Beatriz Martinez-Delgado

Summary

Country: Spain

Publications

  1. pmc Deregulated miRNAs in hereditary breast cancer revealed a role for miR-30c in regulating KRAS oncogene
    Miljana Tanic
    Human Genetics Group, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    PLoS ONE 7:e38847. 2012
  2. doi Shorter telomere length is associated with increased ovarian cancer risk in both familial and sporadic cases
    Beatriz Martinez-Delgado
    Human Genetics Group, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    J Med Genet 49:341-4. 2012
  3. ncbi Peripheral T-cell lymphoma gene expression profiles
    B Martinez-Delgado
    Human Genetics Group, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Hematol Oncol 24:113-9. 2006
  4. pmc Genetic anticipation is associated with telomere shortening in hereditary breast cancer
    Beatriz Martinez-Delgado
    Human Genetics Group, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    PLoS Genet 7:e1002182. 2011
  5. ncbi Expression profiling of T-cell lymphomas differentiates peripheral and lymphoblastic lymphomas and defines survival related genes
    Beatriz Martinez-Delgado
    Human Genetics Department, Bioinformatics Unit, Genomic Analysis Unit, and Genomics Unit, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Clin Cancer Res 10:4971-82. 2004
  6. ncbi Frequent inactivation of the p73 gene by abnormal methylation or LOH in non-Hodgkin's lymphomas
    Beatriz Martinez-Delgado
    Human Genetics Laboratory, Molecular Pathology Department, Spanish National Cancer Centre, Madrid, Spain
    Int J Cancer 102:15-9. 2002
  7. ncbi Coincidental LOH regions in mouse and humans: evidence for novel tumor suppressor loci at 9q22-q34 in non-Hodgkin's lymphomas
    Barbara Melendez
    Dpto Genética Humana, Programa Patologi a Molecular, Centro Nacional Investigaciones Oncologicas CNIO, 28029, Madrid, Spain
    Leuk Res 27:627-33. 2003
  8. doi Mutational analysis of telomere genes in BRCA1/2-negative breast cancer families with very short telomeres
    Kira Yanowsky
    Human Genetics Group, Spanish National Cancer Research Centre CNIO, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Breast Cancer Res Treat 134:1337-43. 2012
  9. doi Evaluation of the BRCA1 interacting genes RAP80 and CCDC98 in familial breast cancer susceptibility
    Ana Osorio
    Group of Human Genetics, Human Cancer Genetics Programme, C Melchor Fernandez Almagro 3, Madrid, 28029, Spain
    Breast Cancer Res Treat 113:371-6. 2009
  10. ncbi Identification of a proliferation signature related to survival in nodal peripheral T-cell lymphomas
    Marta Cuadros
    Human Genetics Group and Genotyping Unit, Human Cancer Genetics Program, Spanish National Cancer Centre, Madrid, Spain
    J Clin Oncol 25:3321-9. 2007

