will provide an updated revision of the function of some natural compounds having main roles in antioxidant function. We will point on some phytochemicals working at two outstanding targets, tumour cells and neurons...
  9. ncbi request reprint Glutamine and its relationship with intracellular redox status, oxidative stress and cell proliferation/death
    José M Matés
    Department of Molecular Biology and Biochemistry, Faculty of Sciences, University of Malaga, Campus de Teatinos, s n 29071 Malaga, Spain
    Int J Biochem Cell Biol 34:439-58. 2002
    ..In conclusion, this article shows evidences for the important role of glutamine in the regulation of the cellular redox balance, including brain oxidative metabolism, apoptosis and tumour cell proliferation...
  10. ncbi request reprint Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology
    J M Mates
    Department of Molecular Biology and Biochemistry, Faculty of Sciences, University of Malaga, Campus de Teatinos, S N, 29071, Malaga, Spain
    Toxicology 153:83-104. 2000
    ..On the other hand, small molecules that mimic antioxidant enzymes are becoming new tools for the treatment of many diseases...
  11. ncbi request reprint Antioxidant enzymes and their implications in pathophysiologic processes
    J M Mates
    Department of Molecular Biology and Biochemistry, Faculty of Sciences, University of Malaga, Campus de Teatinos, s n 29071 Malaga, Spain
    Front Biosci 4:D339-45. 1999
    ..Consequently, toxic oxygen play a role in aging process as well as in a number of human diseases that we list in this review...
  12. ncbi request reprint Allergy to drugs: antioxidant enzymic activities, lipid peroxidation and protein oxidative damage in human blood
    J M Mates
    Department of Molecular Biology and Biochemistry, Faculty of Sciences, University of Malaga, Spain
    Cell Biochem Funct 18:77-84. 2000
    ..To our knowledge, this is the first global study of antioxidant enzyme determinations, including TBARS level and carbonyl content, in patients suffering from allergies to drugs...
  13. ncbi request reprint Chemical and biological activity of free radical 'scavengers' in allergic diseases
    J M Mates
    Department of Molecular Biology and Biochemistry, Faculty of Sciences, University of M alaga, Campus de Teatinos, S N, 29071, M alaga, Spain
    Clin Chim Acta 296:1-15. 2000
    ..Finally, we discuss the published data that relates anti-free radical therapy to the management of human allergic diseases...
  14. ncbi request reprint Role of reactive oxygen species in apoptosis: implications for cancer therapy
    J M Mates
    Department of Molecular Biology and Biochemistry, Sciences Faculty, University of Malaga, Campus de Teatinos, Malaga, Spain
    Int J Biochem Cell Biol 32:157-70. 2000
    ....
  15. ncbi request reprint Antioxidant enzymes and human diseases
    J M Mates
    Department of Molecular Biology and Biochemistry, Faculty of Sciences, University of Malaga, Spain
    Clin Biochem 32:595-603. 1999
    ....
  16. ncbi request reprint Antioxidant enzymatic activities in human blood cells after an allergic reaction to pollen or house dust mite
    J M Mates
    Department of Molecular Biology and Biochemistry, Sciences Faculty, University of Malaga, Spain
    Blood Cells Mol Dis 25:103-9. 1999
    ..To our knowledge, this is the first global study of antioxidant enzymes, including TBARS level determinations, in allergy...
  17. pmc Anti-oxidant enzyme activities and expression and oxidative damage in patients with non-immediate reactions to drugs
    J A Cornejo-Garcia
    Research Laboratory for Allergic Diseases, Carlos Haya Hospital, Malaga, Spain
    Clin Exp Immunol 145:287-95. 2006
    ..Our observations indicate that oxidative damage occurs in non-immediate reactions. Carbonyl stress and the inadequacy of the anti-oxidant defences are probable causes...
  18. pmc Co-expression of glutaminase K and L isoenzymes in human tumour cells
    Cristina Pérez-Gómez
    Departamento de Biologia Molecular y Bioquimica, Laboratorio de Quimica de Proteinas, Facultad de Ciencias, Universidad de Malaga, 29071 Malaga, Spain
    Biochem J 386:535-42. 2005
    ..Furthermore, the present work and other previous data suggest that K isoform is up-regulated with increased rates of proliferation, whereas prevalence of the L isoform seems to be related with resting or quiescent cell states...
  19. ncbi request reprint Antisense glutaminase inhibition decreases glutathione antioxidant capacity and increases apoptosis in Ehrlich ascitic tumour cells
    Jorge Lora
    Departamento de Biologia Molecular y Bioquimica, Laboratorio de Quimica de Proteinas, Facultad de Ciencias, Universidad de Malaga, Spain
    Eur J Biochem 271:4298-306. 2004
    ..Taken together, these results provide insights into the role of glutaminase in apoptosis by demonstrating that the expression of antisense mRNA for glutaminase alters apoptosis and glutathione antioxidant capacity...
  20. ncbi request reprint Inhibition of glutaminase expression increases Sp1 phosphorylation and Sp1/Sp3 transcriptional activity in Ehrlich tumor cells
    Juan Antonio Segura
    Departamento de Biologia Molecular y Bioquimica, Facultad de Ciencias, Campus de Teatinos, Universidad de Malaga, 29071 Malaga, Spain
    Cancer Lett 218:91-8. 2005
    ..28AS-2 cells. In conclusion, the antisense inhibition of glutaminase leads to an increased expression of phosphorylated Sp1 and that correlates with an increase in Sp1 activity...