Collaborators

Detail Information

Publications26

  1. pmc Deregulated miRNAs in hereditary breast cancer revealed a role for miR-30c in regulating KRAS oncogene
    Miljana Tanic
    Human Genetics Group, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    PLoS ONE 7:e38847. 2012
    ..In addition, we provide evidence that KRAS is a target of miR-30c, and that this miRNA suppresses breast cancer cell growth potentially through inhibition of KRAS signaling...
  2. doi Shorter telomere length is associated with increased ovarian cancer risk in both familial and sporadic cases
    Beatriz Martinez-Delgado
    Human Genetics Group, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    J Med Genet 49:341-4. 2012
    ..The present study analysed TL in peripheral blood leucocytes of hereditary and sporadic ovarian cancer cases, as well as in female controls, to evaluate whether TL contributes to ovarian cancer risk...
  3. ncbi Peripheral T-cell lymphoma gene expression profiles
    B Martinez-Delgado
    Human Genetics Group, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Hematol Oncol 24:113-9. 2006
    ..However, microarrays are being a helpful tool in the initial task of dissecting the PTCL expression profile...
  4. pmc Genetic anticipation is associated with telomere shortening in hereditary breast cancer
    Beatriz Martinez-Delgado
    Human Genetics Group, Spanish National Cancer Research Centre CNIO, Madrid, Spain
    PLoS Genet 7:e1002182. 2011
    ..Our results provide evidence that telomere shortening is associated with earlier age of cancer onset in successive generations, suggesting that it might be a mechanism of genetic anticipation in hereditary breast cancer...
  5. ncbi Expression profiling of T-cell lymphomas differentiates peripheral and lymphoblastic lymphomas and defines survival related genes
    Beatriz Martinez-Delgado
    Human Genetics Department, Bioinformatics Unit, Genomic Analysis Unit, and Genomics Unit, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Clin Cancer Res 10:4971-82. 2004
    ..T-Cell lymphomas constitute heterogeneous and aggressive tumors in which pathogenic alterations remain largely unknown. Expression profiling has demonstrated to be a useful tool for molecular classification of tumors...
  6. ncbi Frequent inactivation of the p73 gene by abnormal methylation or LOH in non-Hodgkin's lymphomas
    Beatriz Martinez-Delgado
    Human Genetics Laboratory, Molecular Pathology Department, Spanish National Cancer Centre, Madrid, Spain
    Int J Cancer 102:15-9. 2002
    ..Our results show that deletion or methylation of the p73 gene could be important mechanisms in suppressing p73 expression in B cell non-Hodgkin's lymphomas...
  7. ncbi Coincidental LOH regions in mouse and humans: evidence for novel tumor suppressor loci at 9q22-q34 in non-Hodgkin's lymphomas
    Barbara Melendez
    Dpto Genética Humana, Programa Patologi a Molecular, Centro Nacional Investigaciones Oncologicas CNIO, 28029, Madrid, Spain
    Leuk Res 27:627-33. 2003
    ..Our results support the usefulness of murine models to study human lymphoid neoplasias and reveal novel regions on 9q22-q34 candidate for containing tumor suppressor genes involved in human lymphomas...
  8. doi Mutational analysis of telomere genes in BRCA1/2-negative breast cancer families with very short telomeres
    Kira Yanowsky
    Human Genetics Group, Spanish National Cancer Research Centre CNIO, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Breast Cancer Res Treat 134:1337-43. 2012
    ..However, functional prediction analysis and control population studies of both variants ruled out its possible pathogenic role. Our results discard a major contribution of telomere-specific genes in hereditary breast cancer...
  9. doi Evaluation of the BRCA1 interacting genes RAP80 and CCDC98 in familial breast cancer susceptibility
    Ana Osorio
    Group of Human Genetics, Human Cancer Genetics Programme, C Melchor Fernandez Almagro 3, Madrid, 28029, Spain
    Breast Cancer Res Treat 113:371-6. 2009
    ..Our analysis suggests that RAP80 and CCDC98 do not play an important role as high penetrance breast cancer susceptibility genes...
  10. ncbi Identification of a proliferation signature related to survival in nodal peripheral T-cell lymphomas
    Marta Cuadros
    Human Genetics Group and Genotyping Unit, Human Cancer Genetics Program, Spanish National Cancer Centre, Madrid, Spain
    J Clin Oncol 25:3321-9. 2007
    ..Initial expression profiling studies of T-cell lymphomas have been inconclusive in yielding clinically relevant insights. We applied DNA microarrays to gain insight into the molecular signatures associated with prognosis. Materials and..
  11. pmc Identification of amplified and highly expressed genes in amplicons of the T-cell line huT78 detected by cDNA microarray CGH
    Barbara Melendez
    Human Genetics Department, Spanish National Cancer Centre CNIO, c Melchor Fernéndez Almagro 6, 28029 Madrid, Spain
    Mol Cancer 4:5. 2005
    ..However, no such studies on T-cell lymphomas have been performed. To date T-cell lymphomas analyzed by the use of chromosome CGH have revealed only slight copy number alterations and not gene amplifications...
  12. ncbi Expression of CYP3A4 as a predictor of response to chemotherapy in peripheral T-cell lymphomas
    Cristina Rodriguez-Antona
    Hereditary Endocrine Cancer Group, Spanish National Cancer Centre, c Melchor Fernandez Almagro no 3, 28029 Madrid, Spain
    Blood 110:3345-51. 2007
    ..In conclusion, a high CYP3A4 tumoral expression could be useful to predict poor response to the standard PTCL chemotherapy; in these cases alternative chemotherapy combinations or doses should be explored...
  13. doi Integration of BRCA1-mediated miRNA and mRNA profiles reveals microRNA regulation of TRAF2 and NFκB pathway
    Miljana Tanic
    Human Genetics Group, Spanish National Cancer Research Centre CNIO, Melchor Fernandez Almagro 3, Madrid, 28029, Spain
    Breast Cancer Res Treat 134:41-51. 2012
    ..Our results demonstrate that integration of mRNA and miRNA associated with BRCA1 expression was useful to discover new miRNA-gene interactions as molecular events underlying BRCA1-mediated tumorigenesis...
  14. ncbi Allelic expression and quantitative RT-PCR study of TAp73 and DeltaNp73 in non-Hodgkin's lymphomas
    Marta Cuadros
    Human Genetics Department, Spanish National Cancer Centre CNIO, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Leuk Res 30:170-7. 2006
    ..Finally, we have confirmed that although DeltaNp73 over-expression could be an alternative mechanism of p53 inactivation, both alterations may appear together...
  15. ncbi Short telomeres are frequent in hereditary breast tumors and are associated with high tumor grade
    Beatriz Martinez-Delgado
    Human Genetics Group, Spanish National Cancer Research Centre CNIO and Centro de Investigación Biomédica en Red de Enfermedades Raras CIBERER, Madrid, Spain
    Breast Cancer Res Treat 141:231-42. 2013
    ..These findings highlight the potential interest of TL measurements as markers of aggressiveness in breast cancer...
  16. pmc Different incidence and pattern of p15INK4b and p16INK4a promoter region hypermethylation in Hodgkin's and CD30-Positive non-Hodgkin's lymphomas
    Maria J Garcia
    Department of Pathology, Fundacion Jimenez Diaz, Universidad Autonoma, Madrid, Spain
    Am J Pathol 161:1007-13. 2002
    ....
  17. pmc Molecular signature of response and potential pathways related to resistance to the HSP90 inhibitor, 17AAG, in breast cancer
    Magdalena Zajac
    Human Genetics Group, Spanish National Cancer Centre, Madrid, Spain
    BMC Med Genomics 3:44. 2010
    ..Since HSP90 inhibition leads to global depletion of oncogenic proteins involved in multiple pathways we applied global analysis using gene array technology to study new genes and pathways involved in the drug response in breast cancer...
  18. doi The miR-200 family controls beta-tubulin III expression and is associated with paclitaxel-based treatment response and progression-free survival in ovarian cancer patients
    Susanna Leskela
    Hereditary Endocrine Cancer Group, Human Cancer Genetics Programme, Spanish National Cancer Research Center, Melchor Fernandez Almagro 3, 28029 Madrid, Spain
    Endocr Relat Cancer 18:85-95. 2011
    ..Furthermore, these microRNAs might constitute the biomarkers of response to paclitaxel-based treatments and relapse/progression of advanced stage ovarian carcinoma patients...
  19. ncbi Gross SDHB deletions in patients with paraganglioma detected by multiplex PCR: a possible hot spot?
    Alberto Cascon
    Hereditary Endocrine Cancer Group, Centro Nacional de Investigaciones Oncoloógicas, Madrid, Spain
    Genes Chromosomes Cancer 45:213-9. 2006
    ....
  20. ncbi Characterization of the A673 cell line (Ewing tumor) by molecular cytogenetic techniques
    A Martinez-Ramirez
    Department of Human Genetics, Molecular Pathology Program, Spanish National Cancer Center CNIO, Instituto de Salud Carlos III, Madrid, Spain
    Cancer Genet Cytogenet 141:138-42. 2003
    ..Neither cytogenetics nor molecular alterations specific to RMS were found...
  21. ncbi Complex cytogenetic abnormalities including telomeric associations and MEN1 mutation in a pediatric ependymoma
    M Urioste
    Departamento de Genetica Humana, Programa de Patologia Molecular, Centro Nacional de Investigaciones Oncologicas CNIO, Instituto de Salud Carlos III, Ctra Majadahonda Pozuelo, Km 2, 28220 Majadahonda, Madrid, Spain
    Cancer Genet Cytogenet 138:107-10. 2002
    ..The chromosomal instability produced by the telomeric alterations and the mutation in the MEN1 gene could be important events in the tumorigenesis of ependymomas...
  22. ncbi A haplotype containing the p53 polymorphisms Ins16bp and Arg72Pro modifies cancer risk in BRCA2 mutation carriers
    A Osorio
    Department of Human Genetics, Spanish National Cancer Center, Madrid, Spain
    Hum Mutat 27:242-8. 2006
    ..Our results revealed a decrease in p53 apoptotic rate associated with the No Ins-72Pro haplotype...
  23. ncbi Mitotic catastrophe cell death induced by heat shock protein 90 inhibitor in BRCA1-deficient breast cancer cell lines
    Magdalena Zajac
    Grupo Genética Humana, Centro Nacional de Investigaciones Oncologicas, Melchor Fernandez Almagro 3, Madrid, Spain
    Mol Cancer Ther 7:2358-66. 2008
    ..Our observations show that BRCA1 mediates G(2)-M transition mainly through chek1 on 17-allyloamino-17-demethoxy-geldanamycin treatment...
  24. ncbi A rapid and easy method for multiple endocrine neoplasia type 1 mutation detection using conformation-sensitive gel electrophoresis
    Cebrián Arancha
    Department of Human Genetics, Molecular Pathology Program, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    J Hum Genet 47:190-5. 2002
    ..Mutation screening of the MEN1 gene using CSGE was demonstrated to be a fast, simple, and inexpensive method to study patients suspected of having MEN1 disease...
  25. ncbi Differential expression of NF-kappaB pathway genes among peripheral T-cell lymphomas
    B Martinez-Delgado
    Human Genetics Department, Centro Nacional de Investigaciones Oncologicas CNIO, Madrid, Spain
    Leukemia 19:2254-63. 2005
    ..The expression profile associated to reduced expression of NF-kappaB genes was significantly associated with shorter survival of patients and seems to be an independent prognostic factor in a multivariate analysis...
  26. ncbi Chromosomal changes pattern and gene amplification in T cell non-Hodgkin's lymphomas
    M Renedo
    Department of Human Genetics, Centro Nacional de Investigaciones Oncologicas, Madrid, Spain
    Leukemia 15:1627-32. 2001
    ..Patients with abnormal CGH profiles showed significant associations with advanced stage of disease, overexpression of P53, and higher proliferative index...