  21. doi request reprint Glutamine homeostasis and mitochondrial dynamics
    José M Matés
    Departamento de Biologia Molecular y Bioquimica, Laboratorio de Quimica de Proteinas, Facultad de Ciencias, Universidad de Malaga, 29071 Malaga, Spain
    Int J Biochem Cell Biol 41:2051-61. 2009
    ..Some controversial issues about glutamine catabolism within mitochondria are also reviewed...
  22. pmc Genomic organization and transcriptional analysis of the human l-glutaminase gene
    Cristina Pérez-Gómez
    Departamento de Biologia Molecular y Bioquimica, Laboratorio de Quimica de Proteinas, Facultad de Ciencias, Universidad de Malaga, 29071 Malaga, Spain
    Biochem J 370:771-84. 2003
    ....
  23. doi request reprint New insights into brain glutaminases: beyond their role on glutamatergic transmission
    Javier Marquez
    Departamento de Biologia Molecular y Bioquimica, Facultad de Ciencias, Laboratorio de Quimica de Proteinas, Universidad de Malaga, Malaga, Spain
    Neurochem Int 55:64-70. 2009
    ..Finally, recent progress has identified glutaminase to be also present in astrocytes which precludes its classical consideration as a neuron-specific enzyme...
  24. ncbi request reprint Glutaminase: a multifaceted protein not only involved in generating glutamate
    Javier Marquez
    Laboratorio de Quimica de Proteinas, Departamento de Biologia Molecular y Bioquimica, Facultad de Ciencias, Universidad de Malaga, 29071 Malaga, Spain
    Neurochem Int 48:465-71. 2006
    ..This experimental evidence will then be used to highlight new potential roles for this classical metabolic enzyme...
  25. ncbi request reprint Expression of functional human glutaminase in baculovirus system: affinity purification, kinetic and molecular characterization
    José A Campos-Sandoval
    Departamento de Biologia Molecular y Bioquimica, Laboratorio de Quimica de Proteinas, Facultad de Ciencias, Universidad de Malaga, 29071 Malaga, Spain
    Int J Biochem Cell Biol 39:765-73. 2007
    ..The study also provides a simple and efficient method for affinity purification of the recombinant enzyme. Moreover, the data imply that this human enzyme may represent a new isoform different from classical kidney and liver isozymes...
  26. doi request reprint A novel glutaminase isoform in mammalian tissues
    Vanessa de la Rosa
    Departamento de Biologia Molecular y Bioquimica, Facultad de Ciencias, Laboratorio de Quimica de Proteinas, Universidad de Malaga, Malaga, Spain
    Neurochem Int 55:76-84. 2009
    ..We present convergent evidence supporting the existence of a novel glutaminase isozyme in mammalian tissues...
  27. ncbi request reprint Identification of genes downregulated in tumor cells expressing antisense glutaminase mRNA by differential display
    Mercedes Martín-Rufián
    Departamento de Biologia Molecular y Bioquimica, Laboratorio de Quimica de Proteinas, Facultad de Ciencias, Universidad de Malaga, Malaga, Spain
    Cancer Biol Ther 5:54-8. 2006
    ..Our results show the validity of mRNA differential display technique to get insights into the molecular mechanisms underlying the acquisition of a more differentiated phenotype by tumor cells after inhibition of glutaminase expression...
  28. ncbi request reprint Expression of the scaffolding PDZ protein glutaminase-interacting protein in mammalian brain
    Lucía Olalla
    Departamento de Biologia Molecular y Bioquimica, Universidad de Malaga, Malaga, Spain
    J Neurosci Res 86:281-92. 2008
    ....
  29. ncbi request reprint Sensitisation of Ehrlich ascitic tumour cells to methotrexate by inhibiting glutaminase
    Francisco J Alonso
    Departamento de Biologia Molecular y Bioquimica, Facultad de Ciencias, Universidad de Malaga, 29071 Malaga, Spain
    Anticancer Res 25:3315-20. 2005
    ..Ehrlich ascites tumour cells (EATC) and their derivative 0.28AS-2 cells, which express antisense glutaminase mRNA, show differences in both morphology and tumorigenic capacity...
  30. ncbi request reprint Expression of different mitogen-regulated protein/proliferin mRNAs in Ehrlich carcinoma cells
    B Gil-Torregrosa
    Laboratorio de Bioquimica y Biologia Molecular, Facultad de Ciencias, Universidad de Malaga, Spain
    FEBS Lett 349:343-8. 1994
    ..Ehrlich carcinoma may represent a good model to study regulation of expression and physiological roles of MRP/PLFs in vivo...
  31. ncbi request reprint Nuclear localization of L-type glutaminase in mammalian brain
    Lucía Olalla
    Departamento de Biologia Molecular y Bioquimica, Laboratorio de Quimica de Proteinas, Universidad de Malaga, 29071 Malaga, Spain
    J Biol Chem 277:38939-44. 2002
    ....
  32. ncbi request reprint Expression of recombinant human L-glutaminase in Escherichia coli: polyclonal antibodies production and immunological analysis of mouse tissues
    Jose A Campos
    Laboratorio de Qui mica de Proteínas, Departamento de Biologia Molecular y Bioquimica, Facultad de Ciencias, Universidad de Malaga, Spain
    Biochim Biophys Acta 1648:17-23. 2003
    ..Furthermore, the antibodies were able to immunoprecipitate the in vitro translated enzyme using a reticulocyte lysate system; these antibodies might be a valuable tool for studies on L-glutaminase expression in mammalian tissues...